Article
Immunology
Zheng Wu, Shujuan Cheng, Shaoping Wang, Wenzheng Li, Jinghua Liu
Summary: The study showed that exosomal miR-150-5p derived from bone marrow mesenchymal stem cells can attenuate cardiomyocyte apoptosis through targeting Bax and improve cardiac function in myocardial infarction mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Hongjuan Ning, Haixu Chen, Jingyu Deng, Chun Xiao, Moyan Xu, Lina Shan, Chao Yang, Zheng Zhang
Summary: The exosomes derived from FNDC5-BMMSCs have shown promising therapeutic effects for myocardial infarction by exerting anti-inflammatory effects and promoting M2 macrophage polarization through the NF-kappa B signaling pathway and Nrf2/HO-1 Axis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang
Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Tao Yang, Wei Li, Anquan Peng, Jia Liu, Qin Wang
Summary: In this study, it was found that hypoxic BMSCs-derived exosomes (hypBMSC-Exo) could alleviate cisplatin-induced ototoxicity and had better therapeutic effects compared to BMSC-Exo. This may be achieved by up-regulating the expression of SOD1 and SOD2 to protect auditory function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Jing Li, Yuting Tang, Leijing Yin, Xiaofang Lin, Zhengyang Luo, Shuxin Wang, Ludong Yuan, Pengfei Liang, Bimei Jiang
Summary: Myocardial infarction refers to irreversible cardiac function impairment caused by inadequate blood supply to the heart. Mesenchymal stem cell-derived exosomes play a crucial role in its treatment, primarily through their paracrine secretion of multiple factors. Despite the advantages of exosome therapy, maintaining stability and enhancing targeting effects remain challenging in clinical applications.
JOURNAL OF GENE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Feng Lin, Suihao Zhang, Xia Liu, Meishan Wu
Summary: Exosomal miR-125b-5p from BMSCs inhibits atherosclerotic plaque formation by targeting Map4k4 expression, leading to reduced inflammation, decreased blood lipid levels, smaller plaque areas, increased expression of smooth muscle cell marker α-SMA, as well as inhibition of apoptosis in AS mice.
Article
Cell Biology
Tina B. Marvasti, Faisal J. Alibhai, Lukasz Wlodarek, Anne Fu, Shu-Hong Li, Jun Wu, Richard D. Weisel, Robert J. Cusimano, Maral Ouzounian, Terrence Yau, Ren-Ke Li
Summary: This study investigated the impact of aging on human bone marrow cell responses post-myocardial infarction. The findings revealed that younger patient cells had greater repopulation capacity and lymphoid cell production, while the age of CD34(+) cells influenced donor and host cellular responses following MI.
Article
Biotechnology & Applied Microbiology
Caiqi Shen, Changbo Tao, Aijun Zhang, Xueyang Li, Yanping Guo, Hanxiao Wei, Qichuan Yin, Qiang Li, Peisheng Jin
Summary: The study revealed that BMSC-derived exosomes promote skin wound healing via the miR-93-3p/APAF1 axis, providing a potential new therapeutic strategy.
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Yijin Wu, Wenying Peng, Siyao Chen, Xiaodong Zeng, Jiade Zhu, Ping Zhu
Summary: Extracellular vesicles derived from mouse bone marrow mesenchymal stem cells (mBMSCs) deliver the CAV1 protein, which influences the TGF-beta 1/SMAD2/c-JUN pathway and plays a role in the molecular mechanisms underlying myocardial fibrosis post-myocardial infarction. The study showed a reduced expression of CAV1 in myocardial fibrosis tissue. Furthermore, mBMSC-EVs were found to deliver CAV1 to cardiac fibroblasts and silencing CAV1 in mBMSC-EVs promoted fibrosis in cardiac fibroblasts. In vivo studies supported these findings, demonstrating that mBMSC-EVs mitigate myocardial fibrosis by delivering CAV1 protein and inhibiting the TGF-beta 1/SMAD2/c-JUN pathway.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Lianggeng Gong, Yingying Weng, Wei Zhou, Kunchi Zhang, Wei Li, Jia Jiang, Jun Zhu
Summary: The study utilized glucose-modified gold nanoparticles to label MSC-derived exosomes, and in vivo CT imaging showed these labeled exosomes remained in the MI area for an extended period. Additionally, some MSC-Exo were observed in organs like the liver, spleen, and kidney.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Youming Zhang, Zichun Cai, Yunli Shen, Qizheng Lu, Wei Gao, Xin Zhong, Kang Yao, Jie Yuan, Haibo Liu
Summary: A novel drug delivery system incorporating alginate hydrogel was developed to continuously release DEXs, enhancing the therapeutic effects of DEXs in improving cardiac function after MI.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Physics, Multidisciplinary
Chen Hao, Tian Jian-Min, Sun Xue-Jian, Lu Ke-Zhen, Xu Li-Hua, Li Hong-Rong
Summary: This study investigates the effects of excitation pulse width and excitation interval on the system dynamics and excitation energy transfer efficiency of a multi-pigments model. The results show that there are optimal pulse width and parameter ranges for the system when the donor pigments are excited by a single Gaussian pulse. The mechanism of modulation is analyzed. Additionally, an optimal combination of pulse width and interval is found when the donor pigments are excited by two Gaussian pulses sequentially. The obtained kinetic equations and design principles have reference significance for the optimal design of artificial photosynthesis systems under different light conditions.
