Article
Neurosciences
Meng-Tong Xue, Wen-Jie Sheng, Xue Song, Yu-Jiao Shi, Zhi-Jun Geng, Lin Shen, Rui Wang, He-Zuo Lu, Jian-Guo Hu
Summary: ATL-III improves spinal cord injury by modulating microglial/macrophage polarization, and it possesses anti-inflammatory and neuroprotective effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Murat Kayabas, Levent Sahin, Mustafa Makav, Duried Alwazeer, Levent Aras, Serdar Yigit, Tyler W. LeBaron
Summary: The study investigated the anti-inflammatory and anti-apoptotic effects of hydrogen delivered as hydrogen-rich saline (HRS) on spinal cord injury. Rats were divided into four groups and treated accordingly. The levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were measured, and staining techniques were used to assess tissue samples. The results showed that HRS treatment significantly decreased IL-6 and TNF-alpha levels and reduced apoptosis following spinal cord injury.
Article
Biochemistry & Molecular Biology
Bong Hyo Lee, Jonghoon Kang, Hee Young Kim, Young S. Gwak
Summary: The study investigated superoxide-mediated excitatory nociceptive transmission in at-level neuropathic pain following SCI in male Sprague Dawley rats. Results showed that SCI led to increased iGluRs-mediated neuronal firing rates and pCamKII expression, while t-BOOH treatment did not have significant effects. Mechanical sensitivity at the body trunk in the SCI group was attenuated by CamKII inhibitor KN-93 or Tempol treatment, and the level of superoxide marker Dhet was significantly increased in SCI rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Grazia Maugeri, Alessandra Amato, Martina Sortino, Velia D'Agata, Giuseppe Musumeci
Summary: Spinal cord injury (SCI) leads to sensory and motor function loss. The pathophysiology of SCI involves primary and secondary phases, with oxidative stress playing a significant role in the secondary phase. Exercise is crucial for promoting well-being and quality of life, impacting various systems and potentially regulating the balance between pro-oxidants and antioxidants. This review aims to investigate the effects of exercise on oxidative stress in individuals with SCI, following an overview of spinal cord anatomy and different types of injury.
Article
Immunology
Shingo Yoshizaki, Tetsuya Tamaru, Masamitsu Hara, Ken Kijima, Masatake Tanaka, Dai-jiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Summary: The study demonstrated that beta 1Ab treatment could suppress the expression of TNF alpha in microglia and glial scars within the glial scar after SCI, and this alteration was associated with the role of fibronectin.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Clinical Neurology
Ruideng Wang, Rubing Zhou, Zhengyang Chen, Shan Gao, Fang Zhou
Summary: Glial cells play crucial roles in the healthy functioning of the central nervous system and in the repair of spinal cord injuries.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Wen Wen, Xingrui Gong, Hoiyin Cheung, Yanyan Yang, Meihua Cai, Jijian Zheng, Xiaoping Tong, Mazhong Zhang
Summary: Early life exposure to noxious stimulus and painful experiences can lead to cognitive deficits and abnormal pain sensitivity. Dexmedetomidine (DEX) has demonstrated neuroprotective effects by inhibiting microglial activation and pro-inflammatory cytokine expression, attenuating spinal inflammation and hyperalgesia induced by LPS. The findings suggest that DEX may serve as a protective agent in infection-induced hyperalgesia in neonates and preterm infants.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chengjie Wu, Yalan Pan, Lining Wang, Mengmin Liu, Mao Wu, Jianwei Wang, Guanglu Yang, Yang Guo, Yong Ma
Summary: This study aims to establish a new and efficient primary culture method for microglia in rats with spinal cord injury (SCI). The SCI model was created in SD rats using a modified A11en0s method, and microglia were observed and separated at different time points. The results showed that the number and purity of microglia were the highest after 3 days of SCI, and microglia exhibited a transition from active to resting state.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Dezun Ma, He Shen, Fangman Chen, Weiyuan Liu, Yannan Zhao, Zhifeng Xiao, Xianming Wu, Bing Chen, Junna Lu, Dan Shao, Jianwu Dai
Summary: This study utilized polyethylenimine-conjugated, diselenide-bridged mesoporous silica nanoparticles to deliver siRNA to silence IRF5, effectively regulating the M1-to-M2 macrophage conversion. The functional nanomaterial showed promising results in suppressing excessive inflammation and promoting neuroprotection and locomotor restoration in spinal cord injury.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Cell Biology
Jiaying Zheng, Madhuvika Murugan, Lingxiao Wang, Long-Jun Wu
Summary: Microglia play a crucial role in spinal cord injury, but excessive activation can cause secondary damage. The voltage-gated proton channel Hv1 is found to regulate microglial activation and its deficiency can alleviate secondary damage and improve neuronal recovery.
NEURAL REGENERATION RESEARCH
(2022)
Article
Immunology
Erliang Li, Rongbao Yan, Kang Yan, Rui Zhang, Qian Zhang, Peng Zou, Huimei Wang, Huan Qiao, Shuang Li, Qiong Ma, Bo Liao
Summary: We used single-cell RNA sequencing to study the cell types and signaling pathways related to immune autophagy in the site of spinal cord injury. Our data set provides valuable insights into the pathobiology of spinal cord injury and other traumatic diseases of the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Ying Li, Yi Xie, Rui Liu, Ziyue Wang, Peng Chen, Minghuan Wang, Zhiyuan Yu, Wei Wang, Xiang Luo
Summary: Spinal cord injury (SCI) causes functional deficits and neuronal damage, along with glial activation. The voltage-gated proton channel Hv1, expressed on microglia, is associated with SCI progression. The effect of Hv1 on reactive astrocytes after SCI remains unclear.
Review
Biochemistry & Molecular Biology
Sydney Brockie, James Hong, Michael G. Fehlings
Summary: Neuroinflammation plays a crucial role in the development of spinal cord injury, with microglia being key players in modulating the inflammatory response. Microglia interact with different cell types to facilitate injury response, but further research is needed to fully understand their mechanisms of action and spatial and temporal profiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yu-Xia Yang, Ming-Sheng Liu, Xi-Jian Liu, Yu-Cheng Zhang, Yang-Yang Hu, Rang-Shan Gao, Er-Kai Pang, Lei Hou, Jing-Cheng Wang, Wen-Yong Fei
Summary: Muscle injuries are common and hinder muscle regeneration. Researchers have developed porous Se@SiO2 nanoparticles that protect stem cell function, promote proliferation and differentiation, and facilitate muscle regeneration. This study reveals the potential application of porous Se@SiO2 nanoparticles in skeletal muscle diseases associated with mitochondrial dysfunction.
Article
Nanoscience & Nanotechnology
Chiang-Wen Lee, Zih-Chan Lin, Yao-Chang Chiang, Sin-Yu Li, Jyun-Jia Ciou, Kuan-Wen Liu, Yu-Ching Lin, Bo-Jie Huang, Kuo-Ti Peng, Mei-Ling Fang, Tzu-En Lin, Mei-Yi Liao, Chian-Hui Lai
Summary: We have successfully developed a novel green chemistry method to generate AuAg nanocomposites. The results showed that these nanocomposites were biocompatible and did not induce cell apoptosis or necrosis in human osteoblast cells. Additionally, they effectively inhibited the accumulation of reactive oxygen species (ROS) and suppressed ROS-triggered inflammatory protein expression. Therefore, AuAg nanocomposites have the potential to be a promising therapeutic agent for inflammation in bacteria-infected bone diseases.
Article
Clinical Neurology
Changgui Shi, Yanhai Xi, Bin Sun, Hailong He, Jiankun Wen, Yushan Ruan, Xiaojian Ye
Summary: This study reported a case of titanium allergy symptoms after ACDF surgery using Zero-P device.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Chemistry, Physical
Shaoqi Guan, Xijian Liu, Yang Fu, Chunlin Li, Jinxia Wang, Qixiang Mei, Guoying Deng, Wenrui Zheng, Zhiping Wan, Jie Lu
Summary: The biodegradable Nanodonut (CMPB-MoS2-PEG) with dual therapeutic functions enhances photothermal therapy and chemotherapy through responsive catalysis in the tumor microenvironment. The Nanodonut shows improved photothermal conversion efficiency and excellent biological safety in tumor treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shaoqi Guan, Xijian Liu, Chunlin Li, Xingyan Wang, Dongmiao Cao, Jinxia Wang, Lizhou Lin, Jie Lu, Guoying Deng, Junqing Hu
Summary: An intelligent biodegradable nanocomposite, mZMD, has been developed to enhance sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy by promoting oxidative stress and overcoming multidrug resistance.
Article
Materials Science, Biomaterials
Nannan Zheng, Yang Fu, Xijian Liu, Ziwen Zhang, Jinxia Wang, Qixiang Mei, Xingyan Wang, Guoying Deng, Jie Lu, Junqing Hu
Summary: This study developed a multifunctional biomimetic nanozyme that can release specific substances and catalyze reactions in the acidic environment of tumors to enhance tumor therapy. The nanozyme can also guide MRI-guided therapy, while cutting off the tumor's energy supply by catalyzing glucose to generate H2O2 and enhancing chemotherapy effect by upregulating ROS. Additionally, the nanozyme exhibits good biocompatibility and degradability.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Multidisciplinary
Chunlin Li, Feng Li, Jinyuan Chen, Hongmei Wu, Ying Lin, Canyu Chen, Peng Zhang, Qiugen Wang, Jing Liu, Guoying Deng
Summary: This study fabricated biomimetic cotton-like hollow Al2O3 fibers (HFs) with a unique hemostatic mechanism that can achieve safe and portable hemostasis in different situations. HFs can accelerate hemostasis compared to traditional hemostatic materials, and exhibit superior hemostatic efficacy, biocompatibility, and thermal stability.
MATERIALS & DESIGN
(2022)
Article
Engineering, Environmental
Xiang Wang, Chunlin Li, Hansong Jin, Xingyan Wang, Cheng Ding, Dongmiao Cao, Linjing Zhao, Guoying Deng, Jie Lu, Zhiping Wan, Xijian Liu
Summary: A smart biodegradable nanocatalyst CMFO was prepared to enhance oxidative stress and overload calcium for tumor treatment. CMFO released abundant Ca2+ and H2O2, and catalyzed H2O2 into toxic & BULL;OH, resulting in enhanced apoptosis of tumor cells. In addition, CMFO could be used as MR agent to identify tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Business, Finance
Jin Zou, Shuxin Li, Zihan Xu, Guoying Deng
Summary: This paper provides new evidence on how political uncertainty influences bond default and the efficiency of financial resource allocation through political connections, using China's local officials' turnover as a source of exogenous variation.
EUROPEAN JOURNAL OF FINANCE
(2023)
Article
Business, Finance
Yuwei Liu, Jiangyi Li, Guoying Deng
Summary: This paper examines whether prospect theory can explain stock market participation using panel data from a nationally representative survey in China. The empirical results show that individuals use expected income as a reference point when making investment decisions, with relative losses motivating excessive risk-taking and relative gains increasing risk aversion. These findings provide insights into the limited stock market participation among low-income individuals and the unwillingness of high-income individuals to hold stocks.
EUROPEAN JOURNAL OF FINANCE
(2023)
Article
Chemistry, Multidisciplinary
Xiang Wang, Cheng Ding, Ziwen Zhang, Chunlin Li, Dongmiao Cao, Linjing Zhao, Guoying Deng, Yu Luo, Chunping Yuan, Jie Lu, Xijian Liu
Summary: Researchers propose a new treatment method using CS/MnO2-GOx (CMGOx) nanocatalysts to generate strong oxidants in a hyperglycemic environment, which can inhibit tumors and bacteria, and promote wound healing.
