Article
Genetics & Heredity
Mathis Hildonen, Amanda M. Levy, Christina Dahl, Victoria A. Bjerregaard, Lisbeth Birk Moller, Per Guldberg, Nanette M. Debes, Zeynep Tumer
Summary: This study found that SLC6A4 expression is upregulated in individuals with Gilles de la Tourette syndrome compared to healthy controls. The L-AC/L-AC genotype of the 5-HTTLPR/rs25531/rs25532 three-locus haplotype was associated with higher SLC6A4 mRNA expression levels in GTS individuals.
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychiatry
Ryunosuke Goto, Natsumi Matsuda, Maiko Nonaka, Yu Hamamoto, Yosuke Eriguchi, Mayu Fujiwara, Akane Suzuki, Yukari Yokoyama, Yukiko Kano
Summary: This study provides evidence on the validity and reliability of the GTS-QOL scale in Japanese patients with GTS, making it an effective tool for measuring disease-specific HR-QOL in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Genetics & Heredity
Amanda M. Levy, Peristera Paschou, Zeynep Tumer
Summary: GTS is a childhood-onset neurodevelopmental and psychiatric disorder that is often comorbid with OCD and ADHD. Genetic factors play a significant role in disease etiology, but identifying major susceptibility genes has been challenging due to the complex interplay between multiple genetic factors and environmental influences.
Article
Biochemistry & Molecular Biology
Theresa Paulus, Lynn Wernecke, Annik Lundie, Julia Friedrich, Julius Verrel, Tina Rawish, Anne Weissbach, Christian Frings, Christian Beste, Tobias Baeumer, Alexander Muenchau
Summary: Research shows that inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to the left BA40 is not effective in alleviating tic symptoms in GTS patients. The left BA40 does not appear to be a useful target for modulating tic symptoms in GTS.
Review
Behavioral Sciences
Alessio Bellato, Luke Norman, Iman Idrees, Carolina Y. Ogawa, Alice Waitt, Pedro F. Zuccolo, Charlotte Tye, Joaquim Radua, Madeleine J. Groom, Elizabeth Shephard
Summary: The study found increased electrophysiological markers of performance monitoring in OCD and GTS, while decreased markers in ADHD and autism.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Genetics & Heredity
Mathis Hildonen, Amanda M. Levy, Christine Soholm Hansen, Jonas Bybjerg-Grauholm, Axel Skytthe, Nanette M. Debes, Qihua Tan, Zeynep Tumer
Summary: DNA methylation patterns in TSD were investigated in this study, revealing potential genes and pathways associated with neuropsychiatric disorders, particularly the PI3K/AKT/mTOR pathway. Altered mTOR signaling may play a role in the complex pathogenesis of TSD.
Article
Psychiatry
Kirsten R. Mueller-Vahl, Anna Pisarenko, Natalia Szejko, Martina Haas, Carolin Fremer, Ewgeni Jakubovski, Richard Musil, Alexander Muenchau, Irene Neuner, Daniel Huys, Ludger Tebartz van Elst, Christoph Schroeder, Rieke Ringlstetter, Armin Koch, Eva Beate Jenz, Anika Grosshennig
Summary: Preliminary data suggest that cannabis-based medicines might be a promising new treatment for patients with Tourette syndrome (TS)/chronic tic disorders (CTD) resulting in an improvement of tics, comorbidities, and quality of life. This study aimed to examine efficacy and safety of the cannabis extract nabiximols in adults with TS/CTD. Secondary analyses revealed trends for improvements of tics, depression, and quality of life, and subgroup analyses suggested that certain subgroups may benefit better from treatment with cannabis-based medication.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Joseph Jankovic
Summary: This study found that dystonic tics are present in about a third of patients with Tourette syndrome (TS) and are associated with increased severity of TS.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sara Marceglia, Marco Prenassi, Tommaso F. Galbiati, Mauro Porta, Edvin Zekaj, Alberto Priori, Domenico Servello
Summary: The study found that the 5-15Hz band is a significant biomarker of TS, related to the severity of tics and the long-term response on OCBs. This represents a step towards understanding the mechanisms underlying DBS effects in TS and the development of adaptive DBS strategies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Natalia Szejko, Kirsten R. Muller-Vahl
Summary: Tourette syndrome (TS) is characterized by vocal and motor tics, often accompanied by psychiatric comorbidities. Differential diagnosis between tics and OCD-related phenomena can be challenging, as some symptoms may overlap. "Just right" phenomena are common in patients with TS, showing similarities with both tics and OCD. Treatment strategies for tics and OCD in TS patients should take into consideration these complexities.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Clinical Neurology
K. R. Mueller-Vahl, N. Szejko, A. Saryyeva, C. Schrader, D. Krueger, A. Horn, A. A. Kuehn, J. K. Krauss
Summary: This study compared the efficacy and safety of deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS), finding that the initial effect of pvl GPi DBS was superior to thalamic DBS. While half of the patients discontinued treatment, some individuals continued to benefit from thalamic DBS after years.
