Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Yuehui Su, Yingcui Zhang, Yutong Tong, Luoman Zhang, Panpan Li, Huiping Zhang, Xiaodong Zhang, Yujie Tang, Lihong Qin, Yan Shen, Bingjie Wang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Ting Zhang
Summary: 5-ALA-PDT is a non-invasive, effective, and safe therapy for treating CIN & VAIN. However, its efficacy is relatively poor in patients with endocervical canal lesions involvement, atypical vessels, and HPV16/18 and other hrHPV infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J. Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie
Summary: The HPV vaccination program in British Columbia, Canada has led to a significant decrease in CIN 2 and 3 rates among women aged 16-23, but no decline was observed in women aged 24-28. This suggests a successful population impact of the school-based HPV vaccination program.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Microbiology
Kaori Okayama, Toshiyuki Sasagawa, Koji Teruya, Mizue Oda, Masahiko Fujii, Hirokazu Kimura, Mitsuaki Okodo
Summary: This study found an association between HPV genotypes and MNCs, high-risk HPV genotypes may be related to atypical changes in MNC morphology, and MNCs may predict squamous intraepithelial lesions.
Article
Microbiology
Barbara Gardella, Mattia Dominoni, Cecilia Sosso, Anna Arrigo, Andrea Gritti, Stefania Cesari, Giacomo Fiandrino, Arsenio Spinillo
Summary: A study analyzed the time trends prevalence of HPV genotypes among 5807 subjects with abnormal pap-smears and/or cervical intraepithelial neoplasia over a 15-year period. Results showed a decrease in HPV16 rates in CIN1 biopsies and an increase of HR-HPV types unrelated to nonavalent vaccine in CIN1 lesions. Additionally, HPV 18, 31, and 52 rates decreased in CIN2+ patients.
Review
Oncology
Matejka Rebolj, Alexandra Sargent, Sisse Helle Njor, Kate Cuschieri
Summary: Self-collection of samples for HPV testing has the potential to increase cervical screening uptake and play a crucial role in eliminating cervical cancer. However, the success of self-collection depends on meeting specific thresholds for uptake and sensitivity for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). The available evidence suggests that low uptake among underscreened women combined with high substitution of clinician sampling with self-collection among well-screened women may pose risks to overall program performance.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Virology
Natsumi Noji, Kaori Okayama, Mizue Oda, Atsuyoshi Shimada, Mitsuaki Okodo
Summary: The study validated a simple manual microdissection (MMD) maneuver and investigated the HPV infection status of single cells isolated from women with multiple-type infections. The MMD procedure efficiently collected single cells, and most multiple-type infection samples exhibited only one genotype.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Matejka Rebolj, Christopher S. Mathews, Francesca Pesola, Alejandra Castanon, Henry Kitchener
Summary: International cervical screening guidelines suggest that high-risk human papillomavirus (HR-HPV) testing is more effective than liquid-based cytology (LBC) for diagnosing cervical cancer in women aged 24 to 29, as it not only accelerates cancer diagnosis, but also increases the detection of CIN2/3.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Huiyun Jiang, Ding Jie, Huan Wang, Yuebo Yang, Xiaomao Li
Summary: The prevalence of HPV genotypes in Guangzhou, China, has shown a decreasing trend, but it is still important to monitor the HPV genotypes and associated cancer risks. Age should be taken into consideration in cervical cancer screening and management strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Wei Wang, Aimin Yang, Huina Zhang, Yuanxing Li, Jing Yang, Weihong Zhao, Zhilian Wang, Haixia Lou, Wenhao Wang, Tingting Liang, Lili Zhang, Xiaoqiang Su, Chen Wang, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv, Chengquan Zhao, Min Hao
Summary: This study indicates that RBC folate concentration is associated with the prevalence of CIN grades and the progression of CIN1 in female Chinese adults.
JOURNAL OF NUTRITION
(2022)
Article
Oncology
Y. Y. Zhang, R. Xia, D. Chen, X. Zhang
Summary: This study aimed to explore the risk factors for and prevent misdiagnosis of cervical intraepithelial neoplasia (CIN) coexisting with vaginal intraepithelial neoplasia (VaIN). The results indicated that menopausal status and HPV load were related to the occurrence of VaIN in CIN patients, with menopausal patients at higher risk.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)