Review
Environmental Sciences
Wanitcha Gumtorntip, Nuntana Kasitanon, Worawit Louthrenoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review summarizes and discusses the association between air pollutants and the development or aggravation of rheumatoid arthritis (RA). The findings suggest that air pollutants can stimulate immunological processes and inflammatory mediators and autoantibodies productions. Furthermore, air pollutants can induce and aggravate RA disease activity. However, discrepancies in the results highlight the need for future studies to elucidate these mechanisms and identify reliable biomarkers for individual susceptibility and disease activity assessment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Immunology
Mark A. Hutchinson, Han-Sol Park, Kimberly J. Zanotti, Juan Alvarez-Gonzalez, Jing Zhang, Li Zhang, Richard Telljohann, Mingyi Wang, Edward G. Lakatta, Patricia J. Gearhart, Robert W. Maul
Summary: Current models suggest that IgM has a protective role while IgG is inflammatory in atherosclerosis. Experimenting with mice lacking IgG production, it was found that they had significantly reduced plaque formation and elevated levels of IgM antibodies. Specific antibody analysis revealed that high levels of antibodies against MDA-oxLDL in mice can block macrophage recruitment into plaques.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pit Hui Lew, Mohammad Tariqur Rahman, Syarida Hasnur Safii, Nor Adinar Baharuddin, Peter Mark Bartold, Sargunan Sockalingam, Noor Lide Abu Kassim, Rathna Devi Vaithilingam
Summary: The study found that serum ACPA levels were significantly higher in individuals with RAPd and RA compared to healthy individuals, but there was no significant correlation between ACPA levels and clinical periodontal and RA parameters within the respective groups. Further studies are needed to investigate the causal link between RA and Pd for such a trend.
Article
Biochemistry & Molecular Biology
Salome Araujo-Abad, Jose L. Neira, Bruno Rizzuti, Pilar Garcia-Morales, Camino de Juan Romero, Patricia Santofimia-Castano, Juan Iovanna
Summary: The nuclear protein 1 (NUPR1) and its paralogue nuclear protein 1-like (NUPR1L) are intrinsically disordered proteins involved in stress-mediated cellular conditions. They interact with peptidyl-arginine deiminase 4 (PADI4) in vitro and in cellulo, and the binding regions have been identified. The NUPR1/PADI4 complex may play important roles in DNA repair, metastasis, and protein citrullination.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Physiology
Gianluigi Pironti, Stefano Gastaldello, Dilson E. Rassier, Johanna T. Lanner, Mattias Carlstrom, Lars H. Lund, Hakan Westerblad, Takashi Yamada, Daniel C. Andersson
Summary: This study used a mouse model of rheumatoid arthritis (RA) to find evidence of impaired cardiac contractile function associated with reduced Ca2+ sensitivity, increased expression of PAD2, and citrullination of alpha-actin, which was triggered by TNF-alpha. This provides molecular and physiological evidence for acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.
Article
Immunology
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng
Summary: Citrullinated neoepitopes have been identified as key triggers for the synthesis of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients. This study investigated the expression of citrullinated proteins and enzymes in human platelets and platelet-derived microparticles (PDP). The results revealed the presence of citrullinated autoantigens in platelets and PDPs, suggesting that they could be potential targets for ACPA in RA. These findings provide valuable insights into the role of platelets in triggering ACPA production in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Energy & Fuels
Hui Chen, Wenjing Sun, Xiaomin Hu, Qi Wang, Tong Wu, Shuang An, Chenyu Ding, Congmei Chen, Lihong Huang, Ning Wang
Summary: Nickel-based catalysts show good initial activity in the ATR of acetic acid but face deactivation issues. Ni-2W/SiO2 catalyst with 2 wt% W decoration exhibits the best catalytic performance, maintaining 100% conversion of acetic acid and 2.8 mol-H2/mol-HAc hydrogen yield without sintering or carbon deposition. The excellent catalytic performance is attributed to the interaction between WO2 and Ni, the electron donor effect of WO2, and the enhanced adsorption and dehydrogenation of CH3COOH on the WO2/Ni(1 1 1) interface.
