Article
Biochemistry & Molecular Biology
Lovorka Grgurevic, Rudjer Novak, Grgur Salai, Stela Hrkac, Marko Mocibob, Ivana Kovacevic Vojtusek, Mario Laganovic
Summary: This study reveals the molecular characteristics of different stages of chronic kidney disease (CKD) through proteomic analysis, and identifies key events that may affect disease progression. The study suggests that CKD stage 2 is a turning point in the progression of the disease and a suitable time for developing therapeutic solutions.
Review
Medicine, General & Internal
Bin Wang, Zuo-Lin Li, Yi-Lin Zhang, Yi Wen, Yue-Ming Gao, Bi-Cheng Liu
Summary: This review outlines the characteristics, mechanisms, complications, potential therapeutic approaches, and challenges of chronic hypoxia in chronic kidney disease (CKD).
Article
Biochemistry & Molecular Biology
Pedro Caetano Pinto, Cindy Roennau, Martin Burchardt, Ingmar Wolff
Summary: Kidney cancer and chronic kidney disease have different clinical management strategies, but share closely related cellular and molecular mechanisms, both involving the kidney's response to hypoxia. Fibrosis is a common factor in deteriorating renal function in both conditions.
Article
Medicine, General & Internal
Nihal Martis, Matthieu Jamme, Corinne Bagnis-Isnard, Claire Pouteil-Noble, Claire Presne, Cecile Vigneau, Steven Grange, Stephane Burtey, Jean-Philippe Coindre, Alain Wynckel, Mohamed A. Hamidou, Tarik Kanouni, Elie Azoulay, Miguel Hie, Dominique Chauveau, Agnes Veyradier, Eric Rondeau, Paul Coppo
Summary: The study compared clinical features and treatment outcomes between patients with systemic autoimmune disease-associated thrombotic microangiopathies and those with atypical hemolytic uremic syndrome. Results showed that patients with SAID-TMA generally had pre-existing chronic kidney failure and were less likely to recover if renal replacement therapy was needed at onset. Treatment with immunosuppressive drugs was found to be more effective than therapeutic plasma exchange for SAID-TMA management.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cell Biology
Beatriz F. Corte-Real, Ibrahim Hamad, Rebeca Arroyo Hornero, Sabrina Geisberger, Joris Roels, Lauren Van Zeebroeck, Aleksandra Dyczko, Marike W. van Gisbergen, Henry Kurniawan, Allon Wagner, Nir Yoset, Susanne N. Y. Weiss, Klaus G. Schmetterer, Agnes Schroeder, Luka Krampert, Stefanie Haase, Hendrik Bartolomaeus, Niels Hellings, Yvan Saeys, Ludwig J. Dubois, Dirk Brenner, Stefan Kempa, David A. Hafler, Johannes Stegbauer, Ralf A. Linker, Jonathan Jantsch, Dominik N. Mueller, Markus Kleinewietfeld
Summary: High salt induces metabolic reprogramming in human Tregs, leading to pro-inflammatory features and FOXP3 downregulation, which has important implications for autoimmunity.
Article
Cell Biology
Yan Yang, Yulin Sun, Chan Zhu, Xinyu Shen, Jianmei Sun, Tao Jing, Shi Jun, Changming Wang, Guang Yu, Xinzhong Dong, Meixiao Sheng, Zongxiang Tang
Summary: Chronic kidney disease (CKD) is characterized by decreased renal function and irreversible damage. Pruritus, particularly in end-stage renal disease, is a common skin symptom observed in CKD patients. The precise molecular and neural mechanisms underlying CKD-associated pruritus (CKD-aP) are unclear. Our findings demonstrate elevated levels of allantoin in the serum of CKD-aP patients and CKD model mice. Allantoin induces scratching behavior in mice and activates DRG neurons. Reduced calcium influx and action potential are observed in DRG neurons of MrgprD KO or TRPV1 KO mice. Additionally, U73122, a phospholipase C antagonist, effectively blocks allantoin-induced calcium influx in DRG neurons. Collectively, our results establish the significant role of allantoin, mediated by MrgprD and TrpV1, in CKD-aP among CKD patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Ana C. Maretti-Mira, Matthew P. Salomon, Angela M. Hsu, Gary C. Kanel, Lucy Golden-Mason
Summary: This study found that the dietary cholesterol content directly affects the gene expression of hepatic macrophages. Prolonged high cholesterol intake induces long-lasting hepatic damage and expands a dysfunctional pro-fibrotic restorative macrophage population even after cholesterol reduction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatima O. Martins, Joana F. Sacramento, Elena Olea, Bernardete F. Melo, Jesus Prieto-Lloret, Ana Obeso, Asuncion Rocher, Paulo Matafome, Emilia C. Monteiro, Silvia Conde
Summary: Several studies have shown a connection between obstructive sleep apnea (OSA) and insulin resistance. This study investigated the effects of chronic intermittent hypoxia (CIH) on metabolic deregulation and adipose tissue dysfunction, as well as the impact of obesity on CIH-induced metabolic disturbances. The results suggest that adipose tissue dysfunction may not be the main trigger for initial dysmetabolism in CIH.
