期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 11, 期 3, 页码 210-220出版社
SPRINGER
DOI: 10.1007/s12265-018-9789-x
关键词
Atherosclerosis; Coronary artery disease; Serumbiomarker; Cardiovascular diseases; Plaque rupture; Inflammation
资金
- Finnish Dental Society Apollonia
- Orion Research Foundation
- Lund University Hospital
- Academy of Finland [126650]
- Sigrid Juselius foundation
- Yrjo Jahnsson foundation
- Aulikki and Sakari Sohlberg foundation
- Helsinki University Hospital Research Foundation [TYH 2016251, TYH 2017251, Y1149SUL32]
- Lund University
Matrix metalloproteinase (MMP)-9 is crucial in atherosclerotic plaque rupture and tissue remodeling after a cardiac event. The balance between MMP-9 and endogenous inhibitor, tissue inhibitors of matrix metalloproteinase 1 (TIMP-1), is important in acute coronary syndrome (ACS). This is an age- and gender-matched case-control study of ACS (N = 669). Patients (45.7%) were resampled after recovery, and all were followed up for 6 years. The molecular forms of MMP-9 were investigated by gelatin zymography. Diagnostically, MMP-9 and the MMP-9/TIMP-1 molar ratio were associated with ACS (OR 5.81, 95% CI 2.65-12.76, and 4.96, 2.37-10.38). The MMP-9 concentrations decreased 49% during recovery (p < 0.001). The largest decrease of these biomarkers between acute and recovery phase (Delta MMP-9) protected the patients from major adverse cardiac events, especially the non-fatal events. The fatal events were associated with in vitro activatable MMP-9 levels (p = 0.028). Serum MMP-9 and the MMP-9/TIMP-1 molar ratio may be valuable in ACS diagnosis and prognosis. High serum MMP-9 activation potential is associated with poor cardiovascular outcome.
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