Anisomycin prevents OGD-induced necroptosis by regulating the E3 ligase CHIP

Stroke

(2017) Graeme J Hankey   LANCET

rAAV8-733-Mediated Gene Transfer of CHIP/Stub-1 Prevents Hippocampal Neuronal Death in Experimental Brain Ischemia

(2017) Felipe Cabral-Miranda et al.   MOLECULAR THERAPY

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro

(2017) Mei Yang et al.   Frontiers in Neuroscience

New role of E3 ubiquitin ligase in the regulation of necroptosis

(2016) Jinho Seo et al.   BMB Reports

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling

(2015) Amy M. Palubinsky et al.   ANTIOXIDANTS & REDOX SIGNALING

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

(2015) Wei Ding et al.   BMC NEUROSCIENCE

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

(2015) Bo Yin et al.   BRAIN RESEARCH

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury

(2015) H. Fan et al.   NEUROSCIENCE

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

True Grit: Programmed Necrosis in Antiviral Host Defense, Inflammation, and Immunogenicity

(2014) E. S. Mocarski et al.   JOURNAL OF IMMUNOLOGY

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

The global burden of neurologic diseases

(2014) J. H. Chin et al.   NEUROLOGY

Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state

(2014) D. Jantas et al.   NEUROPHARMACOLOGY

Necroptosis, in vivo detection in experimental disease models

(2014) Sandrine Jouan-Lanhouet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

(2013) Yan Meng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP

(2013) Chang-He Shi et al.   HUMAN MOLECULAR GENETICS

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death

(2012) Yun-Suk Lee et al.   FEBS LETTERS

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Necrostatin Decreases Oxidative Damage, Inflammation, and Injury after Neonatal HI

(2010) Frances J Northington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BDNF-Induced Changes in the Expression of the Translation Machinery in Hippocampal Neurons: Protein Levels and Dendritic mRNA

(2009) Bruno Manadas et al.   JOURNAL OF PROTEOME RESEARCH

Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling

(2009) S Claiborne Johnston et al.   LANCET NEUROLOGY

CHIP Represses Myocardin-Induced Smooth Muscle Cell Differentiation via Ubiquitin-Mediated Proteasomal Degradation

(2009) P. Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Validation of internal control genes for expression studies: Effects of the neurotrophin BDNF on hippocampal neurons

(2008) Ana Rita A. Santos et al.   JOURNAL OF NEUROSCIENCE RESEARCH