期刊
JOURNAL OF DIABETES INVESTIGATION
卷 9, 期 5, 页码 1128-1134出版社
WILEY
DOI: 10.1111/jdi.12819
关键词
Adipsin; First phase of insulin secretion; Type2 diabetes mellitus
资金
- National Natural Science Foundation of China [81270911, 81070639, 30771038, 30570744]
- National Key Clinical Specialties Construction Program of China
Aims/IntroductionTo detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn and the first phase of insulin secretion. Materials and MethodsA total of 56 patients with newly diagnosed type2 diabetes mellitus, 36 patients with impaired glucose tolerance (IGT) and 45 individuals with normal glucose tolerance were enrolled. Intravenous glucose tolerance tests were carried out to evaluate pancreatic -cell function. The serum levels of adipsin, interleukin-1 and high-sensitivity C-reactive protein were assayed. ResultsSerum adipsin levels were significantly lower in the type2 diabetes mellitus and the IGT patients than those in the normal glucose tolerance group (P<0.05). The acute insulin response and area under the curve showed a progressive decrease in the normal glucose tolerance and IGT groups, and decreased to the lowest levels in the type2 diabetes mellitus group (P<0.05). Adipsin was found to be negatively correlated with waist-to-hip ratio, free fatty acid, fasting plasma glucose, 2-h postprandial plasma glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, interleukin-1 and high-sensitivity C-reactive protein (P<0.05 or P<0.001), and positively correlated with homeostasis model assessment of -cell function, high-density lipoprotein cholesterol, the area under the curve of the first phase insulin secretion and acute insulin response (P<0.05 or P<0.001). Stepwise multiple regression analysis showed that homeostasis model assessment for -cell function and acute insulin response were independently related to adipsin (P<0.05). ConclusionsSerum adipsin levels were lower in type2 diabetes mellitus and IGT patients, and correlated with the first phase of insulin secretion. Adipsin might be involved in the pathology of type2 diabetes mellitus.
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