Article
Radiology, Nuclear Medicine & Medical Imaging
Yanan Zhang, Yiran Huang, Ni Liu, Zhenjia Wang, Junchen Wu, Wenxun Li, Jing Xia, Zhidan Liu, Yingqiu Li, Ying Hao, Jianwei Huo
Summary: This study used functional MRI to explore the changes in voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity (FC) in patients with primary dysmenorrhea (PDM). The results revealed enhanced VMHC in the bilateral orbital part of the superior frontal gyrus and the bilateral middle frontal gyrus in PDM patients compared to healthy controls. Further analysis showed enhanced connectivity between these areas and pain-related brain structures. The hyperconnectivity between the left middle frontal gyrus and the right cingulate gyrus in patients was negatively correlated with the severity of pain. These findings provide a new perspective on the central mechanism of pain in PDM.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Jiaxin Peng, Fan Yao, Qiuyu Li, Qianmin Ge, Wenqing Shi, Ting Su, Liying Tang, Yicong Pan, Rongbin Liang, Lijuan Zhang, Yi Shao
Summary: Previous neuroimaging studies have shown significant functional and anatomical changes in the brains of patients with strabismus or amblyopia. However, the current study focused on analyzing alterations in interhemispheric functional connectivity using voxel-mirrored homotopic connectivity (VMHC) in children with strabismus and amblyopia. The results indicated abnormal interhemispheric functional connectivity in multiple brain regions of children with strabismus and amblyopia, potentially reflecting dysfunction in eye movements and visual fusion. These findings might offer insights into the underlying pathogenetic mechanisms of the conditions.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Ronnie Krupnik, Yossi Yovel, Yaniv Assaf
Summary: The structure of the brain's connectome has a significant impact on information transfer efficiency, with a trade-off between inner hemispheric and interhemispheric connectivity. Certain brain regions, such as the cingulate cortex and frontal areas, play a key role in this phenomenon. The connectivity conservation phenomenon observed in the study may explain the functional, behavioral, and cognitive variability among different brains.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychiatry
Ge Yang, Sen Zhang, Youqi Zhou, Yichen Song, Wenyan Hu, Yue Peng, Han Shi, Yan Zhang
Summary: The study found that drug-naive first-episode AOS patients demonstrate abnormalities in interhemispheric functional connectivity, which are not mitigated by short-term antipsychotic treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Yi-ling Wang, Mu-liang Jiang, Li-Xuan Huang, Xia Meng, Shu Li, Xiao-qi Pang, Zi-san Zeng
Summary: The study aimed to investigate alterations in interhemispheric homotopic functional connectivity in SLE patients with and without neuropsychiatric lupus, and their correlations with clinical characteristics and neuropsychological performance. Both NPSLE and non-NPSLE groups showed attenuated homotopic connectivity in various brain regions compared to healthy controls, with the impairment being more pronounced in NPSLE patients. Decreased interhemispheric homotopic functional connectivity in certain brain regions was associated with anxiety symptoms in SLE patients.
Article
Endocrinology & Metabolism
Si-Wen Tan, Guo-Qian Cai, Qiu-Yu Li, Yu Guo, Yi-Cong Pan, Li-Juan Zhang, Qian-Min Ge, Hui-Ye Shu, Xian-Jun Zeng, Yi Shao
Summary: This study aimed to assess abnormal changes in interhemispheric functional connectivity in DON patients using the VMHC method. Results showed significantly lower VMHC values in specific brain areas of DON patients compared to healthy controls. The findings suggest that anomalous interhemispheric functional connectivity in DON patients may indicate neuropathologic mechanisms of vision loss and blurry vision.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Neurosciences
Zhishuai Jin, Sizhu Huyang, Lichen Jiang, Yajun Yan, Ming Xu, Jinyu Wang, Qixiong Li, Daxing Wu
Summary: The study revealed that individuals with congenital amusia exhibit increased interhemispheric functional connectivity in the posterior part of the default mode network, particularly in the posterior superior temporal gyrus and posterior cingulate cortex, which were negatively correlated with music perception ability. These findings suggest that the immature state of the default mode network may serve as a reliable neural marker for amusia.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yang Yang, Tie Li, Yan Deng, Junlong Wang, Yajie Li, Hanqiu Liu, Weiwei Wang
Summary: This study evaluated the interhemispheric functional connectivity in brachial plexus avulsion injury patients using resting-state functional magnetic resonance imaging. It found that an increased functional connectivity between the precentral gyrus and supplementary motor area was positively correlated with motor recovery.
