Review
Physiology
Guo-liang Zhang, Ming-li Sun, Xin-an Zhang
Summary: The loss of cardiomyocytes is a key factor in cardiovascular diseases leading to heart failure, and exercise can enhance the proliferative potential of adult cardiomyocytes to promote myocardial regeneration. By regulating cytokines and miRNAs, exercise can induce dedifferentiation and proliferation of existing cardiomyocytes to form new ones.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuan-Yuan Cheng, Zachery Gregorich, Ray P. Prajnamitra, David J. Lundy, Ting-Yun Ma, Yu-Hsuan Huang, Yi-Chan Lee, Shu-Chian Ruan, Jen-Hao Lin, Po-Ju Lin, Chiung-Wen Kuo, Peilin Chen, Yu-Ting Yan, Rong Tian, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: This study reveals that induction of Yamanaka factors in adult mice can lead to dedifferentiation and proliferation of cardiomyocytes, allowing cardiac regeneration. Upregulation of ketogenesis is found to be central to this process. Similar phenomenon is observed after myocardial infarction and in the border zone tissue.
Article
Cell Biology
Shijie Liu, Ke Li, Leonardo Wagner Florencio, Li Tang, Todd R. Heallen, John P. Leach, Yidan Wang, Francisco Grisanti, James T. Willerson, Emerson C. Perin, Sui Zhang, James F. Martin
Summary: The study demonstrates the potential therapeutic value of local knockdown of the Hippo pathway gene Salvador in pig hearts using AAV9 gene therapy, leading to tissue renewal and improved function in heart failure.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Developmental Biology
Daniel A. Zuppo, Maria A. Missinato, Lucas Santana-Santos, Guang Li, Panayiotis Benos, Michael Tsang
Summary: The poor regenerative capacity of the mammalian heart may be due to the inability of adult cardiomyocytes to proliferate at sufficient levels. However, research has shown that the transcription factor Foxm1 can induce cardiomyocyte proliferation after injury through regulation of cell cycle genes.
Article
Cell & Tissue Engineering
Panagiota Siatra, Giannis Vatsellas, Athanasia Chatzianastasiou, Evangelos Balafas, Theodora Manolakou, Andreas Papapetropoulos, Anna Agapaki, Eleni-Taxiarchia Mouchtouri, Prashant J. Ruchaya, Artemis G. Korovesi, Manolis Mavroidis, Dimitrios Thanos, Dimitris Beis, Ioannis Kokkinopoulos
Summary: Heart transplantation is the only cure for patients with heart failure, but it is limited by donor shortage, immunosuppression and economic costs. Therefore, there is an urgent need to identify cell populations capable of cardiac regeneration. Recent studies have identified a Tbx5-expressing precursor cell population in the injured adult mammalian heart that shows potential for cardiomyocyte regeneration.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Cell Biology
Cesar Vasquez-Trincado, Mario Navarro-Marquez, Pablo E. Morales, Francisco Westermeier, Mario Chiong, Valentina Parra, Alejandra Espinosa, Sergio Lavandero
Summary: Cardiovascular diseases caused by high-fat foods are on the rise, leading to lipotoxicity at the cellular level. This study established a cardiomyocyte lipotoxicity model using the saturated fatty acid myristate and found that increased levels of the mitochondrial protein MUL1 were associated with mitochondrial fragmentation and cardiomyocyte hypertrophy. These findings reveal a novel connection between cardiomyocytes and lipotoxic stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jaslyn Johnson, Sadia Mohsin, Steven R. Houser
Summary: Current therapies for cardiac diseases focus on improving heart contractility and minimizing fibrosis, but face challenges in replenishing cardiomyocyte numbers effectively. Studies show that cardiomyocytes can re-enter the cell cycle through various manipulations, but achieving myocyte renewal without causing issues such as tumorigenesis remains a major challenge.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ernesto Marin-Sedeno, Xabier Martinez de Morentin, Jose M. Perez-Pomares, David Gomez-Cabrero, Adrian Ruiz-Villalba
Summary: Over the past decade, extensive efforts have been made to understand cardiac cell genetic and functional diversity, leading to the utilization of single-cell RNA-Seq technology to redefine cardiac cell subpopulations and even identify novel cell types. These findings are changing the understanding of cell composition and the identification of potential therapeutic targets for different cardiac diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Maria Uscategui Calderon, Brittany A. Gonzalez, Katherine E. Yutzey
Summary: During the postnatal period, the heart undergoes significant remodeling in response to increased circulatory demands. Cardiac cells progressively lose embryonic characteristics, and cardiomyocytes undergo binucleation and cell cycle arrest while fibroblasts proliferate and produce ECM. Interactions between these cells promote heart maturation in the postnatal period.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Hematology
Alice Abelanet, Marion Camoin, Sebastien Rubin, Pauline Bougaran, Valentin Delobel, Mathieu Pernot, Isabelle Forfar, Celine Guilbeau-Frugier, Celine Gales, Marie Lise Bats, Marie-Ange Renault, Pascale Dufourcq, Thierry Couffinhal, Cecile Duplaa
Summary: By studying the specific endothelial dysfunction, we found that an increase of endothelial permeability is responsible for mediating diastolic dysfunction pathophysiology and for aggravating detrimental effects of a high-fat diet on cardiac inflammation and metabolism.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mao Zhang, Junxia Zhang, Wenjia Zhang, Qingmei Hu, Li Jin, Peng Xie, Wen Zheng, Haibao Shang, Yan Zhang
