Article
Anatomy & Morphology
Yong Li, Huiqin Huang, Xiaoyun Chen, Nanding Yu, Xiangli Ye, Limin Chen, Zhenghui Huang
Summary: This study revealed the molecular mechanism of F2RL1 promoting angiogenesis in LUAD and provided a potential therapeutic strategy for LUAD treatment.
Article
Biochemistry & Molecular Biology
Fang Hua, Wenzhuo Hao, Lingyan Wang, Shitao Li
Summary: EGFR-mediated NF-kappa B activation requires the involvement of PKP2 and LUBAC. Upon EGF stimulation, EGFR recruits PKP2 to the plasma membrane, activating the LUBAC complex and leading to NF-kappa B activation, which is crucial for tumor cell proliferation and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qian Gou, Wenbo Zhang, Ying Xu, Jianhua Jin, Qian Liu, Yongzhong Hou, Juanjuan Shi
Summary: The study revealed that EGF treatment increases PPARδ protein stability by inhibiting its lysosomal dependent degradation, which can be reduced by an EGFR inhibitor. Additionally, phosphorylation of PPARδ-Y108 induced by EGF promotes cancer cell metabolism, proliferation, and chemoresistance.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Se Jin Oh, Ji Yeon Lim, Min Kyu Son, Jun Hyeok Ahn, Kwon-Ho Song, Hyo-Jung Lee, Suyeon Kim, Eun Ho Cho, Joon-Yong Chung, Hanbyoul Cho, Hyosun Kim, Jae-Hoon Kim, Jooyoung Park, Jungmin Choi, Sun Wook Hwang, Tae Woo Kim
Summary: The emergence of cisplatin resistance and side-effects are important factors in cancer treatment failure. The authors identify autophagy-mediated EGFR hyperactivation by TRPV1 promotion as a mechanism of cisplatin resistance and demonstrate the efficacy of a TRPV1 inhibitor to sensitize lung cancer to cisplatin. Future studies should provide evidence regarding the mechanisms of potential targets that can overcome the resistance as well as alleviate pain.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Zhuna Wu, Chunxian Huang, Ruixin Li, Hui Li, Huaiwu Lu, Zhongqiu Lin
Summary: Impaired radiosensitivity is a major cause of therapeutic failures in cervical cancer patients undergoing radical radiotherapy. The PRKCI gene, which exhibits tumor-specific copy number amplification in cervical cancer, is found to decrease radiosensitivity by modulating the Hh/GLI1 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kun Shang, Nina Ma, Juanjuan Che, Huihui Li, Jiexuan Hu, Haolin Sun, Bangwei Cao
Summary: This study aims to explore the mechanisms of how PPARs and SLC27A2 regulate FA metabolism in colorectal cancer (CRC) and find new strategies for CRC treatment. The results showed that SLC27A2 was overexpressed in CRC, and PPARs had different expression levels, with PPARG being significantly highly expressed in CRC. There was correlation between SLC27A2 and PPARs in CRC, and both were closely related to fatty acid oxidation (FAO)-related genes. SLC27A2 mediates FA uptake and beta-oxidation through nongenic crosstalk regulation of the PPARs pathway in CRC.
