Review
Environmental Sciences
Jinjin Guo, Keqin Liu, Jixin Yang, Yanwei Su
Summary: This review systematically assessed human studies to comprehensively describe the association between prenatal BPA exposure and neonatal health outcomes. The results showed that prenatal BPA exposure tended to have negative effects on most neonatal health outcomes, but showed inconsistent results on physical health at birth.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Fan Hu, Weifeng Liang, Linke Zhang, Huan Wang, Zimu Li, Yifeng Zhou
Summary: The study found that both BPA and BPS exposure in mice can negatively impact emotion and social interaction, and high-dose exposure can lead to abnormal local neuronal activation. Although BPS has less adverse effects on mice at low doses compared to BPA, there are still risks associated with prolonged high-volume exposure.
Article
Environmental Sciences
Mohammad Mehdi Amin, Zahra Ghasemi, Mehri Khoshhali, Ensiyeh Taheri, Bahare Dehdashti, Ali Fatehizadeh, Nasim Rafiei, Roya Kelishadi
Summary: The study aimed to investigate the impact of maternal exposure to BPA on newborn anthropometric measures, but found no significant associations between BPA and beta-hCG concentrations with birth weight, height, and head circumference. The non-significant findings in this study may be due to lower urinary BPA levels, while adverse effects on infants could be related to high concentrations of BPA passed through the placenta. Future longitudinal studies with larger sample sizes are needed to better understand the adverse health effects of endocrine disruptor chemicals like BPA.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Federica Lamberto, Bachuki Shashikadze, Radwa Elkhateib, Salvo Danilo Lombardo, Alex Horanszky, Andrea Balogh, Kornel Kistamas, Melinda Zana, Joerg Menche, Thomas Froehlich, Andras Dinnyes
Summary: This study investigated the effects of environmentally relevant doses of Bisphenol A (BPA) on developing cardiomyocytes using a human induced pluripotent stem cell (hiPSC)-derived model. The results showed that long-term treatment with low doses of BPA interferes with hiPSC-CMs functionality and alters the surrounding cellular environment, leading to potential diseases. This study contributes to the understanding of BPA effects on developing human foetal cardiomyocytes and provides a suitable model for environmental chemical hazard and risk assessment.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Ravi Sonkar, Ryan Berry, Mary N. Latimer, Sumanth D. Prabhu, Martin E. Young, Stuart J. Frank
Summary: Circadian clocks regulate various biological processes, including hormone secretion and target tissue sensitivity. This study found that genetic disruption of the cardiomyocyte circadian clock leads to cardiomyopathy, potentially due to excessive activation of cardiac GH/IGF1 signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Toxicology
Somin Lee, Kyu Sup An, Hye Jin Kim, Hye Jin Noh, JaeWon Lee, Jiho Lee, Kyung Seuk Song, Chanhee Chae, Hyeon Yeol Ryu
Summary: This study investigated the use, exposure route, and distribution flow of bisphenol F, a household chemical. A series of experiments were conducted to assess its toxicity and safety. The results showed that single oral exposure to bisphenol F resulted in systemic exposure and exhibited a certain level of toxicity. It had adverse effects on the small intestine at a dose of 2 mg/kg/day, but did not induce genotoxicity.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Agnethe Mehlsen, Laerke Hollund, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Signe Bruun, Steffen Husby, Tina Kold Jensen, Clara Amalie Gade Timmermann
Summary: This study suggests that high BPA exposure during pregnancy is associated with shorter duration of breastfeeding. Although the results were not statistically significant, estimates indicate an increased risk of early termination of breastfeeding with high exposure. Future studies should consider measuring BPA more than once.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pediatrics
Pierre Desaunay, Charles Dolladille, Basile Chretien, Lea-Gabrielle Eude, Sophie Fedrizzi, Ceneric Alexandre, Gisele Apter, Joachim Alexandre, Fabian Guenole
Summary: This study found significant associations between neonatal hypotonia and fetal exposure to clomipramine, venlafaxine, and imipramine. Reports from the French database suggested prolonged fetal exposure as a contributing factor. In utero exposure to antidepressants may be associated with neonatal hypotonia.
