Article
Oncology
Shiqiang Qu, Zefeng Xu, Tiejun Qin, Bing Li, Lijuan Pan, Jia Chen, Xin Yan, Junying Wu, Yudi Zhang, Peihong Zhang, Robert Peter Gale, Zhijian Xiao
Summary: Adding PTD to Ruxolitinib improves the hematologic adverse events associated with Ruxolitinib and allows for a higher dose of Ruxolitinib.
HEMATOLOGICAL ONCOLOGY
(2022)
Review
Oncology
Srdan Verstovsek, Chih-Cheng Chen, Miklos Egyed, Martin Ellis, Laura Fox, Yeow T. Goh, Vikas Gupta, Claire Harrison, Jean-Jacques Kiladjian, Mihaela C. Lazaroiu, Adam Mead, Donal McLornan, Mary F. McMullin, Stephen T. Oh, Andrew Perkins, Uwe Platzbecker, Christof Scheid, Alessandro Vannucchi, Sung-Soo Yoon, Mark M. Kowalski, Ruben A. Mesa
Summary: Key features of myelofibrosis (MF) include low blood cell counts, constitutional symptoms and splenomegaly. Anemia and transfusion dependency are important negative prognostic factors. Momelotinib (MMB) is a unique JAK inhibitor that aims to improve MF symptoms and spleen size while also enhancing hemoglobin levels.
Article
Hematology
Xiao-Lu Zhu, Ru Feng, Qiu-Sha Huang, Mei-Ying Liang, Ming Jiang, Hui Liu, Yi Liu, Hong-Xia Yao, Lei Zhang, Shen-Xian Qian, Tong-Hua Yang, Jing-Yu Zhang, Xu-Liang Shen, Lin-Hua Yang, Jian-Da Hu, Ren-Wei Huang, Zhong-Xing Jiang, Jing-Wen Wang, Hong-Yu Zhang, Zhen Xiao, Si-Yan Zhan, Hui-Xin Liu, Xing-Lin Wang, Ying-Jun Chang, Yu Wang, Yuan Kong, Lan-Ping Xu, Kai-Yan Liu, Xiao-Hong Zhang, Cheng-Hong Yin, Yue-Ying Li, Qian-Fei Wang, Jian-Liu Wang, Xiao-Jun Huang, Xiao-Hui Zhang
Summary: This study evaluated the safety and effectiveness of prednisone plus IVIg in pregnant patients with immune thrombocytopenia (ITP). The combination therapy showed a shorter time to response and duration of treatment compared to prednisone monotherapy. Additionally, the combination therapy had a lower predelivery platelet transfusion rate compared to IVIg alone.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2022)
Article
Hematology
Miao Chen, Qingchi Liu, Yan Gao, Xiaohui Suo, Xiaoqing Ding, Ling Wang, Lihong Li, Yingqi Shao, Da Gao, Wanling Sun, Yehui Tan, Wei Wang, Fang Ye, Bing Han
Summary: In this study, the efficacy and safety of CSA combining EPAG with or without ATG were compared in AA patients. The results showed that CSA + EPAG had similar response and fewer side effects compared to standard immunosuppressive therapy + EPAG.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaomeng Feng, Wei Guo, Yinping Wang, Jia Li, Yangzhi Zhao, Limei Qu, Xu Yan, Junna Li, Qiang Guo, Ken H. Young, Ou Bai
Summary: The study demonstrated that BV is a promising treatment for ALCL, AITL, and PTCL-TFH in frontline settings, with high overall remission rates. BV-CEP treatment showed a high objective response rate and potentially improved progression-free survival compared to traditional chemotherapy.
ADVANCES IN THERAPY
(2022)
Article
Pediatrics
Gashaw Kerebeh, Yeneneh Ayalew, Demewoz Kefale, Ermias Sisay Chanie, Natnael Moges Misganaw, Dejen Getaneh Feleke, Amare Kassaw, Agimasie Tigabu, Berihun Bantie, Mahlet Tamirat, Teshale Mengesha, Molla Azmeraw, Aklilu Endalamaw
Summary: This study aimed to assess the incidence and predictors of anemia among HIV-infected children on ART in public health facilities of Bahir Dar City, Northwest Ethiopia. The results showed a high overall incidence rate of anemia, with age, clinical, and ART-related variables contributing to its occurrence.