ACTA PHYSICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Mehrad Gavahi, Hong Rong Li
Summary: In this study, the entanglement dynamics of two related mechanical oscillators in a modified optomechanical system were analyzed to investigate the effects of geometrical shapes of optical cavities on the entanglement of a representative optomechanical system. It was found that the strength of mechanical pairs, which depend on the oscillating temperature, can generate steady-state or dynamic behavior of optomechanical engagement. The entanglement dynamics were also found to be closely related to the stability of the natural state.
MAIN GROUP CHEMISTRY
(2022)
Article
Physics, Multidisciplinary
Xue-Jian Sun, Wen-Xiao Liu, Hao Chen, Cheng-Yuan Wang, Hui-Zhong Ma, Hong-Rong Li
Summary: In this work, a high-fidelity phonon-mediated entangling gate in a hybrid mechanical system based on two silicon-vacancy color centers in diamond is proposed. By using a continuous dynamical decoupling approach and a mechanical driving field, the influence of spin decoherence on the gate is suppressed and the gate fidelity is significantly improved.
COMMUNICATIONS IN THEORETICAL PHYSICS
(2022)
Article
Optics
Yu-xiang Han, Xin Wang, Hong-rong Li
Summary: Negative absolute temperature has various applications and has been studied in a recent paper where two spin ensembles are coupled to the same reservoir. By investigating the coherent coupling and decay between the ensembles, the authors found that the duration of the negative temperature state depends on the distance between the two ensembles.
JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS
(2022)
Article
Physics, Multidisciplinary
Jiao-Jiao Xue, Ke-Hui Yu, Wen-Xiao Liu, Xin Wang, Hong-Rong Li
Summary: In this paper, a quantum speed-up method for the creation of cat states in a Kerr nonlinear resonator (KNR) via optimal adiabatic control is proposed. The method allows for the preparation of cat states with a shorter time, a high-fidelity and a large non-classical volume. The proposal is also robust against single-photon loss and can be implemented in superconducting quantum circuits.
NEW JOURNAL OF PHYSICS
(2022)
Article
Quantum Science & Technology
Xin Wang, Hong-Rong Li
Summary: This paper proposed a novel method to realize chiral quantum networks by exploiting giant atom effects in superconducting quantum circuit platforms. By modulating the coupling points with time, the interaction becomes momentum-dependent, and giant atoms will chirally emit photons due to interference effects. The results demonstrate that high-fidelity state transfer between remote giant atoms can be realized.
QUANTUM SCIENCE AND TECHNOLOGY
(2022)
Article
Physics, Multidisciplinary
Rui Qu, Yunlong Wang, Min An, Feiran Wang, Quan Quan, Hongrong Li, Hong Gao, Fuli Li, Pei Zhang
Summary: Through experiments, we have demonstrated the stronger correlations and better noise robustness of high-dimensional quantum systems, and shown a method to enhance noise resistance by increasing measurement settings without increasing dimension.
PHYSICAL REVIEW LETTERS
(2022)
Article
Physics, Multidisciplinary
Xue-Jian Sun, Wen-Xiao Liu, Hao Chen, Hong-Rong Li
Summary: In this study, we investigate the scattering properties of a driven three-level giant atom chirally coupled to two waveguides simultaneously in both the Markovian and non-Markovian regimes. We show that under the Markovian limit, the chiral photon-atom interactions allow for nonreciprocal scattering in one waveguide and targeted photon routing in two waveguides with a probability of 100%. The presence of the driving field and giant atom structure introduce additional tunable parameters for manipulating single-photon scattering. We also explore the effects of imperfect chirality and atomic dissipation on non-reciprocity and routing capability. In the non-Markovian regime, we demonstrate non-Markovian-induced non-reciprocity and photon routing. These results have potential applications in quantum network engineering.
