Review
Biochemistry & Molecular Biology
Wang Lu, Yuan Shi, Rui Wang, Deding Su, Mingfeng Tang, Yudong Liu, Zhengguo Li
Summary: Natural pigments, such as carotenoids, flavonoids, and anthocyanidins, determine the attractive colors of fruits and play crucial roles in plants' life cycles. Research has shown multiple benefits of these pigments to human health, with promising prospects in various industries like food, medicine, and cosmetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Zaixiao Tao, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zhongguo Fan, Xi Chen, Rong Huang, Xinxin Li, Genshan Ma
Summary: This cross-sectional study aimed to investigate the association between dietary intake of anthocyanidins and heart failure. The results showed a significant negative association between high anthocyanidins intake and the prevalence of heart failure, and this association was stable among different subgroups.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Qin Gao, Chunrong Zhong, Xuezhen Zhou, Renjuan Chen, Ting Xiong, Miao Hong, Qian Li, Man Kong, Guoping Xiong, Weizhen Han, Guoqiang Sun, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: Higher dietary intake of total polyphenols and flavonoids, as well as intake from fruits, was associated with lower risk of GDM.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Zhenlei Zhao, Wenyan Gao, Xiaoli Ding, Xiaogang Xu, Changqian Xiao, Genxiang Mao, Wenmin Xing
Summary: The study found a relationship between total flavonoids intake, flavonoid subclasses, and metabolic syndrome. Q2 and Q3 intake of total flavonoids were associated with a 20% and 19% lower risk of incident metabolic syndrome. Flavanones and anthocyanidins intake in Q2 and Q3 also significantly reduced the risk compared to Q1. The most effective doses of total flavonoids, flavanones, and anthocyanidins for preventing metabolic syndrome were 237.67, 34.37, and 23.13 mg/day, respectively.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Zahra Sadat Asgarian, Rouhollah Karimi, Mehdi Ghabooli, Masoomeh Maleki
Summary: The study found that using 40 mM concentration of GABA can effectively reduce weight loss, rachis browning, and decay incident in grapes during storage, while increasing antioxidant enzyme activity and decreasing membrane electrolyte leakage, leading to higher soluble sugars, organic acids, and phenolic compounds.
Article
Biochemistry & Molecular Biology
Geetika Verma, Rajiv Bhat
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of proteinaceous inclusions called Lewy bodies (LB) in the brain, mainly composed of alpha-synuclein (alpha-syn) aggregates. Anthocyanidins, natural flavonoid compounds, have been found to inhibit alpha-syn fibrillation. Among three anthocyanidins tested, peonidin showed the strongest inhibition of alpha-syn fibrillation and alleviated cell toxicity in neuroblastoma cells. Molecular studies revealed that peonidin binds weakly to the NAC region of alpha-syn and induces the formation of amorphous aggregates. These findings are significant for the development of therapeutic interventions for PD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Yin Zhang, Min Zhu, Huajing Wan, Ling Chen, Fengming Luo
Summary: The study found a protective association between dietary anthocyanidins and the risk of lung cancer in Americans, with higher intake of total anthocyanidins associated with lower risk of lung cancer.
Article
Plant Sciences
Toktam Taghavi, Hiral Patel, Reza Rafie
Summary: Anthocyanins, major plant pigments with antioxidant activities, are influenced by various factors in the extraction process. This study compared different solvents and their combinations to extract anthocyanins from strawberries. The results showed that methanol and methanol:water were the best solvents for anthocyanin assessment, while acetone did not produce a stable extract. The choice of extraction solvent also affected the profile of anthocyanins, with different solvents yielding different major compounds.
Article
Nutrition & Dietetics
Sukyeung Lee, Yu-Mi Choi, Myoung-Jae Shin, Hyemyeong Yoon, Xiaohan Wang, Yoonjung Lee, Jungyoon Yi, Young-ah Jeon, Kebede Taye Desta
Summary: The study highlighted the significant differences in nutritional components, functional metabolites, and antioxidant activities among different sorghum genotypes. Some breeding lines exhibited higher levels of metabolites and antioxidant activities compared to popular cultivars. Principal component analysis was effective in differentiating sorghum genotypes based on seed color and antioxidant index levels, while Pearson's correlation analysis showed strong links between biosynthetically related metabolites and those with synergistic antioxidant properties.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Mingjie Dai, Xiaoru Kang, Yuqiong Wang, Shuai Huang, Yangyang Guo, Rufeng Wang, Nan Chao, Li Liu
Summary: In this study, the MazsF3H gene was cloned and characterized from Morus atropurpurea var. Zhongshen 1, and its important role in the accumulation of anthocyanin in fruits was discovered. The expression levels of F3H varied in different mulberry varieties, possibly related to fruit color. Overexpression of MazsF3H in tobacco resulted in decreased anthocyanin content, while down-regulation of F3H expression levels led to a significant decrease in anthocyanin content.
