Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Article
Biotechnology & Applied Microbiology
Huilin Shao, Yue Zhang, Jie Yan, Xinchao Ban, Xiaojie Fan, Xiaoyan Chang, Zhaohui Lu, Yan Wu, Liju Zong, Shengwei Mo, Shuangni Yu, Jie Chen
Summary: The study observed that miR-483-3p is significantly elevated in PDAC patients, able to distinguish early stage PDAC, and predict survival outcomes. Moreover, miR-483-3p promotes the migration and invasion of pancreatic cancer cells.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Jingwen Yang, Weiwei Dong, He Zhang, Huixia Zhao, Zhiyan Zeng, Fengyun Zhang, Qiuwen Li, Xiaohong Duan, Yanyan Hu, Wenhua Xiao
Summary: This study revealed that the exosomal microRNA panel has high accuracy in diagnosing HCC and has important clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Multidisciplinary
Tao Rui, Xueyou Zhang, Shi Feng, Haitao Huang, Shaowei Zhan, Haiyang Xie, Lin Zhou, Shusen Zheng, Qi Ling
Summary: The study found that miR-516a-3p is highly expressed in HCC and is associated with tumor progression and poor prognosis. They demonstrated that miR-516a-3p promotes malignant behaviors in HCC cells by regulating cellular metabolism and affecting neighboring cells via the exosome delivery system.
Article
Medicine, General & Internal
Sora Kim, Gwang Ha Kim, Su Jin Park, Chae Hwa Kwon, I Hoseok, Moon Won Lee, Bong Eun Lee
Summary: Exosomal miRNAs have the potential to serve as biomarkers for esophageal squamous cell carcinoma (ESCC). This study identified specific exosomal miRNAs that were differentially expressed in ESCC, and validated their expression levels in the plasma of healthy controls and ESCC patients. The results showed that plasma exosomal miR-205-5p, miR-429, and miR-375-3p could be potential biomarkers for the diagnosis of ESCC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Peng Chen, Shanshan Huang, Qiao Yu, Kang Chao, Ying Wang, Gaoshi Zhou, Xiaojun Zhuang, Zhirong Zeng, Minhu Chen, Shenghong Zhang
Summary: Serum exosomal miR-144-3p is a reliable biomarker for monitoring Crohn's disease and can accurately identify endoscopic recurrence after surgery.
GASTROENTEROLOGY REPORT
(2022)
Review
Pharmacology & Pharmacy
Yulai Zeng, Shuyu Hu, Yi Luo, Kang He
Summary: Hepatocellular carcinoma (HCC) is a common cancer with unsatisfactory early diagnosis and treatment. Exosomes, containing various components, play a crucial role in the development and prognosis of HCC. Biomarkers in exosomes show potential for novel diagnostic and prognostic tools for HCC.
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chunyu Huang, Shuiying Tang, Dong Shen, Xiangzhao Li, Li Liang, Yanqing Ding, Bihong Xu
Summary: This study identified metastasis-associated microRNAs (miRNAs) in plasma exosomes of hepatocellular carcinoma patients. The combination of miR-18a, miR-20b, and miR-221 showed superior prognostic efficacy for distinguishing metastatic from non-metastatic HCC. High expression levels of these candidate miRNAs were associated with poor prognosis, indicating their potential as clinical tools for assessing HCC prognosis.
Article
Pharmacology & Pharmacy
Zhiyuan Niu, Lei Wang, Xiaofeng Qin, Zhimin Ye, Bin Xie, Yongbin Hu
Summary: Silicosis is a serious occupational disease characterized by inflammation, fibroblast activation, and extracellular matrix deposition in the lung. Macrophage-derived exosomes have been found to play a role in the development of silicosis by transferring microRNAs (miRNAs). In this study, the researchers identified the up-regulation of miR-7219-3p in both macrophages and their exosomes after silica exposure, as well as in a silicotic mice model. They found that miR-7219-3p promoted fibroblast to myofibroblast trans-differentiation, cell proliferation, and migration. The target gene of miR-7219-3p, Spouty1 (SPRY1), was confirmed to modulate the Ras/ERK/MAPK signaling pathway, and manipulating SPRY1 expression affected fibroblast to myofibroblast trans-differentiation via this pathway. Inhibition of exosomal miR-7219-3p partially suppressed fibroblast to myofibroblast trans-differentiation and silica-induced pulmonary fibrosis. These findings suggest that exosomal miR-7219-3p could be a potential therapeutic target for silicosis.
Article
Cell & Tissue Engineering
Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang, Dianquan Zhang
Summary: The study investigated the potential of MSC-derived exosomes containing miR-542-3p in preventing ischemia-induced inflammatory response in glial cells by targeting TLR4. The results showed a decrease in miR-542-3p and an increase in TLR4 in MCAO mice, and overexpression of miR-542-3p alleviated cell apoptosis and inflammation induced by OGD. The delivery of exosome-miR-21-3p from MSCs also showed potential in relieving cerebral injury and inflammation caused by MCAO or OGD.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Yin Li, Ming Xia, Shuang Meng, Di Wu, Sihai Ling, Xiali Chen, Chengeng Liu
Summary: This study suggests that plasma NCAM/amphiphysin 1 dual-labeled exosomal miR-29c-3p may serve as a potential biomarker for the early diagnosis of Alzheimer's disease. The levels of A beta 42 and miR-29c-3p in the exosomes were significantly higher in the subjective cognitive decline group compared to the control and vascular dementia groups. These findings were further confirmed in the verification stage.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leslie R. Lamb, Geunwon Kim, Tawakalitu O. Oseni, Manisha Bahl
Summary: The study found that the upgrade rate of noncalcified ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) at surgery is 21.8%. Upgrade risk is associated with older patient age and family history of breast cancer in a first-degree relative.
ACADEMIC RADIOLOGY
(2021)