Article
Multidisciplinary Sciences
Daniel Vereb, Balint Kincses, Tamas Spisak, Frederik Schlitt, Nikoletta Szabo, Peter Farago, Krisztian Kocsis, Bence Bozsik, Eszter Toth, Andras Kiraly, Matthias Zunhammer, Tobias Schmidt-Wilcke, Ulrike Bingel, Zsigmond Tamas Kincses
Summary: This study investigated how spatial features of insular resting state functional organization correspond to individual pain sensitivity. The results showed significant associations between spatial features of dominant connectopies in the right insula and thermal as well as composite pain sensitivity, while the left insular gradient was not significantly associated with pain thresholds. This highlights the functional relevance of gradient-like insular organization in pain processing and suggests that considering individual variations in insular connectopy might contribute to understanding neural mechanisms behind pain.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Shunshun Cui, Ping Jiang, Yan Cheng, Huanhuan Cai, Jiajia Zhu, Yongqiang Yu
Summary: Previous literature has shown that there are sex differences in behavioral inhibition and its neural substrates. This study aimed to investigate whether there are sex-dependent associations between behavioral inhibition and resting-state brain function, and how they are modulated by molecular mechanisms. The authors used resting-state functional MRI data to compute functional connectivity density (FCD) and examined its associations with behavioral inhibition ability in a large cohort of healthy young adults. They found a significant negative correlation between behavioral inhibition and FCD in the left superior parietal lobule in females but not in males. Further analyses revealed that the neural correlates of behavioral inhibition were associated with gene expression and neurotransmitter atlases, particularly those related to the cerebral cortex and the serotonergic system. These findings provide important insights into the molecular mechanisms underlying the female-specific neural substrates of behavioral inhibition, and shed light on the contribution of biological sex to variation in behavioral inhibition and its related disease risk.
Article
Neurosciences
Wen Chen, Hao Hu, Qian Wu, Lu Chen, Jiang Zhou, Huan-Huan Chen, Xiao-Quan Xu, Fei-Yun Wu
Summary: This study utilized rs-fMRI to investigate interhemispheric functional connectivity alterations in TAO patients, revealing changes in static and dynamic VMHC in occipital, parietal, and orbitofrontal areas, which could serve as neuroimaging prediction markers of TAO. Connectivity differences were found to be correlated with visual acuity and emotional state in TAO patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neuroimaging
Fengmei Lu, Mengyun Wang, Shiyang Xu, Heng Chen, Zhen Yuan, Lizhu Luo, Xiuli Wang, Jiang Zhang, Jing Dai, Xiaoping Wang, Huafu Chen, Jiansong Zhou
Summary: The study utilized the VMHC method to examine interhemispheric functional connectivity abnormalities in CD patients, finding reduced homotopic connectivity in components of visual and motor networks compared to TDs. Moreover, the VMHC of the MOG and PCL was negatively correlated with clinical scores in the CD group.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Chaira Serrarens, Sriranga Kashyap, Laura Riveiro-Lago, Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Henk Jansma, David E. J. Linden, Therese A. M. J. van Amelsvoort, Claudia Vingerhoets
Summary: This study investigated the effects of triple X syndrome (47,XXX) on functional connectivity in the brain. The results showed abnormal increase in resting-state functional connectivity in patients. However, these changes were not associated with intelligence quotient (IQ) or social cognition function.
Article
Neurosciences
Han Zhao, Huanhuan Cai, Fan Mo, Yun Lu, Shanwen Yao, Yongqiang Yu, Jiajia Zhu
Summary: Functional homotopy is a fundamental characteristic of the brain's intrinsic functional architecture, and research has found that genes related to functional homotopy are enriched for multiple biological functions and associated with neuropsychiatric disorders. Additionally, these genes show specific expression in brain tissue, neurons, and immune cells.
Article
Neurosciences
Eirini Messaritaki, Sonya Foley, Simona Schiavi, Lorenzo Magazzini, Bethany Routley, Derek K. Jones, Krish D. Singh
Summary: The study investigates the relationship between brain structure and function using microstructural MRI and resting-state MEG data. The shortest-path-length algorithm is found to be better at predicting functional connectivity patterns, with streamline count and myelination leading to the highest correlations between predicted and observed functional connectivity.
NETWORK NEUROSCIENCE
(2021)