Article
Oncology
Loreley Calvet, Odette Dos-Santos, Emmanuel Spanakis, Veronique Jean-Baptiste, Jean-Christophe Le Bail, Armelle Buzy, Pascal Paul, Christophe Henry, Sandrine Valence, Colette Dib, Jack Pollard, Sukhvinder Sidhu, Jurgen Moll, Laurent Debussche, Iris Valtingojer
Summary: Research shows that the activity of YAP1 is closely related to the maintenance of tumors in malignant pleural mesothelioma, and its downregulation can inhibit tumor growth and promote tumor regression.
Article
Oncology
Anne Marie Barrette, Halle Ronk, Tanvi Joshi, Zarmeen Mussa, Meenakshi Mehrotra, Alexandros Bouras, German Nudelman, Joe G. Jesu Raj, Dominique Bozec, William Lam, Jane Houldsworth, Raymund Yong, Elena Zaslavsky, Constantinos G. Hadjipanayis, Marc R. Birtwistle, Nadejda M. Tsankova
Summary: In this study, we used the FDA-approved drug Verteporfin (VP) to target YAP-TEAD activity in glioblastoma (GBM) models. The treatment showed efficacy in inhibiting invasion and proliferation, and had a survival benefit.
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Pathology
Xueyan Guo, Yulong Li, Bingbing Wan, Yifei Lv, Xue Wang, Guisheng Liu, Ping Wang
Summary: This study found that KAT7 is upregulated in gastric cancer and is associated with poor prognosis and metastasis. Overexpression of KAT7 promotes the growth, migration, and invasion of gastric cancer cells, and is involved in cell cycle distribution and epithelial-mesenchymal transition. Additionally, KAT7 promotes the transcription and nuclear translocation of YAP1, and silencing YAP1 partially reverses the promoting effect of KAT7 on gastric cancer cell progression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Qiang Guo, Mei-Yu Quan, Le Xu, Yaxin Cai, Jue-Ting Cai, Xue Li, Guifeng Feng, Aiping Chen, Weiwei Yang, Qhaweni Dhlamini, Tian-Fang Jiang, Chengguo Shen, Chengshui Chen, Jin-San Zhang
Summary: In this study, the functions and regulatory mechanisms of YAP1 isoforms YAP1-1 and YAP1-2 were investigated in EGF-induced EMT in non-small cell lung cancer (NSCLC). The results suggest that YAP1-2 is the main isoform that promotes EGF-induced EMT and NSCLC progression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xinran Qiao, Jingyu Lin, Jiajia Shen, Yang Chen, Liyun Zheng, Hangjiang Ren, Xiaoli Zhao, Hang Yang, Pengyu Li, Zhen Wang
Summary: FBXO28 is a crucial negative regulator of migration, invasion, and metastasis in HCC. It acts as an E3 ubiquitin ligase by directly binding to SNAI2 and degrading it through the ubiquitin proteasome system. Low FBXO28 or PRKACA expression is associated with poor prognosis in HCC patients.
Article
Medicine, Research & Experimental
Shurui Cai, Na Li, Xuetao Bai, Lu Liu, Ananya Banerjee, Kousalya Lavudi, Xiaoli Zhang, Jihe Zhao, Monica Venere, Wenrui Duan, Junran Zhang, Meng X. Welliver, Kai He, Qi-En Wang
Summary: This study revealed a potential mechanism of tumor relapse in non-small cell lung cancer after ERK inhibition through the activation of the epithelial-to-mesenchymal transition program and identified the therapeutic benefits of blocking the JAK/STAT pathway.
Article
Cell Biology
Qin Yu, Jianzhang Wang, Tiantian Li, Xinyue Guo, Shaojie Ding, Xuan Che, Libo Zhu, Yangying Peng, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: RON, a receptor tyrosine kinase, promotes endometriosis development by facilitating epithelial-mesenchymal transition (EMT) of endometrial epithelial cells. Inhibition or knockdown of RON expression suppresses the migration and invasion of endometrial epithelial cells. Targeting RON may offer a new therapeutic approach for endometriosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Veterinary Sciences
Shunsuke Noguchi, Asuka Matsui
Summary: This study aimed to investigate the molecular mechanisms underlying the migration and invasion of tonsillar squamous cell carcinoma (TSCC) cells. The study found that miR-203 expression was lower in TSCC tissues than in normal oral mucosa and non-tonsillar SCC (NTSCC) tissues. Transfection of miR-203 mimic inhibited cell migration and invasion in TSCC cells, but not in NTSCC cells. The study suggests that the miR-203/SLUG axis may be involved in the metastatic mechanisms of TSCC.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Pathology
Qi Qi, Chen Chen, Chang Liu, Bin Zhang, Yuchen Ma, Hua Zhang, Wuhao Huang, Changli Wang
Summary: The study demonstrated that linc8087 is downregulated in NSCLC and is significantly associated with poor survival. Overexpression of linc8087 inhibits cell migration and invasion, while its knockdown promotes cell migration and invasion. The findings suggest that linc8087 plays a key role in NSCLC progression and may serve as a meaningful prognostic biomarker and potential therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Wenqiang Zhang, Ruiyu Liu, Lin Zhang, Chao Wang, Ziyan Dong, Jiasheng Feng, Mayao Luo, Yifan Zhang, Zhuofan Xu, Shidong Lv, Qiang Wei
Summary: The study reveals that miR-335 has inhibitory effects in ccRCC, while overexpression of KDM3A promotes carcinogenesis and metastasis of ccRCC. YAP1 is identified as a direct downstream target of KDM3A. This discovery provides new potential targeting for metastatic ccRCC.
