Recent Genetics and Epigenetics Approaches to PTSD

Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder

(2018) Nikolaos P. Daskalakis et al.   BIOLOGICAL PSYCHIATRY

CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein

(2018) M.W. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

(2017) B P F Rutten et al.   MOLECULAR PSYCHIATRY

Neuroinflammatory genes associated with post-traumatic stress disorder

(2017) Lyndon J. Zass et al.   PSYCHIATRIC GENETICS

Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response

(2017) Boris B. Quednow et al.   SCHIZOPHRENIA RESEARCH

Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations

(2017) Whitney E. Melroy-Greif et al.   Twin Research and Human Genetics

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

(2017) Cameron Palmer et al.   PLoS Genetics

Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans

(2017) R Hammamieh et al.   Translational Psychiatry

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

(2017) P-F Kuan et al.   Translational Psychiatry

Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

(2017) A W Charney et al.   Translational Psychiatry

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

(2016) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility

(2016) Nikolaos P. Daskalakis et al.   EXPERIMENTAL NEUROLOGY

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

(2016) Rahul A. Bharadwaj et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice

(2016) K. C. Koenen et al.   PSYCHOLOGICAL MEDICINE

Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers

(2016) Murray B. Stein et al.   JAMA Psychiatry

Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder

(2016) V Kilaru et al.   Translational Psychiatry

Functional evaluation of a PTSD-associated genetic variant: estradiol regulation and ADCYAP1R1

(2016) K B Mercer et al.   Translational Psychiatry

A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces

(2015) Lynn M. Almli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Association ofCRPGenetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of Trauma

(2015) Vasiliki Michopoulos et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq–Afghanistan era veterans

(2015) Allison E. Ashley-Koch et al.   JOURNAL OF AFFECTIVE DISORDERS

Gene networks specific for innate immunity define post-traumatic stress disorder

(2015) M S Breen et al.   MOLECULAR PSYCHIATRY

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala

(2015) Takehito Sawamura et al.   NEUROPSYCHOPHARMACOLOGY

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration

(2015) Mark W Logue et al.   NEUROPSYCHOPHARMACOLOGY

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene

(2015) Caroline M. Nievergelt et al.   PSYCHONEUROENDOCRINOLOGY

Genetics and genomics of psychiatric disease

(2015) D. H. Geschwind et al.   SCIENCE

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors

(2015) Brian G. Dias et al.   TRENDS IN NEUROSCIENCES

R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment

(2014) Robert J. Carroll et al.   BIOINFORMATICS

A GENOME-WIDE ASSOCIATION STUDY OF CLINICAL SYMPTOMS OF DISSOCIATION IN A TRAUMA-EXPOSED SAMPLE

(2014) Erika J. Wolf et al.   DEPRESSION AND ANXIETY

Medical research: Missing patients

(2014) Esteban G. Burchard   NATURE

Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes

(2014) Nikolaos P. Daskalakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study

(2014) Molly A. Hall et al.   PLoS Genetics

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk

(2014) Satish A. Eraly et al.   JAMA Psychiatry

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis

(2014) Bahram Namjou et al.   Frontiers in Genetics

Posttraumatic stress disorder and risk for coronary heart disease: A meta-analytic review

(2013) Donald Edmondson et al.   AMERICAN HEART JOURNAL

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

(2013) Xin He et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disorders and borders: Psychiatric genetics and nosology

(2013) Jordan W. Smoller   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: A pilot study

(2013) Stephen J. Glatt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder

(2013) Pingxing Xie et al.   BIOLOGICAL PSYCHIATRY

Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia

(2013) Victoria E Cosgrove et al.   BMC Medicine

Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

(2013) Nikolaos P. Daskalakis et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

(2013) D M Ruderfer et al.   MOLECULAR PSYCHIATRY

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Neuroligin-1 links neuronal activity to sleep-wake regulation

(2013) J. El Helou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

(2013) D. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women

(2013) Guia Guffanti et al.   PSYCHONEUROENDOCRINOLOGY

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

(2013) Sarah A. Pendergrass et al.   PLoS Genetics

Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD

(2013) Rachel Yehuda et al.   Frontiers in Psychiatry

Common Heritable Contributions to Low-Risk Trauma, High-Risk Trauma, Posttraumatic Stress Disorder, and Major Depression

(2012) Carolyn E. Sartor   ARCHIVES OF GENERAL PSYCHIATRY

A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus

(2012) M W Logue et al.   MOLECULAR PSYCHIATRY

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study

(2012) Mirjam van Zuiden et al.   PSYCHONEUROENDOCRINOLOGY

Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View

(2012) Sarah A Pendergrass et al.   BioData Mining

Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder

(2011) Alicia K. Smith et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Using Polymorphisms in FKBP5 to Define Biologically Distinct Subtypes of Posttraumatic Stress Disorder

(2011) Divya Mehta   ARCHIVES OF GENERAL PSYCHIATRY

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

(2011) Kerry J. Ressler et al.   NATURE

Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: A meta-analysis

(2011) Ellen R. Klaassens et al.   PSYCHONEUROENDOCRINOLOGY

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Epigenetic and immune function profiles associated with posttraumatic stress disorder

(2010) M. Uddin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women

(2010) C. E. Sartor et al.   PSYCHOLOGICAL MEDICINE

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

Mapping complex disease traits with global gene expression

(2009) William Cookson et al.   NATURE REVIEWS GENETICS

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

Revealing the architecture of gene regulation: the promise of eQTL studies

(2008) Yoav Gilad et al.   TRENDS IN GENETICS