Article
Nutrition & Dietetics
Shelby G. Martell, Jeongwoon Kim, Corinne N. Cannavale, Twinkle D. Mehta, John W. Erdman, Brynn Adamson, Robert W. Motl, Naiman A. Khan
Summary: This study aimed to investigate the effects of lutein supplementation on carotenoid status and cognition in individuals with relapse-remitting MS (RRMS). The results showed that lutein supplementation increased carotenoid levels among patients with RRMS, but had no significant effect on cognitive function. However, changes in macular carotenoids were associated with improved attention and memory.
JOURNAL OF NUTRITION
(2023)
Article
Neurosciences
Hongwei Wang, Ge Wang, Rebecca Billings, Daniel Li, Shakaye R. Haase, Pariya F. Wheeler, David E. Vance, Wei Li
Summary: Studies have shown that macular pigments are positively correlated with cognitive function and macular pigment optical density is related to cognitive performance in adults. Higher levels of macular pigments in the blood are associated with a lower risk of mild cognitive impairments or Alzheimer's disease. Diet supplements of Lutein+Zeaxanthin or Lutein+Zeaxanthin+Meso-zeaxanthin are associated with improved cognitive functioning in adults.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Ruyu Liu, Bridget A. Hannon, Katie N. Robinson, Lauren B. Raine, Billy R. Hammond, Lisa M. Renzi-Hammond, Neal J. Cohen, Arthur F. Kramer, Charles H. Hillman, Margarita Teran-Garcia, Naiman A. Khan
Summary: The study found that specific genetic variations, such as in BCO1 and CD36, are associated with lower levels of MPOD in children. The impact of genetic variation in CD36-rs3173798 on MPOD persisted even after adjusting for dietary intake.
JOURNAL OF NUTRITION
(2021)
Article
Medicine, General & Internal
Takeshi Yoshida, Yasutaka Takagi, Tae Igarashi-Yokoi, Kyoko Ohno-Matsui
Summary: This study aimed to evaluate the efficacy and safety of lutein administration in patients with high myopia. A single-center randomized double-blinded placebo-controlled trial was conducted over 24 months, with 22 eyes enrolled in lutein and control groups. The results showed that lutein supplementation was effective in increasing MPOD in patients with high myopia.
Article
Ophthalmology
Marina Green-Gomez, Rachel Moran, James Stringham, Cesar Hernandez-Alcaraz, Kenny Mendoza-Herrera, J. Jans Fromow-Guerra, Alfonso Prado-Cabrero, John Nolan
Summary: The study found that the optical volume of MP and serum concentrations of L and Z in the Mexican sample were significantly higher than in the Irish sample, although this difference was not reflected in dietary analysis. Sunlight exposure and dietary intake were found to have an impact on MP levels, indicating the multifactorial interactions and environmental determinants of MP. These findings will be crucial for future research on eye health, visual function, and ocular pathology in Mexico.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Yuying Ji, Yuhong Gan, Yongyue Su, Yining Zhang, Miaoling Li, Lan Mi, Chengguo Zuo, Feng Wen
Summary: This study found that macular pigment optical density (MPOD) decreased within 7 degrees of eccentricity in patients with acute central serous chorioretinopathy (CSC), but there were no changes in serum lutein and zeaxanthin levels. The decrease in MPOD may be due to subretinal fluid. Further investigation is needed to determine the involvement of local oxidative stress in CSC and whether supplementation with lutein and zeaxanthin is beneficial.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Kwadwo Owusu Akuffo, Billy R. Wooten, Wendy Ofori-Asare, Isaiah Osei Junior Duah, David Ben Kumah, Moses Awuni, Stephannie Rhoda Obiri-Yeboah, Stacy Ewurama Horthman, Emmanuel Kofi Addo, Eldrick Adu Acquah, Bridget Senya Boateng, Elizabeth J. Johnson
Summary: This study aimed to investigate the influence of dietary carotenoid intake on visual and cognitive function. The results showed a positive correlation between macular pigment optical density (MPOD) and phonemic verbal fluency and alcohol intake. Therefore, dietary education to increase carotenoid intake and limit alcohol consumption is necessary for better cognitive functioning.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Nutrition & Dietetics
Xiang Li, Roberta R. Holt, Carl L. Keen, Lawrence S. Morse, Glenn Yiu, Robert M. Hackman
Summary: Regular intake of Z-rich goji berries can increase MPOD and skin carotenoids in healthy middle-aged individuals, which may help prevent or delay the development of AMD.
Article
Ophthalmology
Thomas Lawler, Jackson Korger, Yao Liu, Zhe Liu, Jeong W. Pak, Nancy Barrett, Barbara Blodi, Amitha Domalpally, Elizabeth Johnson, Robert Wallace, Julie A. Mares
Summary: The study found that higher levels of L/Z in serum and retina were associated with larger central retinal vessel calibers, and MPOD levels were also related to vessel calibers, especially in women with stable MPOD over 15 years.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Drake W. Lem, Pinakin Gunvant Davey, Dennis L. Gierhart, Richard B. Rosen
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, with oxidative injury and compromised antioxidant defenses playing key roles in retinal neurodegeneration. Studies have shown that carotenoids such as lutein can provide neuroprotective effects in AMD patients, improving visual function and serving as adjunctive therapy in disease management.
