Article
Peripheral Vascular Disease
Minako Goto, Keiko Koide, Mayumi Tokunaka, Hiroko Takita, Shoko Hamada, Masamistu Nakamura, Ryu Matsuoka, Akihiko Sekizawa, Poon C. Liona
Summary: The study demonstrates that the diagnostic accuracy of the FMF Bayes theorem-based model for predicting preeclampsia in the Japanese population at 11-13 weeks of gestation is feasible, with a high detection rate for preterm PE.
HYPERTENSION RESEARCH
(2021)
Correction
Peripheral Vascular Disease
Minako Goto, Keiko Koide, Mayumi Tokunaka, Hiroko Takita, Shoko Hamada, Masamistu Nakamura, Ryu Matsuoka, Akihiko Sekizawa, Poon C. Liona
Summary: The paper has been corrected and the correction has been published.
HYPERTENSION RESEARCH
(2021)
Correction
Peripheral Vascular Disease
Minako Goto, Keiko Koide, Mayumi Tokunaka, Hiroko Takita, Shoko Hamada, Masamistu Nakamura, Ryu Matsuoka, Akihiko Sekizawa, Poon C. Liona
Summary: A correction to the paper has been published at the following link: https://doi.org/10.1038/s41440-020-00593-y.
HYPERTENSION RESEARCH
(2021)
Correction
Peripheral Vascular Disease
Minako Goto, Keiko Koide, Mayumi Tokunaka, Hiroko Takita, Shoko Hamada, Masamistu Nakamura, Ryu Matsuoka, Akihiko Sekizawa, Poon C. Liona
Summary: The paper has a correction which can be found at the provided link.
HYPERTENSION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Veronica Giorgione, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan
Summary: This study assessed the effectiveness of peripartum screening in predicting CHT after HDP and found that a prediction model combining clinical and echocardiographic features showed excellent accuracy in identifying women at risk of persistent hypertension after HDP.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Carlos A. Link, Jackson Maissiat, Ben W. Mol, Kurt T. Barnhart, Ricardo F. Savaris
Summary: This study aims to verify the accuracy of an online algorithm using Bayes' theorem for diagnosing ectopic pregnancy (EP) using human chorionic gonadotropin (hCG), ultrasound, and clinical data. The study was conducted as a retrospective cohort study in a gynecologic emergency unit in a tertiary teaching hospital. The algorithm showed excellent accuracy in confirming or ruling out EP.
FERTILITY AND STERILITY
(2023)
Review
Allergy
Elissa M. Abrams, Edmond S. Chan, Jay Portnoy
Summary: Diagnostic tests for allergy are used to confirm a diagnosis, monitor activity, and determine prognosis. The Frequentist and Bayesian approaches offer different ways to derive probabilities, each with strengths and limitations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Obstetrics & Gynecology
Liora Elfassy, Ariane Lasry, Yaron Gil, Jacques Balayla
Summary: The study aims to determine the prevalence threshold of various obstetrics and gynecology screening tests, finding that these thresholds are higher than estimated disease prevalence. As a result, a significant proportion of positive screening tests obtained in population-level screening are likely false-positives.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Alexa Campbell, Kaitlyn K. Stanhope, Marissa Platner, Naima T. Joseph, Denise J. Jamieson, Sheree L. Boulet
Summary: The study found that the postpartum blood pressure screening attendance rate was low among women with hypertensive disorders of pregnancy, highlighting the need for further research and creative solutions to address barriers at the individual, provider, and system levels.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Medicine, General & Internal
Ma de la Luz Bermudez Rojas, Virginia Medina Jimenez, Javier Ivan Manzanares Cuadros, Daniel Alberto Diaz Martinez, Nicolas Padilla Raygoza, Elia Lara Lona
Summary: The prenatal approach is important for preventing perinatal complications. A holistic and horizontal perinatal care model is needed. Mexico, an emerging market economy with inequality, faces challenges in healthcare accessibility and distribution. This article aims to describe a care model implemented in Guanajuato, Mexico, which utilizes prenatal screening strategies to improve prenatal care in countries with limited resources. The model focuses on timely identification and specialized care for high-risk patients.
