Article
Medicine, Research & Experimental
Fernanda Batista de Souza, Romulo Dias Novaes, Cynthia Fernandes Ferreira Santos, Franciele Angelo de Deus, Felipe Couto Santos, Luiz Carlos Maia Ladeira, Reggiani Vilela Goncalves, Daniel Silva Sena Bastos, Ana Claudia Ferreira Souza, Mariana Machado-Neves, Eliziaria Cardoso dos Santos
Summary: The study found that the combination of high-fat diet and caffeine reduces weight gain and increases levels of blood lipids. Caffeine alone or combined exacerbates the effects of high-fat diet on bone calcium, phosphorus, and magnesium levels. Biomechanical testing shows that the combination of high-fat diet and caffeine increases bending strength and stiffness of the tibia in animals.
Article
Biochemistry & Molecular Biology
Bruna Caprioli, Rosangela A. S. Eichler, Renee N. O. Silva, Luiz Felipe Martucci, Patricia Reckziegel, Emer S. Ferro
Summary: This study demonstrates the importance of neurolysin oligopeptidase (Nln) in insulin signaling and glucose uptake, as well as its involvement in the physiological mechanisms related to diet-induced obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Food Science & Technology
Jieping Yang, Patrizia Maria Germano, Suwan Oh, Sijia Wang, Jing Wang, Rupo Lee, Hayden Paige, Scarlet Yang, Susanne M. Henning, Jin Zhong, Jonathan P. Jacobs, Zhaoping Li
Summary: This study found that dietary supplementation of pomegranate extract (PomX) can ameliorate colitis and reduce inflammatory markers in mice fed a Western diet. These effects may be mediated by the impact of PomX on the gut microbiome.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Ruediger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Summary: This study found that deficiency of the serotonin transporter (SERT) is associated with metabolic derangements in mice. High-fat diet feeding in SERT-deficient mice resulted in enhanced insulin resistance, liver steatosis, and adipose tissue inflammation. These findings suggest that SERT deficiency may contribute to altered inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Kathryn M. Spitler, Shwetha K. Shetty, Emily M. Cushing, Kelli L. Sylvers-Davie, Brandon S. J. Davies
Summary: Hepatocyte-specific loss of ANGPTL4 does not improve triglyceride phenotypes during high-fat feeding, but these mice show improved glucose tolerance after chronic high-fat diet. Additionally, Angptl4(LivKO) mice have decreased fasting plasma triglyceride levels after an 18-h fast, but not after a 6-h fast.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Pablo Vidal, Lisa A. Baer, Elisa Felix-Soriano, Felix T. Yang, Daniel A. Branch, Kedryn K. Baskin, Kristin Stanford
Summary: The prevalence of metabolic diseases is increasing, with diet being a major contributing factor. Exercise is effective in combating metabolic diseases. This study found that a high-fat diet impairs metabolic function, while a high-phosphate diet does not significantly affect glucose metabolism. Exercise can reverse the detrimental effects of a high-fat diet and restore metabolic function.
Article
Endocrinology & Metabolism
Feiyu Cai, Aihemaitijiang Yusufu, Kai Liu, Wenjiao Chen, Ruomei Zhao, Yanshi Liu, Yi Liu
Summary: The study evaluated the difference in bone regeneration between rats under high-fat diets (HFD) and low-fat diets (LFD) by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals. The results showed that HFD resulted in elevated blood lipids, increased adipose differentiation at the bone marrow level, and delayed bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Lingyun Lu, Mengjia Tang, Jiao Li, Ying Xie, Yujue Li, Jinwei Xie, Li Zhou, Yi Liu, Xijie Yu
Summary: This study identified the potential mechanisms of HFD-induced bone loss, revealing the associations between alterations in GM and serum metabolites with bone loss. These findings provide new insights into understanding HFD-related osteoporosis and suggest the need for further exploration of the regulatory effects of GM and metabolites on bone homeostasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jessica Latorre, Aina Lluch, Francisco J. Ortega, Aleix Gavalda-Navarro, Ferran Comas, Samantha Moron-Ros, Amaia Rodriguez, Sara Becerril, Francesc Villarroya, Gema Fruhbeck, Wifredo Ricart, Marta Giralt, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: The study found that lysozyme is highly expressed in adipose tissue of obese individuals, associated with chronic inflammation, adipose tissue inflammation, and metabolic disturbances. Knocking down the lysozyme gene in experimental models improved adipose tissue inflammation and reduced weight gain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Saeed Daneshyar, Gholamreza Tavoosidana, Mahdi Bahmani, Saeed Shokati Basir, Maryam Delfan, Ismail Laher, Ayoub Saeidi, Urs Granacher, Hassane Zouhal
Summary: This study aims to investigate the combined effects of high-fat diets and exercise training on autophagy in mouse white adipose tissue. The results show that both the high-fat diet and exercise training groups had increased levels of autophagy-related genes and proteins. The combination of high-fat diet and exercise enhances autophagosome formation and modulates lysosomal degradation in white adipose tissue.