Article
Oncology
Lei She, Xuan Gong, Lin Su, Chao Liu
Summary: The combination therapy of nimotuzumab with radiation therapy and temozolomide shows potential efficacy in newly diagnosed EGFR-positive GBM patients, particularly those with unmethylated MGMT promoter.
Article
Pediatrics
Phasuth Chutarattanakul, Kamolporn Kaewpornsawan, Jidapa Wongcharoenwatana, Piyanuch Musikachart, Perajit Eamsobhana
Summary: This study investigated the association between postoperative blood transfusion and 30-day postoperative complications after pediatric hip surgery, as well as factors significantly associated with complications. Results showed that female gender and length of hospital stay were independently associated with 30-day postoperative complications.
Article
Gastroenterology & Hepatology
Xuhua Duan, Hao Li, Donglin Kuang, Pengfei Chen, Kai Zhang, Yanliang Li, Xiang He, Cheng Xing, Haibo Wang, Yaoxian Liu, Limin Xie, Shixi Zhang, Qiang Zhang, Peixin Zhu, Honglin Dong, Jichen Xie, Hui Li, Yong Wang, Ming Shi, Guangbin Jiang, Yandong Xu, Shiqi Zhou, Chunyu Shang, Jianzhuang Ren, Xinwei Han
Summary: The study evaluated the role of TACE plus apatinib (TACE + A) and TACE combined with apatinib plus camrelizumab (TACE + AC) in patients with unresectable hepatocellular carcinoma (HCC). The results showed that the TACE + AC group had better overall survival, progression-free survival, objective response rate, and disease control rate compared to the TACE + A group.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Hematology
Anastasia Martynova, Victor Chiu, Melissa Mert, David Hermel, Ilene Ceil Weitz
Summary: Research suggests that tacrolimus may be a potential treatment option for aplastic anemia with a more favorable toxicity profile compared to CsA.
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Guanghua Chu, Xiangzhen Liu, Weiguang Yu, Meiji Chen, Lingyun Dong
Summary: This study found that postmenopausal women with previously untreated advanced CC who received CPB treatment had superior survival benefits compared to those who received CPA treatment. Despite the long duration of CPB use, the safety profile was manageable.
Article
Oncology
Ying Zhong, Zhe Wang, Yali Xu, Yidong Zhou, Feng Mao, Songjie Shen, Qiang Sun
Summary: This study aimed to assess the safety of breast-conserving surgery without axillary lymph node dissection and radiotherapy in elderly patients with early-stage breast cancer. The results showed that for patients with clinically negative axillary lymph nodes, breast-conserving surgery with radiotherapy is a safe treatment option, and it does not significantly affect distant recurrence-free survival and breast cancer-specific survival compared to mastectomy plus axillary lymph node dissection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Takanobu Hirosawa, Arisa Hayashi, Yukinori Harada, Taro Shimizu
Summary: The clinical manifestations of iron deficiency without anemia in women were investigated. There were no significant differences in symptoms and improvement ratios between iron deficiency with and without anemia. Iron supplementation improved serum ferritin levels in both groups and improved hemoglobin levels in iron deficiency anemia. Iron deficiency without anemia still showed comparable serum ferritin and hemoglobin levels to iron deficiency anemia after treatment.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Song Chen, Zhiqiang Wu, Feng Shi, Qicong Mai, Liguang Wang, Fan Wang, Wenquan Zhuang, Xiaoming Chen, Huanwei Chen, Bo Xu, Jiaming Lai, Wenbo Guo
Summary: This retrospective study compared the clinical outcomes of pembrolizumab-lenvatinib-TACE and lenvatinib-TACE sequential therapy in Chinese uHCC patients with initial PD-L1 expression, indicating that the former had a higher conversion rate, longer OS and PFS.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Satoshi Washino, Hideki Takeshita, Masaharu Inoue, Makoto Kagawa, Takahiko Soma, Hodaka Yamada, Yukio Kageyama, Tomoaki Miyagawa, Satoru Kawakami
Summary: The combination therapy of nivolumab and ipilimumab in patients with renal cell carcinoma may result in a high prevalence of endocrine immune-related adverse events, which may be associated with non-endocrine immune-related adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)