Article
Genetics & Heredity
Myriam Rahmouni, Vincent Laville, Jean-Louis Spadoni, Randa Jdid, Leopold Eckhart, Florian Gruber, Taoufik Labib, Cedric Coulonges, Wassila Carpentier, Julie Latreille, Frederique Morizot, Erwin Tschachler, Khaled Ezzedine, Sigrid Le Clerc, Jean-Francois Zagury
Summary: Skin aging is an inevitable process influenced by various environmental factors and molecular mechanisms. Through genetic association studies and pathway analysis, new pathways and genes related to skin aging have been discovered, revealing both specific and shared molecular mechanisms.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Dev Paudel, Rocheteau Dareus, Julia Rosenwald, Maria Munoz-Amatriain, Esteban F. Rios
Summary: Cowpea, a major crop used for human consumption and livestock feed, has been studied for its genetic basis of flowering time through genome-wide association studies, revealing seven reliable SNP markers and candidate genes associated with flowering time, which could facilitate breeding efforts and knowledge transfer to other legume species.
FRONTIERS IN GENETICS
(2021)
Article
Clinical Neurology
Amy R. Hicks, Regina H. Reynolds, Benjamin O'Callaghan, Sonia Garcia-Ruiz, Ana Luisa Gil-Martinez, Juan Botia, Helene Plun-Favreau, Mina Ryten
Summary: Genes encoding the non-specific lethal complex are highly correlated with and regulate genes associated with Parkinson's disease. The complex plays a potential role in the regulation of genes and pathways implicated in Parkinson's disease. KANSL1 and KAT8 may serve as useful drug targets for Parkinson's disease.
Article
Biochemistry & Molecular Biology
Seong-Hoon Kim, Rupesh Tayade, Byeong-Hee Kang, Bum-Soo Hahn, Bo-Keun Ha, Yoon-Ha Kim
Summary: This study conducted a genome-wide association study (GWAS) on 357 soybean landraces to analyze root traits. It identified 112 significant SNP loci and 55 putative candidate genes. These findings suggest that the combined approach of SNP array and GWAS can be used to understand the genetic basis of soybean root traits and improve soybean breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Peng Su, Hui Wu, Yangming Huang, Xiaofang Lu, Jing Yin, Qingfeng Zhang, Xianyong Lan
Summary: Studying the characteristics of mammalian hoof colors is important for genetic improvements in animals. In this study, a specific single-nucleotide polymorphism (SNP) in the MITF gene was found to be significantly associated with hoof color in Australian White sheep. This research provides novel insights into hoof color genetics and offers molecular markers for selecting sheep with desired hoof color.
Article
Biology
Yunfeng Zhao, Jin Gao, Xiugang Guo, Baofeng Su, Haijie Wang, Runqing Yang, Li Jiang
Summary: This study proposes an efficient gene-based GWAS method for studying economic traits in maize. By comparing different statistical methods, many candidate genes related to maize traits were identified, supporting the reliability of the method. These findings are significant for maize breeding.
Article
Plant Sciences
Rahele Panahabadi, Asadollah Ahmadikhah, Lauren S. McKee, Paer K. Ingvarsson, Naser Farrokhi
Summary: The genetic variability of MLG and starch contents in rice whole grains was analyzed, revealing a negative correlation between MLG content and grain starch content. A new genome-wide association study identified seven significant QTLs associated with MLG content and two QTLs associated with starch content. Novel genes related to MLG content included a hexose transporter and anthocyanidin 5,3-O-glucosyltransferase.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Genetics & Heredity
Yi-Sian Lin, Chia-Chun Wang, Cho-Yi Chen
Summary: This study identified 719 shared genes between MDD and insomnia, and found the most enriched biological pathways are related to epigenetic modification, sensory perception, and immunologic signatures. The research also identified druggable targets using a network approach.
Article
Genetics & Heredity
Zheng Chang Wu, Yifu Wang, Xiaoguo Huang, Shenglong Wu, Wenbin Bao
Summary: Improving the reproductive efficiency of sows is a major challenge in the swine industry. This study identified genetic markers associated with reproductive traits in Large White pigs and suggested the use of marker-assisted selection for genetic improvement.
Review
Immunology
Yueqi Qiu, Delong Feng, Wenjuan Jiang, Tingting Zhang, Qianjin Lu, Ming Zhao
Summary: Three-dimensional (3D) genomics investigates the relationship between gene regulatory function and the spatial structure of chromatin. It uses technologies like chromosome conformation capture (3C) to study chromatin folding and its impact on gene function. Integration of multi-omics data is crucial for a comprehensive analysis of the relationships between regulatory components and gene function. 3D genome folding plays a role in immune cell differentiation, activation, and dysfunction, and is involved in various diseases including autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Ismail Mohamed Abdalla, Jiang Hui, Mudasir Nazar, Abdelaziz Adam Idriss Arbab, Tianle Xu, Shaima Mohamed Nasr Abdu, Yongjiang Mao, Zhangping Yang, Xubin Lu
Summary: Body size is an important economic trait for dairy cows, and understanding the genetic basis of inter-individual variation in body size can accelerate genetic improvement programs. In this genome-wide association study on Chinese Holstein cattle, several genes and functional pathways related to body size traits were identified. These findings can contribute to breeding programs and genomic selection efforts.