Review
Transplantation
Anna Faivre, Carsten C. Scholz, Sophie de Seigneux
Summary: Chronic kidney disease (CKD) is defined as an alteration of kidney structure and/or function lasting for >3 months, affecting 10% of the general adult population. The role of hypoxia in CKD progression has been controversially discussed since the end of the last century.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Thayane Crestani, Renato O. Crajoinas, Leonardo Jensen, Leno L. Dima, Perrine Burdeyron, Thierry Hauet, Sebastien Giraud, Clara Steichen
Summary: After a three-week diet rich in sodium oxalate, rats developed stable chronic kidney disease with reduced glomerular filtration rate, elevated blood urea levels, and proteinuria. The model also displayed classical CKD complications such as elevated blood pressure and reduced hematocrit, making it a potential tool for research into CKD mechanisms and therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yuji Oe, Nobuyuki Takahashi
Summary: Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor plays a key role in promoting coagulation and inflammation, exacerbating renal injury.
Article
Medicine, General & Internal
Patrocinio Rodriguez-Benitez, Irene Aracil Moreno, Cristina Oliver Barrecheguren, Yolanda Cunarro Lopez, Fatima Yllana, Pilar Pintado Recarte, Coral Bravo Arribas, Melchor Alvarez-Mon, Miguel A. Ortega, Juan A. De Leon-Luis
Summary: This study analyzed the maternal and perinatal variables associated with acute kidney injury (AKI) in patients with severe preeclampsia (SP). AKI was found to be mainly associated with a history of CKD, the use of assisted reproductive techniques, and caesarean section in SP patients. The impact of AKI on perinatal outcomes included a higher rate of NICU admission and a lower mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Feifei Xie, Xin Zhen, Zhuoliang Liu, Xiaomei Chen, Zhuanhua Liu, Miaomiao Zhou, Zhanmei Zhou, Zheng Hu, Fengxin Zhu, Qiaobing Huang, Lei Zhang, Jing Nie
Summary: This study found that dietary choline, via gut microbe-generated TMAO, inhibits cardiac angiogenesis by reducing Hif-1 alpha protein level and ultimately aggravates cardiac dysfunction in chronic kidney disease (CKD) mice.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yang Ho, Der-Cherng Tarng
Summary: Anemia is a common issue in patients with chronic kidney disease, and novel iron replacement therapies have shown to be effective in reducing medical costs and improving anemia in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Urology & Nephrology
Chen-Yi Yuan, Yuan-Cheng Gao, Yi Lin, Lin Liu, Xiao-Gang Shen, Wen-Li Zou, Min-Min Wang, Quan-Quan Shen, Li-Na Shao, Yue-Ming Liu, Jia-Wei Zhang, Zhi-Hui Pan, Yan Zhu, Jing-Ting Yu, Xu-Guang Yu, Bin Zhu
Summary: The significance of mineralocorticoid receptor antagonists (MRAs) in treating chronic kidney disease (CKD) is summarized. MRAs can reduce proteinuria, improve renal function and decrease the incidence of chronic renal failure and cardiovascular events, but they may also increase the risk of hyperkalemia and hypotension.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Gastroenterology & Hepatology
Pedro Guimaraes, Andreas Keller, Tobias Fehlmann, Frank Lammert, Markus Casper
Summary: A CNN-based approach was established to distinguish the appearance of EoE from normal findings and candida esophagitis, with significantly higher global accuracy, sensitivity, and specificity compared to trainee endoscopists on the test set. The algorithm also showed high reproducibility and effectively identified characteristic signs for complex endoscopic classification tasks.
