Article
Pharmacology & Pharmacy
Mahsa Sayed Tabatabaei, Farzad Kobarfard, Reza Aboofazeli, Sorour Ramezanpour, Hamid Reza Moghimi
Summary: In this study, different fatty acid conjugates of dipeptide KT with varying chain lengths (C6-C18) were investigated to enhance the skin absorption of anti-aging peptides. The synthesized conjugates outperformed the commercialized Pal-KT in terms of molecular weight, lipophilicity, melting point, and aqueous solubility. Moreover, they demonstrated amphiphilicity-related features and exhibited significantly higher skin permeation compared to KT.
Article
Pharmacology & Pharmacy
Sooho Yeo, Sukkyun Jung, Heui Kyoung Cho, Young Ho Kim, Gi Hwan Kim, Dohyun Kim, Byoung Hyen Ko, Jaehwi Lee
Summary: In this study, an elastic artificial skin for treating wrinkles with poor skin permeation of adenosine was developed, along with a lipid-based nano-carrier to enhance the skin permeation of adenosine. The results showed that the elastic artificial skin incorporated with adenosine-loaded solid lipid nanoparticles exhibited better drug release characteristics.
Article
Pharmacology & Pharmacy
Jeeho Sim, SeongDae Gong, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Jaesung Park, Youngchan Kim, Hyunkyu Lee, Hyunji Jung, Youseong Kim, Chansol Jeon, Hyeri Ahn, Minkyung Kim, Jaibyung Choi, Ho Lee, Hyungil Jung
Summary: This study used a dissolvable micro-channeling system (DMCS) to enhance the delivery of serum through micro-channels embedded with dissolving microneedles (DMNs). The results showed that this combinatorial serum application method significantly improved the transdermal delivery of active compounds and had better skincare efficacy compared to only using serum application.
Article
Biochemistry & Molecular Biology
Sherif Ashraf Fahmy, Asmaa Ramzy, Amany M. Sawy, Mohamed Nabil, Mohamed Z. Gad, Mohamed El-Shazly, Mourad A. M. Aboul-Soud, Hassan Mohamed El-Said Azzazy
Summary: This study designed and optimized a niosomal vesicular nanoplatform loaded with ozonated olive oil (OL) to improve its solubility, skin permeation, and anticancer activity. The encapsulated OL showed enhanced water solubility, skin permeation, and double the anticancer activity compared to free OL.
Review
Chemistry, Applied
Seyedeh Maryam Mortazavi, Hamid Reza Moghimi
Summary: This paper thoroughly reviews the possibility of skin permeation of anti-wrinkle peptides and the various approaches that have been used to increase their permeability. The results indicate that the skin permeability of these peptides can be successfully increased using enhancement methods.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Zelika Mega Ramadhania, Dong Uk Yang, Moelyono Moektiwardojo, Yaxi Han, Jin Kyu Park, Esrat Jahan Rupa, Deok Chun Yang, Seung Jin Lee, Se Chan Kang
Summary: In this study, fermented black ginseng (FBG) was shown to have anti-skin aging properties, including anti-melanogenic, anti-wrinkle, and antioxidant activities. FBG inhibited melanin production, reduced wrinkles, and showed antioxidant effects. FBG demonstrated better results compared to black ginseng (BG) and white ginseng (WG).
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Anna Otterbach, Alf Lamprecht
Summary: Dimethyl sulfoxide is a widely used dermal penetration enhancer, but its volatility poses challenges in incorporating it into transdermal patches. Research shows that transdermal systems containing DMSO can enhance drug permeation through skin and inhibit drug recrystallization.
Article
Plant Sciences
Adchara Prommaban, Suwannee Sriyab, Pachabadee Marsup, Waranya Neimkhum, Jakkapan Sirithunyalug, Songyot Anuchapreeda, Chaiwat To-anun, Wantida Chaiyana
Summary: This study compared the chemical profiles, antioxidant, anti-tyrosinase, and skin extracellular matrix degradation inhibition between mycelium and fruiting body of C. militaris and I. tenuipes. The extracts from both fungi were found to contain a wide range of bioactive compounds, with the fruiting body extract of I. tenuipes showing exceptional antioxidant and anti-wrinkle properties.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lin Hou, Wei Wang, Mei-Kun Wang, Xue-Song Song
Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiabing An, Ivan Steve Nguepi Tsopmejio, Zi Wang, Wei Li
Summary: This review summarizes the relevant literature on peptides from the past decade, including extraction, modification, and synthesis. The unique beneficial effects of peptides on the skin were extensively explored, providing ideas for peptide development and innovation. Additionally, the knowledge foundation for the clinical application of peptides was laid.