Article
Immunology
Hannah F. Jones, Velda X. Han, Shrujna Patel, Brian S. Gloss, Nicolette Soler, Alvin Ho, Suvasini Sharma, Kavitha Kothur, Margherita Nosadini, Louise Wienholt, Chris Hardwick, Elizabeth H. Barnes, Jacqueline R. Lim, Sarah Alshammery, Timothy C. Nielsen, Melanie Wong, Markus J. Hofer, Natasha Nassar, Wendy Gold, Fabienne Brilot, Shekeeb S. Mohammad, Russell C. Dale
Summary: Genetic variation is a major risk factor for neurodevelopmental disorders, but environmental factors during pregnancy and early life also play a significant role. Studies show that mothers and families of children with tic disorders and OCD have higher rates of autoimmune diseases and other pro-inflammatory states, implying a potential link between maternal inflammation and childhood neurodevelopmental disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Julia Friedrich, Tina Rawish, Annet Bluschke, Christian Frings, Christian Beste, Alexander Muenchau
Summary: European clinical guidelines recommend the use of ERP and CBIT as first-line treatments for tic disorders. However, the neurophysiological mechanisms behind these behavioral interventions are poorly understood, which is crucial for tailoring interventions to individual patients.
Article
Clinical Neurology
Komal Bharti, Giulia Conte, Silvia Tommasin, Costanza Gianni, Antonio Suppa, Giovanni Mirabella, Francesco Cardona, Patrizia Pantano
Summary: This study compared early structural white matter changes in drug-naive children with Tourette syndrome (TS) and early-onset obsessive-compulsive disorder (OCD) using diffusion tensor imaging (DTI). The results showed different alterations in white matter microstructure in TS with or without OCD compared to OCD alone, suggesting that TS+OCD is a subtype of TS while OCD has independent pathophysiological mechanisms affecting white matter development.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Miha Tibaut, Martin Caprnda, Peter Kubatka, Andreja Sinkovic, Vanda Valentova, Slavomira Filipova, Katarina Gazdikova, Ludovit Gaspar, Ioana Mozos, Emmanuel E. Egom, Luis Rodrigo, Peter Kruzliak, Daniel Petrovic
HEART LUNG AND CIRCULATION
(2019)
Review
Cardiac & Cardiovascular Systems
Miha Tibaut, Martin Caprnda, Peter Kubatka, Andreja Sinkovic, Vanda Valentova, Slavomira Filipova, Katarina Gazdikova, Ludovit Gaspar, Ioana Mozos, Emmanuel E. Egom, Luis Rodrigo, Peter Kruzliak, Daniel Petrovic
HEART LUNG AND CIRCULATION
(2019)
Review
Medicine, General & Internal
Isabel Perez-Martinez, Luis Rodrigo, Alfredo J. Lucendo
Review
Pharmacology & Pharmacy
Alenka Premus Marusic Kovacic, Martin Caprnda, Ales Mrhar, Peter Kubatka, Igor Locatelli, Barbora Zolakova, Ludovit Gaspar, Robert Prosecky, Peter Kruzliak, Robert Staffa, Luis Rodrigo, Jozef Radonak, Danijel Petrovic
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Review
Medical Laboratory Technology
Arnolfo Petruzziello, Giovanna Loquercio, Rocco Sabatino, Daniel Vasile Balaban, Najeeb Ullah Khan, Mauro Piccirillo, Luis Rodrigo, Lucia di Capua, Annunziata Guzzo, Francesco Labonia, Gerardo Botti
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2019)
Article
Biochemistry & Molecular Biology
