Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease
出版年份 2018 全文链接
标题
Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease
作者
关键词
-
出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-03-13
DOI
10.1038/s41598-018-23122-x
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Extracellular Zn2+Is Essential for Amyloid β1–42-Induced Cognitive Decline in the Normal Brain and Its Rescue
- (2017) Atsushi Takeda et al. JOURNAL OF NEUROSCIENCE
- Fibril structure of amyloid-β(1–42) by cryo–electron microscopy
- (2017) Lothar Gremer et al. SCIENCE
- NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide
- (2017) Nanditha G. Nair et al. JOURNAL OF ALZHEIMERS DISEASE
- PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses
- (2017) Noel G. Faux et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer’s amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity
- (2017) Tien-Wei Lin et al. PLoS One
- Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways
- (2016) Fabiana Morroni et al. BEHAVIOURAL BRAIN RESEARCH
- Alzheimer's disease: The amyloid hypothesis on trial
- (2016) Judith R. Harrison et al. BRITISH JOURNAL OF PSYCHIATRY
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- Structural Insight into an Alzheimer’s Brain-Derived Spherical Assembly of Amyloid β by Solid-State NMR
- (2015) Sudhakar Parthasarathy et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A novel method for expression and purification of authentic amyloid-β with and without 15N labels
- (2015) Yi-Hung Liao et al. PROTEIN EXPRESSION AND PURIFICATION
- Protection of TGF-β1 against Neuroinflammation and Neurodegeneration in Aβ1–42-Induced Alzheimer’s Disease Model Rats
- (2015) Jia-Hui Chen et al. PLoS One
- The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway
- (2014) Yu-Jen Chang et al. FEBS Journal
- Kinetic Intermediates in Amyloid Assembly
- (2014) Chen Liang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Biometals and Their Therapeutic Implications in Alzheimer’s Disease
- (2014) Scott Ayton et al. Neurotherapeutics
- Amyloid β-Mediated Zn2+ Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit
- (2014) Atsushi Takeda et al. PLoS One
- Alzheimer’s Amyloid-β Oligomers Rescue Cellular Prion Protein Induced Tau Reduction via the Fyn Pathway
- (2013) Rong-Jie Chen et al. ACS Chemical Neuroscience
- Extracellular chaperones prevent Aβ42-induced toxicity in rat brains
- (2013) Roberta Cascella et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
- (2012) I. W. Hamley CHEMICAL REVIEWS
- Metallostasis in Alzheimer's disease
- (2012) Scott Ayton et al. FREE RADICAL BIOLOGY AND MEDICINE
- Zn2+-Aβ40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons
- (2012) Inna Solomonov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies
- (2012) Wei-Ting Chen et al. PLoS One
- Zn++ Binding Disrupts the Asp23-Lys28 Salt Bridge without Altering the Hairpin-Shaped Cross-β Structure of Aβ42 Amyloid Aggregates
- (2011) Venus Singh Mithu et al. BIOPHYSICAL JOURNAL
- Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation
- (2011) Wei-Ting Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A New Structural Model of Aβ40Fibrils
- (2011) Ivano Bertini et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity
- (2011) Vello Tõugu et al. Metallomics
- Advances in metabolite identification
- (2011) David S Wishart Bioanalysis
- Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites
- (2011) Darragh B. Freir et al. Nature Communications
- Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features
- (2010) Giorgio Giaccone et al. ACTA NEUROPATHOLOGICA
- Molecular mechanism of Thioflavin-T binding to amyloid fibrils
- (2010) Matthew Biancalana et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Chemical shift tensor – The heart of NMR: Insights into biological aspects of proteins
- (2010) Hazime Saitô et al. PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- Interpreting protein chemical shift data
- (2010) David S. Wishart PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-β
- (2009) Ashley A. Reinke et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation
- (2009) Kana Tsukuda et al. HYPERTENSION
- Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease
- (2009) Guriqbal S. Basi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation
- (2009) Jessica W. Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Role for Synaptic Zinc in Activity-Dependent A Oligomer Formation and Accumulation at Excitatory Synapses
- (2009) A. Deshpande et al. JOURNAL OF NEUROSCIENCE
- Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
- (2009) Juha Laurén et al. NATURE
- Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
- (2009) Summer L. Bernstein et al. Nature Chemistry
- A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis
- (2009) G. Di Fede et al. SCIENCE
- Alzheimer's disease, metal ions and metal homeostatic therapy
- (2009) Paolo Zatta et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
- (2008) Dennis J. Selkoe BEHAVIOURAL BRAIN RESEARCH
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides
- (2008) Velia Minicozzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid β-Protein Assembly and Alzheimer Disease
- (2008) Robin Roychaudhuri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
- (2008) Lars Lannfelt et al. LANCET NEUROLOGY
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
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