期刊
CANCER DISCOVERY
卷 8, 期 4, 页码 386-388出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-18-0123
关键词
-
类别
资金
- NCI grant [K12CA088084-16A1]
- MD Anderson Moonshot program
- Khalifa Bin Zayed Al Nahyan Foundation [U01CA196403, U01CA200468]
Development of pancreatic cancer in spontaneous murine models is associated with enrichment of specific strains of gut and intratumoral bacteria that induce a tolerogenic immunosuppressive microenvironment favoring cancer progression and resistance to immunotherapies. Ablation of the microbiome with antibiotics reshapes the tumor microenvironment, inducing T-cell activation, improving immune surveillance, and increasing sensitivity to immunotherapy in established tumors. (c) 2018 AACR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据