Article
Biochemistry & Molecular Biology
Vojtech Pavlik, Lubos Sobotka, Jaroslav Pejchal, Martin Cepa, Kristina Nesporova, Monika Arenbergerova, Adela Mrozkova, Vladimir Velebny
Summary: The study compared the healing of chronic wounds treated with a standard silver dressing and a dressing containing octenidine antiseptic, finding that the octenidine dressing promoted wound healing, reduced wound slough, and observed direct effects of silver on wound cells during treatment.
Review
Materials Science, Biomaterials
Ana Beatriz Sousa, Artur P. Aguas, Mario A. Barbosa, Judite N. Barbosa
Summary: Successful wound healing involves three phases: inflammatory, proliferative, and remodeling. Chronic wounds are characterized by persistent inflammation that hampers the healing process. Macrophages play a crucial role in wound healing, promoting cleaning and phagocytosis at the early stage and then facilitating the resolution of inflammation, as well as expressing growth factors and cytokines needed for cell proliferation and tissue repair. In chronic wounds, the presence of pro-inflammatory M1 macrophages inhibits tissue repair. Immunomodulatory biomaterials are being explored as potential solutions to overcome the continued inflammatory phase that impairs chronic wound healing.
REGENERATIVE BIOMATERIALS
(2022)
Editorial Material
Cell Biology
Dalibor Mijaljica, Fabrizio Spada, Daniel J. J. Klionsky, Ian P. P. Harrison
Summary: As a highly regulated and dynamic intracellular degradation mechanism, autophagy plays an essential role in skin wound healing at different stages. It operates at different levels and is modulated based on the conditions of wound healing, contributing to rapid and efficient healing. Enhancing autophagy through the localized application of pro-autophagy biologics, such as hydrogels, can provide moisture and immune modulation, creating a conducive environment for skin wound healing.
Article
Engineering, Biomedical
Le Wang, Wenfu Zheng, Qinghong Hou, Leni Zhong, Qizhen Li, Xingyu Jiang
Summary: In this study, L-thioproline and Boc-capped L-thioproline-decorated gold nanoparticles were used to develop wound dressings with potent antibacterial activity against multidrug-resistant bacteria. The dressings, composed of TBT-GNPs and bacterial cellulose, demonstrated excellent antimicrobial performance both in vitro and in vivo. Additionally, the dressings were breathable and stretchable, facilitating gas exchange and accelerating wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Health Care Sciences & Services
Andreea Barbu, Bogdan Neamtu, Marius Zahan, Gabriela Mariana Iancu, Ciprian Bacila, Vioara Miresan
Summary: Chronic wounds pose a major public health issue with high costs globally. An ideal wound dressing should possess various characteristics such as adhesion, non-antigenicity, biocompatibility, semi-permeability, and biodegradability. This paper explores the use of biopolymer materials, specifically alginate forms, in advanced wound healing applications, focusing on hydrogels, nanofibers networks, and 3D-scaffolds.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Ruonan Dong, Baolin Guo
Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.
Article
Engineering, Environmental
Laura Miranda-Calderon, Cristina Yus, Cristina Remirez de Ganuza, Monica Paesa, Guillermo Landa, Elena Tapia, Estela Perez, Marta Perez, Victor Sebastian, Silvia Irusta, Gracia Mendoza, Manuel Arruebo
Summary: Advanced medicated wound dressings fabricated by electrospinning and electrospraying provide dually controlled antibiotic release kinetics, effectively eradicating bacterial infections and preventing biofilm formation. They also exhibit no cytotoxicity to eukaryotic cells and have been proven effective in a chronic wound murine model.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Ovidio Catanzano, Fabiana Quaglia, Joshua S. Boateng
Summary: Recent research has shifted focus from passive wound dressings to advanced dressings that actively promote wound healing. The use of growth factors (GFs) to accelerate wound healing and reduce scar formation is considered a feasible therapeutic approach, with the integration of micro- and nanotechnologies offering control over GF release rates. Multiple studies have shown promising outcomes in in vitro and in vivo wound models, leading to the expectation that some of these technologies will meet clinical needs and become commercially available.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Engineering, Biomedical
Chiranjeevi Korupalli, Hui Li, Nhien Nguyen, Fwu-Long Mi, Yen Chang, Yu-Jung Lin, Hsing-Wen Sung
Summary: The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. Recent advancements in conductive materials, particularly in their incorporation with non-conducting polymers to fabricate electroactive wound dressings, have been deliberated for their potential in monitoring the course of wound healing in vivo while simultaneously accelerating the healing process.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Immunology
Meirong Li, Qian Hou, Lingzhi Zhong, Yali Zhao, Xiaobing Fu
Summary: The review highlights the persistent hyper-inflammation as a distinguishing characteristic of chronic wounds, with macrophage malfunction identified as a major contributor. The study explores the origin, heterogeneity, and dysregulation of macrophages in wound healing, while also evaluating therapeutic approaches for restoring macrophage response. Multidimensional analysis using high-throughput technologies helps assess the diversity, activation states, and communication of macrophages in healing and non-healing wounds, providing promising interventions for chronic wounds.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kamila Raziyeva, Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kuat Kassymbek, Shiro Jimi, Arman Saparov
Summary: Skin wounds significantly impact the global healthcare system, with acute and chronic wounds being the two main types. The immune response is crucial for acute wound healing, but dysregulation can lead to chronic wounds characterized by persistent inflammation and delayed healing. Current research focuses on immunomodulatory therapeutic strategies to improve wound healing, targeting factors such as macrophage phenotype and inflammatory mediators.
Review
Biotechnology & Applied Microbiology
Wentao Shu, Yinan Wang, Xi Zhang, Chaoyang Li, Hanxiang Le, Fei Chang
Summary: Burn treatment is a challenging clinical issue with the future lying in the development of active dressings such as hydrogel dressings that can accelerate wound healing. Various treatment strategies for burns are reviewed, emphasizing the clinical value of hydrogel dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Jiaqi Liu, Minmin Wu, Jie Lu, Qiang He, Jing Zhang
Summary: Long-term recurrent infections hinder the healing of chronic diabetic wounds, posing a significant clinical challenge. In this study, Janus hydrogel dressings were developed with the ability to adjust the wound microenvironment to promote healing. These dressings had an antifouling surface to prevent bacterial adhesion and an adhesive surface for wound fixation. The incorporation of gentamicin sulfate-modified hyaluronic acid allowed intelligent release of antibiotics in response to the infected wound's acidic environment. In vivo results demonstrated that the Janus hydrogel dressings effectively inhibited inflammation, accelerated tissue regeneration, and facilitated wound healing. This multifunctional dressing holds promise for clinical application in chronic wound healing.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Lei Huang, Lei Yu, Xiaohui Yin, Yu Lin, Yuanhong Xu, Yusheng Niu
Summary: This study successfully prepared silver nanoparticles/vanadium oxide nanowires via a one-step reduction strategy, which exhibited remarkable antibacterial effects on textiles and had the potential for wound healing application.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Engineering, Biomedical
Tainara de Paula de Lima Lima, Marcele Fonseca Passos
Summary: Skin wounds result in damage to the epithelial layer and living tissue, with healing process being dynamic and complex. Polymeric hydrogels are effective candidates for wet curing, preventing dehydration of tissue and providing comfort to patients during dressing changes. This review highlights the importance of healing process, different types of skin wounds, and potential benefits of using hydrogels as wound dressings.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)