Review
Endocrinology & Metabolism
Sierra A. Nance, Lindsey Muir, Carey Lumeng
Summary: This review provides an updated overview of ATM activation and function, ATM diversity in humans and rodents, and novel ATM functions that contribute to metabolic homeostasis and disease.
MOLECULAR METABOLISM
(2022)
Article
Multidisciplinary Sciences
Gemma Carreras-Badosa, Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Silvia Xargay-Torrent, Anna Prats-Puig, Elsa Puerto-Carranza, Francis de Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: GDF-15 is positively associated with immunoglobulin levels in apparently healthy children, especially in those with higher body mass index or renal fat accumulation, suggesting a potential role of GDF-15 in regulating the immune adaptive system in human obesity.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopeck, Elie Antoun, Karen A. Lillycrop, Philip C. Calder
Summary: The study found that DHA has an effect on individuals with normal weight and can decrease the expression of genes involved in immune and inflammatory response, with a greater effect in normal weight individuals. In individuals with obesity, downregulation of genes responsible for fatty acid activation and metabolism may contribute to an inflammatory oxylipin profile and limit the effects of LC n-3 PUFAs. Therefore, personalized LC n-3 PUFA supplementation based on obesity status may be needed.
Review
Nutrition & Dietetics
Rosaria Vari, Beatrice Scazzocchio, Annalisa Silenzi, Claudio Giovannini, Roberta Masella
Summary: Obesity is a main risk factor for chronic diseases, while curcumin shows potential anti-inflammatory properties that can combat inflammation caused by obesity.
Review
Endocrinology & Metabolism
RuiYan Mei, WeiWei Qin, YanHua Zheng, Zhuo Wan, Li Liu
Summary: Exosomes secreted by adipose tissue play a crucial role in metabolic disorders, regulating specific mechanisms related to obesity, adipose inflammation, and diabetes. Adipose tissue is a major source of circulating exosomal miRNAs, which not only alter the state of patients with metabolic diseases but also affect the communication between metabolic organs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Review
Endocrinology & Metabolism
Yuan-Yuan Wang, Ya-Di Wang, Xiao-Yan Qi, Zhe-Zhen Liao, Yun-Ni Mai, Xin-Hua Xiao
Summary: Obesity is linked to chronic inflammation and metabolic dysfunction, with alterations in adipose tissue macrophages playing a crucial role. Metabolic organs communicate with adipose tissue macrophages through secretion of organokines or exosomes, influencing obesity treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jessica Latorre, Jordi Mayneris-Perxachs, Nuria Oliveras-Canellas, Francisco Ortega, Ferran Comas, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: This study investigated the role of CDO1 gene expression in adipose tissue and found that higher CDO1 expression was associated with improved metabolic profiles, decreased fasting triglycerides and blood HbA1c levels, as well as gene expression markers of adipocyte function and inflammation in both visceral and subcutaneous adipose tissue.
Review
Environmental Sciences
Aayush Sehgal, Tapan Behl, Ishnoor Kaur, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Inflammasome activity is crucial in non-microbial diseases related to prolonged inflammation, especially in obesity and its associated metabolic disorders. Understanding the regulation of inflammasomes may lead to improved therapeutic strategies. Research is ongoing on compounds that can mitigate inflammasome expression, particularly to manage common disorders like obesity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Valmore Bermudez, Pablo Duran, Edward Rojas, Maria P. Diaz, Jose Rivas, Manuel Nava, Maricarmen Chacin, Mayela Cabrera de Bravo, Ruben Carrasquero, Climaco Cano Ponce, Jose Luis Gorriz, Luis D'Marco
Summary: This article discusses the pathophysiology and consequences of adipose tissue expansion, particularly its association with meta-inflammation and microbiota dysbiosis. It also explores the mechanisms involved in metabolic reprogramming in AT, which may be causative factors for cardiovascular disease. Finally, it clarifies how lifestyle changes can improve myocardial cell function and develop effective non-pharmacologic approaches to combating CVD through changes in AT proteomics and gut microbiome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jose Antonio Fagundes Assumpcao, Gabriel Pasquarelli-do-Nascimento, Mariana Saldanha Viegas Duarte, Martin Hernan Bonamino, Kelly Grace Magalhaes
Summary: Obesity is a complex disease associated with metabolic and cardiovascular conditions as well as cancer development. Recent evidence shows that mild obesity is paradoxically associated with better treatment outcomes in cancer patients, termed as the obesity paradox. Obesity also impacts the response to cancer treatments and has a positive association with immune checkpoint therapy.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Byung Chul Jung, Sona Kang
Summary: Obesity is strongly associated with insulin resistance, and chronic low-grade tissue inflammation and systemic inflammation are proposed as major mechanisms. Adipose tissue serves as a crucial link between inflammation and metabolism, while epigenetic modifications play a key role in gene regulation in response to environmental changes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Physiology
Yvette L. L. Schooneveldt, Sudip Paul, Anna C. C. Calkin, Peter J. J. Meikle
Summary: Ether lipids are a unique class of lipids that play important roles in regulating various physiological processes and providing protection, and they have been found to be associated with obesity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
James C. Garmey, Jack M. Hensien, Daniel B. Harmon, Victoria Osinski, Chantel McSkimming, Melissa A. Marshall, Jens W. Fischer, Maria Grandoch, Coleen A. McNamara, Angelina Misiou
Summary: The deficiency of transcription factor Id3 leads to metabolic dysfunction in visceral obesity by promoting the accumulation of hyaluronic acid (HA) in adipose tissue and increasing the number of proinflammatory B2 cells, contributing to adipose tissue inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Oncology
Giorgio Romano, Giuseppe Di Buono, Massimo Galia, Francesco Agnello, Gabriele Anania, Mario Guerrieri, Marco Milone, Gianfranco Silecchia, Salvatore Buscemi, Antonino Agrusa
Summary: Preoperative radiological assessment using CT angiography and advanced imaging techniques can reduce surgical difficulty and intraoperative complications, resulting in improved short-term outcomes in right colonic resections.