Article
Microbiology
Yan Feng, Jianghao Feng, Lei Wang, Ai Meng, Siang Wei, Jie Cui, Xiongbing Hu, Lihuan Yan
Summary: The study demonstrated that short-chain inulin can ameliorate dysbiosis induced by high-fat diet, promote the growth of probiotics, inhibit the growth of pathogenic bacteria, and have significantly different effects on wild-type and leptin knockout mice.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Dorota Kotowska, Mathis Neuhaus, Lovisa Heyman-Linden, Bjorn Moren, Shuyi Li, Dmytro Kryvokhyzha, Karin Berger, Karin G. Stenkula
Summary: This study highlights the beneficial effects of a lingonberry supplemented diet in preventing obesity and improving insulin levels, which may be achieved through influencing adipose tissue function.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Endocrinology & Metabolism
Zheng Zhang, Zhanrong Zhang, Lei Pei, Xiaozhou Zhang, Boyuan Li, Yichen Meng, Xuhui Zhou
Summary: Based on a systematic review and meta-analysis of 80 articles, this study found that a high-fat diet (HFD) leads to decreased trabecular bone mass and deteriorated architecture in the femur, tibia, and vertebrae of mice. It also identified factors such as sex, age, HFD ingredients, and intervention period that influence the skeletal alterations caused by HFD.
Article
Nutrition & Dietetics
Dean S. Ross, Tzu-Hsuan Yeh, Shalinie King, Julia Mathers, Mark S. Rybchyn, Elysia Neist, Melissa Cameron, Alexander Tacey, Christian M. Girgis, Itamar Levinger, Rebecca S. Mason, Tara C. Brennan-Speranza
Summary: This study explored the effects of a high fat diet on glucose metabolism and bone density in developing and mature male C57BL/6J mice. The results showed that high fat diet significantly impaired glucose tolerance and reduced bone density in both age groups, with more pronounced effects in the mature mice. This mature HFD mouse model accurately represents late-onset impaired glucose tolerance/pre-T2DM cases in humans and provides insights into the mechanisms of skeletal fragility in these patients.
Article
Engineering, Biomedical
Laila A. Damiati, Monica P. Tsimbouri, Virginia-Llopis Hernandez, Vineetha Jayawarna, Mark Ginty, Peter Childs, Yinbo Xiao, Karl Burgess, Julia Wells, Mark R. Sprott, R. M. Dominic Meek, Peifeng Li, Richard O. C. Oreffo, Angela Nobbs, Gordon Ramage, Bo Su, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: This study developed a polymer coating with nano-topographical structure to support osteospecific stem cells and prevent bacterial adhesion and biofilm formation. The experimental results showed that this coating can increase cell adhesion and osteoblast differentiation, and reduce biofilm formation.
Article
Endocrinology & Metabolism
Stuart A. Lanham, Dominique Blache, Richard O. C. Oreffo, Abigail L. Fowden, Alison J. Forhead
Summary: Hormones play a crucial role in the regulation of fetal growth and development. A study investigating the effect of pancreas removal on fetal sheep found that pancreas deficiency caused growth retardation and altered bone structure and strength. This highlights the importance of hormones in the development of the fetal skeleton.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yang-Hee Kim, Richard O. C. Oreffo, Jonathan Dawson
Summary: In the past decade, there has been an increasing recognition of the role of the innate immune response in mediating repair and biomaterial directed tissue regeneration. The macrophage is now seen as a key player in orchestrating the resolution of inflammation and initiating the process of remodeling and repair. In the context of bone, macrophages have been found to have an essential coordinating role in supporting bone repair and facilitating biomaterial driven osteogenesis. This review examines the evidence for the role of macrophages in bone regeneration and repair, and discusses recent approaches that target macrophage modulation to accelerate and enhance bone tissue regeneration.
