期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 10, 期 7, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a032284
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资金
- European Research Council [339778]
- Wellcome Trust Senior Investigator Award
- Cancer Research UK
- City University of Hong Kong Project [9610363, 7200520]
- Croucher Foundation Project [9500030]
- Hong Kong RGC Project [CityU 21302317, N_CityU110/17]
- European Research Council (ERC) [339778] Funding Source: European Research Council (ERC)
RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.
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