Article
Biochemistry & Molecular Biology
Eui-Jong Kwon, Ji Hyeon Ju
Summary: Rheumatoid arthritis (RA) is triggered by a complex interplay of genetic, environmental, and immunologic factors, with posttranslational modifications and cell death mechanisms playing a role in the disease's pathogenesis. Certain microbial infections may induce autoantigens, while anti-modified protein antibodies are crucial in prediction, diagnosis, and prognosis of RA. Smoking is associated with both PTMs and AMPAs in RA development, although evidence linking smoking to the generation of AMPAs is currently lacking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eui-Jong Kwon, Ji Hyeon Ju
Summary: Rheumatoid arthritis is influenced by genetic, environmental, and immunological factors, with protein posttranslational modifications, cell death mechanisms, and autoantigenicity playing crucial roles in its pathogenesis. Microbial infections can induce autoantigens, while anti-modified protein antibodies are important for prediction, diagnosis, and prognosis. Smoking is associated with both posttranslational modifications and anti-modified protein antibodies in RA, although evidence of smoking inducing their generation is lacking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Anthony Murphy, Nirmal Roy, Hong Sun, Chunyuan Jin, Max Costa
Summary: Nickel is carcinogenic to humans, primarily through epigenetic reprogramming and hypoxia mimicry. NUPR1 and AP-1 are stress-response genes overexpressed in cancers, with potential roles in chemoresistance and cancer development. Induction of NUPR1 and AP-1 following nickel exposure suggests their involvement in lung carcinogenesis mechanisms.
Article
Multidisciplinary Sciences
Elodie Fels, Marie-Eve Mayeur, Estelle Wayere, Clementine Vincent, Celine Malleval, Jerome Honnorat, Olivier Pascual
Summary: LGI1, a neuronal secreted protein highly expressed in the hippocampus, plays an essential role in regulating the balance between inhibition and excitation in the neuronal network. The altered function of LGI1 could lead to epileptic seizures. In this study, mice were infused with LGI1 IgG to investigate its effect on AMPA-receptor expression and network excitability. The findings suggest that LGI1 IgG reduces AMPA-R expression, increases network hyperexcitability, and more significantly impairs the inhibitory network activity, shedding light on the crucial role of the inhibitory network in triggering epileptic seizures in LGI1 LE patients.
Review
Dentistry, Oral Surgery & Medicine
Jerian Gonzalez-Febles, Mariano Sanz
Summary: Rheumatoid arthritis and periodontitis are chronic inflammatory diseases characterized by the destruction of cartilage and periodontal tissues, with emerging evidence suggesting a possible link between specific bacterial periodontal pathogens and the development of autoantibodies in rheumatoid arthritis patients. Research is ongoing to explore the epidemiologic association and biological mechanisms between these two diseases, as well as the potential impact of periodontal treatment on the initiation and progression of rheumatoid arthritis.
PERIODONTOLOGY 2000
(2021)
Article
Rheumatology
Y. Yoshizawa, T. Nakao, K. Tsuritani, T. Yamada, N. Watanabe, A. Chiba, W. H. Robinson, S. Miyake
Summary: This study aimed to identify citrullinated proteins that may play an important role in the onset and progression of rheumatoid arthritis (RA) using an individualized anti-citrullinated protein antibody (ACPA) evaluation system with citrullinated peptides as probes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Environmental Sciences
Aline S. E. Santos, Christine G. Parks, Mariana M. Senna, Armando Meyer
Summary: This study aimed to assess the relationship between pesticide use and antibody levels. The results showed that specific pesticides and fertilizers were associated with antibody levels in the healthy agricultural population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Immunology
Claire Drurey, Havard T. Lindholm, Gillian Coakley, Marta Campillo Poveda, Stephan Loser, Rory Doolan, Francois Gerbe, Philippe Jay, Nicola Harris, Menno J. Oudhoff, Rick M. Maizels
Summary: Helminth parasites can manipulate the immune system by modulating intestinal epithelial cells; experiments have shown that excretory/secretory products from parasites can inhibit the effects of IL-4/13, suppress tuft and goblet cell expansion, and induce fetal epithelial growth.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Lara Perryman, Steven G. Gray
Summary: This article discusses the role of fibrosis in difficult-to-treat cancers and the association of the lysyl oxidase family with fibrosis. It also explores the potential therapeutic effects of drugs targeting lysyl oxidases in the treatment and management of mesothelioma.
