Article
Multidisciplinary Sciences
Tadamitsu Morimoto, Tomoko Yoshikawa, Mamoru Nagano, Yasufumi Shigeyoshi
Summary: This study investigated the regional variation of circadian periods in the SCN using a transgenic rat model. The researchers identified a short period region (SPR) and a long period region (LPR) within the SCN. They also discovered the mechanism of synchronization between these regions.
Article
Physics, Multidisciplinary
Matheus M. G. Correia, Joao V. M. Barboza, Aquino L. Espindola
Summary: This study investigates the transmission of Trypanosoma brucei gambiense, the causative agent of Human African Trypanosomiasis, in African rural areas. By using agent-based modeling, it was found that humans and animals act as reservoirs for the pathogen, with transmission depending on the tsetse fly vector. Implementing treatment with Fexinidazole at different percentages in rural zones of the Democratic Republic of the Congo can optimize resources and potentially lead to disease eradication.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Karen J. Tonsfeldt, Laura J. Cui, Jinkwon Lee, Thijs J. Walbeek, Liza E. Brusman, Ye Jin, Michihiro Mieda, Michael R. Gorman, Pamela L. Mellon
Summary: This study examines the effects of disruptions to the circadian system on reproductive capacity, particularly in females. The loss of the Bmal1 gene in specific neuron populations affects circadian activity and temperature rhythms, but does not disrupt estrus cycles, fecundity, kisspeptin responsiveness, or inducible LH surge in female mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kayla E. Rohr, Thomas Inda, Jennifer A. Evans
Summary: The study found that arginine vasopressin (AVP) signaling through V1A and V1B receptors influences molecular rhythmicity in suprachiasmatic nucleus (SCN) neurons. V1A/B receptor agonists reset the phase of the SCN molecular clock in a time-dependent manner, with more pronounced responses observed in female SCN. Additionally, the study showed that both G(alpha q) and G(alpha s) signaling pathways interact with V1A/B-induced SCN resetting, and this response requires vasoactive intestinal polypeptide (VIP) signaling. These findings highlight the importance of studying clock function in both sexes and suggest that signal integration in central clock circuits plays a crucial role in the control of daily rhythms in behavior and physiology.
NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Miebaka Jamabo, Maduma Mahlalela, Adrienne L. L. Edkins, Aileen Boshoff
Summary: Human African trypanosomiasis, caused by Trypanosoma brucei, is a neglected tropical disease targeted for eradication by 2030. The COVID-19 pandemic has disrupted control programs, extending the time frame. Vaccine development has been challenging due to antigenic variation and B cell depletion. Control relies on screening and drugs, with fexinidazole being a recent major breakthrough. Diagnosis, compliance, and resistance pose challenges, while ongoing drug discovery and addressing eradication challenges are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Timna Hitrec, Cheryl Petit, Emily Cryer, Charlotte Muir, Natalie Tal, Jean-Michel Fustin, Alun T. L. Hughes, Hugh D. Piggins
Summary: Timed daily access to a running-wheel synchronizes circadian rhythms and promotes stable rhythms in animals with impaired neuropeptide signaling. The transcriptome of the brain clock showed extensive dysregulation in these animals, but the molecular programs in the liver and lung were partially intact. Furthermore, exercise could correct behavioral abnormalities in circadian rhythms without causing large scale alterations in the brain clock.
Article
Microbiology
Caroline E. Dewar, Aitor Casas-Sanchez, Constentin Dieme, Aline Crouzols, Lee R. Haines, Alvaro Acosta-Serrano, Brice Rotureau, Achim Schnaufer
Summary: This study demonstrates that efficient energy production through mitochondria is critical for the trypanosome's swimming ability and migration within the tsetse fly. Surprisingly, trypanosomes with impaired mitochondrial energy production are only mildly compromised in their ability to colonize the tsetse fly midgut. This study provides new insights into the complex mechanisms of trypanosome infection in tsetse flies.
Article
Microbiology
Caroline E. Dewar, Aitor Casas-Sanchez, Constentin Dieme, Aline Crouzols, Lee R. Haines, Alvaro Acosta-Serrano, Brice Rotureau, Achim Schnaufer
Summary: The single-celled parasite Trypanosoma brucei is transmitted by tsetse flies and its development in the fly's gut depends on efficient energy production by mitochondria.
Article
Multidisciplinary Sciences
Serena Riccitelli, Fabio Boi, Davide Lonardoni, Lidia Giantomasi, Olga Barca-Mayo, Davide De Pietri Tonelli, Silvia Bisti, Stefano Di Marco, Luca Berdondini
Summary: Clock genes in glial cells play an important role in regulating visual information processing in the retina, affecting retinal physiology and the activity of retinal ganglion cells in a circadian manner.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Aurelie Brecier, Vina W. Li, Chloe S. Smith, Katherine Halievski, Nader Ghasemlou
Summary: This review discusses the impact of glial cell clock machinery on the function of the central nervous system, as well as the regulation of the body's circadian rhythm by glial cells. The findings shed new light on the importance of glial cell clock machinery in diseases.
BIOLOGICAL REVIEWS
(2023)
Article
Cell Biology
Maria Luengo-Mateos, Antia Gonzalez-Vila, Nathalia Romanelli Vicente Dragano, Nataliia Ohinska, Maria Silveira-Loureiro, Marco Gonzalez-Dominguez, Anxela Estevez-Salguero, Paula Novelle-Rodriguez, Miguel Lopez, Olga Barca-Mayo
Summary: Here, we show that hypothalamic astrocytic BMAL1 plays a role in computing cyclic metabolic information for optimizing energetic resources in a sexually dimorphic manner. Knockdown of BMAL1 in female astrocytes leads to negative energy balance and alters basal metabolic cycles without affecting circadian locomotor activity. Furthermore, female mice with BMAL1 knockdown in astrocytes exhibit a male-like metabolic obese phenotype when fed a high-fat diet. These findings highlight the importance of astrocytic BMAL1 in the regulation of energy homeostasis and its potential implications in the physiopathology of obesity and related comorbidities.
Article
Neurosciences
Jesse Britz, Emmanuel Ojo, Asmita Dhukhwa, Takashi Saito, Takaomi C. Saido, Erin R. Hascup, Kevin N. Hascup, Shelley A. Tischkau
Summary: This study compares the onset of Alzheimer's disease (AD) in different male and female AD mouse models, and explores the sex-dependent differences in activity patterns, glucose sensitivity, cognitive function, and pathology. The results show significant gender differences in the A beta PP/PS1 and APP(NL-F/NL-F) mouse models, with female A beta PP/PS1 mice performing worse in cognitive tasks and exhibiting increased plaque pathology. The study provides novel insights into the baseline sex differences and diurnal activity variations in AD mouse models.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biology
Charles D. Kato, Dorothy Twesigye, Vincent P. Alibu, Ann Nanteza, Julius Nsubuga, Claire M. Mugasa, Enock Matovu
Summary: The study found that plasma NSE levels were significantly elevated in late-stage patients, with no significant differences observed between early-stage patients and controls. The use of ROC curves demonstrated potential for plasma NSE as a staging biomarker, with a cutoff value of > 346.5 ng/mL showing high sensitivity and specificity in discriminating between early and late-stage HAT patients. Future research could focus on enhancing the specificity of NSE by combining it with other plasma biomarkers.
BMC RESEARCH NOTES
(2022)
Review
Infectious Diseases
Yeimer Ortiz-Martinez, Menan Gerard Kouame, Felix Bongomin, Sulaiman Lakoh, Andres F. Henao-Martinez
Summary: Both forms of the disease, gambiense HAT (gHAT) and rhodesiense HAT (rHAT), have specific epidemiology, risk factors, diagnosis, and treatment. Disease management still requires a high index of suspicion, infectious disease expertise, and specialized medical care. Essential stakeholders in health policy are critical to accomplishing the elimination goals of the NTD roadmap for 2021-2030.
CURRENT TROPICAL MEDICINE REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Kelita Kamoto, Arthur Chiwaya, Peter Nambala, Pricilla Chammudzi, Edward Senga, John Chisi, Enock Matovu, Janelisa Musaya
Summary: The study investigated the levels of three cytokines in plasma samples of HAT cases and controls in Malawi, showing that controls had significantly higher levels of TNF-alpha and IL-8 compared to cases, while IL-10 levels were similar. Among untreated cases, only IL-8 had significantly higher levels.
MALAWI MEDICAL JOURNAL
(2021)
Review
Behavioral Sciences
Valeria Colavito, Chiara Tesoriero, Amenu T. Wirtu, Gigliola Grassi-Zucconi, Marina Bentivoglio
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2015)
Article
Multidisciplinary Sciences
Chiara Tesoriero, Alina Codita, Ming-Dong Zhang, Andrij Cherninsky, Hakan Karlsson, Gigliola Grassi-Zucconi, Giuseppe Bertini, Tibor Harkany, Karl Ljungberg, Peter Liljestrom, Tomas G. M. Hokfelt, Marina Bentivoglio, Krister Kristensson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Infectious Diseases
Claudia Laperchia, Chiara Tesoriero, Paul F. Seke-Etet, Valentina La Verde, Valeria Colavito, Gigliola Grassi-Zucconi, Jean Rodgers, Paul Montague, Peter G. E. Kennedy, Marina Bentivoglio
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Review
Neurosciences
Chiara Tesoriero, Federico Del Gallo, Marina Bentivoglio
BRAIN RESEARCH BULLETIN
(2019)
Article
Anatomy & Morphology
Marina Bentivoglio, Tiziana Cotrufo, Sergio Ferrari, Chiara Tesoriero, Sara Mariotto, Giuseppe Bertini, Antonella Berzero, Paolo Mazzarello
FRONTIERS IN NEUROANATOMY
(2019)
Review
Clinical Neurology
P. M. Rossini, R. Di Iorio, M. Bentivoglio, G. Bertini, F. Ferreri, C. Gerloff, R. J. Ilmoniemi, F. Miraglia, M. A. Nitsche, F. Pestilli, M. Rosanova, Y. Shirota, C. Tesoriero, Y. Ugawa, F. Vecchio, U. Ziemann, M. Hallett
CLINICAL NEUROPHYSIOLOGY
(2019)
Article
Cell Biology
Laurensia Yuniati, Angela Lauriola, Manouk Gerritsen, Susana Abreu, Eric Ni, Chiara Tesoriero, Jacob O. Onireti, Teck Yew Low, Albert J. R. Heck, Andrea Vettori, Timothy Cardozo, Daniele Guardavaccaro
Article
Neurosciences
Laura Padovani, Chiara Tesoriero, Alexei Vyssotski, Marina Bentivoglio, Cristiano Chiamulera
NEUROSCIENCE LETTERS
(2020)
Article
Clinical Neurology
Laura Rossini, Dalia De Santis, Roberta Rosa Mauceri, Chiara Tesoriero, Marina Bentivoglio, Emanuela Maderna, Antonio Maiorana, Francesco Deleo, Marco de Curtis, Giovanni Tringali, Massimo Cossu, Gemma Tumminelli, Manuela Bramerio, Roberto Spreafico, Laura Tassi, Rita Garbelli
Summary: The study revealed that neuronal structures and dendritic spines are generally normal in epileptic neocortex, except for severe alterations in type II focal cortical dysplasia. This suggests that the mechanisms leading to this cortical malformation interfere with normal dendritic organization and synaptic network.
Article
Infectious Diseases
Gabriela C. Olivera, Leonie Vetter, Chiara Tesoriero, Federico Del Gallo, Gustav Hedberg, Juan Basile, Martin E. Rottenberg
Summary: In the early stage of T.b.b. infection, the predominant T cells in the brain express an effector-memory phenotype, while tissue resident memory T cells develop in the late stage. Both CD4 and CD8 T cells are independently redundant for the penetration of T.b.b. into the brain parenchyma.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Green & Sustainable Science & Technology
Giovanna Pesante, Anna Zuliani, Elena Cannone, Francesca Greco, Chiara Tesoriero, Andrea Vettori, Nicola Frison
Summary: The study suggests the possibility of utilizing bacterial biomass produced from the conversion of zootechnical residues as an alternative protein source for fish feed in aquaculture. The results demonstrate that the microbial proteins generated through this process are a suitable replacement for commercially available feed, with improved survival rates when enriched with oils and polyhydroxyalkanoates.
JOURNAL OF CLEANER PRODUCTION
(2022)