JOURNAL OF PEDIATRICS
(2022)
Article
Environmental Sciences
Xiangyu Meng, Shifeng Su, Xiyi Wei, Shangqian Wang, Tao Guo, Junjian Li, Huaidong Song, Mengjing Wang, Zengjun Wang
Summary: We found that BPA, commonly found in household products, is inversely correlated with blood testosterone levels in children. BPA replacements like BHPF and BPAF were found to cause delayed gonadal migration and reduced germ cell lineage in zebrafish larvae. Additionally, these replacements bind strongly to androgen receptors, leading to the downregulation of meiosis-related genes and the overexpression of inflammatory markers. Further research on the toxicological effects of BHPF and BPAF on human health is needed and BPA replacements should be investigated for their anti-estrogenic action.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Anil Yirun, Gizem Ozkemahli, Aylin Balci, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study aimed to investigate the toxicity of BPA and/or DEHP on the central nervous system and neuroendocrine system in Sprague-Dawley rats during prenatal and lactational periods. The results showed that early-life exposure to these chemicals caused significant changes in lipid peroxidation, neurotransmitter levels, and apoptosis in the hippocampus. This suggests that alterations in oxidant/antioxidant status and neurotransmitters may be the underlying mechanisms of neurotoxicity induced by BPA and DEHP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Mary N. Latimer, Lamario J. Williams, Gobinath Shanmugan, Bryce J. Carpenter, Mitchell A. Lazar, Pieterjan Dierickx, Martin E. Young
Summary: Disruption of the cardiomyocyte circadian clock leads to changes in specific miRNAs, potentially influencing processes such as circadian rhythms, cellular signaling, and metabolism, suggesting a connection between circadian regulation and cardiac function.
COMMUNICATIONS BIOLOGY
(2023)
Article
Physiology
Marta Garcia-Arevalo, Estela Lorza-Gil, Leandro Cardoso, Thiago Martins Batista, Thiago Reis Araujo, Luiz Alberto Ferreira Ramos, Miguel Arcanjo Areas, Angel Nadal, Everardo Magalhaes Carneiro, Ana Paula Davel
Summary: Short-term BPA exposure can lead to left ventricular diastolic dysfunction and fibrosis, as well as intramyocardial artery remodeling, exacerbating protein malnutrition-induced hypertension and cardiovascular risk.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Ricki Colman, Peter Pierre, Julie Adriansjach, Kristin Crosno, Kevin K. Noguchi, Chrysanthy Ikonomidou
Summary: The study demonstrated that neonatal exposure to the antiseizure medications PbM can have long-lasting effects on behavior and cognition in nonhuman primates, with treated animals showing lower scores for environmental exploration and higher scores for locomotion and vocalizations compared with controls. Additionally, combined PbM and hypothermia resulted in lower scores for aggression and vigilance at 12 months.
ANNALS OF NEUROLOGY
(2023)
Article
Marine & Freshwater Biology
Long Zhu, Lihong Wang, Xiaoteng Fan, Chenglong Dong, Gaoxue Wang, Zaizhao Wang
Summary: Chronic exposure to BPA in fish can impair male reproductive capacity, leading to decreased fertilization ability and motility of sperm. BPA induces oxidative stress, inflammatory response, and DNA/histone methylation, affecting the normal function of the reproductive system.
AQUATIC TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer Romanowicz, Devon Guerrelli, Zaenab Dhari, Colm Mulvany, Marissa Reilly, Luther Swift, Nimisha Vasandani, Manelle Ramadan, Linda Leatherbury, Nobuyuki Ishibashi, Nikki Gillum Posnack
Summary: Chronic perinatal hypoxia in a mouse model led to abnormalities in cardiomyocyte gene expression, electrophysiological substrate, and contractile function. Persistent changes in electrophysiological substrate and contractile function post-recovery warrant further investigation and may contribute to adverse outcomes in cyanotic CHD patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Toxicology
Tomas M. Prudencio, Luther M. Swift, Devon Guerrelli, Blake Cooper, Marissa Reilly, Nina Ciccarelli, Jiansong Sheng, Rafael Jaimes, Nikki Gillum Posnack
Summary: The study demonstrates that BPA and BPF have an immediate inhibitory effect on cardiac ion channels, while BPS is significantly less potent. Further research is needed to fully elucidate the safety profile of bisphenol analogs on the heart.
TOXICOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Luther M. Swift, Matthew W. Kay, Crystal M. Ripplinger, Nikki Gillum Posnack
Summary: Optical mapping is a valuable imaging technique used in cardiovascular research to study electrophysiology and excitation-contraction coupling of cardiac tissues. The use of excitation-contraction uncoupling agents, such as blebbistatin, can help reduce signal distortion, but may have secondary effects on cardiac electrical activity and metabolic demand. It is essential to carefully consider the potential risks and best practices when using blebbistatin in optical mapping studies of cardiac tissue.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Blake L. Cooper, Nikki Gillum Posnack
Summary: Bisphenol A (BPA) is a commonly used chemical in the manufacturing of plastics, and studies have shown associations between BPA exposure and adverse cardiovascular health outcomes. More research is needed to comprehensively assess the cardiac safety profile of BPA and similar chemicals.