FRONTIERS IN MEDICINE
(2023)
Article
Acoustics
U. Nowacka, I Papastefanou, A. Bouariu, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study investigates the additional value of second-trimester placental growth factor (PlGF) in predicting small-for-gestational-age (SGA) neonates and examines second-trimester contingent screening strategies. The results show that the combination of maternal risk factors, estimated fetal weight (EFW), uterine artery pulsatility index (UtA-PI), and PlGF significantly improves the prediction of SGA compared to maternal risk factors alone. However, the incremental improvement decreases when PlGF is added to screening with a combination of maternal risk factors, EFW, and UtA-PI. By reserving measurements of UtA-PI and PlGF for a certain percentage of the population, similar detection rates and false-positive rates can be achieved. The study concludes that the combination of maternal risk factors, EFW, UtA-PI, and PlGF provides an effective prediction of SGA in the second trimester.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shathiyah Kulandavelu, Raul A. Dulce, Christopher Murray, Michael A. Bellio, Julia Fritsch, Rosemeire Kanashiro-Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan, Jenny E. Van Eyk, Joshua M. Hare
Summary: The deficiency of GSNOR can lead to imbalanced placental S-nitrosylation and induce preeclampsia in mice, characterized by symptoms such as hypertension, proteinuria, and renal pathology. Ascorbate can reverse these pathological changes, except for fetal weight. The decreased GSNOR activity and increased nitrosative stress are also found in human preeclamptic placentas.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Urology & Nephrology
Amy Oi, Michelle A. Hladunewich
Summary: Following the Supreme Court's decision to overturn the right of American women to terminate pregnancy, vulnerable women, including those with chronic kidney disease, require increased care and attention. Nephrologists need to quickly develop expertise in reproductive care to ensure their health and well-being.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anum S. Minhas, Xiumei Hong, Guoying Wang, Dong Keun Rhee, Tiange Liu, Mingyu Zhang, Erin D. Michos, Xiaobin Wang, Noel T. Mueller
Summary: This study found that self-reported higher adherence to a Mediterranean-style diet is associated with lower preeclampsia odds, and the benefit of this diet is present among Black women as well.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Obstetrics & Gynecology
Anna Kajdy, Dorota Sys, Artur Pokropek, Steven W. Shaw, Tung-Yao Chang, Pavel Calda, Ganesh Acharya, Maya Ben-Zion, Tal Biron-Shental, Dariusz Borowski, Bartosz Czuba, Adolfo Etchegaray, Stepan Feduniw, Rosario Garcia-Mandujano, Monica Garcia Santacruz, Maria M. Gil, Sonia Hassan, Sebastian Kwiatkowski, Arancha Martin-Arias, Raigam Jafet Martinez-Portilla, Federico Prefumo, Michal Rabijewski, Laurent J. Salomon, Heidi Tiller, Stefan Verlohren, Hian Yan Voon, Omar Fernando Yanque-Robles, Soon Leong Yong, Liona C. Poon
Summary: This study examines risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. The results indicate that pregnant women in high-income economies experience higher levels of anxiety and depression. Factors such as the need for psychiatric treatment before pregnancy, restrictions in social distancing and access to leisure activities, pregnancy-related complications, fear of adverse outcomes in children related to COVID-19, and financial burden are associated with increased risk of anxiety and depression during pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Acoustics
A. Arechvo, D. A. Nikolaidi, M. M. Gil, V. Rolle, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study aimed to examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and evaluate whether IMD contributes to the prediction of stillbirth provided by maternal demographic characteristics and elements of medical history. The study found that women living in the most deprived areas in South East England had higher rates of stillbirth, particularly placental dysfunction-related stillbirth. However, including IMD in stillbirth screening did not improve the prediction provided by race, other maternal characteristics, and elements of medical history.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sani Tsz Kei Wong, So Ling Lau, Christopher Pak Hey Chiu, Patricia Nga Ping Ip, Lo Wong, Dorota Sys, Anna Kajdy, Liona Chiu Yee Poon