Article
Nanoscience & Nanotechnology
L. G. Powell, S. Gillies, T. F. Fernandes, F. Murphy, E. Giubilato, V. Cazzagon, D. Hristozov, L. Pizzol, M. Blosi, A. L. Costa, A. Prina-Mello, H. Bouwmeester, H. Sarimveis, G. Janer, V. Stone
Summary: This article provides guidance for implementing tailored safety assessment strategies for nanomaterials in order to increase their translation from bench development to clinical use. Integrated Approaches to Testing and Assessment (IATAs) are key tools in developing these strategies.
Correction
Instruments & Instrumentation
Melissa Anne Tutty, Gabriele Vella, Antje Vennemann, Martin Wiemann, Adriele Prina-Mello
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Blanka Halamoda-Kenzaoui, Robert Geertsma, Joost Pouw, Adriele Prina-Mello, Moreno Carrer, Matthias Roesslein, Adrienne Sips, Klaus Michael Weltring, Kathleen Spring, Susanne Bremer-Hoffmann
Summary: The identification of regulatory challenges for nanotechnology-enabled health products is crucial, and greater collaboration between regulatory and research communities is needed to support regulatory decision-making with academic data. Through cross-sector workshops, common and sector-specific challenges can be identified and solutions can be discussed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Melissa Anne Tutty, Gabriele Vella, Adriele Prina-Mello
Summary: Nanobiomaterials (NBMs) have wide applications in medicine and bioimaging, but evaluating their safety, especially their impact on the liver, is a challenge. Current pre-clinical methods cannot accurately predict liver toxicity of NBMs. 3D cell culture models provide a more accurate assessment of NBM-tissue interaction.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Editorial Material
Instruments & Instrumentation
Kathleen Spring, Klaus-M Weltring, Adriele Prina-Mello, Ruth Schmid
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Analytical
Thierry Bastogne, Fanny Caputo, Adriele Prina-Mello, Sven Borgos, Muriel Barberi-Heyob
Summary: Quality-by-Design (QbD) is a risk-based and proactive approach widely used in the pharmaceutical field for drug development. Analytical Quality by Design (AQbD) is the adaptation of QbD for analytical method development, aiming to optimize the accuracy and robustness of analysis results. However, there are challenges in understanding and implementing the AQbD approach in practice.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Medicine, General & Internal
Martin P. Barr, Anne-Marie Baird, Sophia Halliday, Petra Martin, Emma H. Allott, James Phelan, Greg Korpanty, Linda Coate, Cathal O'Brien, Steven G. Gray, Jane S. Y. Sui, Brian Hayes, Sinead Cuffe, Stephen P. Finn
Summary: Liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). It can be used to monitor EGFR mutations and inflammatory markers as prognostic indicators in NSCLC.
Article
Biochemistry & Molecular Biology
Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Hassan H. Alhassan, Afnan Elayyan Mousa Elayyan, Mehnaz Kamal, Hamad Alanazi, Bandar Alharby, Salem Hussain Alharethi, Bashir M. Mohamed
Summary: SphK1 dysfunction is associated with various severe diseases. Small molecule inhibitors with high specificity and efficacy are needed for therapeutic use. Through a structure-based virtual screening, two compounds, Gummadiol and Isoarboreol, were identified as promising inhibitors of SphK1.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Mark Bates, Bashir M. Mohamed, Mark P. Ward, Tanya E. Kelly, Roisin O'Connor, Victoria Malone, Robert Brooks, Doug Brooks, Stavros Selemidis, Cara Martin, Sharon O'Toole, John J. O'Leary
Summary: This review provides an overview of circulating tumour cells (CTCs), which are highly lethal cancer cells and play a crucial role in cancer metastasis. CTCs have clinical utility as diagnostic, prognostic, and therapeutic targets. However, their complex biology and the challenges involved in their isolation and identification hinder their clinical translation. CTCs are capable of forming microemboli composed of diverse populations, which interact with other circulating cells and may increase their malignant potential. These microemboli represent a prognostically important subset, but the presence of phenotypic gradients adds complexity to the situation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Afnan Elayyan Mousa Elayyan, Ziad H. Al-Oanzi, Hassan H. Alhassan, Bashir M. Mohamed, Hamad H. Alanazi, Mohammad Saquib Ashraf, Shadman Moiz, Mitesh Patel, Mirav Patel, Mohd Adnan
