Article
Agriculture, Dairy & Animal Science
Christina Bradshaw, Aridany Suarez Trujillo, Sarah M. Luecke, Lea D. Logan, Rodrigo Mohallem, Uma K. Aryal, Kara R. Stewart, Theresa M. Casey, Radiah C. Minor
Summary: The composition of milk in swine lactation changes significantly across the three phases, with the highest levels of fat and lactose in the early transitional period, and a significant decrease in protein content in colostrum. Proteomic analysis reveals specific proteins that vary in abundance throughout lactation, potentially reflecting mammary function and developmental needs of the neonate.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Fabian Lanuza, Tomas Merono, Raul Zamora-Ros, Nicola P. Bondonno, Agnetha Linn Rostgaard-Hansen, Alex Sanchez-Pla, Berta Miro, Francesc Carmona-Pontaque, Gabriele Riccardi, Anne Tjonneland, Rikard Landberg, Jytte Halkjaer, Cristina Andres-Lacueva
Summary: This study found that metabolites associated with plant-based dietary patterns were inversely associated with metabolic syndrome and its components. These findings may partially explain the effects of plant-based diets on cardiometabolic risk factors.
Article
Agriculture, Dairy & Animal Science
Prince Chisoro, Uffe Krogh, Peter Kappel Theil, Maria Eskildsen
Summary: The present study aimed to characterize the performance of suckling piglets from high prolific sows and investigate the impact of milk composition on piglet growth during a 4-wk lactation period. The results showed that the stage of lactation influenced piglet growth, milk intake, nutrients in milk, energy in milk, and the energy metabolism of the suckling piglets. Moreover, maximizing milk protein concentration does not optimize piglet growth.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Isabel Ten-Domenech, Mari Merce Cascant-Vilaplana, Victor Navarro-Esteve, Birgit Felderer, Alba Moreno-Gimenez, Ivan Rienda, Maria Gormaz, Marta Moreno-Torres, David Perez-Guaita, Guillermo Quintas, Julia Kuligowski
Summary: This preliminary study aimed to characterize the cellular metabolome of human milk over the course of lactation. Cells were isolated and characterized, and their metabolites were analyzed using mass spectrometry. The results showed significant variations in the cellular composition and phenotypic properties of human milk during lactation. This study provides a basis for future investigations on the metabolomic fraction of the cellular compartment of human milk.
Article
Plant Sciences
Shengrui Yao, Dikshya Sapkota, Jordan A. A. Hungerford, Roland D. D. Kersten
Summary: This study reveals the metabolic differences between jujube fruits from different cultivars and growth sites using metabolomics. The results show that the cultivar is the primary factor influencing metabolite profiles, while the location is secondary. Furthermore, specific metabolites vary significantly among different cultivars. This research provides valuable guidance for selecting jujube cultivars with nutritional and medicinal value and for fruit metabolic breeding.
Article
Microbiology
Leli Wang, Qihang Liu, Yuwei Chen, Xinlei Zheng, Chuni Wang, Yining Qi, Yachao Dong, Yue Xiao, Cang Chen, Taohong Chen, Qiuyun Huang, Zongzhao Zhai, Cimin Long, Huansheng Yang, Jianzhong Li, Lei Wang, Gaihua Zhang, Peng Liao, Yong-Xin Liu, Peng Huang, Jialu Huang, Qiye Wang, Huanhuan Chu, Jia Yin, Yulong Yin
Summary: A study identified a potentially probiotic strain of Pediococcus in sow milk that confers antioxidant capacity by activating the Nrf2-Keap1 signaling pathway in piglets. The findings provide useful resources for understanding the relationship between maternal microbiota and offspring.
Article
Nutrition & Dietetics
Dominick J. Lemas, Xinsong Du, Bethany Dado-Senn, Ke Xu, Amanda Dobrowolski, Marina Magalhaes, Juan J. Aristizabal-Henao, Bridget E. Young, Magda Francois, Lindsay A. Thompson, Leslie A. Parker, Josef Neu, Jimena Laporta, Biswapriya B. Misra, Ismael Wane, Samih Samaan, Timothy J. Garrett
Summary: This study aims to identify unique metabolites that may impact infant health outcomes by analyzing the metabolome of human and bovine milk at 2 weeks of life. The results showed that more than 80% of the milk metabolome is shared between human and bovine milk during early lactation. These findings highlight untargeted metabolomics as a potential strategy to identify unique and shared metabolites in bovine and human milk that may relate to and impact infant health outcomes.