Summary: This study assessed the anxiety and depression levels of pregnant women in Hong Kong during the COVID-19 pandemic and examined the influence of demographic, economic, and social factors on these levels. The findings showed that pregnant women with psychiatric illness had higher scores in anxiety and depression. Factors such as financial difficulty, education, and in-vitro fertilization were associated with higher levels of depression, while partner support was associated with reduced levels of depression and anxiety. Therefore, addressing the needs of pregnant women with psychiatric illness and providing partner support are crucial during the COVID-19 pandemic.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Yi Man Isabella Wah, Ye Cao, Chun Yiu Law, Kwong Wai Choy, Tak Yeung Leung, Hoi Wan Angel Kwan, Liona C. Poon Poon
Summary: This article reports a case of recurrent congenital microcephaly in a Chinese family. Two affected fetuses presented with microcephaly early in the second trimester with agenesis of the corpus callosum. Whole-exome sequencing analysis detected two compound heterozygous candidate variants in the SASS6 gene, but the pathomechanism is still unknown.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Obstetrics & Gynecology
Sumaiya Adam, Harold David McIntyre, Kit Ying Tsoi, Anil Kapur, Ronald C. Ma, Stephanie Dias, Pius Okong, Moshe Hod, Liona C. Poon, Graeme N. Smith, Lina Bergman, Esraa Algurjia, Patrick O'Brien, Virna P. Medina, Cynthia Maxwell, Lesley Regan, Mary L. Rosser, Bo Jacobsson, Mark A. Hanson, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: Gestational diabetes (GDM) affects approximately 17 million pregnancies worldwide. Women with a history of GDM are at a significantly higher risk of developing type 2 diabetes and cardiovascular disease compared to those without prior GDM. Although prevention and delayed progression of GDM to type 2 diabetes is possible, it is not widely practiced. Considering the increasing rates of type 2 diabetes and CVD in women globally, it is crucial to utilize pregnancy as an opportunity for early identification and preventive intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Marcos Javier Cuerva, Elena Rodriguez, Marta Perez De Aguado, Maria del Mar Gil, Valeria Rolle, Francisco Lopez, Jose Luis Bartha
Summary: The aim of this study was to assess whether intrapartum ultrasound (ITU) measurements in maternal lateral posture are comparable to ITU measurements in semi-recumbent position. The results showed that the angle of progression (AOP) and head-perineum distance (HPD) were lower in the lateral posture compared to semi-recumbent position, while they were higher with contractions. Therefore, monitoring the second stage of labor with ITU in lateral maternal posture is feasible.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Editorial Material
Pediatrics
Lai Ling Hui, Karene H. T. Yeung, Ka Ming Chow, Liona C. Poon, Patricia L. S. Ip, E. Anthony S. Nelson
Summary: Barriers to breastfeeding during the COVID-19 pandemic in Hong Kong include mother-baby separations in hospitals and vaccine safety concerns. However, the pandemic has also created new opportunities to support breastfeeding, such as receiving post-natal care from family doctors, online antenatal classes, work-from-home policies, and telemedicine.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Obstetrics & Gynecology
Adriana Aquise, Nieves Rayo, Irene Fernandez-Buhigas, Ana Alfonso, Natalia Pagola, Miguel Rodriguez, Laura de Miguel, Irene Santacruz, Santiago Valor, Liona C. Poon, Maria M. Gil, Belen Santacruz
