Article
Endocrinology & Metabolism
Dennis Boyle, Orit Levi-Shachar, Hila Z. Gvirts, Orna Zagoory-Sharon, Ruth Feldman, Yuval Bloch, Uriel Nitzan, Hagai Maoz
Summary: This study did not find a statistical correlation between the severity of ADHD symptoms and salivary OT levels in children. It suggests that impairments in the reactivity of the OT system, associated with interpersonal difficulties, may be a distinct aspect of the clinical presentation of ADHD, different from other symptoms.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Revital Hamerman, Noga Cohen
Summary: Previous research has shown that training individuals to recruit cognitive control before exposure to negative pictures can increase the likelihood of using reappraisal and achieving success. This study found that individuals with high ADHD symptoms were more likely to use reappraisal after training and experienced a greater reduction in negative emotions.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Rong Wang, Yongchen Fan, Ying Wu, Yu-Feng Zang, Changsong Zhou
Summary: The neural mechanisms and symptom correlations of ADHD may be shared between children and adults with ADHD. This study found that ADHD patients have a quadratic association in the whole-brain and most functional systems, while the limbic system shows a linear association with ADHD. The limbic system predicts hyperactivity better, while the salient attention system predicts inattention better.
Article
Pediatrics
Bezawit E. Kase, Nanda Rommelse, Qi Chen, Lin Li, Anneli Andersson, Ebba Du Rietz, Melissa Vos, Samuele Cortese, Henrik Larsson, Catharina A. Hartman
Summary: This study found a stable link between ADHD symptoms and BMI during adolescence, primarily with hyperactive and impulsive symptoms rather than inattention. No direct effects were found between ADHD symptoms and BMI increase or enhanced ADHD symptoms due to BMI during this period.
Article
Health Care Sciences & Services
Antonella Gambadauro, Simone Foti Randazzese, Arianna Curro, Francesca Galletta, Giuseppe Crisafulli, Lucia Caminiti, Eva Germano, Gabriella Di Rosa, Antonio Gennaro Nicotera, Sara Manti
Summary: This study aimed to analyze therapeutic adherence in patients with attention deficit hyperactivity disorder (ADHD) and allergic rhinitis (AR) and estimate the impact of adherence on ADHD symptoms. The results showed a negative correlation between therapeutic adherence and AR symptoms as well as ADHD scores. Better adherence to AR therapy was associated with a reduction in inattention symptoms in children with ADHD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Mana Oguchi, Toru Takahashi, Yusuke Nitta, Hiroaki Kumano
Summary: ADHD symptoms exacerbate the impact of procrastination and internalizing symptoms on emotional burden, but do not enhance the association between procrastination and internalizing symptoms. Procrastination should be the treatment target for individuals with ADHD and comorbid internalizing symptoms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Gustavo Sudre, Marine Bouyssi-Kobar, Luke Norman, Wendy Sharp, Saadia Choudhury, Philip Shaw
Summary: The study found significant heritability in the rates of change of white matter tract microstructural properties and connectivity between different brain networks. Changes in hyperactivity-impulsivity were associated with heritable changes in white matter tracts metrics and connectivity between attention and cognitive networks. This suggests that these heritable ADHD-associated neural phenotypes can be useful for future gene discovery and understanding.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
E. Martin, C. T. Dourish, R. Hook, S. R. Chamberlain, S. Higgs
Summary: The study found that symptoms of ADHD and impulsivity are associated with disordered eating, and depression plays a mediating role in this relationship.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Gustavo Sudre, Wendy Sharp, Paul Kundzicz, Marine Bouyssi-Kobar, Luke Norman, Saadia Choudhury, Philip Shaw
Summary: Research on a cohort of 362 youth found significant associations between certain measures of polygenic risk, cognition, and neuroimaging with the future course of ADHD symptoms, suggesting potential predictive power. Machine-learning algorithms showed good performance in classifying individuals with ADHD symptoms into different groups based on symptom course. These features warrant further exploration for their potential use as prognostic tools.
