期刊
RSC ADVANCES
卷 8, 期 39, 页码 22216-22225出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra03898h
关键词
-
资金
- National Natural Science Foundation of China [21527809, 21475059, 21775069]
NaGdF4:Yb3+/Er3+ nanoparticles were synthesized via a modified hydrothermal route. The dependence of structure and morphology on the dosage of sodium polyacrylate was studied by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The as-prepared nanoparticles could be used for T-2 weighted magnetic resonance imaging due to the paramagnetism of Gd3+. cis-dichlorodiamineplatinum (CDDP) could be loaded onto NaGdF4:Yb3+/Er3+ nanoparticles through binding carboxyl in the form of Pt-O bonds, and doxorubicin (DOX) could be loaded via hydrogen bonding. DOX could also be loaded onto the NaGdF4-CDDP composite in the same manner, and the loading efficiency of both drugs remained unchanged. Three as-prepared drug delivery systems were used for tumor inhibition both in vitro and in vivo, and the results indicated that NaGdF4-CDDP-DOX displayed the greatest inhibitory capacity.
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