Summary: The seroprevalence of SARS-CoV-2 among first-trimester pregnant women was 8.2% between January 1 and May 15, 2020. Seropositive women did not show significant differences in complications.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Cell Biology
Lin Gao, Vrinda Mathur, Sabrina Ka Man Tam, Xuemeng Zhou, Ming Fung Cheung, Lu Yan Chan, Guadalupe Estrada-Gutierrez, Bo Wah Leung, Sakita Moungmaithong, Chi Chiu Wang, Liona C. Poon, Danny Leung
Summary: Recent studies have found that COVID-19 infection can cause disruptions in the maternal-fetal interface, potentially leading to pregnancy complications. By analyzing transcriptomic and epigenomic data from COVID-19 patients and control samples, researchers discovered abnormal immune activation and angiogenesis patterns in specific cells, as well as dysregulation of retrotransposons. In particular, they found that reduced enhancer activities of LTR8B elements were linked to downregulation of pregnancy-specific glycoprotein genes in syncytiotrophoblasts.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sakita K. Moungmaithong, Angel H. S. Kwan, Ada W. Tse, Natalie K. C. Wong, Michelle S. S. Lam, Jing Wang, Liona C. Poon, Daljit S. Sahota
Summary: International professional organizations recommend aspirin prophylaxis to women at high risk for preterm preeclampsia (PE) in the first trimester. However, the UK Fetal Medicine Foundation (FMF) screening test using mean arterial pressure (MAP), uterine artery pulsatility index (UTPI), and placental growth factor (PlGF) has shown lower detection rates (DRs) in Asian population studies. Additional biomarkers are needed in Asian women to improve screening for preterm and term PE.
Review
Obstetrics & Gynecology
Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Ling Wu, Liona C. Poon, Chi Chiu Wang
Summary: This meta-analysis confirmed that platelet count was significantly lower in preeclamptic women, irrespective of severity and presence or absence of associated complications, even before the onset of preeclampsia and in the second trimester of pregnancy. Our findings suggest that platelet count may be a potential marker to identify and predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Raquel Gonzalez, Anna Gonce, M. del Mar Gil, Edurne Mazarico, Elena Ferriols-Perez, Paloma Toro, Elisa Llurba, Elisa Saez, Miguel angel Rodriguez-Zambrano, Laura Garcia-Otero, Marta Lopez, Belen Santacruz, M. angeles Roman, Antoni Paya, Sofia Alonso, Monica Cruz-Lemini, Clara Pons-Duran, Luis Bernardo Herrera, Haily Chen, Azucena Bardaji, Llorenc Quinto, Clara Menendez
Summary: This study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) in pregnant and postpartum women with SARS-CoV-2 infection. The results showed that although the prevalence of infection was lower in the HCQ group, there were no significant differences between the two groups in terms of COVID-19 progression, adverse events, and electrocardiogram changes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Maria M. Gil, Noppadol Chaiyasit, Diana Cuenca-Gomez, Walter Plasencia, Valeria Rolle, Liona C. Poon
Summary: This study aimed to assess the diagnostic accuracy of placental growth factor and placental growth factor-based models in predicting the development of preeclampsia in asymptomatic women. The findings suggest that placental growth factor combined with maternal factors has the highest predictive performance for early preeclampsia, while placental growth factor-based models perform similarly to soluble fms-like tyrosine kinase-1-placental growth factor ratio for any-onset preeclampsia in the third trimester. Standardized research using consistent models is needed to accurately predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Raquel Martin-Alonso, Valeria Rolle, Ranjit Akolekar, Catalina de Paco Matallana, Irene Fernandez-Buhigas, Maria Isabel Sanchez-Camps, Tara Giacchino, Miguel Rodriguez-Fernandez, Jose Eliseo Blanco-Carnero, Belen Santacruz, Maria M. Gil
Summary: In late-term uncomplicated singleton pregnancies, the cerebroplacental ratio (CPR) has shown poor predictive capacity for adverse perinatal outcomes.
MEDICINA-LITHUANIA
(2023)