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Cell Biology
Zhifei Xu, Zezheng Pan, Ying Jin, Zizheng Gao, Feng Jiang, Huangxi Fu, Xueqin Chen, Xiaochen Zhang, Hao Yan, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo
Summary: This study revealed a novel mechanism for Crizotinib-induced cardiotoxicity, demonstrating that reviving the autophagy flux can reverse cardiomyocyte damage and mitochondrial injury, with metformin potentially serving as a therapeutic approach for Crizotinib-induced cardiotoxicity.
Article
Cell Biology
Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu
Summary: The study revealed that high expression of E2F2 in gastric cancer is associated with poor prognosis, and it promotes cancer cell migration and invasion by inhibiting autophagy through the PI3K/Akt/mTOR pathway. E2F2 may also modulate tumor immunity.
Article
Biochemistry & Molecular Biology
Yi-Xuan Wang, Yi-Yuan Jin, Jie Wang, Zi-Cheng Zhao, Ke-Wen Xue, He Xiong, Hui-Lian Che, Yun-Jun Ge, Guo-Sheng Wu
Summary: Icaritin (ICT), a derivative of Epimedium Genus, can inhibit the proliferation and stemness of breast cancer cells. This study found that IC2, a derivative of ICT, induced apoptosis in breast cancer cells by inhibiting SCD1 and also stimulated autophagy through AMPK and MAPK signaling pathways. The combination of autophagy inhibitor enhanced the anticancer activity of IC2, suggesting the potential of IC2 in combination therapy for breast cancer.
Article
Medicine, Research & Experimental
Baixin Wang, Yuanzhi Zhu, Lei Liu, Binshan Wang, Mei Chen, Jingtao Wang, Limin Yang, JiGuang Liu
Summary: EV71 infection can induce autophagy in the brains, lungs, and muscles of infected mice by simultaneously inhibiting mTOR and activating the ERK pathway. The mTOR and ERK signaling pathways are independent and do not interfere with each other.
Review
Biochemistry & Molecular Biology
Karla Rubio, Alejandro Molina-Herrera, Andrea Perez-Gonzalez, Hury Viridiana Hernandez-Galdamez, Carolina Pina-Vazquez, Tania Araujo-Ramos, Indrabahadur Singh
Summary: Fibrosis is a pathological condition characterized by excessive deposition of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have highlighted the role of the histone acetyltransferase EP300 in mediating epigenetic changes associated with fibrosis. EP300-mediated histone acetylation alters chromatin structure and gene expression, promoting fibrosis development and progression. This review discusses the involvement of EP300 in multi-organ fibrosis and its potential as a therapeutic target, including the use of small molecule inhibitors and gene therapy approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou
Summary: Despite efforts to improve treatment for cholangiocarcinoma, the long-term survival rate remains poor. HCQ, an antimalarial drug, inhibits autophagy and shows therapeutic effects on various cancers. In this study, HCQ effectively suppressed cholangiocarcinoma by inhibiting autophagy, inducing apoptosis and cell cycle arrest through ROS accumulation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Ha Jung Lee, Seong Hyun Kim, Yong Hwan Kim, So Hyun Kim, Gyeong Seok Oh, Ji-Eun Bae, Joon Bum Kim, Na Yeon Park, Kyuhee Park, Eunbyul Yeom, Kwiwan Jeong, Pansoo Kim, Doo Sin Jo, Dong-Hyung Cho
Summary: Selective autophagy, specifically melanophagy, can be induced by activating kappa-opioid receptors and inhibiting protein kinase A (PKA) activation, resulting in reduced melanin content. The chemical nalfurafine hydrochloride acts as a potent inducer of melanophagy and can suppress excessive melanin production in melanocytes. Moreover, forskolin, a PKA activator, can restore PKA activation and reverse the decrease in melanin content caused by nalfurafine hydrochloride, suggesting the involvement of PKA in melanophagy.
Article
Oncology
Liwei Wang, Jiazhong Shi, Sha Liu, Yaqin Huang, Hua Ding, Baixiong Zhao, Yuting Liu, Wuxing Wang, Jin Yang, Zhiwen Chen
Summary: The study found that RAC3 is highly expressed in bladder cancer and is associated with poor prognosis. Silencing RAC3 can exert anti-tumor effects by enhancing PI3K/AKT/mTOR-mediated autophagy. Simultaneously targeting RAC3 and autophagy may be a potential therapeutic strategy for inhibiting bladder cancer progression and prolonging survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Hyun-Ji Cho, Jeong-A Hwang, Eun Jae Yang, Eok-Cheon Kim, Jae-Ryong Kim, Sung Young Kim, Young Zoon Kim, Sang Chul Park, Young-Sam Lee
Summary: In this study, it was found that Nintedanib can be used as a new senolytic agent, selectively inducing the death of senescent cells. It achieves drug-induced death by inhibiting the STAT3 pathway and reduces the number of senescent cells and collagen deposition.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Summary: The study uncovers that mutations in histone acetyltransferases CREBBP/EP300 can increase homologous recombination, making tumors more sensitive to radiation, and have a synergistic effect with HAT inhibitors. These findings not only provide a resistance mechanism but also offer potential for genomically-driven treatment.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Cheong-Yong Yun, Nahyun Choi, Jae Un Lee, Eun Jung Lee, Ji Young Kim, Won Jun Choi, Sang Ho Oh, Jong-Hyuk Sung
Summary: This study demonstrated that the marliolide derivative DMF02 can induce melanosome degradation through autophagy pathway by activating Nrf2, leading to reduced melanin pigmentation. Additionally, DMF02 was effective in reducing UVB-induced hyperpigmentation and regulating melanosome degradation via suppression of p62. These findings suggest that Nrf2 activators could be promising therapeutic agents for reducing hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yinfeng Xu, Wei Wan
Summary: This review summarizes the importance of acetylation modifications in the regulation of autophagy and their regulatory roles on multiple autophagy proteins. Acetylation regulates autophagy initiation, autophagosome formation, and transcriptional regulation by targeting core protein complexes and key regulatory molecules.
Article
Environmental Sciences
Jiangnan Yi, Jianzhao Liao, Tian Bai, Bole Wang, Chamba Yangzom, Zulfiqar Ahmed, Khalid Mehmood, Rao Zahid Abbas, Ying Li, Zhaoxin Tang, Hui Zhang
Summary: Battery waste has toxic effects on kidney function, leading to changes in mitochondria division-related genes and proteins, increased expression of autophagy and apoptosis-related genes and proteins, and decreased expression of certain genes and proteins.
Article
Biochemistry & Molecular Biology
Yeo-Eun Cha, Rackhyun Park, Minsu Jang, Yea-In Park, Ayane Yamamoto, Won Keun Oh, Eun-Ju Lee, Junsoo Park
Summary: The study reveals that 6-AZA regulates autophagy-mediated cell death in various human cancer cells by activating lysosomal function. The compound exhibits cytotoxicity in different cancer cells with diverse mechanisms, including inducing apoptosis or causing cell cycle arrest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Lu Yu, Zhanjun Lv, Siyu Li, Huijie Jiang, Biqi Han, Xiaoyan Zheng, Yunfeng Liu, Zhigang Zhang
Summary: This study found that long-term exposure to arsenic in the environment can cause liver injury in chickens, which is induced by activating autophagy to degrade ferritin and promote iron-dependent lipid peroxidation, leading to cell death. Blocking this process may provide insights for preventing and treating liver injury induced by environmental arsenic exposure in livestock and poultry.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)