Article
Biochemistry & Molecular Biology
Joon Seok Lee, Gyeong Hwa Kim, Jong Ho Lee, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Keun Hur, Ho Yun Chung
Summary: In this study, miR-365a/b-3p was identified as a potential biomarker for hypertrophic scarring, suggesting its contribution to the formation of hypertrophic scars.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mengxia Ying, Yan Chen, Bo Yuan
Summary: This study found that LOXL1 is upregulated in HS tissues and TGF-beta 1-induced HSFs, and inhibition of LOXL1 effectively suppresses proliferation, migration, and ECM deposition of TGF-beta 1-induced HSFs by inactivating the Smad pathway. Targeting LOXL1 may hold potential therapeutic implications for the treatment of hypertrophic scars.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shuchen Gu, Xin Huang, Xiangwen Xu, Yunhan Liu, Yimin Khoong, Zewei Zhang, Haizhou Li, Yashan Gao, Tao Zan
Summary: The study confirmed the role of CSMD1 in hypertrophic scar and revealed that miR-190a-3p regulates fibroblast migration and FN1 secretion by targeting CSMD1. Furthermore, the knockdown of CSMD1 activated the JAK/STAT signaling pathway.
Review
Ophthalmology
Steven E. Wilson
Summary: This review highlights the interactions and regulatory roles of interleukin (IL)-1 and transforming growth factor (TGF) beta in the corneal wound healing process. Both systems play crucial roles in regulating cellular functions and gene expressions during the healing response to injuries or infections, and their coordinated downregulation is necessary to terminate the response and prevent fibrosis in the cornea. Understanding the IL-1 and TGF beta systems better can lead to improved approaches for controlling excessive healing responses and scarring corneal fibrosis caused by infections and injuries.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, Research & Experimental
Yun Li, Zhencheng Yu, Danyang Zhao, Dong Han
Summary: The study showed that corilagin has multiple effects on HSFs, including inhibition of collagen production, cell proliferation, cell migration, and suppression of HSF activation. Corilagin also significantly suppressed HS formation and collagen deposition in a rabbit ear scar model, as well as inhibited fibroblast proliferation and alpha-SMA expression in vivo. Additionally, western blot analysis revealed that corilagin downregulated the protein levels of TGF-beta 1 and TGF-beta receptor type I (TGF beta RI), thus affecting the levels of p-smad2/3, MMPs, and TIMP1.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Article
Cell Biology
You -Tien Tsai, Hsiang -Yuan Yeh, Chia -Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang
Summary: This study found that the transforming growth factor-beta (TGF-beta) plays a crucial role in vascular calcification (VC). The mechanism of TGF-beta's involvement in VC was investigated using experimental models and clinical specimens. The results revealed that TGF-beta 1 can regulate the occurrence and progression of VC by modulating the miR-378a-3p/CTGF signaling pathway at specific time points.
Article
Dermatology
Huanhuan Fei, Yao Qian, Tianyun Pan, Ying Wei, Yun Hu
Summary: Curcumin plays an anti-scar role through regulating fibroblast activation and tissue inflammation, providing scientific reference for the clinical use of curcumin in the treatment of hypertrophic scar.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Dandan Lin, Yi Sun, Yuzhu Wang, Di Yang, Min Shui, Yiming Wang, Ziyi Xue, Xiao Huang, Yan Zhang, Anshi Wu, Changwei Wei
Summary: Perioperative neurocognitive disorder (PND) is a common complication of surgery and anesthesia, especially in older patients. This study investigated the role of transforming growth factor beta 1 (TGF-β1) in microglial activation and cognitive dysfunction in a PND mouse model. The results showed that surgery and anesthesia led to decreased TGF-β1 expression, while exogenous TGF-β1 treatment attenuated microglial activation, reduced neuroinflammation, and improved cognitive function in PND mice. This study suggests that TGF-β1 may be a potential therapeutic target for preventing and treating PND.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Piotr Kmiec, Stephan Rosenkranz, Margarete Odenthal, Evren Caglayan
Summary: Angiotensin II, a major factor in cardiovascular disease, activates mediators that are involved in pathological cardiac remodeling. In this study, the effects of aldosterone and transforming growth factor beta-1 (TGF-beta-1) were investigated in an in vivo model. The findings suggest that aldosterone induces cardiac hypertrophy independently of TGF-beta-1, while both factors may converge in the signaling pathways related to fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jesmin Jahan, Ildamaris Monte De Oca, Brian Meissner, Shrinidh Joshi, Ahmad Maghrabi, Julio H. Quiroz-Olvera, Chrisitne Lopez-Yang, Stephen H. Bartelmez, Charles Garcia, Yagna P. Jarajapu
Summary: Aging with diabetes results in impaired vasoprotective functions and decreased NO generation in CD34(+) cells. This study finds that TGF-beta 1 is upregulated in diabetic CD34(+) cells and impairs NO generation via the TSP-1/CD47/NO pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Biochemistry & Molecular Biology
Jing Wang, Ming Zhao, Hongyun Zhang, Fangfang Yang, Liang Luo, Kuo Shen, Xujie Wang, Yan Li, Jian Zhang, Jinxin Zhang, Kejia Wang, Jin Li, Yunwei Wang, Dahai Hu, Yunshu Yang
Summary: This study reveals that KLF4 can inhibit fibrosis by suppressing the transdifferentiation of fibroblasts into myofibroblasts. The downregulation of KLF4 in hypertrophic scars suggests its potential regulatory role in scar formation. Additionally, KLF4 is associated with BMP4 in inhibiting skin fibrosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)