MOLECULAR PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Min-Jing Lee, Hsin-Chih Lai, Yu-Lun Kuo, Vincent Chin-Hung Chen
Summary: This study investigated the relationship between gut microbiome and emotional-behavioral symptoms in children with attention-deficit/hyperactivity disorder (ADHD). The results showed that children with ADHD had lower diversity in their gut microbiota compared to the healthy control group. Certain bacteria phylotypes were found to be significantly associated with emotional-behavioral symptoms in children with ADHD. However, further research is needed to understand the exact mechanisms underlying the role of gut microbiota in ADHD pathophysiology.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Getinet Ayano, Kim Betts, Robert Tait, Berihun Assefa Dachew, Rosa Alati
Summary: The study found that offspring of mothers with anxiety and comorbid anxiety and depressive symptoms have an increased risk of ADHD symptoms in late adolescence, while there is no such risk among offspring of mothers with depressive symptoms alone. Early screening and intervention for offspring with maternal anxiety and comorbid anxiety and depressive symptoms are recommended.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Developmental
Valerie Brandt, Praveetha Patalay, Julia Kerner Auch Koerner
Summary: This study used objective activity data to predict symptoms and diagnosis of ADHD, finding that less sedentary behavior at age 7 predicted more ADHD symptoms at age 14 and also predicted ADHD diagnosis at age 14.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Psychology, Developmental
Anna R. Van Meter, Margaret H. Sibley, Pankhuree Vandana, Boris Birmaher, Mary A. Fristad, Sarah Horwitz, Eric A. Youngstrom, Robert L. Findling, L. Eugene Arnold
Summary: The course of childhood-onset attention deficit hyperactivity disorder (ADHD) varies across individuals, with some experiencing persistent symptoms and others having fluctuating or remitting symptoms. This study examined the longitudinal course of ADHD symptoms and associated clinical characteristics in adolescents with childhood-onset ADHD. The findings showed that about half of the participants had a consistent course of ADHD, while nearly 40% experienced symptom remission and the remaining participants had fluctuating symptoms.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Review
Pediatrics
Huan Huang, Zhijuan Jin, Changshuang He, Shaoyu Guo, Yiwen Zhang, Minghui Quan
Summary: This study synthesized the current evidence on the effects of chronic exercise interventions (CEIs) on core symptoms and executive functions (EFs) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). The results showed that CEIs have a positive effect on overall core symptoms and EFs in children and adolescents with ADHD.
Article
Immunology
Ting-Sheng Lin, Jyh-Hong Lee, Li-Chieh Wang, Yao-Hsu Yang, Yu-Lung Lau, Wen- Lee, Yu-Tsan Lin, Bor-Luen Chiang, Hsin-Hui Yu
Summary: This study aimed to investigate the clinical features, genetic characteristics, treatment, and prognosis of patients with chronic granulomatous disease (CGD). Results showed that there were six patients with X-linked CGD and three patients with autosomal recessive CGD. Patients with X-linked CGD had earlier onset and diagnosis ages compared to those with autosomal recessive CGD. Prophylactic use of antibiotics, antifungal agents, and interferon-gamma might alleviate infection episodes in CGD patients. Rating: 7 out of 10.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Biochemistry & Molecular Biology
Vanessa Joy Timoteo, Kuang-Mao Chiang, Hsin-Chou Yang, Wen-Harn Pan
Summary: Human iron nutrition is influenced by both genetic and environmental factors. This study compared the genetic determinants of hemoglobin (Hb) concentration between Taiwanese Han Chinese and European Whites. The results showed consistent associations of specific SNPs in TMPRSS6, ABO, and PRKCE with Hb levels in both ethnic groups. Ethnic-specific associations were also observed, such as the association of AXIN1 with Hb levels in Taiwanese Han Chinese. The findings highlight the importance of both common and ethnic-specific genetic factors in Hb regulation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Virology
Yung-Yu Hsieh, Wei-Ming Chen, Kao-Chi Chang, Te-Sheng Chang, Chao-Hung Hung, Yao-Hsu Yang, Shui-Yi Tung, Kuo-Liang Wei, Chen-Heng Shen, Cheng-Shyong Wu, Yuan-Jie Ding, Jing-Hong Hu, Yu-Ting Huang, Meng-Hung Lin, Chung-Kuang Lu, Yi-Hsiung Lin, Ming-Shyan Lin
Summary: This retrospective cohort study aims to evaluate the real-world benefits of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on the occurrence and progression of esophageal varices (EV) in patients with hepatitis C virus (HCV)-related liver cirrhosis (LC). The study found that DAA-induced SVR was significantly associated with a lower risk of de novo EV occurrence and progression.
Article
Geriatrics & Gerontology
Shao-Yuan Chuang, Wen-Ling Liu, Hsing-Yi Chang, Chih-Cheng Hsu, Wen-Harn Pan
Summary: This study found that metabolic disorders in midlife are associated with physical and cognitive function decline in later life. Waist circumference and blood pressure are associated with physical function decline, while high blood pressure is associated with cognitive function decline. Managing waist circumference and blood pressure in midlife may slow the decline of physical and cognitive function in later life.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cell Biology
Ching-Hui Tsai, Alan Chuan-Ying Lai, Yu-Cheng Lin, Po-Yu Chi, Yun-Chi Chen, Yao-Hsu Yang, Chien-Han Chen, Sheng-Yeh Shen, Tsong-Lon Hwang, Ming-Wei Su, I-Ling Hsu, Yu-Chi Huang, Anke H. Maitland-van der Zee, Michael J. McGeachie, Kelan G. Tantisira, Ya-Jen Chang, Yungling L. Lee
Summary: The association between neutrophil extracellular traps (NETs) and response to inhaled corticosteroids (ICS) in asthma was investigated. It was found that neutrophils play a potential role in uncontrolled asthma, and NET abundance is associated with nonresponse to ICS. Furthermore, CCL4L2 was identified as a potential therapeutic target for individuals with asthma refractory to ICS.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Szu-Yun Wu, Yu-Yao Cheng, Hsing-Yi Chang, Pei-Hsuan Wang, I-Ching Hsieh, Nai-Hua Yeh, Kuo-Chin Huang, Wen-Harn Pan
Summary: To make learning more interesting and practical, geriatric community centers offer group activity sessions for older adults. A study conducted in Taiwan found that a 3-month nutrition intervention combined with exercise significantly improved dietary intake, frailty status, working memory, and reduced depression symptoms among older adults.