Article
Gastroenterology & Hepatology
Ilaria Barchetta, Carla Lubrano, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Arianna Dellanno, Alberto Di Biasio, Frida Leonetti, Gianfranco Silecchia, Andrea Lenzi, Maria Gisella Cavallo
Summary: This study found a close relationship between NAFLD-related liver fibrosis, lower bone mineral density, and degraded microarchitecture in obese individuals. This suggests potential common pathways underlying liver and bone involvement in obesity and insulin resistance-associated disorders.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
D. Bruttomesso, C. Irace, P. Pozzilli
Summary: This study reported on glycemic control in Italian participants with type 1 diabetes and found that younger patients had better glycemic control compared to older patients. Factors such as body mass index and adherence to diet were associated with glycemic control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini
Summary: This study compared the effectiveness of dapagliflozin to DPP-4 inhibitors in achieving individualized HbA1c targets and extra-glycaemic endpoints in elderly patients with type 2 diabetes. The results showed that patients initiating dapagliflozin had a lower likelihood of reaching individualized HbA1c targets compared to those initiating DPP-4 inhibitors. However, they experienced greater improvements in body weight and blood pressure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ernesto Maddaloni, Lucia Coraggio, Rocco G. Amendolara, Marco G. Baroni, Maria Cavallo, Massimiliano Copetti, Efisio Cossu, Paola D'Angelo, Luca D'Onofrio, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Kyoungmin R. Park, Rury Holman, Vincenzo Trischitta, Raffaella Buzzetti, UMMER Study Diabet Grp
Summary: This study evaluated the possible associations of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease (CVD) and diabetic retinopathy (DR) in type 2 diabetes patients. The findings showed that osteocalcin was associated with CVD, while osteoprotegerin and osteopontin were associated with DR.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Federica Sentinelli, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Diego Bailetti, Efisio Cossu, Arcangelo Barbonetti, Maria Totaro, Olle Melander, Maria Gisella Cavallo, Marco Giorgio Baroni
Summary: Neurotensin (NT) is a small protein that regulates energy balance and functions as both a neurotransmitter in the brain and a gastrointestinal peptide. This study aimed to investigate the genetic regulation of plasma pro-NT levels. Seven sequence variations in the NT gene (NTS) were identified, including a polymorphism (rs2234762) that was more frequent in individuals with lower pro-NT levels. Carriers of the rs2234762 variant had lower pro-NT levels and reduced insulin resistance, independent of metabolic confounders. This suggests that the NTS rs2234762 gene variant may contribute to a more favorable metabolic profile in overweight and obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavia Agata Cimini, Antonella Tramutola, Ilaria Barchetta, Valentina Ceccarelli, Elena Gangitano, Simona Lanzillotta, Chiara Lanzillotta, Maria Gisella Cavallo, Eugenio Barone
Summary: BVRA protein levels can change dynamically in response to insulin and are greater in individuals with lower insulin sensitivity, indicating a correlation with insulin resistance and secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandra Dei Cas, Raffaella Aldigeri, Alessandro Mantovani, Maria Masulli, Luisa Palmisano, Franco Cavalot, Katia Bonomo, Marco Giorgio Baroni, Efisio Cossu, Gisella Cavallo, Flavia Agata Cimini, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Mario Luca Morieri, Riccardo Maria Pollis, Giovanni Targher, Saula Vigili de Kreutzenberg
Summary: This observational study aimed to evaluate sex-related differences in cardiovascular disease (CVD) prevalence and risk in adults with type 1 diabetes. The study found that men had a higher prevalence of CVD than women aged 55 years and above, but the prevalence was comparable between the two sexes in those below 55 years of age. In patients without pre-existing CVD, men had a higher 10-year estimated CVD risk than women until the age of 55, but this difference disappeared after that age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D'Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
Summary: This study aimed to validate the association of a 14-metabolite score with all-cause mortality in type 2 diabetes and explore whether it could improve existing mortality prediction models. The results showed a significant association between the 14-metabolite score and mortality in type 2 diabetes, although the effect size was lower compared to the general population. However, a simplified version of the score without two specific metabolites improved patient analysis and classification of mortality risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
A. Concistre, L. Petramala, C. L. Pugliano, M. Celi, F. Vinci, E. Assanto, I. Barchetta, E. P. Perrone, S. Rella, F. Iannazzo, A. Angheloni, L. Coraggio, F. Di Rienzo, D. Maggi, F. Circosta, G. Galardo, M. Muscaritoli, C. Letizia
Summary: COVID-19 clinical presentation varies greatly, and identifying high-risk patients is crucial for early treatment and intensive follow-up. This study investigated negative prognostic factors in hospitalized COVID-19 patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)