Epigenome-wide analysis reveals specific DNA hypermethylation of T cells during human hematopoietic differentiation

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

(2017) Masafumi Seki et al.   NATURE GENETICS

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling

(2017) Oscar Navarro-Montero et al.   STEM CELLS

Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer

(2016) Min Gyun Bae et al.   BMC Medical Genomics

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

(2016) Ana C. Queirós et al.   CANCER CELL

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

(2016) Lu Chen et al.   CELL

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

(2016) Matthias Farlik et al.   Cell Stem Cell

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

(2016) Debbie K. Goode et al.   DEVELOPMENTAL CELL

Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action

(2016) Alba Cico et al.   FEBS LETTERS

Epigenetics of hematopoiesis and hematological malignancies

(2016) Deqing Hu et al.   GENES & DEVELOPMENT

Enhancer methylation dynamics contribute to cancer plasticity and patient mortality

(2016) Rachel E. Bell et al.   GENOME RESEARCH

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

(2016) Sebastian Moran et al.   LANCET ONCOLOGY

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences

(2016) Sebastian Moran et al.   Epigenomics

DNA methylation and healthy human aging

(2015) Meaghan J. Jones et al.   AGING CELL

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor

(2015) Nathan C. Sheffield et al.   BIOINFORMATICS

Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1

(2015) Ameya Champhekar et al.   GENES & DEVELOPMENT

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

(2015) Xabier Agirre et al.   GENOME RESEARCH

Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility

(2015) Rocío G. Urdinguio et al.   HUMAN REPRODUCTION

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

(2015) Marta Kulis et al.   NATURE GENETICS

Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation

(2015) Alvaro J González et al.   NATURE GENETICS

ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip

(2015) Zongli Xu et al.   NUCLEIC ACIDS RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis

(2015) Namyoung Jung et al.   Nature Communications

'From blood to blood': de-differentiation of hematopoietic progenitors to stem cells

(2014) C.-F. Pereira et al.   EMBO JOURNAL

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

Discovery of Consensus Gene Signature and Intermodular Connectivity Defining Self-Renewal of Human Embryonic Stem Cells

(2014) Jeffrey J. Kim et al.   STEM CELLS

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

DNA methylation and differentiation: silencing, upregulation and modulation of gene expression

(2013) Melanie Ehrlich et al.   Epigenomics

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

(2013) Jessica Nordlund et al.   GENOME BIOLOGY

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

(2012) Takaomi Sanda et al.   CANCER CELL

A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification

(2012) Clara Bueno et al.   CELL RESEARCH

Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites

(2012) A. Hogart et al.   GENOME RESEARCH

DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells

(2012) Christoph Bock et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

BLUEPRINT to decode the epigenetic signature written in blood

(2012) David Adams et al.   NATURE BIOTECHNOLOGY

Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

(2012) Marta Kulis et al.   NATURE GENETICS

DNA methylation profiling in the clinic: applications and challenges

(2012) Holger Heyn et al.   NATURE REVIEWS GENETICS

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

The NIH Roadmap Epigenomics Program data resource

(2012) Lisa Helbling Chadwick   Epigenomics

Hypomethylation of LINE-1, and not centromeric SAT-α, is associated with centromeric instability in head and neck squamous cell carcinoma

(2012) Jorge García Martínez et al.   CELLULAR ONCOLOGY

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

(2011) M. T. Bocker et al.   BLOOD

The role of the GATA2 transcription factor in normal and malignant hematopoiesis

(2011) Carmen Vicente et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

High density DNA methylation array with single CpG site resolution

(2011) Marina Bibikova et al.   GENOMICS

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Epigenetic alterations in autoimmune rheumatic diseases

(2011) Esteban Ballestar   Nature Reviews Rheumatology

A promoter DNA demethylation landscape of human hematopoietic differentiation

(2011) Vincenzo Calvanese et al.   NUCLEIC ACIDS RESEARCH

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global DNA Demethylation During Mouse Erythropoiesis in Vivo

(2011) J. R. Shearstone et al.   SCIENCE

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

(2010) Hong Ji et al.   NATURE

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

Epigenetic control of neural precursor cell fate during development

(2010) Yusuke Hirabayashi et al.   NATURE REVIEWS NEUROSCIENCE

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

(2009) S. T. Chou et al.   BLOOD

Mesenchymal stem cells facilitate the derivation of human embryonic stem cells from cryopreserved poor-quality embryos

(2009) J.L. Cortes et al.   HUMAN REPRODUCTION

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

DNA methylation is a guardian of stem cell self-renewal and multipotency

(2009) Laurraine-Marcelle Gereige et al.   NATURE GENETICS

X Chromosome Dosage Compensation: How Mammals Keep the Balance

(2008) Bernhard Payer et al.   Annual Review of Genetics

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS