期刊
INTERNATIONAL JOURNAL OF SURGERY
卷 52, 期 -, 页码 266-271出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijsu.2018.02.055
关键词
Caspase-3; Apoptosis; Gastric cancer
类别
资金
- Taipei Veterans General Hospital [V106C-083]
- Ministry of Science and Technology [MOST 105-2314-B-075-005-MY2]
Background: Caspase-3 acts as a major executioner protein in proteolytic degradation during apoptosis. The role of Caspase-3 in gastric cancer remains controversial. Methods: A total of 366 gastric cancer patients who received curative surgery were enrolled. Caspase-3 expression in gastric tumors was examined by immunohistochemical staining. Correlations between Caspase-3 expression and the survival rates and between Caspase-3 expression and the clinicopathological parameters of the gastric cancer patients were analyzed. Results: The 5-year overall survival rates of gastric cancer patients with and without Caspase-3 expression were 51.2% and 37.3%, respectively (P=0.030). The 5-year disease-free survival rates of gastric cancer patients with and without Caspase-3 expression were 49.2% and 34.6%, respectively (P=0.029). Analyses of the clinicopathological features showed that larger tumor size (P=0.030), more advanced Borrmann type (P=0.012), more aggressive stromal reaction (P=0.001), higher classification using Ming's infiltrating histology type (P=0.018), more lymph node involvement (P=0.019), and more lymphovascular involvement (P=0.045) were significantly correlated with a lack of Caspase-3 expression. The multivariate analysis showed that age (P=0.001), Borrmann classification (P=0.032), stromal reaction type (P=0.018), TNM pathological T category (P=0.002), TNM pathological N category (P < 0.001), and Caspase-3 expression (P=0.041) were significantly correlated with the overall survival of gastric cancer patients. Conclusion: Caspase-3 expression in gastric cancer patients is related to favorable clinicopathological features and a positive prognosis after curative surgery. Caspase-3 may act as a tumor suppressor in human gastric cancer.
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