Review
Nutrition & Dietetics
Drake W. Lem, Dennis L. Gierhart, Pinakin Gunvant Davey
Summary: Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness globally, with oxidative stress and compromised antioxidant defenses playing a key role in its onset. Studies have shown that macular carotenoids, such as lutein, have neuroprotective benefits on glaucomatous neurodegeneration, suggesting their potential as adjunctive nutraceutical treatment for glaucoma.
Article
Nutrition & Dietetics
Coralie Schnebelen-Berthier, Niyazi Acar, Emilie Simon, Clementine Thabuis, Anne Bourdillon, Adeline Mathiaud, Luc Dauchet, Cecile Delcourt, Pascale Benlian, Martine Crochet, Sabine Defoort, Anne Tailleux, Bart Staels, Lionel Bretillon, Jean-Michel Lecerf
Summary: MPOD levels slightly increased in both groups after consuming two eggs enriched with lutein/zeaxanthin and DHA daily for 4 months. Plasma and lipoprotein concentrations of lutein, zeaxanthin, and DHA significantly increased, with greater enhancements in the enriched group compared to the standard group. A significant correlation was found between lutein concentration in HDL and MPOD levels.
Review
Nutrition & Dietetics
Naomi Fitzpatrick, Veronique Chachay, Joanna Bowtell, Sarah Jackman, Sandra Capra, Angela Shore, David Briskey
Summary: This review critically evaluates the effect of increasing dietary intake of lutein and zeaxanthin (L/Z) on macular pigment optical density (MPOD) in adults. The results of the included studies showed inconsistent relationships between dietary L/Z interventions and MPOD response. Limited monitoring of habitual dietary L/Z intake was identified as a major limitation of the studies.
Article
Nutrition & Dietetics
Pinakin Gunvant Davey, Richard B. Rosen, Dennis L. Gierhart
Summary: The study aimed to analyze measurement protocols using Macular Pigment Reflectometry (MPR), compare MPOD measurements from MPR and heterochromatic flicker photometry (MPS II), and assess lutein and zeaxanthin optical density in the central macula. Results showed high correlation and agreement between MPR-MPOD and MPS II-MPOD values, with the 10-30 interval providing the most accurate measurements. Dilation improved repeatability of lutein and zeaxanthin values, and MPR was able to generate unique optical density data not available from other clinical devices.
Article
Ophthalmology
Srinivasa Rao Kotagiri, Abhijeet Morde, Deshanie Rai, Kalmanoor Babji, Mohan Lal, Muralidhara Padigaru, Chirag Khatri
Summary: The study demonstrates that our novel LZO formulation has superior bioavailability for lutein and zeaxanthin compared to the LZC formulation. This enhanced bioavailability can be advantageous for individuals wishing to quickly improve their levels of L and Z and enhance their vision performance.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Neurosciences
Caitlyn G. Edwards, Anne M. Walk, Sharon Thompson, Ginger E. Reeser, Ryan N. Dilger, John W. Erdman, Nicholas A. Burd, Hannah D. Holscher, Naiman A. Khan
Summary: Among middle-aged adults with overweight and obesity, higher intake of choline and lutein+zeaxanthin was associated with faster performance on a cognitive flexibility task. Dietary intake and biomarker data had an impact on cognitive outcomes, but were not related to the N2 and P3 ERP components.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Neurosciences
Corinne N. Cannavale, Annemarie R. Mysonhimer, Melisa A. Bailey, Neal J. Cohen, Hannah D. Holscher, Naiman A. Khan
Summary: This study aimed to investigate the effects of consuming a fermented dairy beverage containing probiotics on mood, stress, and memory in healthy adults. The results showed that fermented dairy consumption increased the presence of Lactobacillus in the gut and improved relational memory. However, changes in Lactobacillus were not related to memory performance.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Neurosciences
Billy R. Hammond, Lisa Renzi-Hammond
Summary: The mortality-morbidity paradox refers to the inconsistency in survival and disease between males and females. Dietary intake of pigmented carotenoids, such as lutein and zeaxanthin, appears to be particularly important for issues such as visual and cognitive loss.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Hospitality, Leisure, Sport & Tourism
Nicole E. Logan, Donovan A. Henry, Charles H. Hillman, Arthur F. Kramer
Summary: As physical inactivity levels continue to rise, participating in sport-related physical activity may have positive implications for cognitive development. Elite athletes outperform control groups in cognitive tasks, such as attentional allocation and cognitive flexibility. Athlete type and experience play important roles in this relationship.
INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY
(2023)
Article
Ophthalmology
Billy R. Hammond, John Buch, Lisa M. Renzi-Hammond, Jenny M. Bosten, Derek Nankivil
Summary: The effect of a contact lens that filters short-wavelength visible light on color appearance was assessed. The results showed that this filtering lens did not significantly alter color appearance for both younger and older subjects.