Article
Biochemistry & Molecular Biology
Ana T. Rufino, Ana Ramalho, Adelaide Sousa, Jose Miguel P. Ferreira de Oliveira, Paulo Freitas, Manuel A. Gonzalez Gomez, Yolanda Pineiro-Redondo, Jose Rivas, Felix Carvalho, Eduarda Fernandes, Marisa Freitas
Summary: This study evaluated the toxic effects of AgNP in gastrointestinal cells and showed that certain flavonoids can protect against these effects. They hold promise for playing a significant role in future food safety and hygiene product development.
Article
Chemistry, Medicinal
Piyatida Pojtanadithee, Kowit Hengphasatporn, Aphinya Suroengrit, Siwaporn Boonyasuppayakorn, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, I. Putu Sukanadi, Warinthorn Chavasiri, Peter Wolschann, Thierry Langer, Yasuteru Shigeta, Phornphimon Maitarad, Kamonpan Sanachai, Thanyada Rungrotmongkol
Summary: SWC423, a sulfonamide chalcone, has been identified as a potential inhibitor of the 3CL(pro) enzyme and shows promising antiviral activity against SARS-CoV-2. Its competitive inhibition and low cytotoxicity make it a suitable candidate for further research on COVID-19 treatment development.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Food Science & Technology
Jakub Frankowski, Anna Przybylska-Balcerek, Kinga Stuper-Szablewska
Summary: The study revealed that sorghum grains are rich in antioxidant compounds and nutrients, making them a potential functional food source.
Article
Food Science & Technology
Talyta Mayara Silva Torres, Jose Antonio Mendiola, Gerardo Alvarez-Rivera, Simone Mazzutti, Elena Ibanez, Alejandro Cifuentes, Sandra Regina Salvador Ferreira
Summary: Ora-pro-nobis leaves were used as raw material for biorefinery application, and compressed fluid extractions with green solvents were performed. Different extraction methods were applied in a sequential manner, and the chemical composition and activity of the extracted compounds were evaluated.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Review
Chemistry, Inorganic & Nuclear
Luciana G. Naso, Evelina G. Ferrer, Patricia A. M. Williams
Summary: This passage discusses the potential medicinal benefits of flavonoids, such as antioxidant, anti-inflammatory, anticancer, and antiviral actions, which can be enhanced by metal complexation. The study specifically highlights the antioxidant activities of twelve flavonoids and their oxidovanadium(IV) complexes. When tested on different cell lines, these compounds exhibited pro-oxidant properties, demonstrating anticancer effects by selectively killing tumor cells without harming normal cells. The review aims to find a correlation between the chemical structure of these compounds and their anticancer action in each tested cancer cell line. The design and synthesis of new antitumor VO-flavonoid complexes hold promise for cancer treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Respiratory System
Jate Ratanachina, Andre F. S. Amaral, Sara De Matteis, Herve Lawin, Kevin Mortimer, Daniel O. Obaseki, Imed Harrabi, Meriam Denguezli, Emiel F. M. Wouters, Christer Janson, Rune Nielsen, Amund Gulsvik, Hamid Hacene Cherkaski, Filip Mejza, Padukudru Anand Mahesh, Asma Elsony, Rana Ahmed, Wan Tan, Li Cher Loh, Abdul Rashid, Michael Studnicka, Asaad A. Nafees, Terence Seemungal, Althea Aquart-Stewart, Mohammed Al Ghobain, Jinping Zheng, Sanjay Juvekar, Sundeep Salvi, Rain Jogi, David Mannino, Thorarinn Gislason, A. Sonia Buist, Paul Cullinan, Peter Burney
Summary: This study aimed to assess the association between chronic obstructive pulmonary disease and occupation. Through cross-sectional data analysis of 28,823 adults aged 40 and above in 34 countries, it was found that working in environments with potential exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. Therefore, respiratory surveillance should be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Infectious Diseases
Filip Styrzynski, Damir Zhakparov, Marco Schmid, Damian Roqueiro, Zuzanna Lukasik, Julia Solek, Jakub Nowicki, Milosz Dobrogowski, Joanna Makowska, Milena Sokolowska, Katja Baerenfaller