Rocio G. Urdinguio, Virginia Lopez, Gustavo F. Bayon, Rafael Diaz de la Guardia, Marta I. Sierra, Estela Garcia-Torano, Raul F. Perez, Maria G. Garcia, Antonella Carella, Patricia C. Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalia Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramon Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, Clara Bueno, Alejandra Sanjuan-Pla, Ramon M. Rodriguez, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Teresa Bernal, Enrique Colado, Milagros Balbin, Olivia Garcia-Suarez, Maria Dolores Chiara, Ines Saenz-de-Santa-Maria, Francisco Rodriguez, Ana Pando-Sandoval, Luis Rodrigo, Laura Santos, Ana Salas, Jesus Vallejo-Diaz, Ana C. Carrera, Daniel Rico, Inmaculada Hernandez-Lopez, Amparo Vaya, Jose M. Ricart, Edward Seto, Nuria Sima-Teruel, Alejandro Vaquero, Luis Valledor, Maria Jesus Canal, David Pisano, Osvaldo Grana-Castro, Tim Thomas, Anne K. Voss, Pablo Menendez, Ana Villar-Garea, Rainer Deutzmann, Agustin F. Fernandez, Mario F. Fraga
NUCLEIC ACIDS RESEARCH
(2019)
Review
Oncology
Marek Samec, Alena Liskova, Peter Kubatka, Sona Uramova, Pavol Zubor, Samson Mathews Samuel, Anthony Zulli, Martin Pec, Tibor Bielik, Kamil Biringer, Erik Kudela, Jozef Benacka, Mariusz Adamek, Luis Rodrigo, Rachele Ciccocioppo, Taeg Kyu Kwon, Denis Baranenko, Peter Kruzliak, Dietrich Busselberg
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Yulian Mytsyk, Yuriy Borys, Lesia Tumanovska, Dmytro Stroy, Askold Kucher, Katarina Gazdikova, Luis Rodrigo, Peter Kruzliak, Robert Prosecky, Peter Urdzik, Victor Dosenko
CLINICAL AND EXPERIMENTAL MEDICINE
(2019)
Article
Pathology
Stefan Toth, Zuzana Jonecova, Milan Maretta, Kristina Curgali, Theodoros Kalpakidis, Martin Pribula, Matus Kusnier, Zuzana Fagova, Julia Fedotova, Giampiero La Rocca, Luis Rodrigo, Martin Caprnda, Anthony Zulli, Rachele Ciccocioppo, Eva Mechirova, Peter Kruzliak
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2019)
Editorial Material
Medicine, General & Internal
Luis Rodrigo
MEDICINA-LITHUANIA
(2020)
Article
Infectious Diseases
Maria Caldas, Angeles Perez-Aisa, Manuel Castro-Fernandez, Luis Bujanda, Alfredo J. Lucendo, Luis Rodrigo, Jose M. Huguet, Jorge Perez-Lasala, Javier Molina-Infante, Jesus Barrio, Luis Fernandez-Salazar, Angel Lanas, Monica Perona, Manuel Dominguez-Cajal, Juan Ortuno, Blas Jose Gomez-Rodriguez, Pedro Almela, Josep Maria Botargues, Oscar Nunez, Ines Modolell, Judith Gomez, Rafael Ruiz-Zorrilla, Cristobal De la Coba, Alain Huerta, Eduardo Iyo, Liliana Pozzati, Rosario Anton, Merce Barenys, Teresa Angueira, Miguel Fernandez-Bermejo, Ana Campillo, Javier Alcedo, Ramon Pajares-Villaroya, Marianela Mego, Fernando Bermejo, Jose Luis Dominguez-Jimenez, Llucia Tito, Nuria Fernandez, Manuel Pabon-Carrasco, Angel Cosme, Pilar Mata-Romero, Noelia Alcaide, Ines Arino, Tommaso Di Maira, Ana Garre, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: The management of Helicobacter pylori infection in Spain relies on optimized therapy achieving over 90% success. The best results were obtained with the 10-day bismuth single-capsule therapy (95% cure rate by intention-to-treat). In second-line treatments, one of the most effective therapies was the triple quinolone scheme (PPI-amoxicillin-levofloxacin/moxifloxacin), with an effectiveness of 92%.