Article
Nanoscience & Nanotechnology
Jie Chen, Xiaolu Xia, Xiaoqian Yan, Wenjing Wang, Xiaoyi Yang, Jie Pang, Renhui Qiu, Shuyi Wu
Summary: In this study, biomass flexible piezoresistive sensors were prepared by mimicking the microstructures of human skins, using konjac glucomannan and k-carrageenan composite hydrogel. The sensor demonstrated high sensitivity, fast response time, and excellent stability, making it suitable for detecting various slight body movements. Machine learning was utilized to enhance the identification of similar and short throat vibration signals, and experiments and numerical simulations were conducted to understand the mechanism of sensor preparation and sensing performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Wanessa S. C. Quintao, Amandda E. Silva-Carvalho, Leandro A. Hilgert, Tais Gratieri, Marcilio Cunha-Filho, Felipe Saldanha-Araujo, Guilherme M. Gelfuso
Summary: This study aims to develop a chitosan-based film for the transdermal delivery of naringenin, a bioflavonoid with anti-inflammatory activity, for long-term treatment of inflammatory conditions. The study found that naringenin has anti-inflammatory effects and can inhibit T-cell proliferation. A chitosan film was successfully developed, which can continuously release naringenin across the skin over 72 hours.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Mi Jung Kim, Kyung Jong Won, Do Yoon Kim, Yu Rim Won, Nan Young Kim, Da Kyoung Lee, Bok Sil Hong, Hwan Myung Lee
Summary: This study investigated the effects of Caragana sinica flower absolute (CSFAb) on skin repair responses, including wound healing and anti-wrinkle effects. The results showed that CSFAb promoted proliferation, migration, and sprouting of keratinocytes, and influenced various signaling pathways and molecular phosphorylation levels. These findings suggest the potential use of CSFAb in skin repair and care preparations.
Article
Dermatology
Daejin Min, Yujin Ahn, Hae Kwang Lee, Woonggyu Jung, Hyoung-June Kim
Summary: In this study, a novel in vitro technique was developed to directly detect skin wrinkles using 3D tissue engineering and Swept Source-Optical Coherence Tomography (SS-OCT) imaging technologies. Full-thickness skin wrinkle mimics were fabricated and the size of the wrinkles was validated using image analysis. The results showed that retinoic acid treatment significantly decreased both the depth and width of wrinkles.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xinyue Wen, Tobias Foller, Xiaoheng Jin, Tiziana Musso, Priyank Kumar, Rakesh Joshi
Summary: Water transport through graphene oxide membranes is influenced by interactions between water molecules and impurities on the channel walls. Experimental results show that the slip length of nanochannels decay exponentially with the hydrated diameter of intercalated cations, confirming the governing role of interactions between water molecules and impurities on water transport.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Marcus Lee, Sathya Kannan, Giridharan Muniraj, Vinicius Rosa, Wen Feng Lu, Jerry Y. H. Fuh, Gopu Sriram, Tong Cao
Summary: The role of angiogenesis in health and disease is gaining attention. Two-photon excitation fluorescence microscopy provides high-quality imaging for studying the molecular mechanisms of angiogenesis. Understanding angiogenesis is important for studying disease responses, tissue model development, and therapeutic strategies.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Vinicius Rosa, Gopu Sriram, Neville McDonald, Bruno Neves Cavalcanti
Summary: This review discusses various methods used in research and clinical practice for pulp regeneration, including laboratory-based methods, animal studies, and clinical translation. It highlights the advantages, disadvantages, and contributions of these methods to pulp regeneration.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shijia Hu, Giridharan Muniraj, Apurva Mishra, Kanglun Hong, Jing Li Lum, Catherine Hsu Ling Hong, Vinicius Rosa, Gopu Sriram
Summary: The study characterizes the cytotoxicity potential of silver diamine fluoride (SDF) on dental pulp stem cells (DPSC) and gingival equivalents. The results show that SDF can penetrate dentin and induce death of pulp cells, while also disrupting gingival epithelial integrity and causing mucosal corrosion.
Article
Chemistry, Multidisciplinary
Vinicius Rosa, Shruti Vidhawan Agarwalla, Bing Liang Tan, Si Yi Choo, Yu Fan Sim, Freddy Yin Chiang Boey, Sudarshan Anantharaman, Mandeep Singh Duggal, Kai Soo Tan
Summary: The study evaluated the ability of the D-DART to reduce the spread of aerosols generated during dental treatment. The results showed that the D-DART effectively contained and prevented the spread of aerosols generated during deep scaling procedures.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Melissa Mei-Yi Khor, Vinicius Rosa, Chien Joo Sim, Catherine Hsu Ling Hong, Shijia Hu
Summary: This study aimed to investigate the effect of silver diamine fluoride (SDF) on the bond strength of glass ionomer cement (GIC). The results showed that application of SDF on sound dentin before GIC restoration may decrease the bond strength.
