Article
Food Science & Technology
Jaeeun Jung, Jeongjin Park, Minhee Lee, Jinhak Kim, Dongchan Oh, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: In this study, the potential anti-obesity effects of Salacia reticulata extracts (SC) were explored in obese mice and 3T3-L1 adipocytes, revealing that SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size. SC treatment also exerted inhibitory effects on adipogenesis and lipogenesis, while promoting lipolysis and thermogenesis pathways. These findings suggest that SC has a direct influence on lipid metabolism of adipocytes, making it a promising candidate for weight loss interventions.
Article
Biochemistry & Molecular Biology
Jie Cai, Gu Qiong, Chanjuan Li, Lulu Sun, Yuhong Luo, Shengheng Yuan, Frank J. Gonzalez, Jun Xu
Summary: MNSB isolated from Saururus chinensis has been identified as a potent inhibitor of adipogenesis/lipogenesis by increasing phosphorylation of AMPK. In animal studies, MNSB showed preventive and therapeutic effects on obesity, along with decreasing adipocyte size. Additionally, MNSB was found to increase AMPK phosphorylation in subcutaneous white adipose tissue and brown adipose tissue in vivo.
Article
Food Science & Technology
Wenrui Liu, Lihua Wang, Jie Zhang
Summary: Peanut shells, as agricultural waste, contain luteolin (LUT) which has anti-obesity properties. The study found that the extract from peanut shells can inhibit adipogenesis, accelerate lipolysis, and promote lipid browning, making it a potential dietary supplement for weight management.
Article
Pharmacology & Pharmacy
Hye-Young Joung, Jung-Mi Oh, Min-Suk Song, Young-Bae Kwon, Sungkun Chun
Summary: Obesity is a serious health problem associated with various chronic diseases. Increased MAO activity has been found in the adipose tissue of obese individuals. In this study, the anti-obesity effect of selegiline, a selective MAO-B inhibitor, was investigated using animal models. The results showed that selegiline reduced body weight and fat accumulation, improved glucose metabolism, and increased energy expenditure by promoting browning of white adipose tissue. These findings suggest that selegiline has the potential to be an anti-obesity treatment by inhibiting MAO-B activity.
Article
Food Science & Technology
Seong-Hoo Park, Jeongjin Park, Minhee Lee, Jinhak Kim, Sangwon Eun, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: This study aimed to investigate the antiobesity effects of Kaempferia parviflora extracts (PF) in high-fat diet-induced obese mice and 3T3-L1 adipocytes, and to demonstrate the lipid mechanisms underlying these effects. The results showed that PF supplementation significantly reduced body weight gain, adipose tissue weight, adipose tissue mass, and size of adipocytes in HFD-fed mice. Furthermore, PF supplementation suppressed adipogenesis and lipogenesis pathways, while activating lipolysis and thermogenesis pathways in the adipose tissues of HFD-fed mice. Therefore, PF is suggested to be effective for weight loss by directly affecting the lipid metabolism of adipocytes.
FOOD & NUTRITION RESEARCH
(2023)
Article
Food Science & Technology
Jeong Moon Yun, Jaeeun Jung, Seong-Hoo Park, Young Ha Seo, Jae Kyoung Lee, Mun Hyoung Bae, Sangwon Eun, Ok-Kyung Kim, Jeongmin Lee
Summary: The study found that the extract from sunflower seed (SUNCA) can prevent obesity in high-fat diet-induced obese mice by suppressing the adipogenesis/lipogenesis pathway and stimulating the lipolysis/thermogenesis pathway.