Article
Gastroenterology & Hepatology
Olga P. Nyssen, Angeles Perez-Aisa, Manuel Castro-Fernandez, Rinaldo Pellicano, Jose M. Huguet, Luis Rodrigo, Juan Ortuno, Blas J. Gomez-Rodriguez, Ricardo M. Pinto, Miguel Areia, Monica Perona, Oscar Nunez, Marco Romano, Antonietta G. Gravina, Liliana Pozzati, Miguel Fernandez-Bermejo, Marino Venerito, Peter Malfertheiner, Luis Fernanadez-Salazar, Antonio Gasbarrini, Dino Vaira, Ignasi Puig, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: Single-capsule bismuth quadruple therapy achieved approximately 90% H. pylori eradication in real-world clinical practice, both as a first-line and rescue treatment, with good compliance and a favorable safety profile.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Infectious Diseases
Maria Caldas, Angeles Perez-Aisa, Bojan Tepes, Alma Keco-Huerga, Luis Bujanda, Alfredo J. Lucendo, Luis Rodrigo, Dino Vaira, Luis Fernandez-Salazar, Jose M. Huguet, Jorge Perez-Lasala, Natasa Brglez Jurecic, Galina Fadeenko, Jesus Barrio, Miguel Areia, Juan Ortuno, Rinaldo Pellicano, Marcis Leja, Javier Molina-Infante, Pavel Bogomolov, Sergey Alekseenko, Manuel Dominguez-Cajal, Judith Gomez-Camarero, Vassiliki Ntouli, Samuel J. Martinez-Dominguez, Rafael Ruiz-Zorrilla, Oscar Nunez, Aiman Silkanovna Sarsenbaeva, Pedro Almela, Perminder Phull, Marta Espada, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: The study found that statin use may be associated with the effectiveness of H. pylori eradication therapies, but the association varies depending on the specific treatment scheme.
Meeting Abstract
Gastroenterology & Hepatology
A. G. McNicholl, O. P. Nyssen, D. S. Bordin, B. Tepes, A. Perez-Aisa, D. Vaira, M. Caldas, L. Bujanda, M. Castro-Fernandez, F. Lerang, M. Leja, L. Rodrigo, T. Rokkas, L. V. Jonaitis, J. Perez-Lasala, O. Shvets, A. Gasbarrini, H. Simsek, A. Axon, G. M. Buzas, J. C. Machado, Y. Niv, L. Boyanova, A. Goldis, V. Lamy, M. Katicic, K. Przytulski, M. Venerito, P. Bytzer, T. Milosavljevic, G. Fiorini, M. G. Donday, I. Arino, L. G. Capelle, L. I. Veijola, J. Molina-Infante, L. Vologhzanina, G. Fadeenko, M. Ramas, F. Megraud, C. O'Morain, J. P. Gisbert
Review
Ophthalmology
Radka Opatrilova, Peter Kubatka, Martin Caprnda, Dietrich Busselberg, Vladimir Krasnik, Pavol Vesely, Sandeep Saxena, Surabhi Ruia, Ioana Mozos, Luis Rodrigo, Peter Kruzliak, Katia Goncalves dos Santos
ACTA OPHTHALMOLOGICA
(2018)