Summary: A study found that CaMKII-delta9-mediated cardiomyocyte death is a promoting factor in the development of cardiomyopathy and heart failure, but it does not directly regulate cardiac hypertrophy. Furthermore, CaMKII-delta9 induces cell death in adult cardiomyocytes by impairing the UBE2T/DNA repair signaling pathway. The study also revealed no gender difference in the expression of CaMKII-delta9 in the hearts.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Sanford P. Bishop, Yang Zhou, Yuji Nakada, Jianyi Zhang
Summary: The inability of adult cardiomyocytes to repair injuries leads to severe cardiac disability and even death, while fetal cardiomyocytes can continuously replicate. Recent studies showing complete repair of severe injuries in early neonatal mice and pigs have prompted further research into regulating the cardiomyocyte cell cycle.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Robert Lakin, Nazari Polidovitch, Sibao Yang, Mihir Parikh, Xueyan Liu, Ryan Debi, Xiaodong Gao, Wenliang Chen, Camilo Guzman, Simona Yakobov, Farzad Izaddoustdar, Marianne Wauchop, Qian Lei, Weimin Xu, Sergei A. Nedospasov, Vincent M. Christoffels, Peter H. Backx
Summary: Our findings indicate that adverse atrial remodeling and AF vulnerability induced by intense exercise require TNF in atrial cardiomyocytes, while the impact of endothelial-derived TNF is limited to hypertrophy modulation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Adam D. Langenbacher, Fei Lu, Lauren Crisman, Zi Yi Stephanie Huang, Douglas J. Chapski, Thomas M. Vondriska, Yibin Wang, Chen Gao, Jau-Nian Chen
Summary: In this study, the importance of Rtf1 in neonatal and adult cardiomyocytes was investigated through knockdown and knockout approaches. The results showed that loss of Rtf1 activity disrupted cell morphology, sarcomeres, cell-cell junctions, and led to fibrosis and systolic dysfunction. Moreover, Rtf1 knockout hearts exhibited structural and gene expression defects resembling dilated cardiomyopathy, indicating that Rtf1 is continuously required for the expression of the cardiac gene program.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Youchen Yan, Rong Tang, Bin Li, Liangping Cheng, Shangmei Ye, Tiqun Yang, Yan-Chuang Han, Chen Liu, Yugang Dong, Liang-Hu Qu, Kathy O. Lui, Jian-Hua Yang, Zhan-Peng Huang
Summary: This study focused on the translational controls behind cardiomyocyte hypertrophy, revealing that the increased efficiency of protein synthesis in hypertrophied cardiomyocytes was attributed to an increased quantity of ribosomes rather than an increase in the translational rate. The study also detected uncharacterized short ORFs in long noncoding RNA genes from Ribo-seq, with potential micropeptide coding functions that were experimentally supported to regulate cardiomyocyte hypertrophy.
Article
Cardiac & Cardiovascular Systems
Jessica C. Garbern, Gabriela O. Escalante, Richard T. Lee
Summary: Cell replacement therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is still in the research phase, with various challenges that need to be addressed before successful clinical translation can be achieved.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell & Tissue Engineering
Jessica C. Garbern, Richard T. Lee
Summary: Current methods to differentiate cardiomyocytes from human pluripotent stem cells inadequately recapitulate complete development, resulting in cardiomyocytes with an immature or fetal-like phenotype. Metabolic changes and mitochondrial dynamics play key roles in the maturation of cardiomyocytes, with the transitions in mitochondria responding to metabolic signals throughout development.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Ecology
Francois Thomas, Nolwen Le Duff, Ting-Di Wu, Aurelie Cebron, Stephane Uroz, Pascal Riera, Cedric Leroux, Gwenn Tanguy, Erwan Legeay, Jean-Luc Guerquin-Kern
Summary: Algal polysaccharides, such as alginate, are an important organic matter source for marine heterotrophic bacteria, playing a key role in the oceanic carbon cycle. Research on the uptake of alginate by microbial communities revealed that specific bacteria can uptake alginate at the single-cell level, indicating niche specialization within heterotrophic communities and their quantitative role in coastal ecosystems.
Article
Environmental Sciences
Diane Lebeau, Nathalie Leroy, Denis Doizi, Ting-Di Wu, Jean-Luc Guerquin-Kern, Laura Perrin, Richard Ortega, Claire Voiseux, Jean-Baptiste Fournier, Philippe Potin, Bruno Fievet, Catherine Leblanc
Summary: The study focused on the chemical and isotopic speciation of iodine in brown algal tissues, specifically noting the presence of radioactive isotope I-129 in some samples with variations detected in samples collected from different locations.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2021)
Article
Cell Biology
Jacob P. Keller, Jonathan S. Marvin, Haluk Lacin, William C. Lemon, Jamien Shea, Soomin Kim, Richard T. Lee, Minoru Koyama, Philipp J. Keller, Loren L. Looger
Summary: A family of highly sensitive glucose sensors was described to study glucose transport and metabolism in cells. Differential glucose kinetics were observed in different cell types, revealing the existence of specific transport pathways for intracellular glucose flux.
