Review
Biochemistry & Molecular Biology
Luca Giannella, Jacopo Di Giuseppe, Giovanni Delli Carpini, Camilla Grelloni, Mariasole Fichera, Gianmarco Sartini, Serena Caimmi, Leonardo Natalini, Andrea Ciavattini
Summary: Cervical cancer is a major cause of death in women, particularly in developing countries. Cervical adenocarcinoma, a subtype of the disease, often presents at an advanced stage and has a poorer prognosis compared to squamous lesions. Treatment options and the impact of HPV vaccination and screening in managing these lesions require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Maria Teresa Bruno, Sara Boemi, Giuseppe Caruso, Francesco Sgalambro, Salvatore Ferlito, Antonio Cavallaro, Maria Chiara Sudano, Marco Palumbo
Summary: In recent years, the oral transmission of HPV and the risk of oral cancer have increased. This study aimed to evaluate the coexistence of HPV in the oral and genital mucosa of women with histologically confirmed HPV lesions. It found a high prevalence of oral HPV infection in women with concomitant genital HPV infection and identified several risk factors for HPV infections in the oropharynx and genitals.
Review
Virology
Xiangjin Gong, Hao Chi, Zhijia Xia, Guanhu Yang, Gang Tian
Summary: With the increasing incidence of cervical cancer, anal cancer, and other cancers, the concern over human papillomavirus (HPV) infection has grown. Persistent infection with high-risk HPV is a major cause of malignant tumors. Moreover, HPV infection is closely associated with microbiota and viruses such as human immunodeficiency virus, herpes simplex virus, and Epstein-Barr virus. The limited effectiveness of current treatments for HPV-associated tumors and the high rates of recurrence and metastasis create the need for innovative approaches. The article provides a comprehensive overview of HPV biology, microbiome, viral interactions, and highlights the importance of a more holistic approach to cancer prevention and treatment. Current and emerging strategies for HPV-related cancer control and treatment are also explored.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Craig Haifer, Sudarshan Paramsothy, Thomas J. Borody, Annabel Clancy, Rupert W. Leong, Nadeem O. Kaakoush
Summary: Oral lyophilized fecal microbiota transplantation (FMT) is effective in treating Clostridioides difficile infection (CDI), improving microbial diversity and resulting in durable engraftment up to 6 months post-treatment, with better efficacy observed in primary CDI compared to recurrent cases. Changes in bacterial and fungal communities are associated with therapy outcomes.
Article
Oncology
Anne M. Schultheis, Ino de Bruijn, Pier Selenica, Gabriel S. Macedo, Edaise M. da Silva, Salvatore Piscuoglio, Achim A. Jungbluth, Kay J. Park, David S. Klimstra, Eva Wardelmann, Wolfgang Hartmann, Claus Dieter Gerharz, Mareike von Petersdorff, Reinhard Buettner, Jorge S. Reis-Filho, Britta Weigelt
Summary: The study found that uterine cervix SCCs have a low mutation burden and few copy number alterations, with the majority being HPV-positive, leading to inactivation of the suppressors p53 and RB, which differentiate them from SCLCs.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Margareta Strojan Flezar, Neza Nedelko, Mario Poljak, Anja Ostrbenk Valencak, Helena Gutnik
Summary: Stratified mucin-producing intraepithelial lesion (SMILE) is a rare high-grade cervical precancerous lesion, predominantly associated with single high-risk HPV genotypes. SMILE shows typical immunohistochemical features with variable mucin presence and squamous differentiation. The study indicates the characteristics of SMILE in cervical precancerous lesions.
Review
Health Care Sciences & Services
Camelia Liana Buhas, Andrei Pascalau, Claudia Teodora Judea-Pusta, Ovidiu Laurean Pop, Adrian Sorin Judea, Bianca-Maria Negrutiu, Lavinia Marcut, Bogdan Adrian Buhas, Daniela Gheorghita, Alin Danut Bodog
Summary: This is a rare case of epidermoid cyst in the uterine cervix of a female patient. The patient underwent biopsy and uterine curettage, followed by total hysterectomy. The histopathologic analysis and immunohistochemical assay confirmed the cervical epidermoid cyst. High-risk HPV was only detected in the cervical mucosa. The exact etiopathogenesis is unknown, but implantation of embryonic tissue after childbirth could be involved in the development of these lesions.
Review
Biochemistry & Molecular Biology
Maja Ptasiewicz, Ewelina Grywalska, Paulina Mertowska, Izabela Korona-Glowniak, Agata Poniewierska-Baran, Paulina Niedzwiedzka-Rystwej, Renata Chalas
Summary: The oral cavity is inhabited by a diverse range of microbial species, and their colonization is based on commensalism. The oral mucosa reduces microbial colonization through secretion of cytokines and antimicrobial proteins. The healthy oral mucosa functions as a mechanical barrier, preventing microbial penetration into tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Brittney L. Dickey, Wenyi Fan, Deepti Bettampadi, Richard R. Reich, Bradley Sirak, Martha Abrahamsen, Maria Luiza Baggio, Lenice Galan, Roberto Carvalho Silva, Jorge Salmeron, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano
Summary: Research shows that men are at significantly higher risk of developing oral HPV infection of the same type after prior genital infection of the same type. Sequential infections present a higher risk, highlighting the importance of vaccination to prevent all HPV infections.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, Research & Experimental
Ling Mei, Tao Wang, Yueyue Chen, Dongmei Wei, Yueting Zhang, Tao Cui, Jian Meng, Xiaoli Zhang, Yuqing Liu, Lisha Ding, Xiaoyu Niu
Summary: Persistent HR-HPV infection is associated with dysbiosis of the vaginal microbiota, and microbiome regulation with Bifidobacteria and Lactobacillus may affect HPV clearance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Susanna Esposito, Stefania Ballarini, Alberto Argentiero, Luca Ruggiero, Giovanni A. Rossi, Nicola Principi
Summary: This study describes the microbiota profiles in pre-school children with recurrent respiratory tract infections (rRTIs) and investigates the potential influencing factors. The study also evaluates the changes in microbiota associated with the treatment of OM-85 oral bacterial lysate. The findings suggest that there are differences in microbiota composition in gut and nasopharynx samples, and some changes occur during the treatment process.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Maria Teresa Bruno, Salvatore Caruso, Francesca Bica, Giulia Arcidiacono, Sara Boemi
Summary: This study demonstrates that papillomavirus DNA can infect the placenta and that placental HPV infection can occur as early as the first trimester of pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Oncology
Marjorie M. A. de Souza, Gunter Hartel, Catherine M. Olsen, David C. Whiteman, Annika Antonsson
Summary: This Australian-based study assessed the prevalence of oral HPV infection in Australian residents and found that the prevalence was 7.2%. The study also found a strong association between oral HPV infection and sexual behaviors, and suggested that HPV vaccination may result in a lower risk of infection with nonavalent HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Karen Braeutigam, Stefanie Meier, Sabina Meneder, Louisa Proppe, Katharina Stroschein, Stephan Polack, Frank Koester, Achim Rody, Sascha Baum
Summary: In this study, HPV subtypes in anogenital and oral samples were investigated, and new HPV subtypes associated with precursors and cancers in these areas were identified.
Article
Infectious Diseases
Heidi Tuominen, Jaana Rautava, Katja Kero, Stina Syrjanen, Maria Carmen Collado, Samuli Rautava
Summary: This study investigated the association between HPV DNA and changes in semen bacterial microbiota composition in 31 fertile healthy men. HPV-positive semen samples showed differences in bacterial microbiota composition compared to HPV-negative samples, potentially impacting male health. Further research is needed to explore viral-bacterial interactions in the male reproductive system.
