Article
Oncology
Fei Zhou, Yan Huang, Weijing Cai, Jin Li, Chunxia Su, Shengxiang Ren, Chunyan Wu, Caicun Zhou
Summary: The study investigated the genomic and immunologic profiles of pure pulmonary sarcomatoid carcinoma (PSC) patients, finding that 45% of them carried actionable genetic mutations and over 60% could potentially benefit from immune checkpoint inhibitors.
Article
Biochemistry & Molecular Biology
Susann Stephan-Falkenau, Anna Streubel, Thomas Mairinger, Torsten-Gerriet Blum, Jens Kollmeier, Fabian D. Mairinger, Torsten Bauer, Joachim Pfannschmidt, Manuel Hollmann, Michael Wessolly
Summary: Pulmonary sarcomatoid carcinoma (PSC) is a highly aggressive subtype of lung cancer with poor clinical outcomes. In this study, we characterized 179 PSC cases and identified clinical, immunological, and molecular features using various techniques. We found that PSC is more common in men, older individuals, and smokers. Surgery was associated with improved overall survival. PD-L1 expression was detected in the majority of patients, and altered epitopes due to processing mutations contributed to immune escape and decreased survival. Genomic alterations for which there are approved drugs were present in a subset of patients. MET exon 14 skipping was found to be more frequent compared to other non-small cell lung cancers. In conclusion, the unique genomic and immunological features of PSC should be considered in therapy stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Esther Coronado, Yania Yanez, Enrique Vidal, Luis Rubio, Francisco Vera-Sempere, Antonio Jose Canada-Martinez, Joaquin Panadero, Adela Canete, Ruth Ladenstein, Victoria Castel, Jaime Font de Mora
Summary: High-risk neuroblastoma patients with 11q deletion exhibit immune inhibitory mechanisms and poorer outcomes, despite benefits from standard anti-GD2 immunotherapy. Combination immunotherapy may be a potential therapeutic strategy to overcome this immune checkpoint blockade.
MOLECULAR ONCOLOGY
(2021)
Article
Medicine, General & Internal
Maren Holand, Kaja C. G. Berg, Ina A. Eilertsen, Bodil Bjerkehagen, Matthias Kolberg, Kjetil Boye, Ole Christian Lingjaerde, Tormod K. Guren, Nils Mandahl, Eva van den Berg, Emanuela Palmerini, Sigbjorn Smeland, Piero Picci, Fredrik Mertens, Anita Sveen, Ragnhild A. Lothe
Summary: MPNSTs were classified into two transcriptomic subtypes: immune active type with sustained immune signals and favorable prognosis, and immune deficient type with aggressive disease course, PRC2 loss, and expression of potential therapeutic targets. Copy number-based proliferative transcriptomic signatures were associated with patient prognosis.
Article
Multidisciplinary Sciences
Fanying Tang, Duo Xu, Shangqian Wang, Chen Khuan Wong, Alexander Martinez-Fundichely, Cindy J. Lee, Sandra Cohen, Jane Park, Corinne E. Hill, Kenneth Eng, Rohan Bareja, Teng Han, Eric Minwei Liu, Ann Palladino, Wei Di, Dong Gao, Wassim Abida, Shaham Beg, Loredana Puca, Maximiliano Meneses, Elisa de Stanchina, Michael F. Berger, Anuradha Gopalan, Lukas E. Dow, Juan Miguel Mosquera, Himisha Beltran, Cora N. Sternberg, Ping Chi, Howard Scher, Andrea Sboner, Yu Chen, Ekta Khurana
Summary: This study classified CRPC into different subtypes using ATAC-seq, RNA-seq, and DNA sequencing. The identified subtypes include AR-dependent, neuroendocrine, Wnt-dependent, and stem cell-like subtypes driven by AP-1 transcription factors. Transcriptomic signatures were used for patient classification, and SCL was found to be the second most common subtype of CRPC.
Article
Biochemistry & Molecular Biology
Biqiang Zheng, Zhijian Song, Yong Chen, Wangjun Yan
Summary: Whole-exome sequencing of MSCs from different organs revealed TP53 and KMT2D as the most frequently mutated genes, with KMT2D mutations associated with low expression, large tumor size, and unfavorable prognosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Fiona J. Ruiz, Aishwarya Sundaresan, Jin Zhang, Chandra S. Pedamallu, Mari K. Halle, Vinodh Srinivasasainagendra, Jianqing Zhang, Naoshad Muhammad, Jennifer Stanley, Stephanie Markovina, Hemant K. Tiwari, Perry W. Grigsby, Camilla Krakstad, Julie K. Schwarz, Akinyemi Ojesina
Summary: Persistent HPV infection is a known driver of cervical carcinogenesis, but the significance of HPV undetected (HPVU) cervical cancer has been debated. This study demonstrates that HPVU status can serve as a predictive biomarker of poor patient response to standard treatments and suggests personalized treatment plans for such patients. Palbociclib emerges as a promising alternative treatment for HPVU cervical cancer patients.