FOOD & NUTRITION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Soo-Jeung Park, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, Jeongmin Lee
Summary: This study investigated the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. The results showed that TJ reduced lipid accumulation by promoting lipolysis and inhibiting adipogenesis and lipogenesis. The component ellagic acid in TJ might contribute to its effectiveness.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Shim Han, Ilavenil Soundharrajan, Mariadhas Valan Arasu, Dahye Kim, Ki-Choon Choi
Summary: This study investigated the effects of Leuconostoc citreum (LSC) cell-free metabolites on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes. The results showed that LSC treatment reduced lipid droplet accumulation and the expression of key adipogenic and lipogenic markers while increasing lipolysis. Additionally, LSC treatment elevated adiponectin levels, suggesting its potential as a novel probiotic strain for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hong Chen, Qilin Pei, Linfen Tao, Jing Xia, Guocai Lu, Ying Zong, Wenhua Xie, Wanqing Li, Chenglong Huang, Ting Zeng, Xinyu Yu, Weixuan Wang, Gaojun Chen, Song Yang, Rui Cheng, Xi Li
Summary: Obesity poses a significant threat to human health due to chronic inflammation and metabolic diseases. Apoptosis-associated speck-like protein (ASC) acts as a critical link between inflammasome and apoptosis-inducing proteins. This study reveals that ASC deficiency promotes lipid accumulation by increasing lipogenesis and decreasing lipolysis in subcutaneous adipose tissue, aggravating obesity and metabolic imbalance. In addition, ASC regulation of p53/AMPKα axis contributes to the dysregulation of lipid metabolism. The findings suggest that ASC could be a potential therapeutic target for obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jung-Mi Oh, Sungkun Chun
Summary: In this study, it was found that Compound-K, an active ingredient in ginseng, inhibits lipid droplet and adipogenesis by downregulating the expression of specific genes and proteins involved in adipocyte differentiation. This compound also exhibits antioxidant properties by decreasing reactive oxygen species production and increasing antioxidant enzymes. The findings suggest that Compound-K exerts its anti-adipogenic effects through the activation of the AMPK signaling pathway and inhibition of the ERK/p38 and AKT signaling pathways.
Article
Food Science & Technology
Jinhee Song, Hana Lee, Huijin Heo, Junsoo Lee, Younghwa Kim
Summary: We investigated the effects of chrysoeriol on fat cell formation and breakdown and identified the underlying mechanisms. Chrysoeriol inhibited fat accumulation in adipocytes and downregulated the expression of key genes involved in fat synthesis. Furthermore, chrysoeriol activated a protein kinase that promotes fat breakdown and increased the levels of free glycerol and fatty acids. Overexpression of specific enzymes for fat breakdown contributed to the enhanced lipolysis induced by chrysoeriol. Overall, chrysoeriol exhibited anti-adipogenic and lipolytic properties in fat cells.
Article
Biochemistry & Molecular Biology
Sung Ho Ahn, Hyun Jung Lee, Do Hyeon Pyun, Tae Jin Kim, A. M. Abd El-Aty, Jin-Ho Song, Yong Kyoo Shin, Ji Hoon Jeong, Eon Sub Park, Tae Woo Jung
Summary: CAP can attenuate lipogenesis and enhance lipolysis in adipocytes through the irisin/AMPK pathway, suggesting that it may be a novel therapeutic agent for obesity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Yeon Ju Kim, Sung Yun Park, Ju-Hee Lee
Summary: The study revealed that berteroin significantly inhibits lipid synthesis and lipid droplet formation, potentially mediated by AMPK activation.
Article
Pharmacology & Pharmacy
Gangadharan Leela Shyni, Kaithathara Francis Sajin, Sivasankaran Nair Mangalam, Kozhiparambil Gopalan Raghu
Summary: TM from Myristica fragrans has shown anti-obesity effects in 3T3-L1 adipocytes by reducing lipid accumulation, promoting lipolysis, and regulating genes and proteins involved in lipid metabolism. It also enhances glucose uptake and increases carnitine palmitoyltransferase levels, suggesting its potential as an anti-obesity therapeutic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Gloria Itzel Pena-Vazquez, Maria Teresa Dominguez-Fernandez, Bianka Dianey Camacho-Zamora, Marcelo Hernandez-Salazar, Vania Urias-Orona, Maria-Paz De Pena, Ana Laura de la Garza
Summary: This study simulated the bioaccessibility of polyphenols in sweet orange during the digestion process and found that the bioaccessibility of polyphenols decreased in the intestinal phase. Flavanones were found to be the most abundant subgroup of polyphenols in sweet orange.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Lihang Chen, Dexin Jiao, Huimin Liu, Chen Zhu, Ying Sun, Jinshan Wu, Mingzhu Zheng, Dali Zhang
Summary: High-pressure processing delayed microbial growth and reduced TVB-N values of shrimp, but did not completely inhibit enzyme activity and promoted denaturation of myofibrillar proteins. Water-holding capacity and protein solubility were affected by HPP, but mechanical properties remained stable in 500 MPa-treated samples due to changes in water phase state and distribution.