CHINESE CHEMICAL LETTERS
(2023)
Article
Clinical Neurology
Weiheng Wang, Bing Xiao, Lei Yu, Haotian Wang, Junqiang Qi, Yanhai Xi, Guoying Deng, Xin Gu, Guohua Xu
Summary: This study aimed to investigate the effects of species, concentration, and volume of local anesthetics on intervertebral disk degeneration (IDD) in rats undergoing discoblock. The results showed that among the three local anesthetics, ropivacaine was the least toxic to nucleus pulposus cells (NPCs). The concentration of ropivacaine did not have a significant effect on IDD, but the volume did. Acupuncture itself significantly increased IDD.
EUROPEAN SPINE JOURNAL
(2022)
Article
Orthopedics
Zhihua Han, Qian Luo, Guoying Deng, Chun Bi, Gang Yin, Haodong Lin, Jianhong Wu, Xiaoming Wu
Summary: The study aimed to improve the mechanical properties of osteosynthesis plates used in clavicle fracture surgeries to prevent implant failure. The results showed that canceling the notch and filling the screw holes near the fracture site significantly reduced stress concentration under axial compression.
ORTHOPAEDIC SURGERY
(2023)
Article
Orthopedics
Jianxin Wu, Lei Yu, Yi Liu, Bing Xiao, Xiaojian Ye, Hong Zhao, Yanhai Xi, Zhicai Shi, Weiheng Wang
Summary: This study investigates the impact of hypoxia on adipose mesenchymal stem cells (ADSCs) proliferation, migration, and NPC-like differentiation through the regulation of HIF-1a and ER stress. The results show that hypoxia and HIF-1a overexpression increase ADSCs proliferation and migration, while HIF-1a inhibition reduces these processes. Additionally, hypoxia regulates ER stress in ADSCs through the HIF-1a pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yanhai Xi, Wenming Pan, Yanyan Liu, Ji Liu, Guohua Xu, Yanguo Su, Daquan Chen, Xiaojian Ye
Summary: Osteoporosis, a common disease in the ageing society, is caused by oxidative stress due to excessive accumulation of reactive oxygen species (ROS). Alpha-lipoic acid (ALA) is an antioxidant that can eliminate excess ROS and inhibit oxidative stress. In this study, PEGylated hollow gold nanoparticles (HGNPs) loaded with ALA were designed to treat osteoporosis. The results showed that mPEG@HGNPs-ALA had good biocompatibility and the ability to reduce oxidative stress.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Shengchang Luo, Jianxin Wu, Yuanyuan Qiu, Bing Xiao, Yanhai Xi, Chengwei Yang, Zhicai Shi, Weiheng Wang
Summary: This study aimed to investigate whether hydrogen can enhance the therapeutic effect of BMSC transplantation in the treatment of SCI. The results showed that hydrogen can significantly enhance BMSC proliferation and migration, and improve tolerance to SDM. In addition, hydrogen and BMSC co-delivery can improve the migration and proliferation capacity of BMSCs to repair SCI by reducing inflammatory response and oxidative stress, thus improving the treatment outcomes.
STEM CELLS INTERNATIONAL
(2023)
Article
Economics
Jingxi Wang, Manuel A. Hernandez, Guoying Deng
Summary: This paper evaluates the impact of a large-scale school meal program in rural China on the health and nutritional status of students aged 6-16 in compulsory education. The results show that program participation is associated with a higher child height-for-age, particularly among students in better health condition. However, the impact on the most disadvantaged students is small or not significant. There are no significant differences in effects across individual and household characteristics. The study suggests that more support is needed to achieve broader impacts that effectively reach all vulnerable students.
CHINA ECONOMIC REVIEW
(2023)