Summary: This study provides a set of easily obtainable parameters that can be used to rapidly identify SARS-CoV-2 positive patients, assess the risk of death during hospitalization, and predict the disease outcome.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Critical Care Medicine
Nirav R. Bhakta, Christian Bime, David A. Kaminsky, Meredith C. McCormack, Neeta Thakur, Sanja Stanojevic, Aaron D. Baugh, Lundy Braun, Stephanie Lovinsky-Desir, Rosemary Adamson, Jonathan Witonsky, Robert A. Wise, Sean D. Levy, Robert Brown, Erick Forno, Robyn T. Cohen, Meshell Johnson, John Balmes, Yolanda Mageto, Cathryn T. Lee, Refiloe Masekela, Daniel J. Weiner, Charlie G. Irvin, Erik R. Swenson, Margaret Rosenfeld, Richard M. Schwartzstein, Anurag Agrawal, Enid Neptune, Juan P. Wisnivesky, Victor E. Ortega, Peter Burney
Summary: The use of race and ethnicity in pulmonary function test (PFT) interpretation is being questioned due to concerns of perpetuating false fixed differences between races and masking the effects of differential exposures. The American Thoracic Society (ATS) recommended replacing race and ethnicity-specific reference equations with race-neutral average equations, accompanied by a broader re-evaluation of how PFTs are used in clinical, employment, and insurance decisions. Further research and education are also recommended to better understand the impact of this change and improve the evidence for PFT use.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Budlewski, Joanna Sarnik, Grzegorz Galita, Grzegorz Dragan, Olga Brzezinska, Marta Poplawska, Tomasz Poplawski, Joanna Makowska
Summary: The polymorphisms of PADI4, PTPN22, and STAT4 genes have been detected in the Polish population, which are also known risk factors for rheumatoid arthritis (RA) in various other populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Grzegorz Galita, Joanna Sarnik, Olga Brzezinska, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Ireneusz Majsterek, Tomasz Poplawski, Joanna S. S. Makowska
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic arthritis and joint deformities. The risk of malignant neoplasms among patients with RA is being studied due to the autoimmune nature of RA and the use of immunomodulatory therapy. Impaired DNA repair efficiency in individuals with RA may contribute to this risk. In our study, we evaluated genetic variation in DNA damage repair genes and found associations between RA occurrence and certain polymorphisms. These findings suggest that DNA damage repair gene polymorphisms may play a role in RA pathogenesis and can potentially serve as markers of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
R. Ahmed, N. Osman, B. Noory, R. Osman, H. ElHassan, H. Eltigani, R. Nightingale, A. F. S. Amaral, J. Patel, P. G. Burney, K. Mortimer, A. El Sony
Summary: This study aimed to determine the prevalence and determinants of chronic respiratory diseases in Khartoum, Sudan. The prevalence of chronic airflow obstruction was found to be 10%, with older age being the main risk factor. Lower education, high body mass index, and a history of TB were also identified as significant risk factors.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Letter
Critical Care Medicine
Peter Burney, Ben Knox-Brown, Andre F. S. Amaral
LANCET RESPIRATORY MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Peter Burney, Ben Knox-Brown, Andre F. S. Amaral
LANCET RESPIRATORY MEDICINE
(2023)
Editorial Material
Allergy
Helena Pires Pereira, Joao Cardoso Lopes, Isabel Carrapatoso, Ana Todo-Bom
CONTACT DERMATITIS
(2023)
Review
Nutrition & Dietetics
Arpita Das, Yu Lung Malcolm Tang, Nora A. Althumiri, Vanessa Garcia-Larsen, Joern M. Schattenberg, Saleh A. Alqahtani