Article
Food Science & Technology
Lihang Chen, Dexin Jiao, Xiaona Yu, Chen Zhu, Ying Sun, Meihong Liu, Huimin Liu
Summary: The study found that high pressure processing can delay microbial growth in scallop muscle, leading to denaturation of myosin and actin at certain pressures, along with increased hardness and whiteness. Pressure-treated scallop muscles showed no significant difference in sensory properties after cooking compared to the control group, and remained edible after 28 days of storage.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Sheng Li, Huimin Liu, Qihang Zheng, Nannan Hu, Mingzhu Zheng, Jingsheng Liu
Summary: The effects of soluble and insoluble dietary fiber from corn bran on the properties and microstructure of corn starch were investigated in this study. The addition of dietary fiber inhibited starch retrogradation and decreased the relaxation time of water. Both soluble and insoluble dietary fiber reduced the enthalpy of corn starch. Soluble dietary fiber significantly inhibited starch gelatinization and decreased viscosity.
Article
Food Science & Technology
Sitong Ge, Rui Jia, Qi Li, Wei Liu, Meihong Liu, Dan Cai, Mingzhu Zheng, Huimin Liu, Jingsheng Liu
Summary: This study demonstrated that the AST-loaded Pickering emulsion stabilized by a combination of zein and Adzuki bean seed coat polyphenol had improved stability against high ionic strength and temperature treatments, with a high remaining ratio of AST after UV light exposure. The in vitro digestion process led to changes in droplet size, zeta potential, and microstructure of the emulsion, resulting in high bioaccessibility of AST. These findings suggest that this system may be effective for delivering AST and other hydrophobic bioactive compounds, contributing to the development of novel functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Sanabil Yaqoob, Huimin Liu, Meihong Liu, Mingzhu Zheng, Kanza Aziz Awan, Dan Cai, Jingsheng Liu
Summary: The application of lactic acid bacteria in corn flour can improve the properties of the dough, making it more suitable for food production. After bacterial treatment, the hardness of corn decreases, while the gelatinization temperature and enthalpy increase, leading to enhanced thermal, morphological, and rheological properties of corn flour.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jinshan Wu, Rong Huang, Dexin Jiao, Shuying Liu, Huimin Liu, Hongzhang Liu
Summary: This study focused on the isolation, purification, and characterization of Hosta ventricosa root polysaccharides (HVRPp-1). The research also investigated the effect of HVRPp-1 on oxidative damage in HepG2 cells. The results revealed that HVRPp-1 is a nonhomogeneous polysaccharide that protects the cells from oxidative damage through a specific signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Sheng Li, Nannan Hu, Jinying Zhu, Mingzhu Zheng, Huimin Liu, Jingsheng Liu
Summary: This study evaluated the extraction of soluble dietary fiber (SDF) from corn bran using twin-screw extrusion and ultrasonic treatment, as well as the combination of these methods with dual enzyme hydrolysis. The results showed that the modified SDF had improved extraction yield, physicochemical and functional properties, making it suitable as a functional food additive.
Article
Chemistry, Applied
Sitong Ge, Rui Jia, Wei Liu, Jiahan Xie, Meihong Liu, Dan Cai, Mingzhu Zheng, Huimin Liu, Jingsheng Liu
Summary: This study utilized adzuki bean seed coat polyphenol (ABSCP) to modify zein and form covalent nanoparticles (ZAP), which were then used as an emulsifier to stabilize Pickering emulsion (ZAE). The physicochemical properties of ZAP and ZAE were controlled by the ratio of zein-ABSCP. ZAP could be absorbed on the water-oil surface and stabilized ZAE, which exhibited non-Newtonian fluid characteristics. ABSCP inhibited lipid oxidation in a dose-dependent manner and decreased the release of free fatty acids (FFA) during in vitro gastrointestinal digestion of ZAE. ABSCP also imparted a strong red-yellow color to ZAE, making it suitable for specific applications such as natural pigments.