Article
Ophthalmology
Billy R. Hammond, Colin R. Gardner, Lisa Renzi-Hammond
Summary: This study aims to determine whether blue-light filtering intraocular lenses (IOLs) can reduce the size of halos and starbursts in patients after cataract surgery. The results showed that patients with blue-light filtering IOLs had significantly smaller halo size compared to those with regular IOLs, while the difference in starburst size was not significant.
CURRENT EYE RESEARCH
(2023)
Review
Physiology
Jacob B. B. Harth, Lisa M. M. Renzi-Hammond, Billy R. R. Hammond Jr
Summary: Visual range, crucial for athletes, varies greatly among individuals despite similar personal characteristics. We propose that individual response to scattered short-wave light, moderated by dietary retinal pigments lutein and zeaxanthin, is the primary driver of these differences.
EXERCISE AND SPORT SCIENCES REVIEWS
(2023)
Article
Nutrition & Dietetics
Corinne N. Cannavale, Shelby A. Keye, Laura M. Rosok, Shelby G. Martell, Tori A. Holthaus, Lauren R. Raine, Sean P. Mullen, Hannah D. Holscher, Charles H. Hillman, Arthur F. Kramer, Neal J. Cohen, Billy R. Hammond, Lisa Renzi-Hammond, Naiman A. Khan
Summary: This study aimed to investigate macular and skin carotenoids in children and their relationships with factors including age, sex, race, weight status, and dietary intake. The results showed no significant correlation between macular and skin carotenoids, but both were associated with dietary carotenoid intake. Additionally, skin carotenoids may be more negatively influenced by higher weight status.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Corinne N. Cannavale, Caitlyn G. Edwards, Ruyu Liu, Shelby A. Keye, Samantha J. Iwinski, Hannah D. Holscher, Lisa Renzi-Hammond, Naiman A. Khan
Summary: This study aimed to investigate the relationship between macular xanthophyll status and inflammation in children. The results showed that higher macular pigment was associated with lower concentrations of C-reactive protein. This suggests that macular xanthophylls provide protective effects in children.
NUTRITION RESEARCH
(2023)
Article
Ophthalmology
Billy R. Hammond Jr, Taylor A. Leathers, Billy R. Wooten, Lisa M. Renzi-Hammond
Summary: This study designed a simple optical device for measuring CSF and compared it with a computer-based system, finding slightly different results between the two methods, with the optical system showing higher sensitivity and test-retest reliability. Using simple optics to measure CSF reduces noise, increases sensitivity and reliability, and allows for direct calibration of stimuli.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Chemistry, Analytical
Diego Arguello, Ethan Rogers, Grant H. Denmark, James Lena, Troy Goodro, Quinn Anderson-Song, Gregory Cloutier, Charles H. Hillman, Arthur F. Kramer, Carmen Castaneda-Sceppa, Dinesh John
Summary: Supervised personal training is most effective for improving exercise health effects in older adults. However, low frequency of trainer contact limits behavior change outside sessions. Implementing strategies to extend trainer contact and provide meaningful two-way communication can motivate older adults to move more and sit less, leading to improved health outcomes.
Article
Nutrition & Dietetics
Shelby G. Martell, Jeongwoon Kim, Corinne N. Cannavale, Twinkle D. Mehta, John W. Erdman, Brynn Adamson, Robert W. Motl, Naiman A. Khan
Summary: This study aimed to investigate the effects of lutein supplementation on carotenoid status and cognition in individuals with relapse-remitting MS (RRMS). The results showed that lutein supplementation increased carotenoid levels among patients with RRMS, but had no significant effect on cognitive function. However, changes in macular carotenoids were associated with improved attention and memory.
JOURNAL OF NUTRITION
(2023)
Article
Education & Educational Research
Mengyi Wei, Kevin Andrew Richards, Naiman A. Khan, Amelia Mays Woods, Dorothy L. Espelage, Kim C. Graber
Summary: The purpose of this study was to investigate the effects of a 4-week teaching personal and social responsibility model-based summer learning and enrichment program on reducing bullying behaviors among school-age children, according to the perceptions of children, camp counselors, and activity leaders. Data was collected through interviews, surveys, and observations, and analyzed using descriptive statistics and correlations. The results showed that the implementation of the teaching model was associated with a reduction in bullying behaviors. Therefore, teaching personal and social responsibility can facilitate social and emotional learning and improve children's personal and social responsibility.
JOURNAL OF TEACHING IN PHYSICAL EDUCATION
(2023)
Article
Sport Sciences
Jose Mora-Gonzalez, Irene Esteban-Cornejo, Patricio Solis-Urra, Maria Rodriguez-Ayllon, Cristina Cadenas-Sanchez, Charles H. Hillman, Arthur F. Kramer, Andres Catena, Francisco B. Ortega
Summary: The study found that a 20-week exercise program can change brain current density in children with overweight/obesity, leading to positive effects on working memory and inhibitory control.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