Editorial Material
Endocrinology & Metabolism
Jillian Cornish, Richard O. C. Oreffo
Article
Materials Science, Biomaterials
Antonio Conde-Gonzalez, Michael Glinka, Deepanjalee Dutta, Robert Wallace, Anthony Callanan, Richard O. C. Oreffo, Mark Bradley
Summary: Regenerative medicine demands sophisticated 3D biomaterials to promote tissue formation. This study presents a novel technique for screening potential biocompatible 3D scaffolds, identifying a porous acrylate-based scaffold that promotes cell proliferation and tissue formation. The scaffold was fabricated through freeze-casting and photo-polymerization techniques and demonstrated tunable properties suitable for skeletal repair. This platform offers an innovative approach to scanning synthetic biomaterials for tissue regeneration.
BIOMATERIALS ADVANCES
(2023)
Article
Clinical Neurology
Diego A. Ojeda, Oliver Hutton, Robert Hopkins, Felino Cagampang, Neil R. Smyth, Tom P. Fleming, Judith Eckert, Sandrine Willaime-Morawek
Summary: Maternal high-fat diet during the preimplantation period or throughout pregnancy and lactation, without obesity, leads to changes in metabolic-related parameters and hippocampal neurogenesis and glial density in the adult offspring mice.
BRAIN COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Roxanna S. Ramnarine-Sanchez, Janos M. Kanczler, Nicholas D. Evans, Richard O. C. Oreffo, Jonathan I. Dawson
Summary: This paper reports a new reaction-diffusion self-assembly system, in which proteins function as diffusive reactants to assemble stable clay-protein composite hydrogels. Using this method, scalable and highly stable 3D protein patterns can be generated at sub-cellular resolution, and can guide cell behavior to achieve precise bone tissue template formation.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Duanyang Xu, Konstantinos N. Bourdakos, Anna Crisford, Peter Johnson, Ibrahim Abughazaleh, Panuwat Srisamran, Richard O. C. Oreffo, Sumeet Mahajan, David J. Richardson, Lin Xu
Summary: We present an all-fiber ized 1840-nm thulium-fiber-laser source for label-free biological imaging through nonlinear microscopy. The source consists of a dissipative-soliton mode-locked seed laser and a chirped-pulse-amplification system. It utilizes short pulses generated by the mode-locked laser and pulse compression techniques to achieve high-quality imaging of biological samples.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Cell & Tissue Engineering
Elloise Z. Matthews, Stuart Lanham, Kate White, Maria-Eleni Kyriazi, Konstantina Alexaki, Afaf H. El-Sagheer, Tom Brown, Antonios G. Kanaras, Jonathan West, Ben D. MacArthur, Patrick S. Stumpf, Richard O. C. Oreffo
Summary: Researchers have developed a new method to isolate and enrich skeletal stem cells from human bone marrow, which have the potential to differentiate into bone, cartilage, and fat cells. This study provides valuable insights for further understanding and utilization of these stem cells.
JOURNAL OF TISSUE ENGINEERING
(2023)
Meeting Abstract
Cell & Tissue Engineering
Yang-Hee Kim, Agnieszka Janeczek, Richard O. C. Oreffo, Jonathan I. Dawson
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Roxanna Ramnarine Sanchez, Nicholas Evans, Richard Oreffo, Jonathan Dawson
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Yuanhao Wu, Babatunde O. Okesola, John Connelly, Richard O. C. Oreffo, Jose Carlos Rodriguez-Cabello, Giovanni Vozzi, Helena S. Azevedo, Nicola M. Pugno, Alvaro Mata
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Gianluca Cidonio, Federico Salaris, Janos Kanczler, Alessandro Soloperto, Chiara Scognamiglio, Andrea Barbetta, Jonathan Dawson, Richard Oreffo, Alessandro Rosa, Giancarlo Ruocco
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Abshar Hasan, Karen Marshall, Jonathan Wojciechowski, Sherif Elsharkawy, David Eglin, Richard Oreffo, Molly Stevens, Alvaro Mata
TISSUE ENGINEERING PART A
(2022)
Review
Biotechnology & Applied Microbiology
Yang-Hee Kim, Jonathan Dawson, Richard O. C. Oreffo, Yasuhiko Tabata, Dhiraj Kumar, Conrado Aparicio, Isha Mutreja
Summary: Musculoskeletal disorders pose a significant burden on the global economy and public health. Hydrogels, especially Gelatin methacryloyl (GelMA) hydrogel, hold great potential for enhancing the repair of damaged musculoskeletal tissues. This review provides a comprehensive overview of GelMA synthesis, hydrogel design, and its applications in regenerative medicine, particularly in the field of musculoskeletal drug delivery.
BIOENGINEERING-BASEL
(2022)