Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Shan Huang, Jiayi Zhang, Yi Li, Yaqiong Xu, Hui Jia, Lei An, Xiaotan Wang, Yuting Yang
Summary: This study found that downregulation of Claudin5 promotes the malignant progression and radioresistance of ESCC through the activation of the Beclin1-autophagy pathway. Therefore, Claudin5 may serve as a promising biomarker for predicting radiotherapy response and patient outcome in ESCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: High expression of plasma exosomal HMGB1 is associated with an adverse radiotherapy response in ESCC patients. IR-induced exosomal HMGB1 enhances the radioresistance of ESCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Huandi Zhou, Guohui Wang, Zhiqing Xiao, Yu Yang, Zhesen Tian, Chen Gao, Xuetao Han, Wei Sun, Liubing Hou, Junling Liu, Xiaoying Xue
Summary: This study investigates the mechanism by which NRAGE enhances radioresistance of esophageal squamous cell carcinoma (ESCC) and identifies NRAGE nuclear accumulation as a key factor in radioresistance. The activation of the Wnt/β-catenin signaling pathway may be involved in this process. NRAGE nuclear expression could potentially serve as a biomarker for monitoring radiotherapeutic response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kan Jiang, Xin Yin, Qingyi Zhang, Jie Yin, Qiuying Tang, Mengyou Xu, Lingyun Wu, Yifan Shen, Ziyang Zhou, Hao Yu, Senxiang Yan
Summary: Radioresistance is a major challenge in esophageal squamous cell carcinoma (ESCC) radiotherapy, and this study identified STC2 as a potential predictor and facilitator of ESCC radioresistance. Increased STC2 expression in ESCC tissues was associated with poor prognosis. STC2 was found to interact with PRMT5 and activate it, leading to increased H4R3me2s expression. Moreover, STC2 promoted DNA damage repair and ferroptosis in a PRMT5-dependent manner.
Article
Biochemistry & Molecular Biology
Xuan Chen, Wenzhe Xu, Shichao Zhuo, Xue Chen, Pengxiang Chen, Shanghui Guan, Di Huang, Xiaozheng Sun, Yufeng Cheng
Summary: This study indicates that low expression of SNPH is a novel indicator of radioresistance in ESCC, and targeting SNPH could be a promising approach to enhance radiotherapeutic efficiency in patients with ESCC.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Fen Zhao, Hui Tian, Yungang Wang, Jianbo Zhang, Fang Liu, Lei Fu
Summary: This study reveals that SIGLEC9 expressed on TAMs in esophageal squamous cell carcinoma promotes radioresistance and the formation of immunosuppressive tumor microenvironment through interaction with MUC1.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei-Qun Ding, Jundong Zhou
Summary: TAB182 is identified as a key regulator of radiation sensitivity in ESCC cells, with its downregulation sensitizing cancer cells to ionizing radiation and overcoming radioresistance by interacting with FHL2 to modulate the G2-M checkpoint.
Article
Medicine, Research & Experimental
Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang, Hongbing Ma
Summary: In this study, miR-4443 was found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, providing a new perspective and clue to alleviate radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jinxian He, Gaofeng Liang, Hui Tian, Yiqing Wang, Li Yu, Wang Lv, Jian Hu, Weiyu Shen
Summary: In this study, 47 overlapping genes were identified by intersecting up-regulated genes, down-regulated genes, and Wnt signaling pathway-related genes in esophageal squamous cell carcinoma (ESCC). PRICKLE1 was determined to be an independent prognostic factor for ESCC, and its high expression was associated with better overall survival. Furthermore, experiments showed that overexpression of PRICKLE1 reduced cell viability, migration ability, and increased apoptosis rate in ESCC cells. Therefore, high expression of PRICKLE1 could be a potential molecular indicator for predicting the prognosis of ESCC and has potential applications in ESCC clinical treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
L. K. Kadian, M. Arora, C. P. Prasad, R. Pramanik, S. S. Chauhan
Summary: Esophageal cancer, particularly ESCC, is a highly lethal malignancy with limited treatment options. Understanding the molecular pathways and identifying novel therapeutic agents are crucial for improving the outcomes of ESCC patients. In this review, the key signaling pathways and their crosstalk during disease progression are discussed, providing insights into the potential targets for targeted cancer therapy in ESCC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen, Chaojie Wang, Songqiang Xie
Summary: This study found that NUAK1 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is associated with tumor invasion depth, lymph node metastasis, and poor prognosis. Moreover, NUAK1 promotes the migration and invasion of ESCC cells by activating the JNK/c-Jun/Slug signaling pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jiarui Yu, Wei Wang, Baolin Liu, Jinling Gu, Siyuan Chen, Yishuang Cui, Guogui Sun
Summary: T-96 inhibits the proliferation and migration of esophageal cancer cells through Wnt/beta-catenin pathway, leading to cell cycle arrest and apoptosis, providing a potential treatment for esophageal squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Rui Ma, Mei Shi, Jing Hu, Li-Na Zhao
Summary: SOCS6 deficiency in esophageal cancer cells leads to radioresistance by promoting radiation-induced G2/M arrest, DNA damage repair, and inhibiting apoptosis, which is partially dependent on p53 transcription. Lower expression of SOCS6 and P53 is correlated with radioresistant esophageal cancer tissues.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)