Summary: This review examines the effects of dietary and supplemental fatty acids on non-alcoholic fatty liver disease (NAFLD). The results show that a diet high in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and low in saturated fatty acids (SFA), can reduce liver fat and stiffness. The use of culinary fats high in MUFA can reduce liver steatosis. Supplementation of omega-3 PUFA in combination with a low SFA diet improves liver enzyme levels and steatosis score.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Andre F. S. Amaral, James Potts, Ben Knox-Brown, Emmanouil Bagkeris, Imed Harrabi, Hamid Hacene Cherkaski, Dhiraj Agarwal, Sanjay Juvekar, Mahesh Padukudru Anand, Thorarinn Gislason, Asaad Ahmed Nafees, Kevin Mortimer, Christer Janson, Li Cher Loh, Stefanni Nonna Paraguas, Meriam Denguezli, Mohammed Al Ghobain, David Mannino, Martin W. Njoroge, Graham Devereux, Terence Seemungal, Cristina Barbara, Ali Kocabas, Rana Ahmed, Althea Aquart-Stewart, Michael Studnicka, Tobias Welte, Wan C. Tan, Richard N. van Zyl-Smit, Parvaiz Koul, Vanessa Garcia-Larsen, Cosetta Minelli, A. Sonia Buist, Peter Burney, BOLD Study Collaborative Network
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Respiratory System
Jaymini H. Patel, Andre F. S. Amaral, Cosetta Minelli, Fadlalla G. Elfadaly, Kevin Mortimer, Asma El Sony, Karima El Rhazi, Terence A. R. Seemungal, Padukudru Anand Mahesh, Daniel O. Obaseki, Meriam Denguezli, Rana Ahmed, Hamid Cherkaski, Parvaiz Koul, Abdul Rashid, Richard Li Cher Loh, Herve Lawin, Mohammed Al Ghobain, Asaad Ahmed Nafees, Althea Aquart-Stewart, Imed Harrabi, Sonia Buist, Peter G. J. Burney
Summary: Poverty is strongly linked to increased all-cause and chronic obstructive pulmonary disease (COPD) mortality. However, the impact of poverty on spirometry-defined chronic airflow obstruction (CAO), a key characteristic of COPD, is less understood. Using data from the Burden of Obstructive Lung Disease study, poverty was found to contribute to up to 6% of CAO in individuals over 40 years old. Understanding the relationship between poverty and CAO may provide insights for improving lung health, especially in low and middle-income countries.
Article
Public, Environmental & Occupational Health
Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Asma Elsony, Frits M. E. Franssen, Mohammed Al Ghobain, Imed Harrabi, Christer Janson, Rain Jogi, Sanjay Juvekar, Herve Lawin, David Mannino, Kevin Mortimer, Asaad Ahmed Nafees, Rune Nielsen, Daniel Obaseki, Stefanni Nonna M. Paraguas, Abdul Rashid, Li-Cher Loh, Sundeep Salvi, Terence Seemungal, Michael Studnicka, Wan C. Tan, Emiel E. F. M. Wouters, Cristina Barbara, Thorarinn Gislason, Kirthi Gunasekera, Peter Burney, Andre F. S. Amaral, BOLD Collaborative Res Grp
Summary: Small airways obstruction is common worldwide and has a higher prevalence than chronic airflow obstruction. It shares the same risk factors as chronic airflow obstruction. Further research is needed to investigate its association with respiratory symptoms and lung function decline.
LANCET GLOBAL HEALTH
(2023)
Article
Respiratory System
Ben Knox-Brown, Jaymini Patel, James Potts, Rana Ahmed, Althea Aquart-Stewart, Cristina Barbara, A. Sonia Buist, Hamid Hacene Cherkaski, Meriam Denguezli, Mohammed Elbiaze, Gregory E. Erhabor, Frits M. E. Franssen, Mohammed Al Ghobain, Thorarinn Gislason, Christer Janson, Ali Kocabas, David Mannino, Guy Marks, Kevin Mortimer, Asaad Ahmed Nafees, Daniel Obaseki, Stefanni Nonna M. Paraguas, Li Cher Loh, Abdul Rashid, Sundeep Salvi, Terence Seemungal, Michael Studnicka, Wan C. Tan, Emiel F. M. Wouters, Hazim Abozid, Alexander Mueller, Peter Burney, Andre F. S. Amaral
Summary: This study found that spirometric small airways obstruction (SAO) is associated with respiratory symptoms, cardiovascular disease, and quality of life (QoL). The results suggest that measurement of FEF25-75 and FEV3/FVC should be considered in spirometry.
RESPIRATORY RESEARCH
(2023)
Review
Rheumatology
Alaa Sherri, Mohamad Mahdi Mortada, Joanna Makowska, Anna Lewandowska-Polak
Summary: This article compares the similarities between central nervous system vasculitis and ANCA-associated vasculitis in terms of pathogenesis, clinical presentation, diagnosis, and treatment, and highlights the importance of brain biopsy in differentiation.
RHEUMATOLOGY INTERNATIONAL
(2023)