CANCER GENE THERAPY
(2022)
Article
Oncology
Shasha Zhu, Xiangbing Kong, Mengru Song, Mingyang Chi, Yitong Liu, Peng Zhang, Qiao Zhang, Pingping Shang, Feifei Feng
Summary: miR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.
Article
Gastroenterology & Hepatology
Jing Liu, Weiwei Bai, Tianxing Zhou, Yongjie Xie, Bo Yang, Jingyan Sun, Yifei Wang, Xueyang Li, Xupeng Hou, Ziyun Liu, Danqi Fu, Jingrui Yan, Wenna Jiang, Kaili Zhao, Bodong Zhou, Shuai Yuan, Yu Guo, Hongwei Wang, Antao Chang, Song Gao, Lei Shi, Chongbiao Huang, Shengyu Yang, Jihui Hao
Summary: This study identifies syntenin1 as a novel targetable factor in promoting PDAC tumour progression and explores a therapeutic strategy for suppressing its expression. High expression of syntenin1 is associated with shorter overall survival and recurrence-free survival rates in PDAC patients. Syntenin1 promotes PDAC proliferation and metastasis by inhibiting YAP1 degradation and interacts directly with YAP1. ZnPT could be a promising therapeutic strategy to inhibit PDAC progression by suppressing syntenin1.
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Yi-ning Wang, Jia-ming Ju, Azaliia Shabanova, Yue Li, Ruo-nan Fang, Jia-bin Sun, Ying-ying Guo, Tong-zhu Jin, Yan-yan Liu, Tian-yu Li, Hong-li Shan, Hai-hai Liang, Bao-feng Yang
Summary: Mzb1 plays a crucial role in cardiomyocytes post-MI by improving mitochondrial function and reducing inflammatory signaling pathways, suggesting it as a promising therapeutic target in ischemic cardiomyopathy.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jian Sun, Tongzhu Jin, Wei Su, Yingying Guo, Zhihui Niu, Jiayu Guo, Liangliang Li, Jiayi Wang, Lu Ma, Tong Yu, Xuelian Li, Yuhong Zhou, Hongli Shan, Haihai Liang
Summary: This study highlighted the crucial role of lncRNA PFI in mitigating pulmonary fibrosis by negatively regulating the expression and activity of SRSF1, reducing the formation of the EDA+Fn1 splicing isoform. These findings suggest that PFI and SRSF1 could be potential targets for the treatment of lung fibrosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Correction
Biochemistry & Molecular Biology
Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Cell Biology
Tingting Chen, Yingying Guo, Jiayi Wang, Liqiang Ai, Lu Ma, Wenxin He, Zhixin Li, Xiaojiang Yu, Jinrui Li, Xingxing Fan, Yunyan Gu, Haihai Liang
Summary: The study identified a key lncRNA, CTD-2528L19.6, that plays a critical role in regulating fibroblast activation in the progression of idiopathic pulmonary fibrosis (IPF). Results suggest that CTD-2528L19.6 may prevent the progression of IPF and alleviate fibroblast activation during the advanced-stage, providing potential new insights for IPF treatment.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Jinjing Wei, Yongting Zhao, Haihai Liang, Weijie Du, Lihong Wang
Summary: This article provides the most updated data on cell death in diabetic cardiomyopathy (DCM) and emphasizes the critical role of cell death in the pathophysiological process. It offers valuable insights and directions for future studies.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Wang, Tong Zhu, Zhangxiang Zhao, Bo Chen, Tingting Chen, Qi Dong, Mingyue Liu, Shuping Zhuang, Fan Yang, Yaoyao Liu, Min Yang, Yunyan Gu, Haihai Liang
Summary: The Hippo signaling pathway plays a crucial role in carcinogenesis, with downstream effector YAP1 being identified as potentially inhibiting CD8+ T cell infiltration in uterine corpus endometrial carcinoma by upregulating CREB1. Furthermore, esophageal carcinoma patients were classified into three subtypes based on a Hippo-immune gene panel, each with distinct characteristics in immune cell infiltration, immune pathways, and prognosis, suggesting a new classification of immune subtypes with prognostic implications in esophageal carcinoma.