BMC INFECTIOUS DISEASES
(2021)
Review
Food Science & Technology
Carolina de Weerth, Anna-Katariina Aatsinki, Meghan B. Azad, Frank F. Bartol, Lars Bode, Maria Carmen Collado, Amanda M. Dettmer, Catherine J. Field, Meagan Guilfoyle, Katie Hinde, Aniko Korosi, Hellen Lustermans, Nurul Husna Mohd Shukri, Sophie E. Moore, Shikha Pundir, Juan Miguel Rodriguez, Carolyn M. Slupsky, Sarah Turner, Johannes B. van Goudoever, Anna Ziomkiewicz, Roseriet Beijers
Summary: Human milk is a complex liquid food that is customized to meet the needs of infants. The non-nutrient bioactives in milk have an impact on child cognitive and behavioral development, a process known as 'Lactocrine Programming'. This review discusses the links between human milk composition and child cognitive and behavioral development, and provides recommendations for future studies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Multidisciplinary Sciences
Mireia Valles-Colomer, Aitor Blanco-Miguez, Paolo Manghi, Francesco Asnicar, Leonard Dubois, Davide Golzato, Federica Pinto, Fabio Cumbo, Kun D. Huang, Serena Manara, Giulia Masetti, Federica Pinto, Elisa Piperni, Michal Puncochar, Liviana Ricci, Moreno Zolfo, Olivia Farrant, Adriana Goncalves, Marta Selma-Royo, Ana G. Binetti, Jimmy E. Becerra, Bei Han, John Lusingu, John Amuasi, Loredana Amoroso, Alessia Visconti, Claire M. Steves, Mario Falchi, Michele Filosi, Adrian Tett, Anna Last, Qian Xu, Nan Qin, Huanlong Qin, Juergen May, Daniel Eibach, Maria Valeria Corrias, Mirco Ponzoni, Edoardo Pasolli, Tim D. Spector, Enrico Domenici, Maria Carmen Collado, Nicola Segata
Summary: The human microbiome is an essential part of the human body and plays a role in various health conditions. However, we still have limited understanding of the genetic differences in the microbiome between individuals and how it spreads within and across populations.
Article
Plant Sciences
Enni Mannila, Francisco J. Marti-Quijal, Marta Selma-Royo, Marta Calatayud, Irene Falco, Beatriz de la Fuente, Francisco J. Barba, Maria Carmen Collado, Kaisa M. Linderborg
Summary: This study tested the effects of extracts from Yarrow and Nettle on bacterial growth and virus, as well as their anti-inflammatory properties. The extracts had no significant effect on beneficial bacteria, but were more effective against gram-positive bacteria and potential pathogens. The results support the use of Yarrow and Nettle in functional food applications, but further research is needed to understand their precise biological activity for gastric health.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Erika Cortes-Macias, Marta Selma-Royo, Karla Rio-Aige, Christine Bauerl, Maria Jose Rodriguez-Lagunas, Cecilia Martinez-Costa, Francisco J. Perez-Cano, Maria Carmen Collado
Summary: The study aimed to evaluate the impact of milk microbiota, cytokine, and adipokine profiles on the risk of overweight in infants at 12 months of life and identify possible mechanisms of host-microbe interactions. The findings indicated that milk microbiota and cytokines were associated with infant development. Further research is needed to understand the specific effects of milk microbiota and cytokines on infant growth and the risk of overweight.
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Review
Gastroenterology & Hepatology
Anna Samarra, Maria Esteban-Torres, Raul Cabrera-Rubio, Manuel Bernabeu, Silvia Arboleya, Miguel Gueimonde, Maria Carmen Collado
Summary: Resistance to antibiotics is a global threat, especially for newborns whose immune systems are still developing. The moment of birth exposes infants to antibiotic-resistant microorganisms that can colonize their gut and other body sites. Understanding the vertical transmission of antibiotic resistance from mothers to their offspring is crucial for developing strategies to reduce antibiotic resistance in early life.
