Pause sequences facilitate entry into long-lived paused states by reducing RNA polymerase transcription rates

Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue

(2017) Larry E. Tetone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of a transcribing-translating expressome

(2017) R. Kohler et al.   SCIENCE

Mechanisms of Bacterial Transcription Termination: All Good Things Must End

(2016) Ananya Ray-Soni et al.   Annual Review of Biochemistry

A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure

(2016) Jinwei Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions

(2015) Shun-ichi Sekine et al.   MOLECULAR CELL

Direct observation of structure-function relationship in a nucleic acid-processing enzyme

(2015) M. J. Comstock et al.   SCIENCE

Molecular Mechanisms of Transcription through Single-Molecule Experiments

(2014) Manchuta Dangkulwanich et al.   CHEMICAL REVIEWS

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

Interactions between RNA polymerase and the "core recognition element" counteract pausing

(2014) I. O. Vvedenskaya et al.   SCIENCE

Structural Basis of Transcriptional Pausing in Bacteria

(2013) Albert Weixlbaumer et al.   CELL

RNA polymerase and the ribosome: the close relationship

(2013) Katelyn McGary et al.   CURRENT OPINION IN MICROBIOLOGY

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

(2013) Manchuta Dangkulwanich et al.   eLife

Intrinsic Translocation Barrier as an Initial Step in Pausing by RNA Polymerase II

(2012) Masahiko Imashimizu et al.   JOURNAL OF MOLECULAR BIOLOGY

Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases

(2012) B. Zamft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Unified Model of Transcription Elongation: What Have We Learned from Single-Molecule Experiments?

(2011) Dáibhid Ó Maoiléidigh et al.   BIOPHYSICAL JOURNAL

Applied Force Provides Insight into Transcriptional Pausing and Its Modulation by Transcription Factor NusA

(2011) Jing Zhou et al.   MOLECULAR CELL

Structural basis of RNA polymerase II backtracking, arrest and reactivation

(2011) Alan C. M. Cheung et al.   NATURE

Ultrahigh-resolution optical trap with single-fluorophore sensitivity

(2011) Matthew J Comstock et al.   NATURE METHODS

A general strategy for the evolution of bond-forming enzymes using yeast display

(2011) I. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origin of Short Transcriptional Pauses

(2009) Martin Depken et al.   BIOPHYSICAL JOURNAL

Characterization of Photoactivated Singlet Oxygen Damage in Single-Molecule Optical Trap Experiments

(2009) Markita P. Landry et al.   BIOPHYSICAL JOURNAL

Millisecond phase kinetic analysis of elongation catalyzed by human, yeast, and Escherichia coli RNA polymerase

(2009) Maria Kireeva et al.   METHODS

Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II

(2009) C. Hodges et al.   SCIENCE