Article
Immunology
Bin Huang, Wenjie Wen, Shandong Ye
Summary: This study identified BMI, TSH, and FT3 as significant independent risk factors for NAFLD; FT3 and TSH showed significant changes between NAFLD and non-NAFLD in the obesity subgroup; in obese mice fed a high-fat diet, serum TSH levels significantly increased, SPP1 expression intensified, while TR beta decreased.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Binshan Zhang, Guolan Xing
Summary: This study found that TMA is an independent risk factor for renal survival in LN patients, and the activation of complement lectin pathway and alternative pathway are involved in the pathogenesis of LN-associated TMA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Thomas Bartl, Christoph Grimm, Robert M. Mader, Christoph Zielinski, Gerald Prager, Matthias Unseld, Merima Herac-Kornauth, Alessandro Antonio Buda, Francesco Fanfani
Summary: This exploratory study evaluates the interaction between the mTOR pathway and ER expression in a preclinical cervical cancer model. The results show that ER expression is significantly correlated with phosphorylated-mTOR positive samples and is associated with improved survival in the subgroup of phosphorylated-mTOR positive tumors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Chi Chi, Wenjie Hou, Yi Zhang, Jie Chen, Zongji Shen, Youguo Chen, Min Li
Summary: In this study, it was found that the long non-coding RNA PDHB-AS is down-regulated in cervical cancer cells. Overexpression of PDHB-AS can suppress malignant behaviors of cervical cancer cells. PDHB-AS functions as a tumor suppressor by inhibiting the Wnt/β-catenin pathway, and it also interacts with other molecules such as miR-4536-5p, miR-582-5p, and DKK1 to regulate cisplatin resistance and tumor growth in cervical cancer. These findings suggest the therapeutic potential of PDHB-AS as a target for cervical cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Chong Liu, Zhao-Wei Gao, Xi Wang, Fang Lin, Hui-Zhong Zhang, Ke Dong
Summary: This study found that CD73 overexpression can promote the proliferation of cervical cancer cells and tumor growth, and it exerts its effect by activating the EGFR/AKT1 signaling pathway.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Sook-hee Hong, Nahyeon Kang, Okran Kim, Soon Auck Hong, Juyeon Park, Joori Kim, Myung-Ah Lee, Jinhyoung Kang
Summary: This article reports the impact of the CXCL10/CXCR3 pathway on EGFR-TKI resistance in EGFR-mutant lung cancer. It was found that in the co-culture of EGFR-mutant tumor cells and activated PBMCs treated with EGFR-TKI, CXCL10 increased in the supernatant, activating CXCR3 in tumor cells and leading to phosphorylation of Src and NF-KB subunit p65 as well as the expression of HIF-1a. Furthermore, treatment with CXCL10 siRNA decreased CXCL10 levels in the supernatant, suggesting that CXCL10 acts through autocrine and paracrine pathways. Importantly, the elevated CXCL10/CXCR3 signaling was also observed in a transgenic lung cancer mouse model. Overall, the results indicate that increased CXCL10 levels during early EGFR-TKI treatment stimulate persistent tumor cell signaling and contribute to EGFR-TKI resistance via autocrine and paracrine pathways.
Article
Microbiology
Stephanie D. Nofal, Caia Dominicus, Malgorzata Broncel, Nicholas J. Katris, Helen R. Flynn, Gustavo Arrizabalaga, Cyrille Y. Botte, Brandon M. Invergo, Moritz Treeck
Summary: In the lytic cycle of Toxoplasma gondii, calcium and cyclic nucleotide signaling pathways are connected by a positive feedback loop, which is regulated by a plant-like calcium dependent kinase (CDPK3) and a cAMP-specific phosphodiesterase (PDE2). This feedback loop allows the parasite to respond faster to egress inducers.
Article
Biology
Jingyan Li, Hongbing Wang
Summary: This study found that EGFR-AS1 is overexpressed in cervical cancer cells and acts as a sponge for miR-2355-5p, promoting cell growth through the ACTN4-mediated WNT pathway.
Article
Genetics & Heredity
Pasumarthi Deepti, Akbar Pasha, Divya Vishambhar Kumbhakar, Ravinder Doneti, S. K. Heena, Shivaji Bhanoth, Pavan Kumar Poleboyina, Rajesh Yadala, S. D. Annapurna, Smita C. Pawar
Summary: This study reveals the overexpression of SPP1 in cervical cancer and its significant association with patient prognosis. By validating and analyzing data from different databases, the high expression of SPP1 is confirmed to have important diagnostic and prognostic value in cervical squamous cell carcinoma.