Article
Clinical Neurology
Yu-Chin An, Chia-Lin Tsai, Chih-Sung Liang, Yu-Kai Lin, Guan-Yu Lin, Chia-Kuang Tsai, Yi Liu, Sy-Jou Chen, Shih-Hung Tsai, Kuo-Sheng Hung, Fu-Chi Yang
Summary: In this study, several novel loci associated with insomnia in migraineurs were identified through GWAS in a Han Chinese population in Taiwan, providing insights into the possible genetic basis of insomnia and migraine comorbidity.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Obstetrics & Gynecology
Shufan Yue, Ling Pei, Fenghua Lai, Huangmeng Xiao, Zeting Li, Rui Zeng, Li Chen, Wenzhan Chen, Huiling Liu, Yanbing Li, Haipeng Xiao, Xiaopei Cao
Summary: This study identified five novel SNPs associated with GDM susceptibility in Chinese Han women through GWAS and verified the relationships between these SNPs and glucose metabolism during pregnancy using clinical data. Among the newly-identified susceptibility loci, TRPV3 gene was associated with worse insulin resistance postpartum.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Plant Sciences
Juyun Zheng, Zeliang Zhang, Zhaolong Gong, Yajun Liang, Zhiwei Sang, Yanchao Xu, Xueyuan Li, Junduo Wang
Summary: This study analyzed the population structure and genetic diversity of 149 cotton plant materials, and identified SNP markers associated with salt tolerance traits using genome-wide association analysis. The findings provide insights into the genetic mechanisms underlying salt tolerance in cotton and can be used for the selection and breeding of salt-tolerant cotton varieties.
Article
Medicine, General & Internal
Byung-Keun Kim, Hyun-Seung Lee, Suh-Young Lee, Heung-Woo Park
Summary: This study investigates gene regulatory networks in adult asthma patients to determine the factors influencing responsiveness to inhaled corticosteroids. The top-10 transcription factors and their associated genes were found to be significantly enriched in distinct biological pathways, providing potential targets to enhance corticosteroid sensitivity in asthma patients.
FRONTIERS IN MEDICINE
(2021)
Article
Agronomy
Leticia Maria Pereira Sanglard, David Esteban Contreras Marquez, Walmir Silva, Marta Maria dos Santos, Thais Correia Costa, Dante Teixeira Valente, Mateus Pies Gionbelli, Nick Vergara Lopes Serao, Claudia Batista Sampaio, Marcio de Souza Duarte
Summary: This study evaluated the effect of maternal protein supplementation during mid or late gestation on energy metabolism of beef calves' skeletal muscle. The results indicated that lack of protein supplementation in pregnant cows alters the energy metabolism of their calves and leads to metabolic inflexibility.
Article
Engineering, Electrical & Electronic
Marc Pous, Dongsheng Zhao, Marco A. Azpurua, Teodor Bozhanov, Ferran Silva, Johannes Wolf
Summary: The electromagnetic characterization of reaction wheels is essential for space science missions to meet the ac magnetic field cleanliness requirements and prevent interference on sensitive instrumentation. This article proposes a complete assessment, including measuring the magnetic flux vector under different operational modes and dynamic conditions, using a test setup based on multichannel acquisition and multidomain postprocessing. The focus of the measurement campaign was on the low-frequency range, and capturing the B-field in the time-domain enabled complementary analysis for understanding the reaction wheel's electromagnetic performance.
IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY
(2023)
Article
Agriculture, Dairy & Animal Science
Eula Regina Carrara, Maria Gabriela Campolina Diniz Peixoto, Alessandra Alves da Silva, Frank Angelo Tomita Bruneli, Henrique Torres Ventura, Lenira El Faro Zadra, Luiz Antonio Josahkian, Renata Veroneze, Paulo Savio Lopes
Summary: This study aimed to explore the feasibility of using single-step genomic best linear unbiased prediction (ssGBLUP) for genomic prediction of productive and reproductive traits in Guzera cattle. The results showed that ssGBLUP was feasible and could increase the accuracy of breeding values without significantly impacting predictive ability and bias. Although the number of genotyped animals and the size of the database were small for some traits, the individual accuracies of breeding values were evidently increased in the genomic evaluation.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
Leticia Fernanda de Oliveira, Paulo Savio Lopes, Layla Cristien Cassia Miranda Dias, Leandro Magno Dornelas e Silva, Hugo Teixeira Silva, Simone Eliza Facioni Guimaraes, Daniele Botelho Diniz Marques, Delvan Alves da Silva, Renata Veroneze
Summary: This study estimated genetic parameters, effective population size, inbreeding, and inbreeding depression in Piau pigs. The results showed low direct heritabilities for birth weight and weaning weight, while average pre-weaning daily weight gain showed moderate heritability. There were high genetic correlations between weight at birth and weight at weaning, as well as weight at weaning and average pre-weaning daily weight gain. Inbreeding increased over generations and led to a reduction in effective population size. Inbreeding had a significant effect on average pre-weaning daily weight gain, with a decrease of 0.005 g for every 1% increase in inbreeding coefficient. Increasing effective population size is necessary to control inbreeding and preserve genetic variability in the Piau pig population.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Biophysics
Eula Regina Carrara, Paulo Savio Lopes, Aricia Chaves Zanetti Reis, Jessica Xavier Silva, Layla Cristien de Cassia Miranda Dias, Erica Beatriz Schultz, Daniele Botelho Diniz Marques, Delvan Alves da Silva, Renata Veroneze, Ricardo Guimaraes Andrade, Maria Gabriela Campolina Diniz Peixoto
Summary: Heat stress has negative effects on livestock production and reproduction. The study compared THI estimates from INMET weather stations and NASA POWER meteorological information sources, finding that NASA POWER satellite-based weather system is a suitable tool for obtaining accurate average and maximum THI values in Brazil, providing additional data for analyzing the impact of heat stress on livestock production.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Editorial Material
Genetics & Heredity
Lucas Lima Verardo, Luiz F. Brito, Nuno Carolino, Ana Fabricia Braga Magalhaes
FRONTIERS IN GENETICS
(2023)
Article
Food Science & Technology
M. M. Santos, T. C. Costa, W. Silva, L. Z. Pistillo, D. T. Valente Junior, L. L. Verardo Jr, P. V. R. Paulino, C. B. Sampaio, M. P. Gionbelli, M. Du, M. S. Duarte
Summary: This study aimed to evaluate the impact of pre-weaning nutrient supplementation on adipogenic determination in beef female calves. The results showed that early nutritional supplementation can enhance fat and muscle development and promote the conversion of adipogenic progenitor cells into adipocytes.
Article
Agriculture, Dairy & Animal Science
Pedro Vital Brasil Ramos, Gilberto Romeiro de Oliveira Menezes, Delvan Alves da Silva, Daniela Lourenco, Gustavo Garcia Santiago, Roberto A. A. Torres Junior, Fabyano Fonseca e Silva, Paulo Savio Lopes, Renata Veroneze
Summary: Feed efficiency is crucial for the profitability and sustainability of the beef cattle industry. This study proposed genomic evaluations for feed efficiency traits using random regression models. The models were compared based on goodness-of-fit and genetic parameter behavior. The findings provide evidence for new selection strategies in the beef cattle industry.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
E. R. Carrara, P. S. Lopes, R. Veroneze, R. J. Pereira, L. E. F. Zadra, M. G. C. D. Peixoto
Summary: This study quantified runs of homozygosity (ROH) and heterozygosity-rich regions (HRR) in a subpopulation of Guzer & aacute; cattle and examined ROH and HRR islands. The results showed that the inbreeding coefficients determined by ROH were higher than other cattle breeds' and higher than pedigree-based inbreeding in the Guzer & aacute; breed obtained in previous studies. Additionally, genes identified in ROH and HRR islands were associated with dairy and beef traits, reproductive traits, and disease resistance.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
Benjamin M. Bohrer, Justice B. Dorleku, Cheryl P. Campbell, Marcio S. Duarte, Ira B. Mandell
Summary: This study compared carcass characteristics, cutting yields, and meat quality between market barrows and market gilts. The results showed that gilt carcasses were leaner, while barrow loins were higher quality. These findings provide valuable information for the commercial industry.
TRANSLATIONAL ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Margareth Evangelista Botelho, Marcos Soares Lopes, Pramod K. Mathur, Egbert F. Knol, Daniele B. D. Marques, Paulo Savio Lopes, Fabyano Fonseca e Silva, Simone Eliza Facioni Guimaraes, Renata Veroneze
Summary: This study aimed to investigate the causal relationship and causal effects among boar taint compounds measured in pig adipose tissue from carcasses and biopsies. The results showed that boar taint compounds measured in biopsies have direct effects on the compounds measured in carcasses.
ANIMAL PRODUCTION SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Thiago Ferreira Diana, Arele Arlindo Calderano, Horacio Santiago Rostagno, Maria Rita de Lima Marques, Fernando de Castro Tavernari, Renata Veroneze, Luiz Fernando Teixeira Albino
Summary: The particle size of limestone in the diet of laying hens affects the apparent retention and digestibility coefficients of calcium. This study aimed to determine these coefficients for limestone of different particle sizes. The results showed that the coefficients increased linearly with increasing calcium concentrations in the diet, regardless of the particle size of limestone.