Article
Pediatrics
Celina Jagodzinski, Sophia Mueller, Rika Kluck, Kerstin Froede, Leo Pavicic, Jutta Gellermann, Dominik Mueller, Uwe Querfeld, Dieter Haffner, Miroslav Zivicnjak
Summary: The study found that children with chronic kidney disease who received recombinant human growth hormone (rhGH) treatment before kidney transplantation had better outcomes and growth, which were related to better transplant function, less anemia, lower C-reactive protein levels, and less steroid exposure.
PEDIATRIC NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Bianca Nitzsche, Wen Wei Rong, Andrean Goede, Bjoern Hoffmann, Fabio Scarpa, Wolfgang M. Kuebler, Timothy W. Secomb, Axel R. Pries
Summary: The study introduces a new non-sprouting mode of angiogenesis, termed coalescent angiogenesis, which involves the gradual enlargement of preferential flow pathways by merging capillaries and eliminating internal tissue pillars. This process remodels the initial inefficient mesh-like capillary network into a hierarchical tree structure that ensures efficient convective transport and rapid expansion of the vasculature.
Article
Hematology
Peilun Li, Qing Pan, Sheng Jiang, Wolfgang M. Kuebler, Axel R. Pries, Gangmin Ning
Summary: The study proposed a new method to describe the spatial distribution of the vascular networks in the yolk sac membrane, revealing diverse patterns of complexity distribution at different stages. The complexity increased significantly at the intersection areas between arteries and sinus terminalis during angiogenesis.
Article
Urology & Nephrology
Rizky Sugianto, Nima Memaran, Bernhard M. W. Schmidt, Anke Doyon, Daniela Thurn-Valsassina, Harika Alpay, Ali Anarat, Klaus Arbeiter, Karolis Azukaitis, Aysun K. Bayazit, Ipek K. Bulut, Salim Caliskan, Nur Canpolat, Ali Duzova, Jutta Gellerman, Jerome Harambat, Denise Homeyer, Mieczyslaw Litwin, Francesca Mencarelli, Lukasz Obrycki, Dusan Paripovic, Bruno Ranchin, Rukshana Shroff, Uwe Tegtbur, Jeannine von der Born, Ebru Yilmaz, Uwe Querfeld, Elke Wuehl, Franz Schaefer, Anette Melk
Summary: This study investigated the pulse wave velocity (PWV) in children with kidney failure and found that girls are more susceptible to cardiovascular complications and have higher mortality rates compared to boys. The PWVz values significantly increased in girls and were associated with GFR decline, high blood pressure, and low LDL levels. After transplantation, GFR decline and longer time to transplantation were associated with higher PWVz values in girls.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Hugo Ferreira, Pedro Serranho, Pedro Guimaraes, Rita Trindade, Joao Martins, Paula Moreira, Antonio Francisco Ambrosio, Miguel Castelo-Branco, Rui Bernardes
Summary: The early diagnosis of neurodegenerative disorders, especially Alzheimer's disease, remains a challenge. This study trained a convolution neural network using a mouse model to diagnose AD through fundus images with promising accuracy.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Pedro Guimaraes, Pedro Serranho, Joao Martins, Paula I. Moreira, Antonio Francisco Ambrosio, Miguel Castelo-Branco, Rui Bernardes
Summary: This study investigates the differences in the aging of the central nervous system through the retina of 3x Tg-AD and wild-type mice. The results show that the presence of mutated genes affects the aging of the retina, which contradicts the observations in the brain for Alzheimer's disease. The study also introduces a reliable retinal OCT aging marker using deep learning.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Physiology
Laura Golusda, Anja A. Kuehl, Malte Lehmann, Katja Dahlke, Susanne Mueller, Philipp Boehm-Sturm, Jessica Saatz, Heike Traub, Joerg Schnorr, Christian Freise, Matthias Taupitz, Karina Biskup, Veronique Blanchard, Oliver Klein, Ingolf Sack, Britta Siegmund, Daniela Paclik
Summary: Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation of the gastrointestinal tract. This study utilized very small superparamagnetic iron oxide nanoparticles (VSOPs) in magnetic resonance imaging (MRI) to detect intestinal inflammation in mouse models. The results suggest that VSOPs can serve as a potential contrast agent for early non-invasive diagnosis of IBD, depending on the hyaluronic acid content.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Karolis Azukaitis, Marietta Kirchner, Anke Doyon, Mieczyslaw Litwin, Aysun Bayazit, Ali Duzova, Nur Canpolat, Augustina Jankauskiene, Rukshana Shroff, Anette Melk, Uwe Querfeld, Franz Schaefer