Article
Medicine, General & Internal
Shao-Ju Chien, Yi-Ju Tseng, Ying-Hua Huang, Hsi-Yun Liu, Yi-Hua Wu, Ling-Sai Chang, Yao-Hsu Yang, Ying-Jui Lin
Summary: This study compares clinical outcomes between pediatric patients with and without heart disease diagnosed with infective endocarditis (IE), and determines the risk of in-hospital death. The results show that patients with heart disease are more prone to streptococcal infections and cardiac complications, but have a lower mortality rate. Platelet count can serve as a risk factor for in-hospital mortality in pediatric patients with IE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Hsin-Yu Chang, Zon-Min Lee, Ling-Sai Chang, Wei-Ling Feng, Yao-Hsu Yang, Mei-Chen Ou-Yang
Summary: Food sensitization in early life can identify children at risk of developing allergic diseases. This study investigated sensitization to cow milk, egg whites, and wheat. Data from the Chang Gung Research Database was used to conduct a retrospective survey. The study found that boys were more likely to have a positive immunoglobulin E (IgE) reaction to cow milk and egg whites, and early-life sensitization to egg whites and wheat was associated with increased birth weight and length. A multivariate analysis revealed that egg white IgE positivity was linked to higher levels of total IgE, and younger age and higher birth weight and length were associated with food sensitization, particularly to egg whites and wheat.
Article
Medicine, General & Internal
Chao-Yang Chang, Yu-Ying Chen, Chih-Hsuan Lin, Jiunn-Ming Sheen, Wei-Tai Shih, Ko-Jung Chen, Yao-Hsu Yang
Summary: This study investigated the risk factors associated with recurrent intussusception in children aged ≤ 3 years. Male patients had a higher risk of recurrent intussusception, and higher birth weight may increase the risk. Surgical treatment and delayed onset of intussusception were associated with a reduced risk. It is suggested to closely follow up early infancy patients who received non-surgical treatment for potential recurrence.
Article
Otorhinolaryngology
Wei-Chih Chen, Ching-Nung Wu, Yu-Ming Wang, Tai-Jan Chiu, Shao-Chun Wu, Yao-Hsu Yang, Sheng-Dean Luo
Summary: The objective of this retrospective cohort study was to investigate the clinical benefit of routine esophageal screening in newly diagnosed HNSCC patients. The study found that esophageal screening can detect esophageal tumors at an early stage and improve overall survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Multidisciplinary Sciences
Ching-Yuan Wu, Yao-Hsu Yang, Yu-Shih Lin, Li-Hsin Shu, Yu -Ching Cheng, Hung-Te Liu, Yin -Yin Lin, I-Yun Lee, Wei -Tai Shih, Pei-Rung Yang, Ying-Ying Tsai, Geng-He Chang, Cheng-Ming Hsu, Reming-Albert Yeh, Yu-Huei Wu, Yu-Heng Wu, Rou-Chen Shen, Ming-Shao Tsai
Summary: The Chiehyuan herbal oral protection solution (GB-2) is a traditional Chinese medicine commonly used in Taiwan to combat SARS-CoV-2. This study found that GB-2 can reduce the expression of ACE2 and TMPRSS2 in oral mucosal cells. It also showed that GB-2 can decrease the entry efficiency of various variants of SARS-CoV-2 and block the interaction between ACE2 and the RBD with specific mutations. These findings suggest that GB-2 may be a potential candidate for further research as a preventive measure against SARS-CoV-2.
Article
Multidisciplinary Sciences
Ching-Yuan Wu, Yao-Hsu Yang, Yu-Shih Lin, Li-Hsin Shu, Hung-Te Liu, Yu-Huei Wu, Yu-Heng Wu
Summary: Danshen compound dihydroisotanshinone I (DT) inhibits viability of endometrial cancer cells by inducing apoptosis and ferroptosis, achieved by blocking GPX4 expression. In vivo experiments show that DT treatment significantly reduces tumor size without adverse effects.
Article
Clinical Neurology
Yu Lee, Pao-Yen Lin, Nien-Mu Chiu, Chi-Fa Hung, Liang-Jen Wang
Summary: Depressive disorder has a significant impact on patients' daily activities and quality of life, as well as on caregivers who may experience psychological distress. This study aimed to evaluate the prevalence and associated factors of depression in caregivers of patients with depressive disorder. The results showed that depression was the most common psychiatric diagnosis among caregivers, highlighting the importance of early psychiatric diagnosis and appropriate support for improving caregivers' quality of life.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Cell Biology
Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan, Bor-Luen Chiang
Summary: This study found that the polysaccharide PS-G from Ganoderma lucidum can be used as a potential adjuvant for developing mucosal bivalent vaccines against EV-A71 and EV-D68. The vaccines induced strong immune responses, producing specific antibodies that neutralized the viruses and provided protection.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