CARDIOVASCULAR TOXICOLOGY
(2022)
Letter
Pharmacology & Pharmacy
Nikki Gillum Posnack
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Letter
Hematology
Pranava Sinha, Mark Nuszkowski, Morgan Burke, Nikki Gillum Posnack
Article
Physiology
Blake L. Cooper, Chris Gloschat, Luther M. Swift, Tomas Prudencio, Damon McCullough, Rafael Jaimes, Nikki G. Posnack
Summary: Cardiac optical mapping, using fluorescence dyes to image cardiac tissue, has become a gold standard for cardiac research, but analyzing optical signals can be challenging. A new open-source software script named KairoSight has been developed to facilitate analysis of complex cardiac optical mapping datasets, making it accessible to basic and clinical scientists without requiring specialized computer science expertise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Kazi T. Haq, Blake L. Cooper, Fiona Berk, Anysja Roberts, Luther M. Swift, Nikki Gillum Posnack
Summary: This study investigated variables influencing ECG metric measurements in cardiovascular research, including recording technique, anesthesia use, and animal model characteristics. Awake and anesthetized ECG recordings were performed in adult guinea pigs, revealing significant heterogeneities in ECG metric values.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Crystal M. Ripplinger, Alexey V. Glukhov, Matthew W. Kay, Bastiaan J. Boukens, Nipavan Chiamvimonvat, Brian P. Delisle, Larissa Fabritz, Thomas J. Hund, Bjorn C. Knollmann, Na Li, Katherine T. Murray, Steven Poelzing, T. Alexander Quinn, Carol Ann Remme, Stacey L. Rentschler, Robert A. Rose, Nikki G. Posnack
Summary: Cardiac arrhythmias are a significant global health issue, and animal models play a critical role in studying cardiovascular diseases. This article provides an overview of the strengths and limitations of common techniques used to assess cardiac electrophysiology and arrhythmia mechanisms, with a focus on small animal models.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kazi T. Haq, Blake L. Cooper, Fiona Berk, Nikki Gillum Posnack
Summary: Our study found that sex-specific differences in guinea pig cardiac electrophysiology are likely influenced by the in vivo environment and less dependent on the intrinsic electrical properties of the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Food Science & Technology
Blake L. Cooper, Nikki Gillum Posnack
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Eleonora Grandi, Manuel F. Navedo, Jeffrey J. Saucerman, Donald M. Bers, Nipavan Chiamvimonvat, Rose E. Dixon, Dobromir Dobrev, Ana M. Gomez, Osama F. Harraz, Bence Hegyi, David K. Jones, Trine Krogh-Madsen, Walter Lee Murfee, Matthew A. Nystoriak, Nikki G. Posnack, Crystal M. Ripplinger, Rengasayee Veeraraghavan, Seth Weinberg
Summary: This white paper summarises the outcomes of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. The Symposium aimed to bring together experts in cardiovascular biomedicine to focus on the diversity and signaling involved in cardiovascular function. The paper presents an overview of major cell types, explores the complexity of cardiovascular development and disease at various levels, and discusses technological innovations for advancing understanding of integrated cardiovascular function and dysfunction.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Neurosciences
Shatha Salameh, Vanessa Ogueri, Nikki Gillum Posnack
Summary: The postnatal mammalian heart undergoes significant developmental changes due to the transition from the intrauterine to the extrauterine environment. Studies suggest that human atrial and ventricular myocytes rapidly evolve within the first year but may not reach a fully mature adult phenotype until nearly the first decade of life. However, limitations such as scarcity of human tissue, small sample size, and reliance on diseased tissue samples hinder fetal, neonatal, and pediatric cardiac physiology studies. Future developmental studies are needed to enhance our understanding of normal cardiac physiology/pathophysiology and guide age-appropriate treatment strategies for cardiac disease.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Environmental Sciences
Lars Lind, Jesus A. Araujo, Aaron Barchowsky, Scott Belcher, Brian R. Berridge, Nipavan Chiamvimonvat, Weihsueh A. Chiu, Vincent J. Cogliano, Sarah Elmore, Aimen K. Farraj, Aldrin V. Gomes, Cliona M. McHale, Kathleen B. Meyer-Tamaki, Nikki Gillum Posnack, Hugo M. Vargas, Xi Yang, Lauren Zeise, Changcheng Zhou, Martyn T. Smith
Summary: The concept of key characteristics (KCs) has been developed to identify carcinogenic hazards and has now been applied to identify cardiovascular (CV) toxicants. This study identified 12 KCs of CV toxicants, divided into those affecting cardiac tissue, the vascular system, or both. These KCs can be used to identify potential CV toxicants and evaluate CV toxicity in a more comprehensive and standardized manner.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Blake Cooper, Devon Guerrelli, Nikki Posnack