Article
Medicine, General & Internal
Konstantinos Karampatsas, Amadou Faal, Mustapha Jaiteh, Isabel Garcia-Perez, Sean Aller, Alexander G. Shaw, Aleksandra Kopytek, Adam A. Witney, Kirsty Le Doare
Summary: The composition of microbiota and metabolomic content in breast milk can influence the colonization of intestinal and respiratory microbiota and the development of the mucosal immune system in infants. This study found that the composition of breast milk changes during lactation and the bacterial communities in infant gut and respiratory system are different from maternal gut and breast milk.
Article
Agriculture, Multidisciplinary
Ling Mo, Chaochao Zhao, Bo Huang, Jiawei Niu, Siyan Hong, Jingjing Li, Yintao Lin, Fengqiong Qin
Summary: Intake of oxidized milk during pregnancy may increase the risk of liver and kidney injury in male offspring by interfering with amino acid and energy metabolism, leading to oxidative stress and inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Julia E. Stroud, Michael S. Gale, Sara R. Zwart, Martina Heer, Scott M. Smith, Tony Montina, Gerlinde A. S. Metz
Summary: This study investigated the longitudinal metabolic changes of male and female astronauts during long-duration missions to the International Space Station using a metabolomics-based approach. The research found that space travel resulted in sex-specific changes in energy metabolism, bone and muscle regulation, immunity, and macromolecule synthesis. Furthermore, metabolic signatures suggest that females require more time to adjust to returning to Earth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Plant Sciences
Xinxin Zhang, Yuxi Li, Huiling Yan, Kewei Cai, Hanxi Li, Zhiwei Wu, Jianguo Wu, Xiangdong Yang, Haichen Jiang, Qingcheng Wang, Guanzheng Qu, Xiyang Zhao
Summary: Light is a vital energy source and regulator for plant growth and development. The mechanism of plant growth and development under low light conditions is a significant scientific question. This study measured the growth and physiological indexes of Juglans mandshurica under different shade treatments and analyzed the molecular mechanism and metabolite accumulation under light stress. The results showed that seedling height was significantly higher in the shade treatment group, especially with 50% light intensity. The transcriptome and metabolome analyses revealed differential gene expression and metabolite accumulation related to photosynthesis, plant hormone signal transduction, and chlorophyll synthesis pathways. Flavonoids were identified as the major differential metabolites under light stress. These findings enhance our understanding of the molecular mechanisms and metabolite accumulation under light stress in J. mandshurica.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Xing Du, Qiqi Li, Liu Yang, Qiang Zeng, Siqi Wang, Qifa Li
Summary: The study revealed that NORFA plays a crucial role in controlling the transcriptome of porcine granulosa cells, affecting cell functions and survival status, involving multiple signaling pathways. Its deficiency may lead to abnormal apoptosis and impaired function of porcine granulosa cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Hanqing Song, Wei Chai, Fei Yang, Man Ren, Fang Chen, Wutai Guan, Shihai Zhang
Summary: The study showed that dietary supplementation of MGDG can effectively reduce back fat loss in sows during lactation, lower inflammatory factor levels, and control total cholesterol concentrations.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shelley Jager, Dario A. T. Cramer, Max Hoek, Nadia J. Mokiem, Britt J. van Keulen, Johannes B. van Goudoever, Kelly A. Dingess, Albert J. R. Heck
Summary: In this study, the proteoform profiles of A1AT purified from human serum and milk were compared to determine the origin of human milk A1AT. The results showed that the proteoform profiles of the same donor were highly similar between serum and milk, while they were highly distinct between different donors. This variability was mainly due to differences in the abundances of different N-glycoforms.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Nutrition & Dietetics
Linda P. Siziba, Marko Mank, Bernd Stahl, John Gonsalves, Bernadet Blijenberg, Dietrich Rothenbacher, Jon Genuneit
Summary: The study found that HMO concentrations in breast milk generally decreased over lactation, with some exceptions. The trajectories of HMO concentrations were mainly attributed to milk group and secretor status. Further investigation is warranted to determine the potential impact of these variations on child health outcomes.
