Article
Oncology
Yujing Liu, Chunyan Wang, Peiqiu Cheng, Shengan Zhang, Wenjun Zhou, Yangxian Xu, Hanchen Xu, Guang Ji
Summary: This study found that low FHL1 expression is associated with poor patient survival in colorectal cancer. Experimental results indicate that FHL1 acts as a tumor suppressor in CRC, primarily by inhibiting cell proliferation through regulating the Wnt/beta-catenin signaling pathway.
Article
Cell Biology
Pengfei Bao, Peng Li, Xiaoqing Zhou, Huijiang Zhang, Shengjie You, Zhaoyu Xu, Qi Wu
Summary: This study aimed to investigate the effects of scaffold matrix attachment region binding protein 1 (SMAR1) on the development of bladder cancer (BCa). The results showed that down-regulation of SMAR1 was associated with worse prognoses in BCa patients. SMAR1 was found to inhibit the viability, proliferation, migration, invasion, and Warburg effect of BCa cells. It is suggested that SMAR1 may suppress the Wnt/beta-catenin signaling pathway to inhibit the progression of BCa.
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Xiang Li, Jiepeng Huang, Tingting Yu, Xiaoting Fang, Liqin Lou, Shijun Xin, Ling Ji, Feizhao Jiang, Yongliang Lou
Summary: This study demonstrates that Fusobacterium nucleatum abundance is significantly higher in CRC tissues and is closely associated with CRC progression. F. nucleatum enhances CRC cell proliferation and migration through activating Cdk5 and the Wnt/beta-catenin signaling pathway, revealing a novel mechanism for CRC development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Zhao-Hui Chen, Yao Tian, Guang-Lei Zhou, Hao-Ran Yue, Xue-Jie Zhou, Hai-Yan Ma, Jie Ge, Xin Wang, Xu-Chen Cao, Yue Yu
Summary: This study found that the promoter region of CMTM7 is hypermethylated in breast cancer tissues and cell lines, indicating the tumor suppressor role of CMTM7 both in vitro and in vivo. Furthermore, CMTM7 interacts with CTNNA1 and regulates Wnt/beta-catenin signaling. Lastly, TCF3 regulates the expression of miR-182-5p. These findings highlight the important role of CMTM7 in breast cancer progression and suggest CMTM7 and other elements in the feedback loop as potential targets for breast cancer therapy.
BREAST CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen
Summary: This study found that Portulaca oleracea extract (POE) inhibited the development of colorectal cancer (CRC) by regulating gut microbiota imbalance, inactivating the Wnt/beta-catenin signaling pathway, and downregulating the expression of c-Myc and cyclin D1.
Article
Pharmacology & Pharmacy
Xingming Zhao, Zhuo Han, Jiahui Ma, Shiqing Jiang, Xia Li
Summary: The study investigated a novel N-sulfonylamidine derivative 26ag in suppressing CRC cell proliferation and migration, revealing its strong anti-cancer activity by inhibiting C-met and reducing expression of hallmarks associated with EMT, involving the β-catenin-dependent pathway. This research demonstrates the potential of 26ag as a promising drug candidate for the therapy of CRC by inhibiting the Wnt/β-catenin pathway.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhongxue Fu
Summary: This study found that Sestrin2 inhibits the progression of colorectal cancer by suppressing cell proliferation, migration, and colony formation. It also affects the cancer stemness properties. This is achieved through downregulation of the Wnt signaling pathway. The findings suggest that Sestrin2 could be a promising therapeutic target for colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih-Cherng Liou, Edouard C. Nice, Jingwen Jiang, Canhua Huang
Summary: The heat shock 70 kDa protein 8 (HSPA8) is identified as an important regulator in the development of refractory BRAF V600E colorectal cancer (CRC), promoting the activation of the Wnt/beta-catenin signaling pathway and contributing to cancer metastasis and progression. HSPA8 may serve as a predictive biomarker and therapeutic target in clinical practice.
Article
Pharmacology & Pharmacy
Chaojun Zhu, Zihuan Wang, Jianqun Cai, Chunqiu Pan, Simin Lin, Yue Zhang, Yuting Chen, Mengxin Leng, Chengcheng He, Peirong Zhou, Changjie Wu, Yuxin Fang, Qingyuan Li, Aimin Li, Side Liu, Qiuhua Lai
Summary: The study found that vitamin D-3 inhibits CRC progression by promoting NAT2, possibly through the JAK1/STAT3 signaling pathway. Low expression of NAT2 was associated with higher metastasis risk and lower survival rates in CRC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Peng Liu, Fuao Cao, Jinke Sui, Yonggang Hong, Qizhi Liu, XianHua Gao, Haifeng Gong, Liqiang Hao, Zheng Lou, Wei Zhang
Summary: The study identified that miR-142-3p acts as a tumor suppressor in colorectal cancer by directly targeting CTNNB1 and inhibiting Wnt signaling activation. Overexpression of miR-142-3p repressed cell proliferation and reduced beta-catenin levels, suggesting its potential as a therapeutic target for CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.