标题
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1
作者
关键词
-
出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-04-30
DOI
10.1038/s41598-018-25007-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization
- (2018) Emile S. Pinarbasi et al. Scientific Reports
- Amyotrophic lateral sclerosis
- (2017) Michael A van Es et al. LANCET
- Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases
- (2017) Hong Joo Kim et al. NEURON
- Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding
- (2017) Bagdeser A. Ozdilek et al. NUCLEIC ACIDS RESEARCH
- Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
- (2017) Tariq Afroz et al. Nature Communications
- Inside out: the role of nucleocytoplasmic transport in ALS and FTLD
- (2016) Steven Boeynaems et al. ACTA NEUROPATHOLOGICA
- Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
- (2016) Jelena Scekic‐Zahirovic et al. EMBO JOURNAL
- Simple rules for passive diffusion through the nuclear pore complex
- (2016) Benjamin L. Timney et al. JOURNAL OF CELL BIOLOGY
- Nucleocytoplasmic Transport of RNAs and RNA–Protein Complexes
- (2016) Katherine E. Sloan et al. JOURNAL OF MOLECULAR BIOLOGY
- Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia
- (2016) Ana Jovičić et al. JOURNAL OF NEUROCHEMISTRY
- Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies
- (2016) Ian R. A. Mackenzie et al. JOURNAL OF NEUROCHEMISTRY
- Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins
- (2016) Antonia Ratti et al. JOURNAL OF NEUROCHEMISTRY
- Altered mRNP granule dynamics in FTLD pathogenesis
- (2016) Hilary A. Bowden et al. JOURNAL OF NEUROCHEMISTRY
- ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
- (2016) Aarti Sharma et al. Nature Communications
- Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
- (2016) Steven Boeynaems et al. Scientific Reports
- The Nuclear Proteome of a Vertebrate
- (2015) Martin Wühr et al. CURRENT BIOLOGY
- Subcellular localization and RNAs determine FUS architecture in different cellular compartments
- (2015) Liuqing Yang et al. HUMAN MOLECULAR GENETICS
- Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex
- (2015) Petra Popken et al. MOLECULAR BIOLOGY OF THE CELL
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
- (2015) Brian D. Freibaum et al. NATURE
- Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination
- (2015) Jeffery D Haines et al. NATURE NEUROSCIENCE
- Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- (2015) Ana Jovičić et al. NATURE NEUROSCIENCE
- An acetylation switch controls TDP-43 function and aggregation propensity
- (2015) Todd J. Cohen et al. Nature Communications
- A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
- (2015) Koray Kırlı et al. eLife
- A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques
- (2015) Fermin Moreno et al. Acta Neuropathologica Communications
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Analysis of Nuclear Export Sequence Regions of FUS-Related RNA-Binding Proteins in Essential Tremor
- (2014) Oswaldo Lorenzo-Betancor et al. PLoS One
- Self-assembled FUS binds active chromatin and regulates gene transcription
- (2014) Liuqing Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Compromised paraspeckle formation as a pathogenic factor in FUSopathies
- (2013) Tatyana A. Shelkovnikova et al. HUMAN MOLECULAR GENETICS
- ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
- (2013) Caroline Vance et al. HUMAN MOLECULAR GENETICS
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- Inhibition of TDP-43 Aggregation by Nucleic Acid Binding
- (2013) Yi-Chen Huang et al. PLoS One
- The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis
- (2013) Yoshinori Nishimoto et al. Molecular Brain
- Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
- (2012) Glenda Halliday et al. ACTA NEUROPATHOLOGICA
- The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site
- (2012) Xuehui Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
- (2012) Dorothee Dormann et al. EMBO JOURNAL
- RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
- (2012) J. G. Daigle et al. HUMAN MOLECULAR GENETICS
- Several Phenylalanine-Glycine Motives in the Nucleoporin Nup214 Are Essential for Binding of the Nuclear Export Receptor CRM1
- (2012) Stephanie Roloff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells
- (2012) Claudia Colombrita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry
- (2012) Ketan Thakar et al. MOLECULAR & CELLULAR PROTEOMICS
- Sequence and structural analyses of nuclear export signals in the NESdb database
- (2012) Darui Xu et al. MOLECULAR BIOLOGY OF THE CELL
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
- (2012) Clotilde Lagier-Tourenne et al. NATURE NEUROSCIENCE
- Structural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
- (2012) Zi Chao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NEX-TRAP, a Novel Method for In Vivo Analysis of Nuclear Export of Proteins
- (2012) Verena Raschbichler et al. TRAFFIC
- Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
- (2012) Boris Rogelj et al. Scientific Reports
- mRNA export and the TREX complex
- (2011) Jun Katahira Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Ran-dependent nuclear export mediators: a structural perspective
- (2011) Thomas Güttler et al. EMBO JOURNAL
- A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43
- (2011) N. A. Lanson et al. HUMAN MOLECULAR GENETICS
- Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA
- (2011) Cuong D. Nguyen et al. JOURNAL OF MOLECULAR BIOLOGY
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- TDP-43 and FUS: a nuclear affair
- (2011) Dorothee Dormann et al. TRENDS IN NEUROSCIENCES
- Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
- (2011) Zhihui Sun et al. PLOS BIOLOGY
- Molecular determinants responsible for the subcellular localization of HSV-1 UL4 protein
- (2011) Wei-wei Pan et al. VIROLOGICA SINICA
- Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
- (2010) Agnes L. Nishimura et al. BRAIN
- ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
- (2010) Peer-Hendrik Kuhn et al. EMBO JOURNAL
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y
- (2010) Sonja M. Wiedemann et al. JOURNAL OF CELL BIOLOGY
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- Nuclear localization sequence of FUS and induction of stress granules by ALS mutants
- (2010) Jozsef Gal et al. NEUROBIOLOGY OF AGING
- Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
- (2010) Laetitia Miguel et al. NEUROBIOLOGY OF DISEASE
- Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations
- (2010) Yoshihiro Kino et al. NUCLEIC ACIDS RESEARCH
- TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
- (2010) Aaron Voigt et al. PLoS One
- Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
- (2009) Manuela Neumann et al. ACTA NEUROPATHOLOGICA
- FUS-Immunoreactive Intranuclear Inclusions in Neurodegenerative Disease
- (2009) John Woulfe et al. BRAIN PATHOLOGY
- Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA
- (2009) Jun Katahira et al. EMBO JOURNAL
- Characterisation of the passive permeability barrier of nuclear pore complexes
- (2009) Dagmar Mohr et al. EMBO JOURNAL
- Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies
- (2009) Serhiy Pankiv et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
- (2009) Dorothee Dormann et al. JOURNAL OF NEUROCHEMISTRY
- TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea
- (2009) Gabor G. Kovacs et al. MOVEMENT DISORDERS
- Recent insights into the molecular genetics of dementia
- (2009) Rosa Rademakers et al. TRENDS IN NEUROSCIENCES
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- The Nup358-RanGAP Complex Is Required for Efficient Importin α/β-dependent Nuclear Import
- (2008) Saskia Hutten et al. MOLECULAR BIOLOGY OF THE CELL
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now