Article
Cell Biology
Mo Li, Xin Shen, Hui Liu, Bei Yang, Siying Lu, Min Tang, Yan Ling, Yuezhen Li, Haibin Kuang
Summary: Recent studies have shown that NTE plays a crucial role in normal placental and blood vessel development, but its involvement in abnormal placental angiogenesis of pre-eclampsia remains unclear. The study found that reduced NTE levels in pre-eclamptic placentas had significant effects on the migration and tube formation of HUVECs. Furthermore, dysregulation of PC and LPC metabolism due to altered NTE expression may contribute to abnormal placental angiogenesis in pre-eclampsia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Hikari Yoshizawa, Haruki Nishizawa, Hidehito Inagaki, Keisuke Hitachi, Akiko Ohwaki, Yoshiko Sakabe, Mayuko Ito, Kunihiro Tsuchida, Takao Sekiya, Takuma Fujii, Hiroki Kurahashi
Summary: A long non-coding RNA gene called MG828507 was found to be overexpressed in pre-eclamptic placentas, and it is located in the same genomic region as the FLT1 gene. While overexpression or knockdown of MG828507 did not affect FLT1 expression, the transcript level of MG828507 was associated with genetic variants linked to pre-eclampsia and correlated with birth weight and placental weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sammy Hermans, Jacob Pilon, Dennis Eschweiler, Johannes Stegmaier, Carmen A. H. Severens-Rijvers, Salwan Al-Nasiry, Marc van Zandvoort, Dimitrios Kapsokalyvas
Summary: Pre-eclampsia is a severe complication in pregnancy with limited diagnostic and therapeutic options, and there is controversy surrounding its etiology and phenotypes. Using multiphoton microscopy (MPM) imaging, the native placental three-dimensional morphology can be visualized with subcellular resolution, allowing for the identification of various imaging targets such as trophoblast organization, villous tree structure, syncytial knots, fibrosis, and vascular networks. Preliminary data suggests that pre-eclampsia is characterized by increased syncytial knot density, paddle-like villous sprouts, abnormal villous volume-to-surface ratio, and decreased vascular density. Quantifying 3D microscopic images shows potential for phenotyping pre-eclampsia in placental villous tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jessica Schuster, Shi-Bin Cheng, James Padbury, Surendra Sharma
Summary: Pre-eclampsia is a hypertensive disease of pregnancy with mechanisms centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion. Extracellular vesicles (EVs) are suggested to play a crucial role in pre-eclampsia, potentially influencing immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Hematology
Viktoria Bitsadze, Sylvie Bouvier, Jamilya Khizroeva, Eva Cochery-Nouvellon, Eric Mercier, Antonia Perez-Martin, Alexander Makatsariya, Jean-Christophe Gris
Summary: This study found that ADAMTS13 activity, antibodies, and antigen levels in newly pregnant women with obstetric antiphospholipid syndrome (oAPS) are associated with the occurrence of pre-eclampsia (PEcl). These markers serve as significant risk factors for PEcl and its subgroups, exhibiting acceptable discrimination power in predicting clinical events. ADAMTS13 may help identify pregnant women with oAPS who do not require escalated treatment strategies to prevent PEcl.
THROMBOSIS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Michelle Broekhuizen, Rene de Vries, Marja A. W. Smits, Willem A. Dik, Sam Schoenmakers, Birgit C. P. Koch, Daphne Merkus, Irwin K. M. Reiss, A. H. Jan Danser, Sinno H. P. Simons, Emilie Hitzerd
Summary: This study investigated the placental transfer, vascular effects, and anti-inflammatory actions of pentoxifylline in healthy and pre-eclamptic human placentas. The results showed that while pentoxifylline had beneficial effects on vasodilation and inflammation in healthy placentas, these effects were not retained in pre-eclamptic placentas. This limits the application of pentoxifylline in the treatment of pre-eclampsia, but it may still have value for other placenta-related disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone
Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Peripheral Vascular Disease
Arthur Colson, Christophe Louis Depoix, Isaline Lambert, Camille Leducq, Marie Bedin, Michele De Beukelaer, Laurent Gatto, Axelle Loriot, Maureen Peers de Nieuwburgh, Khadija Bouhna, Pamela Baldin, Corinne Hubinont, Pierre Sonveaux, Frederic Debieve
Summary: This study aims to evaluate the benefits of using PT2385, an oral specific HIF-2a inhibitor, to treat severe placental dysfunction. The research found that PT2385 can promote placental cell differentiation and angiogenesis, and reduce the production of sFLT-1, thus preventing the onset of hypertension and proteinuria in pregnant mothers. These results support the use of PT2385 to treat severe preeclampsia.