Article
Oncology
Asad Ullah, Asim Ahmed, Abdul Qahar Khan Yasinzai, Kue Tylor Lee, Israr Khan, Bina Asif, Imran Khan, Bisma Tareen, Kaleemullah Kakar, Gul Andam, Saleh Heneidi, Jaffar Khan, Hina Khan, Nabin R. Karki, Jaydira Del Rivero, Nagla Abdel Karim
Summary: This study analyzed the demographics, tumor characteristics, treatment modalities, and outcomes of pulmonary sarcomatoid carcinoma (PSC). The results showed that PSC is a rare and aggressive subtype of non-small cell lung cancer, primarily affecting elderly Caucasian males. Treatment with surgery was associated with better survival outcomes.
Article
Medicine, Research & Experimental
Ting Gong, Bin Jia, Chen Chen, Zhenfa Zhang, Changli Wang
Summary: The study aimed to evaluate clinical factors influencing the prognosis of postoperative pulmonary sarcomatoid carcinoma (PSCs). The findings showed that pure PSCs occurred more frequently with large tumors, while airway dissemination, pleural retraction, and metastatic mediastinal lymph node number were associated with patient survival.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Redel-Traub, Kevin J. Sampson, Robert S. Kass, Michael S. Bohnen
Summary: Pulmonary arterial hypertension (PAH) is a devastating disease with complex pathogenesis. Recent studies have identified potassium channelopathies as novel causes of PAH. KCNK3, KATP, and Kv potassium channels have been proposed as promising therapeutic targets in PAH, and experimental pharmacologic discoveries have significantly advanced the field.
Review
Cell Biology
Liu Yang, Naifu Wan, Fanpeng Gong, Xianfeng Wang, Lei Feng, Guizhu Liu
Summary: Pulmonary hypertension is a fatal disease with excessive pulmonary arterial cell remodeling. Various cellular abnormalities contribute to pulmonary arterial remodeling, leading to increased pulmonary vascular resistance and pressure. Studies have identified transcription factors as key regulators in this process, highlighting the importance of understanding their molecular mechanisms for developing novel therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Jing Qin, Bo Chen, Chenghui Li, Junrong Yan, Hongyang Lu
Summary: Genetic heterogeneity and predictive biomarkers were investigated in patients with pulmonary sarcomatoid carcinoma (PSC). The study found common mutations between the carcinomatous and sarcomatous components, as well as significantly higher PD-L1 expression in the carcinomatous components. High PD-L1 expression suggests potential efficacy of immunotherapy for PSC patients, emphasizing the importance of genetic alteration and PD-L1 expression detection in treatment.
Article
Biochemistry & Molecular Biology
Xuewen Liu, Fang Wang, Chunwei Xu, Xinru Chen, Xue Hou, Qian Li, Pansong Li, Zhi Xie, Yongdong Liu, Lianpeng Chang, Yanfang Guan, Xuchao Zhang, Ling Yang, Hui Wang, Xin Yi, Jianjun Zhang, Xuefeng Xia, Cesar Moran, Likun Chen
Summary: Most PSCs originate from a monoclonal population accompanied by genomic ITH, which is a potential independent prognostic factor. Patients with a lower proportion of component-shared alterations in PSC may have a prolonged disease-free survival, and more proportion of PSCs may benefit from immune checkpoint inhibitors.
Article
Oncology
Qiong Shi, Lin Liu, Jianru Chen, Weigang Zhang, Weinan Guo, Xiao Wang, Huina Wang, Sen Guo, Qiao Yue, Jingjing Ma, Yu Liu, Guannan Zhu, Tao Zhao, Jianhong Zhao, Ying Liu, Tianwen Gao, Chunying Li
Summary: This study conducted genomic research on acral melanoma in Asian populations, identifying mutated genes associated with the disease and analyzing its pathogenesis and therapeutic targets. Additionally, it reconstructed the mutational processes of the samples and identified early mutational events. This study provides a foundation for the development of personalized strategies for treating acral melanoma in Asian populations.
CLINICAL CANCER RESEARCH
(2022)
Review
Hematology
Karen Aymonnier, Charlotte Kawecki, Veronique Arocas, Yacine Boulaftali, Marie Christine Bouton
Summary: Hemostasis is a regulated process involving a balance between procoagulant and anticoagulant systems. Hemophilia, a well-known bleeding disorder, is caused by deficiencies in FVIII or FIX and recent studies suggest that targeting natural serpins could rebalance coagulation in hemophilia.
THROMBOSIS AND HAEMOSTASIS
(2021)