Article
Engineering, Biomedical
Can Liu, Lei Fan, Zhenming Tian, Huiquan Wen, Lei Zhou, Pengfei Guan, Yian Luo, Chuncheung Chan, Guoxin Tan, Chengyun Ning, Limin Rong, Bin Liu
Summary: Conductive scaffolds have shown therapeutic effects for patients with peripheral nerve injuries. The development of biocompatible electroconductive hydrogels has been proposed in this study, which can promote nerve repair and functional recovery.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Neurosciences
Tianhao Yu, Yingxi Xu, Muhammad Arslan Ahmad, Rabia Javed, Haruo Hagiwara, Xiaohong Tian
Summary: Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but their usability is reduced by inherent drawbacks. Exosomes, as key players in intercellular communication, have shown promising potential in treating peripheral nerve injury and enhancing the repairing capacity of nerve grafts.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Benjamin R. Slavin, Karim A. Sarhane, Nicholas von Guionneau, Phillip J. Hanwright, Chenhu Qiu, Hai-Quan Mao, Ahmet Hoke, Sami H. Tuffaha
Summary: IGF-1 shows promise as a therapeutic target for peripheral nerve injuries, with various administration approaches being investigated in the literature. However, further research is needed to determine the optimal dosage ranges for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Gonzalez, Miguel L. Allende
Summary: Wallerian degeneration is a genetically conserved mechanism where peripheral nervous system axons have a higher capacity to regenerate. The use of zebrafish larvae and time-lapse microscopy allows for monitoring of the regenerative process of peripheral nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Bo Jia, Wei Huang, Yu Wang, Peng Zhang, Zhiwei Wang, Ming Zheng, Tianbing Wang
Summary: The study revealed that Nogo protein promotes Schwann cell apoptosis and inhibits Schwann cell dedifferentiation following peripheral nerve injury, ultimately hindering peripheral nerve regeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Chunyi Jiang, Yan Lu, Ran Zhu, Ying Zong, Yuchen Huang, Dong Wang, Zhanyun Da, Bin Yu, Longxiang Shen, Qianqian Cao
Summary: Key metabolic enzymes regulate glucose, lipid, and amino acid metabolism for cellular energy needs and also play a role in nonmetabolic signaling pathways. The role of glycometabolism in peripheral nerve axon regeneration is not well understood. This study found that the up-regulation of Pyruvate dehydrogenase beta subunit (Pdhb), a key enzyme, at the early stage of peripheral nerve injury promotes axon regeneration. Pdhb relies on lactate for energy supply and affects gene expression through histone acetylation, thereby enhancing axon regeneration.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Ming-yue Tian, Yi-duo Yang, Wan-ting Qin, Bao-nian Liu, Fang-fang Mou, Jing Zhu, Hai-dong Guo, Shui-jin Shao
Summary: Although the benefits of electroacupuncture (EA) for peripheral nerve injury (PNI) are well accepted in clinical practice, the underlying mechanism remains incompletely elucidated. In our study, we observed that EA intervention led to a reduction in the expression of the long non-coding RNA growth-arrest-specific transcript 5 (GAS5) and an increased in miR-21 levels within the injured nerve, effectively promoting functional recovery and nerve regeneration following sciatic nerve injury (SNI). Consequently, the targeting of GAS5 by miR-21 represents a potential mechanism through which EA enhances reinnervation and functional restoration following SNI. Mechanistically, the GAS5/miR-21 axis can modulate the proliferation, migration, and apoptosis of SCs while potentially influencing the neurite growth of neurons.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Xiaobin Luo, Baolong Li, Dupiao Zhang, Hongyu Chen, Xijie Zhou, Chenglun Yao, Mazhar Ali Raza, Liang Wang, Nana Tang, Guotong Zheng, Hede Yan
Summary: The application of internal nerve splinting in nerve repair effectively prevents the formation of traumatic neuroma-in-continuity and inhibits neuropathic pain without affecting nerve regeneration in rats.
JOURNAL OF NEUROSURGERY
(2022)
Article
Immunology
Chunjie Liu, Dengxiang Liu, Xiaochong Zhang, Limin Hui, Lili Zhao
Summary: Appropriate levels of inflammation are necessary for nerve damage repair, but excessive inflammation can lead to immune cell activation and nerve degeneration. A multi-layer multifunctional nanofiber composite membrane of polycaprolactone (PCL) and amniotic membrane (AM) was used in this study. In vitro studies demonstrated that the PCL/AM composite promoted axon growth and neuron differentiation. This composite facilitated nerve regeneration, blocked scar tissue invasion, promoted macrophage recruitment and M2 polarization, and induced myelin sheath and axon regeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Yinying Shen, Zhangchun Cheng, Sailing Chen, Yunsong Zhang, Qi Chen, Sheng Yi
Summary: miR-29a-3p is up-regulated in injured sciatic nerves and inhibits Schwann cell proliferation and migration by negatively regulating PMP22. Injection of miR-29a-3p agomir hinders Schwann cell activities, delays axon elongation and myelination, and retards the functional recovery of injured nerves. This highlights the important role of miR-29a-3p/PMP22 in regulating Schwann cell phenotype following sciatic nerve injury and peripheral nerve regeneration.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Surgery
Jonathan I. Leckenby, Miranda A. Chacon, David Milek, Jeff W. Lichtman, Adriaan O. Grobbelaar
Summary: Two-stage free functional muscle transfers for long-standing facial palsy can have unpredictable results. This study investigated the impact of axonal count in autologous grafts on functional outcomes and found that higher axonal count resulted in a higher percentage of regeneration across neurorrhaphies.
JOURNAL OF SURGICAL RESEARCH
(2022)