Article
Endocrinology & Metabolism
Duke Appiah, Monique M. Hedderson, Catherine Kim, Stephen Sidney, Barbara Sternfeld, Charles P. Quesenberry Jr, Melissa F. Wellons, Erica P. Gunderson
Summary: This 28-year study followed 455 women with a mean age of 26 years and found that polycystic ovary syndrome (PCOS) was associated with a 2.6-fold higher risk of gestational diabetes (GDM). However, hyperandrogenism or oligo-menorrhea without PCOS was not associated with GDM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Annie W. Lin, David Siscovick, Barbara Sternfeld, Pamela Schreiner, Cora E. Lewis, Erica T. Wang, Sharon S. Merkin, Melissa Wellons, Lyn Steffen, Ronit Calderon-Margalit, Patricia A. Cassano, Marla E. Lujan
Summary: The study found little to no association between diet and physical activity with polycystic ovary syndrome (PCOS) and its symptoms. Therefore, the need for tailored dietary and physical activity recommendations for patients with PCOS is still debated.
Article
Public, Environmental & Occupational Health
Catherine Kim, Pamela J. J. Schreiner, David Siscovick, Ange E. Wang, Melissa F. F. Wellons, Imo Ebong, Thanh-Huyen Vu, Duke Appiah, Janet Catov, Enrique F. F. Schisterman, Zhe Yin, Cora E. E. Lewis
Summary: This study compared the characteristics of women with self-reported PCOS, unrecognized PCOS, and without PCOS. It found that unrecognized PCOS is common. Women who report PCOS are more likely to be obese and have diabetes, while unrecognized PCOS is associated with hypertension and food insecurity.
Review
Biochemistry & Molecular Biology
Dorte Glintborg, Naja Due Kolster, Pernille Ravn, Marianne Skovsager Andersen
Summary: The prospective risk of type 2 diabetes in normal weight women with polycystic ovary syndrome (PCOS) is still debated, with conflicting results from different studies. Individual risk markers such as hyperandrogenism, age >40 years, Asian ethnicity, and weight gain should be considered in prospective screening programs for normal weight women with PCOS.
Review
Medicine, General & Internal
Andreas A. Vyrides, Essam El Mahdi, Konstantinos Giannakou
Summary: Anovulation is a common condition characterized by amenorrhea, oligomenorrhea, and abnormal uterine bleeding. The most common chronic disorder associated with anovulation is polycystic ovary syndrome (PCOS), which affects 6% to 10% of the global population. Ovulation induction (OI) techniques are used in women with PCOS who are unable to conceive naturally. This narrative review provides an overview of the current evidence and available techniques for OI in women with PCOS, discussing their performance and applicability.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Aya Mousa, Kevin Huynh, Stacey J. Ellery, Boyd J. Strauss, Anju E. Joham, Barbora de Courten, Peter J. Meikle, Helena J. Teede
Summary: This study demonstrates that high levels of LPI(18:0) and low levels of DHA-containing lipids are associated with key metabolic risk factors in women with and without polycystic ovary syndrome (PCOS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Claire Falzarano, Taylor Lofton, Adjoa Osei-Ntansah, Trinitee Oliver, Taylor Southward, Salim Stewart, Stanley Andrisse
Summary: Recent research has shown a high prevalence of nonalcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS). Women with normal weight can also develop NAFLD. The majority of studies focus on adult, premenopausal women and little attention has been given to young and adolescent women with NAFLD. Future research should include more diverse populations and study the contribution of excess androgens and insulin resistance to NAFLD risk in women with PCOS of varying weights, ages, and ethnicities.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Noha M. Shawky
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, characterized by reproductive and metabolic abnormalities. Offspring of PCOS women may have increased risk of hypertension and cardiovascular diseases. Limited studies have been conducted on the long-term risks of hypertension and cardiovascular diseases in PCOS offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Carolyn Guan, Salman Zahid, Anum S. Minhas, Pamela Ouyang, Arthur Vaught, Valerie L. Baker, Erin D. Michos
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and is associated with increased risk of cardiovascular disease (CVD). However, there is a lack of consistent definitions and research results, and further studies are needed to determine the association and causality. In clinical practice, CVD risk screening should be performed, and lifestyle management and pharmacotherapy should be implemented as appropriate.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Xiying Zeng, Jiawen Ye, Xiaohong Yan, Jiayu Zhang, Jinru Guo, Xinge Tao, Xin Zheng, Meifeng Tong, Yinxiang Huang, Mulin Zhang, Chunmei He, Xueqin Chen, Changqin Liu
Summary: The association between late bedtime, night sleep duration, and lifetime cardiovascular disease (CVD) risk in women with polycystic ovary syndrome (PCOS) was investigated. It was found that both late bedtime (>= 1:00) and short sleep duration (<7 h/night) were independently associated with a high-lifetime CVD risk among women with PCOS. This study highlights the need for early interventions to improve sleep and cardiovascular outcomes in women with PCOS.
HUMAN REPRODUCTION
(2023)
Article
Medicine, Research & Experimental
Fatemeh Mahboobifard, Maryam Rahmati, Atrin Niknam, Ehsan Rojhani, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study explored the impact of Polycystic Ovary Syndrome (PCOS) on the risk of developing cardiovascular disease (CVD), and found that PCOS status did not increase the risk of silent coronary artery disease (CAD). However, women with a history of silent CAD had a higher incidence of CVD events. PCOS status independently reduced the incidence of CVD, regardless of silent CAD or traditional risk factors.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Thomas R. Berni, Christopher L. Morgan, D. Aled Rees
Summary: The study found that young women with PCOS have an increased risk of myocardial infarction, angina, and revascularization, with weight and type 2 diabetes being potentially modifiable risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Thomas R. Berni, Christopher L. Morgan, D. Aled Rees
Summary: The study found that young women with PCOS have an increased risk of developing myocardial infarction, angina, and revascularization. Weight gain and type 2 diabetes were identified as modifiable risk factors that can be intervened upon.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Iris Lee, Julia Vresilovic, Maryam Irfan, Robert Gallop, Anuja Dokras
Summary: The study found that there is a difference in the risk of metabolic syndrome in women with polycystic ovary syndrome between Black and White women, with Black women having a higher incidence rate. In addition to early cardiometabolic screening at the time of diagnosis, this population also requires ongoing and frequent screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)