Correction
Biochemical Research Methods
Saba Goodarzi, Audrey Prunet, Fabien Rossetti, Guillaume Bort, Olivier Tillement, Erika Porcel, Sandrine Lacombe, Ting-Di Wu, Jean-Luc Guerquin-Kern, Helene Delanoe-Ayari, Francois Lux, Charlotte Riviere
Article
Engineering, Biomedical
Xinming Wang, Ali Ansari, Valinteshley Pierre, Kathleen Young, Chandrasekhar R. Kothapalli, Horst A. von Recum, Samuel E. Senyo
Summary: dECM microparticles are developed as an injectable solid biomaterial for the treatment of post-ischemic heart injury. These microparticles have longer retention, higher stiffness, and slower protein release compared to liquid dECM hydrogel precursor. They protect cardiac function, promote vessel density, and reduce ventricular remodeling.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Carolin Lerchenmueller, Ana Vujic, Sonja Mittag, Annie Wang, Charles P. Rabolli, Chiara Hess, Fynn Betge, Ashraf Y. Rangrez, Malay Chaklader, Christelle Guillermier, Frank Gyngard, Jason D. Roh, Haobo Li, Matthew L. Steinhauser, Norbert Frey, Beverly Rothermel, Christoph Dieterich, Anthony Rosenzweig, Richard T. Lee
Summary: Exercise can stimulate cardiomyogenesis in aged hearts, and pathways associated with circadian rhythm may play a role in physiologically stimulated cardiomyogenesis.
Article
Medicine, Research & Experimental
Zachary M. Howard, Chetan K. Gomatam, Charles P. Rabolli, Jeovanna Lowe, Arden B. Piepho, Shyam S. Bansal, Federica Accornero, Jill A. Rafael-Fortney
Summary: Mineralocorticoid receptor antagonists have anti-inflammatory properties without altering leukocyte distribution within skeletal muscles, while glucocorticoids reduce cytokines in quadriceps but increase cytokines and pathology in the diaphragm.
Article
Biology
John Lian, Ryan G. Walker, Andrea D'Amico, Ana Vujic, Melanie J. Mills, Kathleen A. Messemer, Kourtney R. Mendello, Jill M. Goldstein, Krystynne A. Leacock, Soraya Epp, Thomas B. Thompson, Amy J. Wagers, Richard Lee
Summary: Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGF-beta family proteins, but GDF11 activates SMAD2/3 more potently than GDF8. By genetically modifying their mature signaling domains, distinct features between GDF11 and GDF8 in vivo were uncovered, revealing a specific requirement for GDF11 in early-stage skeletal development.
LIFE SCIENCE ALLIANCE
(2023)
Article
Nanoscience & Nanotechnology
Pauline Maury, Michele Mondini, Cyrus Chargari, Arthur Darricau, Mona Shahin, Samy Ammari, Sophie Bockel, Catherine Genestie, Ting-Di Wu, Francois Lux, Olivier Tillement, Sandrine Lacombe, Eric Deutsch, Charlotte Robert, Erika Porcel
Summary: This study proposes a complete method to evaluate the radiation-induced biological effects of metallic nanoparticles (NPs) and quantifies the radio-enhancement effects of NPs in radiotherapy treatment. The results show that NPs have a positive impact on local tumor control for both radiotherapy and brachytherapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Stephanie Solier, Sebastian Mueller, Tatiana Caneque, Antoine Versini, Arnaud Mansart, Fabien Sindikubwabo, Leeroy Baron, Laila Emam, Pierre Gestraud, G. Dan Pantos, Vincent Gandon, Christine Gaillet, Ting-Di Wu, Florent Dingli, Damarys Loew, Sylvain Baulande, Sylvere Durand, Valentin Sencio, Cyril Robil, Francois Trottein, David Pericat, Emmanuelle Naeser, Celine Cougoule, Etienne Meunier, Anne-Laure Begue, Helene Salmon, Nicolas Manel, Alain Puisieux, Sarah Watson, Mark A. Dawson, Nicolas Servant, Guido Kroemer, Djillali Annane, Raphael Rodriguez
Summary: Inflammation is a complex physiological process that involves immune cells clearing sources of injury. Excessive inflammation is associated with infection and several diseases. The cell surface glycoprotein CD44 mediates the uptake of metals, including copper, and affects the metabolic and epigenetic states involved in inflammation.
Article
Chemistry, Analytical
Craig Watson, Chao Liu, Ali Ansari, Helen C. Miranda, Rodrigo A. Somoza, Samuel E. Senyo
Summary: This article presents a microfluidic chip that allows the culture of cells in adjacent chambers and enables selective exchange of paracrine signals. The chip offers both high throughput and control over the onset and duration of cell-cell communication.