Article
Obstetrics & Gynecology
S. Yogeshkumar, Shobha Dhananjay, Sarvamangala Gowdar, Guruprasad Gowdar, Vardendra Kulkarni, Sunil Byranahalli, Shivaprasad S. Goudar, Sangappa M. Dhaded, Manjunath S. Somannavar, Shiyam Sunder Tikamani, Sarah Saleem, Imran Ahmed, Najia Karim Ghanchi, Zeeshan Uddin, Haleema Yasmin, Kay Jackson, Elizabeth M. McClure, Robert L. Goldenberg
Summary: The objective of the study was to compare placental findings in women with and without pre-eclampsia. The study evaluated the placenta of women with stillbirths, preterm births, and term births as controls using the Amsterdam criteria. The main findings were that maternal vascular malperfusion was more common in women with pre-eclampsia, while inflammatory lesions were less common in these women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cell Biology
Fang Guo, Bao Zhang, Hao Yang, Yixi Fu, Yaning Wang, Jianming Huang, Mi Cheng, Xiaobo Li, Zhuojian Shen, Li Li, Ping He, Andy Peng Xiang, Shuaiyu Wang, Hongbo Zhang
Summary: The study revealed that the transcriptomes of placentae from EOPE were significantly different from controls, while those from LOPE were not. Conversely, the transcriptomes of peripheral blood from LOPE showed more differences from controls compared to EOPE. Classical biomarkers of pre-eclampsia were specifically expressed in extravillous trophoblast and syncytiotrophoblast, only being upregulated in EOPE. New biomarkers for EOPE and LOPE, such as EBI3, IGF2, ORMDL3, GATA2, and KIR2DL4, were experimentally verified with patient samples.
CELL PROLIFERATION
(2021)
Article
Acoustics
J. Hu, J. Gao, J. Liu, H. Meng, N. Hao, Y. Song, L. Ma, W. Luo, J. Sun, W. Gao, W. Meng, Y. Sun
Summary: The study evaluated the performance of screening for preterm pre-eclampsia in a Chinese population using the FMF competing-risks model and found it to be effective. Women who screened positive for preterm pre-eclampsia had an increased risk for other placenta-associated pregnancy complications, demonstrating the clinical applicability of the screening strategy in mainland China.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tingting Zhang, Xiaotong Tang, Yuanyuan Zhu, Cong Wang, Ziyan Jiang, Nana Yang, Tianjun Wang, Lijun Shu, Yetao Xu, Lizhou Sun
Summary: This study discovered that linc01116 expression was significantly reduced in pre-eclampsia (PE) patients and was associated with poor uterine spiral artery remodeling. Knockdown of linc01116 decreased trophoblast cell angiogenesis both in vitro and in vivo. Mechanistically, IGF2BP2 regulated linc01116 RNA stability through m(6)A methylation. Further experiments revealed that linc01116 upregulated AAMP expression by adsorbing miR-210-3p in trophoblast cells. In conclusion, this study uncovered the crucial role of linc01116 in regulating trophoblast angiogenesis and provided new insights for detecting placental pathology in PE.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Shlomi Toussia-Cohen, Inna Zaslavsky-Paltiel, Adel Farhi, Yael Brantz, Dror Maymon, Raanan Meyer, Yoav Yinon, Liat Lerner-Geva, Shali Mazaki-Tovi, Abraham Tsur
Summary: This study aimed to investigate the effectiveness of low-dose aspirin (LDA) in preventing pre-eclampsia (PE) in otherwise low-risk twin gestations. A historical cohort study was conducted on pregnant individuals with dichorionic diamniotic twin pregnancy from 2014 to 2020. The results showed that LDA treatment was not associated with a reduction in the rate of preterm PE in twin gestations without additional major risk factors.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Shuai Zhang, Yanfen Zou, Xiaotong Tang, Yuanyuan Zhang, Nana Yang, Kun Xu, Yetao Xu
Summary: Long noncoding RNA AFAP1-AS1 is significantly downregulated in pre-eclamptic placentas, and its knockdown inhibits trophoblast proliferation, migration, and invasion, suggesting its involvement in the pathogenesis of PE.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Hematology
Zifang Wu, Quanhang Xiang, Li Feng, Deyuan Wu, Shuangbo Huang, Longmiao Zhang, Sujuan Rao, Jinxi Luo, Wenyu Xiong, Jinping Deng, Kai Zhou, Yulong Yin, Wei Shi, Chengquan Tan
Summary: This study reveals that abnormal placental angiogenesis is associated with decreased adenosine concentration and downregulated expression of adenosine A2a receptor in fetal intrauterine growth restriction (IUGR). Adenosine improves IUGR pregnancy outcomes and enhances adenosine signaling and angiogenesis in IUGR mice placenta. Mechanistically, adenosine activates ADORA2A to promote phosphorylation of Stat3 and Akt, leading to increased Ang-dependent angiogenesis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)