Summary: This study investigated the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression. The results showed that pulse wave velocity increased in children with CKD but did not associate with eGFR or CKD progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benedikt Fels, Arne Beyer, Violeta Cazana-Perez, Teresa Giraldez, Juan F. Navarro-Gonzalez, Diego Alvarez de la Rosa, Franz Schaefer, Aysun K. Bayazit, Lukasz Obrycki, Bruno Ranchin, Johannes Holle, Uwe Querfeld, Kristina Kusche-Vihrog
Summary: This study found that chronic kidney disease disrupts endothelial mechanics, leading to endothelial dysfunction. The data showed that serum from CKD patients increased the stiffness of the endothelial glycocalyx and cortex, while decreasing the height of the glycocalyx. Furthermore, the study found that serum from hemodialysis patients increased the expression of MR and the mechanical stiffness of the endothelial cortex, an effect that could be reversed by MR and ENaC antagonists.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Urology & Nephrology
Rizky I. Sugianto, Nima Memaran, Bernhard M. W. Schmidt, Anke Doyon, Daniela Thurn-Valsassina, Harika Alpay, Ali Anarat, Klaus Arbeiter, Karolis Azukaitis, Aysun K. Bayazit, Ipek K. Bulut, Salim Caliskan, Nur Canpolat, Ali Duzova, Jutta Gellerman, Jerome Harambat, Denise Homeyer, Mieczyslaw Litwin, Francesca Mencarelli, Lukasz Obrycki, Dusan Paripovic, Bruno Ranchin, Rukshana Shroff, Uwe Tegtbur, Jeannine von der Born, Ebru Yilmaz, Uwe Querfeld, Elke Wuehl, Franz Schaefer, Anette Melk
KIDNEY INTERNATIONAL
(2022)
Meeting Abstract
Ophthalmology
Rui Bernardes, Maryam Ghalati, Hugo Ferreira, Joao Martins, Pedro Guimaraes, Paula Moreira, Antonio Ambrosio, Miguel Castelo-Branco, Pedro Serranho
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, General & Internal
Pedro Guimaraes, Helen Finkler, Matthias Christian Reichert, Vincent Zimmer, Frank Gruenhage, Marcin Krawczyk, Frank Lammert, Andreas Keller, Markus Casper
Summary: This study developed AI-based algorithms to differentiate inflammatory bowel disease (IBD) from other colitis types using endoscopic images and clinical data. The image-based algorithm had lower accuracy compared to the clinical data-based algorithm, suggesting the need for larger image datasets for better performance.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Geriatrics & Gerontology
Ana Batista, Pedro Guimaraes, Joao Martins, Paula I. Moreira, Antonio Francisco Ambrosio, Miguel Castelo-Branco, Pedro Serranho, Rui Bernardes
Summary: Animal models are crucial for understanding retinal development, eye diseases, and neurodegeneration. In this study, a comprehensive normative database of retinal thickness in mice was created using OCT data. The findings revealed changes in retinal thickness over time, with different patterns among individual retinal layers. Additionally, a comparison between wild-type and Alzheimer's disease model mice showed significant differences in retinal thickness. This database will be an important reference for future studies on retinal changes and the pathophysiology of neurodegenerative and eye diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Pediatrics
Thimoteus Speer, Stefan J. Schunk, Tamim Sarakpi, David Schmit, Martina Wagner, Ludger Arnold, Stephen Zewinger, Karolis Azukaitis, Aysun Bayazit, Lukasz Obrycki, Ipek Kaplan Bulut, Ali Duzova, Anke Doyon, Bruno Ranchin, Salim Caliskan, Jerome Harambat, Alev Yilmaz, Harika Alpay, Francesca Lugani, Ayse Balat, Klaus Arbeiter, Germana Longo, Anette Melk, Uwe Querfeld, Elke Wuehl, Otto Mehls, Danilo Fliser, Franz Schaefer
Summary: This study evaluated the usefulness of the urinary biomarker DKK3 in determining the short-term risk of chronic kidney disease progression in children. The results showed that high levels of urinary DKK3 were associated with greater decline in kidney function and indicated potential benefit from intensified blood pressure control.
LANCET CHILD & ADOLESCENT HEALTH
(2023)