COMMUNICATIONS IN THEORETICAL PHYSICS
(2023)
Article
Optics
Jiao-Jiao Xue, Wen-Xiao Liu, Shan-Shan Liang, Ai-Ping Fang, Xin Wang, Hong-Rong Li
Summary: We propose a scheme using coupled nanomechanical cantilever resonators and superconducting flux qubits to create a parity-time-(PT-)symmetric phononic system with active and passive modes. By coupling the resonator and fast dissipative superconducting qubit longitudinally and using blue-sideband driving (red-sideband driving), we achieve effective gain (loss) for the phonon mode. A transition from PT-symmetric to broken-PT-symmetric phase can be observed for both balanced and unbalanced gain-to-loss cases. Our work presents an experimentally feasible method for designing PT-symmetric phononic systems and enables controllable acoustic signal transmission in a hybrid quantum system.
Article
Nanoscience & Nanotechnology
Muhammad Sultan Irshad, Naila Arshad, Gang Liu, Naveed Mushtaq, Arshad Ali Lashari, Wancheng Qin, Muhammad Sohail Asghar, Hongrong Li, Xianbao Wang
Summary: In this study, a hybrid solar evaporator was designed by printing pyrolyzed Kudzu biochar on hydrophilic cotton fabric. The evaporator integrates multiple functions such as solar evaporation, salt collection, waste heat recovery, oil emulsion sieving, and water disinfection. The hybrid evaporator exhibited enhanced evaporation rate, high solar to vapor conversion efficiency, and efficient bacterial killing capability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Physics, Multidisciplinary
Yu-xiang Han, Hao Chen, Wenxiao Liu, Jiao-jiao Xue, Hong-rong Li
Summary: This paper explores the dynamics of spin wave exchange between two dipole-coupled atomic ring arrays and finds that subradiant spin waves lead to low-loss and high efficiency of ring-to-ring transfer. The optimal spin wave exchange occurs at appropriate separations between coplanar rings. The rotation of the rings and the orientation of transition dipole moments also affect the effectiveness of the interaction between the rings.
NEW JOURNAL OF PHYSICS
(2023)
Article
Optics
Xin Wang, Zhao -Min Gao, Jia-Qi Li, Huai -Bing Zhu, Hong-Rong Li
Summary: We propose a quantum electrodynamics platform in which quantum emitters interact with a Hofstadter-ladder waveguide. We demonstrate several intriguing phenomena, including chiral spontaneous emission, periodically modulated dynamics of emitters of the giant atom form, and the dipole-dipole interaction between two giant emitters mediated by bound states.
Article
Physics, Multidisciplinary
XueJian Sun, WenXiao Liu, Hao Chen, ChengYuan Wang, HuiZhong Ma, HongRong Li
Summary: The study focuses on single-photon transport properties in a hybrid waveguide quantum electrodynamics system, demonstrating the observation of double electromagnetically induced transparency (EIT) effect when the waveguide is coupled to the cavity and the atom at the same point. The controllable nonreciprocal scattering effect can be achieved by modulating the non-zero cavity-emitter separation and the phase associated with the cavity-emitter coupling strength when the waveguide is coupled to the cavity and the atom at different points.
INTERNATIONAL JOURNAL OF THEORETICAL PHYSICS
(2022)
Article
Physics, Multidisciplinary
Xing-Liang Dong, Cai-Peng Shen, Shao-Yan Gao, Hong-Rong Li, Hong Gao, Fu-Li Li, Peng-Bo Li
Summary: This study proposes a reliable scheme for coupling spins and phonons in solid-state defects and diamond phononic crystals. They predict a series of unconventional sound-matter interaction phenomena in this hybrid quantum system.
PHYSICAL REVIEW RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Sultan Irshad, Xianbao Wang, Naila Arshad, M. Qasim Javed, Tariq Shamim, Zhenzhen Guo, Hong Rong Li, Jianying Wang, Tao Mei
Summary: The inadequate supply of water and energy in remote areas is a significant issue. Portable solar-driven evaporation setups can provide a solution, but current techniques have high energy consumption and salt accumulation problems. In this study, the researchers developed nanocomposites for improved solar evaporation and chemical convection, leading to enhanced photo-thermoelectricity. The novel design allows for efficient evaporation and desalination. This research is important for practical implementation of solar-driven seawater desalination and clean energy generation.
ENVIRONMENTAL SCIENCE-NANO
(2022)