DENTAL MATERIALS JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Ritika Malhotra, Christian Eberhard Halbig, Yu Fan Sim, Chwee Teck Lim, David Tai Leong, A. H. Castro Neto, Slaven Garaj, Vinicius Rosa
Summary: Graphene and other 2D materials have made significant contributions to science and technology. However, the lack of quality control and toxicity assessment has become a concern. This study investigates the cytotoxicity of 36 products labeled as graphene and reveals that the presence of impurities is the main determinant of cellular toxicity in these commercially available materials.
NPJ 2D MATERIALS AND APPLICATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mi-Ah Kim, Vinicius Rosa, Kyung-San Min
Summary: This study investigated the antibacterial efficacy and cytotoxicity of two graphene derivatives - graphene oxide (GO) and reduced graphene oxide (RGO) - against Enterococcus faecalis in biofilms formed on hydroxyapatite discs. GO and RGO had similar antibacterial effects on E. faecalis biofilms. SEM images showed the ability of GO and RGO to disrupt E. faecalis, while GO had significantly higher cytotoxicity than RGO. The results suggest that RGO has the potential to be used as a more effective disinfecting agent than GO.
DENTAL MATERIALS JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Junying Zhang, Yiwen Zhang, Hufang Wang, Wenlin Chen, Aiyu Lu, Hailiang Li, Lifeng Kang, Chunyong Wu
Summary: This study prepared a solid dispersion of CUR in Mogroside V (Mog-V), a non-nutritive natural sweetener, which can self-assemble into micelles in water and effectively improve the water solubility and oral absorption of CUR. The results showed that compared with pure CUR crystals, the solid dispersion increased the solubility of CUR by nearly 6000 times and the oral absorption of CUR by 29 folds in rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Klaudia Englezos, Lingxin Wang, Edwin C. K. Tan, Lifeng Kang
Summary: The healthcare dynamic has shifted to patient-centred care, requiring more individualised therapies. However, the pharmaceutical industry has not fully adapted to this shift, preventing pharmacists from providing completely personalised medicine to patients. This article reviews the limitations of current pharmaceutical manufacturing methods, discusses the benefits of 3D printing for personalised medicine, and explores the implications for pharmacy practice and policy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Toan V. Phan, Yamin Oo, Khurshid Ahmed, Teerapat Rodboon, Vinicius Rosa, Supansa Yodmuang, Joao N. Ferreira
Summary: Hyposalivation and severe dry mouth syndrome are common complications in HNC patients after radiation therapy. Conventional treatment with sialogogues is limited due to the destruction of the salivary gland's secretory parenchyma and reduced regenerative potential. Adipose mesenchymal stem cells (AdMSC) show promise in addressing this issue.
Article
Biotechnology & Applied Microbiology
Yunong Yuan, Yiting Han, Chun Wei Yap, Jaspreet S. S. Kochhar, Hairui Li, Xiaoqiang Xiang, Lifeng Kang
Summary: Stratum corneum as the outermost layer of the skin prevents external substances from entering the human body. Microneedles can facilitate drug permeation through the skin by penetrating the stratum corneum. Machine learning methods are employed to predict drug permeation through the skin, eliminating the need for costly and time-consuming experiments.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Arief Cahyanto, Marcos Vinicius Surmani Martins, Otavio Bianchi, Deepa Perumbodathu Sudhakaran, Nikolaos Sililkas, Sergio Graniero Echeverrigaray, Vinicius Rosa
Summary: This study investigated the effects of graphene oxide (GO) on the reliability and lifetime of PMMA. The results showed that GO improved the fatigue resistance and predicted lifetime of PMMA, but had no significant effect on its Weibull parameters.
Article
Dentistry, Oral Surgery & Medicine
A. Cahyanto, P. Rath, T. X. Teo, S. S. Tong, R. Malhotra, B. N. Cavalcanti, L. Z. Lim, K. S. Min, D. Ho, W. F. Lu, V. Rosa
Summary: This study used Taguchi's methods and genetic algorithms to optimize the properties of calcium silicate cements, achieving personalized treatment for patients' specific needs. By simultaneously analyzing multiple input factors, the study successfully designed cement formulations with predicted properties, which were experimentally validated. The study also demonstrated the bioactivity of the cement in dental pulp stem cells.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Dentistry, Oral Surgery & Medicine
Shiyao Liu, Ahmed El-Angbawi, Ruidong Ji, Vinicius Rosa, Nick Silikas
Summary: The objective of this study was to investigate the effects of adding graphene to orthodontic fixed retainer adhesives on colour and optical transmission. The results showed that adding graphene significantly darkened the adhesive colour and reduced translucency, but had no adverse effect on degree of conversion. The optical transmission of the adhesive decreases with increasing graphene concentration.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)