Article
Agriculture, Multidisciplinary
Baichuan Deng, Xiaojun Ni, Zhenya Zhai, Tianyue Tang, Chengquan Tan, Yijing Yan, Jinping Deng, Yulong Yin
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Microbiology
Hao Wang, Yongcheng Ji, Cong Yin, Ming Deng, Tianyue Tang, Baichuan Deng, Wenkai Ren, Jinping Deng, Yulong Yin, Chengquan Tan
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Baichuan Deng, Hongrong Long, Tianyue Tang, Xiaojun Ni, Jialuo Chen, Guangming Yang, Fan Zhang, Ruihua Cao, Dongsheng Cao, Maomao Zeng, Lunzhao Yi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Chengjun Hu, Yunyu Yang, Jiaying Li, Hao Wang, Chuanhui Cheng, Linfang Yang, Qiqi Li, Jinping Deng, Zuman Liang, Yulong Yin, Zhengjtm Xie, Chengquan Tan
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Reproductive Biology
Hao Wang, Chengjun Hu, Chuanhui Cheng, Jiajie Cui, Yongcheng Ji, Xiangyu Hao, Qiqi Li, Wenkai Ren, Baichuan Deng, Yulong Yin, Jinping Deng, Chengquan Tan
Article
Microbiology
Wence Wang, Shuangshuang Zhai, Yaoyao Xia, Hao Wang, Dong Ruan, Ting Zhou, Yongwen Zhu, Hongfu Zhang, Minhong Zhang, Hui Ye, Wenkai Ren, Lin Yang
Article
Cell Biology
Yuanyuan Zhao, Jing Wang, Hao Wang, Yonggang Huang, Ming Qi, Simeng Liao, Peng Bin, Yulong Yin
MEDIATORS OF INFLAMMATION
(2020)
Article
Agriculture, Dairy & Animal Science
T. Tang, C. M. C. van der Peet-Schwering, N. M. Soede, B. F. A. Laurenssen, E. M. A. M. Bruininx, E. J. Bos, W. J. J. Gerrits
Summary: Accurate estimation of individual feed intake in pigs is essential for understanding performance variations between individual animals. This study investigated dual marker methods to estimate individual feed intake by measuring the ratio of two indigestible markers in feces. The results showed that the dual marker technique could accurately predict feed intake in pigs under specific dosage and timing conditions, providing valuable insights for complex feeding systems.
Article
Agriculture, Dairy & Animal Science
T. Tang, W. J. J. Gerrits, I. Reimert, C. M. C. van der Peet-Schwering, N. M. Soede
Summary: This study investigated the causes of variation in body weight gain and dry matter intake of solid feed in piglets in a multi-suckling system. The results showed that genetic background, birth weight, feed intake, behavior, and skin lesions collectively influenced body weight gain and dry matter intake, but these factors explained only a portion of the variation, indicating a need for further investigation.
Article
Agriculture, Dairy & Animal Science
Tianyue Tang, Walter J. J. Gerrits, Nicoline M. Soede, Carola M. C. van der Peet-Schwering, Inonge Reimert
Summary: The study examined the timing of grouping and split-weaning as two intervention strategies to improve the body weight gain of low birthweight piglets in a multi-suckling system. The results showed that the timing of grouping and split-weaning had no significant effects on body weight gain, but did affect feed intake and suckling behaviors of the piglets.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Tianyue Tang, Walter J. J. Gerrits, Carola M. C. van der Peet-schwering, Nicoline M. Soede, Inonge Reimert
Summary: Multi-suckling systems aim to improve animal welfare, but there is a large variation in piglet growth rate. This study investigated the relationship between birthweight and growth rate, and other piglet traits in this system. It was found that birthweight was positively related to survival, growth rate, suckling behavior, milk and feed intake, and skin lesion scores. Regardless of birthweight, fast-growing piglets tended to eat more feed, were less often present at teats of unfamiliar sows, and had more skin lesions.