Article
Chemistry, Multidisciplinary
Tian-yu Li, Wei Su, Liang-liang Li, Xiao-guang Zhao, Na Yang, Jia-xin Gai, Xin Lv, Jing Zhang, Meng-qin Huang, Qing Zhang, Wei-hang Ji, Xiao-ying Song, Yu-hong Zhou, Xue-lian Li, Hong-li Shan, Hai-hai Liang
Summary: Abnormal activation of cardiac fibroblasts is the main cause of cardiac fibrosis. This study reveals the important roles of platelet-activating factor (PAF) and the Hippo pathway in cardiac fibrosis. PAF induces fibrosis through activation of the effector YAP1 and promotes its nuclear translocation via PAFR interaction. Furthermore, YAP1 promotes the expression of PAFR. Inhibiting PAFR or YAP1 can impede cardiac fibrosis and improve cardiac function. These findings suggest the potential of PAFR/YAP1 as therapeutic targets for cardiac fibrosis.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Tingting Chen, Tong Yu, Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu, Yunyan Gu
Summary: This study developed a qualitative signature for detecting BRCAness in OvCa and showed that patients classified as BRCAness had improved overall survival and progression-free survival, as well as increased sensitivity to immune checkpoint blockade.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Yue Zhang, Zhiying Wang, Dingming Lan, Jingjing Zhao, Lexun Wang, Xiaoqi Shao, Dongwei Wang, Kaili Wu, Mengxian Sun, Xueying Huang, Meiling Yan, Haihai Liang, Xianglu Rong, Hongtao Diao, Jiao Guo
Summary: MiR-24-3p expression is downregulated in cardiac fibrosis and its forced expression can inhibit fibroblast proliferation and migration, as well as reduce collagen and alpha-SMA levels. MiR-24-3p can alleviate cardiac fibrosis by suppressing mitophagy and autophagic flux.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ya-Jia Xie, Min Huang, Dan Li, Jin-Cai Hou, Hai-Hai Liang, Ali Adnan Nasim, Ju-Min Huang, Chun Xie, Elaine Lai-Han Leung, Xing-Xing Fan
Summary: Bacteria-based immunotherapy combined with nanotechnology shows promise in enhancing the efficacy of cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jian Sun, Tongzhu Jin, Zhihui Niu, Jiayu Guo, Yingying Guo, Ruoxuan Yang, Qianqian Wang, Huiying Gao, Yuhan Zhang, Tianyu Li, Wenxin He, Zhixin Li, Wenchao Ma, Wei Su, Liangliang Li, Xingxing Fan, Hongli Shan, Haihai Liang
Summary: This study found that lncRNA DACH1 is downregulated in patients with pulmonary fibrosis and in a mouse model of the disease. LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Jian Sun, Yingying Guo, Tingting Chen, Tongzhu Jin, Lu Ma, Liqiang Ai, Jiayu Guo, Zhihui Niu, Ruoxuan Yang, Qianqian Wang, Xiaojiang Yu, Huiying Gao, Yuhan Zhang, Wei Su, Xiaoying Song, Weihang Ji, Qing Zhang, Mengqin Huang, Xingxing Fan, Zhimin Du, Haihai Liang
Summary: In this study, we identified TP53TG1 as a crucial lncRNA involved in the regulation of fibroblast activation and idiopathic pulmonary fibrosis (IPF). TP53TG1 overexpression inhibited fibroblast proliferation and differentiation, reduced the expression of IPF-related proteins, and prevented and reversed lung fibrosis. Mechanistically, TP53TG1 bound to MYH9 to suppress its protein expression and inhibit fibroblast activation.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Summary: This study found that Gankyrin is upregulated in non-small cell lung cancer (NSCLC) and plays a role in promoting cancer progression through the regulation of YAP1 and glycolysis. The inhibition of Gankyrin could potentially be a therapeutic strategy for NSCLC.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Qi Dong, Mingyue Liu, Bo Chen, Zhangxiang Zhao, Tingting Chen, Chengyu Wang, Shuping Zhuang, Yawei Li, Yuquan Wang, Liqiang Ai, Yaoyao Liu, Haihai Liang, Lishuang Qi, Yunyan Gu
Summary: PARP inhibitors are designed based on synthetic lethality, aiming to broaden patient benefits and overcome drug resistance. Genetic interactions, such as synthetic lethality and synthetic viability, play a role in drug response. By developing novel computational methods and utilizing functional screens, sensitive and resistant genes related to PARP inhibitors have been identified, providing new insights for precision therapeutics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)