Article
Oncology
Xuqi Sun, Ziliang Yang, Jie Mei, Ning Lyu, Jinfa Lai, Minshan Chen, Ming Zhao
Summary: For HCC patients with MVI (+) and early small recurrence, TACE-RFA could achieve better prognosis than hepatectomy or RFA alone, while RFA alone provided comparable survival benefits compared with hepatectomy or TACE-RFA in other HCC patients with small recurrence.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Oncology
Wei Xu, Yonggang Wang, Zhanwei Yang, Jingdong Li, Ruineng Li, Fei Liu
Summary: In this study, we developed and validated a MVI prediction model for patients with hepatocellular carcinoma (HCC) that differentiates MVI classification and may provide useful guidance for treatment planning.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Laihui Luo, Renfeng Shan, Lifeng Cui, Zhao Wu, Junlin Qian, Shuju Tu, WenJian Zhang, Yuanpeng Xiong, Wei Lin, Hongtao Tang, Yang Zhang, Jisheng Zhu, Zeyu Huang, Zhigang Li, Shengping Mao, Hui Li, Zemin Hu, Peng Peng, Kun He, Yong Li, Liping Liu, Wei Shen, Yongzhu He
Summary: This study retrospectively analyzed 1505 patients with hepatocellular carcinoma (HCC) and compared the efficacy of postoperative adjuvant transarterial chemoembolisation (PA-TACE) with no PA-TACE. The results showed that patients who received PA-TACE had significantly higher disease-free survival and overall survival than those who did not. Among patients with microvascular invasion (MVI), PA-TACE treatment was associated with even higher survival rates. Therefore, PA-TACE may be a potentially beneficial treatment for HCC patients, especially those with MVI.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Haoyu Hu, Shuo Qi, Silue Zeng, Peng Zhang, Linyun He, Sai Wen, Ning Zeng, Jian Yang, Weiqi Zhang, Wen Zhu, Nan Xiang, Chihua Fang
Summary: The study established a predictive model to forecast the occurrence of microvascular invasion in HCC patients, and compared the efficacy of anatomic resection and non-anatomic resection for hepatocellular carcinoma. The predictive model was found to be convenient and accurate, highlighting the importance of performing anatomic resection in patients with high risk of MVI or low risk of MVI with larger tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Xubiao Wei, Yabo Jiang, Shuang Feng, Chongde Lu, Lei Huo, Bin Zhou, Yan Meng, Wan Yee Lau, Yaxin Zheng, Shuqun Cheng
Summary: For patients with a resectable single and small hepatitis B virus-related HCC predicted to have high risks of MVI, neoadjuvant RT gave a promising response rate with mild toxicity. Nevertheless, neoadjuvant RT yielded similar long-term DFS and OS rates compared with patients who underwent upfront surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Lan-Qing Yao, Chao Li, Yong-Kang Diao, Lei Liang, Hang-Dong Jia, Shi-Chuan Tang, Yong-Yi Zeng, Han Wu, Ming-Da Wang, Li-Hui Gu, Timothy M. Pawlik, Wan Yee Lau, Cheng-Wu Zhang, Feng Shen, Kui Wang, Tian Yang
Summary: This study aimed to determine whether the grading severity of microscopic vascular invasion (MVI) was associated with recurrence and survival in patients with solitary hepatocellular carcinoma (HCC). The results showed that the severity of MVI was independently associated with recurrence-free survival (RFS) and overall survival (OS) after hepatectomy for solitary HCC, with more severe MVI grading (M2) being particularly important.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Hanyu Jiang, Jingwei Wei, Fangfang Fu, Hong Wei, Yun Qin, Ting Duan, Weixia Chen, Kunlin Xie, Jeong Min Lee, Mustafa R. Bashir, Meiyun Wang, Bin Song, Jie Tian
Summary: This study aimed to develop and validate a scoring system for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC). The results showed that the preoperative MVI score, which integrated five EOB-MRI features and serum alpha-fetoprotein level, accurately predicted MVI and postoperative survival in HCC. This score could be useful in making individualized treatment decisions.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Wencui Li, Hongru Shen, Lizhu Han, Jiaxin Liu, Bohan Xiao, Xubin Li, Zhaoxiang Ye
Summary: This study aimed to develop a predictive model based on radiomics analysis of multiparametric magnetic resonance images to predict early recurrence of hepatocellular carcinoma (HCC). The predictive model incorporating clinico-radiological factors and fusion radiomics signature showed promising results in predicting individualized risk of postoperative early recurrence in HCC patients.
JOURNAL OF ONCOLOGY
(2022)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.
Article
Oncology
Zhancheng Qiu, Weili Qi, Youwei Wu, Lingling Li, Chuan Li
Summary: This study examines the impact of public insurance status on the survival outcomes of HCC patients after liver resection in China. The results show that underinsured HCC patients have worse survival outcomes after liver resection. This may be due to the limited access to care for underinsured patients, but further exploration is needed for conclusive evidence.
Article
Oncology
Yunshi Cai, Kunlin Xie, Mohammad Natheir Adeeb Alhmoud, Tian Lan, Haifeng Wan, Die Hu, Ling Lan, Chang Liu, Hong Wu
Summary: This study evaluated the diagnostic and prognostic values of Prothrombin induced by vitamin K absence-II (PIVKA-II) and Alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC), and investigated their clinical utility in patient selection for different surgical approaches. The results showed that both PIVKA-II and AFP were independent prognostic markers, and their combined status performed better in predicting overall survival (OS) and recurrence-free survival (RFS) of HCC patients compared to using PIVKA-II or AFP alone. Extra caution is needed when applying the laparoscopic approach in HCC patients with PIVKA-II (+) and AFP (+) status.
Article
Surgery
Sunyoung Lee, Tae Wook Kang, Kyoung Doo Song, Min Woo Lee, Hyunchul Rhim, Hyo Keun Lim, So Yeon Kim, Dong Hyun Sinn, Jong Man Kim, Kyunga Kim, Sang Yun Ha
Summary: In this study, surgical resection (SR) was found to be associated with a lower rate of early recurrence compared to radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) based on the risk of microvascular invasion (MVI). The predictive model developed in the study accurately predicted the risk of MVI in HCC patients with high accuracy, indicating that patients with MVI who underwent RFA were more prone to recurrence than those who underwent SR.
Article
Gastroenterology & Hepatology
Zhen-Hua Chen, Xiu-Ping Zhang, Jin-Kai Feng, Le-Qun Li, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jie Shi, Wei-Xing Guo, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: One-third of HCC patients with MVI achieved the long-term survival milestone of 5 years after resection. Anatomical hepatectomy, controlling intraoperative blood loss, a wide resection margin, and postoperative adjuvant TACE should be considered to improve long-term survival outcomes.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Hongguang Li, Tao Li, Jinhua Hu, Jun Liu
Summary: The study demonstrates that a preoperative nomogram combining PIVKA-II, AFP and tumor size can predict the risk of microvascular invasion in early hepatocellular carcinoma patients, providing clinicians with guidance for treatment options and prognosis evaluation.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Review
Gastroenterology & Hepatology
Leonard Depotte, Juliette Palle, Cosimo Rasola, Chloe Broudin, Vlad-Adrian Afrasanie, Antoine Mariani, Aziz Zaanan
Summary: Advanced gastric adenocarcinoma is a disease with poor prognosis. In recent years, new drugs, such as trastuzumab for HER2-positive tumors, ramucirumab alone or in combination with paclitaxel, and trifluridine-tipiracil, have improved patient survival. Other drugs, including monoclonal antibodies and targeted therapies, are also being evaluated.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2024)