Article
Food Science & Technology
Chen Zhu, Lihang Chen, Xinyao Zeng, Ying Sun, Dexin Jiao, Meihong Liu, Mingzhu Zheng, Jingsheng Liu, Huimin Liu
Summary: This study investigated the effects of UHP-MF treatment on the protein properties and quality deterioration of stored Litopenaeus Vannamei. The results showed that UHP treatment improved the texture of the shrimp while MF storage inhibited texture softening and water holding capacity. Furthermore, UHP-MF treatment slowed down lipid oxidation, protein oxidation, and degradation, and prolonged the shelf life of the stored shrimp.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Jing Chen, Ruiguo You, Yao Lv, Huimin Liu, Guoqing Yang
Summary: CLA increases the expression of A-FABP through PPAR alpha signaling pathway and regulates the expression of genes and enzymes related to IMF deposition, thus increasing IMF content.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Huimin Liu, Jie Yan, Fengtao Guan, Zhibo Jin, Jiahan Xie, Chongrui Wang, Meihong Liu, Jingsheng Liu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder worldwide and is associated with obesity and diabetes. This study demonstrates that Zeaxanthin (ZEA) exerts protective effects against NAFLD by acting as an antioxidant and anti-inflammatory agent. Furthermore, ZEA inhibits ferroptosis and improves mitochondrial dysfunction in NAFLD cells. These findings suggest that ZEA has potential as an intervention for NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Chemistry, Applied
Yuying Wang, Lihang Chen, Huimin Liu, Jiahan Xie, Wandi Yin, Zhenghang Xu, Huijing Ma, Wenzhuo Wu, Mingzhu Zheng, Meihong Liu, Jingsheng Liu
Summary: This study identified novel pancreatic lipase (PL) inhibitors, cyanidin-3-O-glucoside (C3G) and catechin, extracted from black rice and adzuki bean coat extracts. The combination of C3G and catechin showed a synergistic effect in inhibiting PL, and molecular docking analysis revealed that these polyphenols formed interactions with PL amino acid residues. These findings suggest that C3G and catechin have potential for developing food supplements to prevent obesity.
Article
Food Science & Technology
Yunlong Guo, Meihong Liu, Xin Liu, Mingzhu Zheng, Xiuying Xu, Xiaokang Liu, Jiyu Gong, Huimin Liu, Jingsheng Liu
Summary: This study investigated the potential mechanism of Sporisorium reilianum polysaccharide (SRP) in improving obesity. Male Sprague Dawley rats were fed with a high-fat diet and treated with different doses of SRP for 8 weeks. The results showed that SRP reduced obesity and serum lipid levels in rats, improved liver lipid accumulation and adipocyte hypertrophy, and had a greater effect at higher doses. SRP also improved the composition and function of gut microbiota in rats fed with a high-fat diet, regulating lipid and amino acid metabolism. Untargeted metabolomics identified several metabolic pathways, such as linoleic acid metabolism and phenylalanine biosynthesis, that played a role in improving obesity in rats treated with SRP.
Article
Dentistry, Oral Surgery & Medicine
Lu Chang, Dongxu Wang, Shaoning Kan, Ming Hao, Huimin Liu, Zhijing Yang, Qianyun Xia, Weiwei Liu
Summary: Ginsenoside Rd inhibits the migration and invasion of tongue cancer cells via the H19/miR-675-5p/CDH1 axis.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiahan Xie, Huimin Liu, Wandi Yin, Sitong Ge, Zhibo Jin, Mingzhu Zheng, Dan Cai, Meihong Liu, Jingsheng Liu
Summary: This study found that zeaxanthin (ZEA) induces structural and metabolic remodeling of lipid droplets (LDs) by activating beta 3-adrenergic receptor (β3-AR) signaling and enhancing PLIN5-mediated LD-mitochondrion interactions, thereby enhancing oxidative capacity and potentially serving as a nutritional intervention for the prevention and treatment of obesity and associated metabolic syndrome.