Article
Gastroenterology & Hepatology
Daniel Merenstein, Bruno Pot, Gregory Leyer, Arthur C. Ouwehand, Geoffrey A. Preidis, Christopher A. Elkins, Colin Hill, Zachery T. Lewis, Andrea L. Shane, Niv Zmora, Mariya I. Petrova, Maria Carmen Collado, Lorenzo Morelli, Gina A. Montoya, Hania Szajewska, Daniel J. Tancredi, Mary Ellen Sanders
Summary: Probiotics are used by both healthy individuals and in clinical settings, but there are potential risks associated with their consumption. This has led to the need for concise recommendations on how to ensure the safe and effective use of new probiotic strains and products, especially in vulnerable populations.
Article
Microbiology
Sofia Oddi, Anastasia Mantziari, Paula Huber, Ana Binetti, Seppo Salminen, Maria Carmen Collado, Gabriel Vinderola
Summary: The composition of breast milk microbiota is influenced by the gestational age of the infants. Full-term infants have lower levels of Staphylococcus and higher levels of Rothia and Streptococcus in their breast milk compared to pre-term infants. However, at the corrected age, there were no significant differences in the microbial composition of breast milk between pre-term and full-term infants. These findings suggest the importance of considering the corrected age in future studies.
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Samuli Rautava, Marta Selma-Royo, Teo Oksanen, Maria Carmen Collado, Erika Isolauri
Summary: The composition of gut microbiota in pregnant women from different time periods was investigated, revealing distinct profiles in each period. The pregnant women from 1997 exhibited higher microbiota richness and diversity compared to those from 2007 to 2017. The cause of the decline in gut microbiota richness and diversity remains unclear, as there were no major changes in the population, dietary practices, or antibiotic use during the study.
Review
Microbiology
Silvia Saturio, Alejandra Rey, Anna Samarra, Maria Carmen Collado, Marta Suarez, Laura Mantecon, Gonzalo Solis, Miguel Gueimonde, Silvia Arboleya
Summary: The development of the neonate's intestinal microbiome begins at birth when the mother provides the initial microbial inoculum. This microbiome contains antibiotic resistance genes, which are affected by different perinatal factors. Antibiotics, commonly used in pediatrics, can disrupt the early microbiota and increase the levels of antibiotic resistance genes. Understanding the factors influencing the development of the resistome in early life is crucial due to the emergence of antibiotic-resistant microorganisms.
Article
Biochemistry & Molecular Biology
Nelli T. Suominen, Michel Roger, Marie-Claude Faucher, Kari J. Syrjaenen, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study evaluated the importance of human leukocyte antigen (HLA)-G alleles in father-to-child human papillomavirus (HPV) transmission during the perinatal period. The results showed that HLA-G allele concordance was associated with the father's urethral and child's oral high-risk HPV concordance at birth. In addition, HLA-G allele concordance increased the risk of father's oral and child's postpartum oral any- and high-risk HPV concordance.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar, Maria Carmen Collado
Summary: The gut microbiome plays a crucial role in host metabolism and immunity, and its dysbiosis can have detrimental effects on human health. This review focuses on the interactions between the gut microbiome and the immune system during pregnancy and their impact on offspring development. Current knowledge is limited, highlighting the need for further research in this area.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Pediatrics
Andrea Asensio-Grau, Ana Heredia, Jorge Garcia-Hernandez, Raul Cabrera-Rubio, Etna Masip, Carmen Ribes-Koninckx, Maria Carmen Collado, Ana Andres, Joaquim Calvo-Lerma
Summary: The study demonstrated that beta-glucan supplementation has positive effects on colonic microbiota in children with CF, increasing richness and diversity. In an in vitro simulated environment, beta-glucan supplementation shows potential in improving the colonic microbiota of CF patients.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Laxmi Yeruva, Bharat Kumar Mulakala, Dhivyaa Rajasundaram, Sonia Gonzalez, Raul Cabrera-Rubio, Cecilia Martinez-Costa, Maria Carmen Collado
Summary: The study found that maternal dietary source affects the expression profile of milk miRNA, and miRNA is associated with maternal dietary nutrients, milk microbiota, infant gut microbiota, and infant growth and development.
CLINICAL NUTRITION
(2023)