Summary: Traditional cancer treatment faces obstacles such as drug resistance, toxicity, and financial constraints. Phytochemicals that regulate molecular mechanisms are gaining interest as alternative medicine. This study used network pharmacology to explore the regulatory mechanisms of 6-shogaol in cervical cancer treatment. Various databases were screened to identify target genes of 6-shogaol and disease-related targets. Protein-protein interactions and topology analysis identified hub genes. Gene ontology and pathway enrichment analysis were conducted, and molecular docking and survival analysis revealed potential target genes for treatment. The study provides scientific evidence supporting the use of 6-shogaol as a treatment for cervical cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Bandar Alharbi, Husam Qanash, Naif K. K. Binsaleh, Salem Alharthi, Abdulbaset M. M. Elasbali, Chandranil H. H. Gharekhan, Muhammad Mahmoud, Emmanouil Lioudakis, John J. J. O'Leary, Derek G. G. Doherty, Bashir M. M. Mohamed, Steven G. G. Gray
Summary: Immunotherapies, including immune checkpoint inhibitors, have limitations in effectively treating malignancies. Nanotechnology-based platforms for delivering immunotherapeutic agents are being investigated to improve the efficacy of immune checkpoint blockade therapy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Bashir M. Mohamed, Mark P. Ward, Mark Bates, Cathy D. Spillane, Tanya Kelly, Cara Martin, Michael Gallagher, Sheena Heffernan, Lucy Norris, John Kennedy, Feras Abu Saadeh, Noreen Gleeson, Doug A. Brooks, Robert D. Brooks, Stavros Selemidis, Sharon O'Toole, John J. O'Leary
Summary: We developed a new methodology to culture CTCs using primary cancer cells and found that the presence of CTC clusters is essential for long-term culture. This technique will greatly contribute to the development of CTC theranostics.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Joanna Lazniewska, Ka Lok Li, Ian R. D. Johnson, Alexandra Sorvina, Jessica M. Logan, Carmela Martini, Courtney Moore, Ben S. -Y. Ung, Litsa Karageorgos, Shane M. Hickey, Sarita Prabhakaran, Jessica K. Heatlie, Robert D. Brooks, Chelsea Huzzell, Nicholas I. Warnock, Mark P. Ward, Bashir Mohammed, Prerna Tewari, Cara Martin, Sharon O'Toole, Laura Bogue Edgerton, Mark Bates, Paul Moretti, Stuart M. Pitson, Stavros Selemidis, Lisa M. Butler, John J. O'Leary, Douglas A. Brooks
Summary: The development and progression of prostate cancer are closely related to the regulation of glucose and lipid metabolism, as well as alterations in androgen receptor expression and signaling. This study reveals a previously unrecognized molecular mechanism for prostate cancer, which involves the dynamic balance between sortilin and syndecan-1 and their impact on different metabolic phenotypes. In androgen-sensitive cells, sortilin enhances glucose metabolism while limiting lipid metabolism, whereas in androgen-insensitive cells, syndecan-1 promotes lipid metabolism. Additionally, androgen-deprived cells show decreased expression of sortilin and increased expression of syndecan-1, contributing to altered glucose and lipid metabolism. These findings have important implications for understanding disease progression and castration-resistant prostate cancer in the context of androgen-deprivation therapy.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jirova, Kristina Kejlova, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thoene-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Kraemer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliska Kuchovska, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kraenzlin, Bettina Seeger, Maren von Koeckritz-Blickwede, Jose M. Sanchez-Morgado, Viola Galligioni, Daniel Ruiz-Perez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stepnik, Zuzanna Sobanska, Edyta Reszka, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R. Cederroth, Jenny Sandstroem, Ian Ragan, Nataliia Bubalo, Jens Kurreck, Horst Spielmann
Summary: Three Rs centres and platforms are dedicated to the Replacement, Reduction and Refinement of animal use in experiments. They play a crucial role in promoting the implementation of Directive 2010/63/EU and disseminating information.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS
(2022)