Review
Immunology
Pablo Mata-Martinez, Marta Bergon-Gutierrez, Carlos del Fresno
Summary: Dectin-1, a C-type lectin receptor, plays a crucial role in antifungal responses and immune memory. It recognizes various ligands and triggers different immune reactions. However, the underlying mechanisms of its involvement in trained immunity are not fully understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alice Hamilton, Raffaella Rizzo, Samuel Brod, Masahiro Ono, Mauro Perretti, Dianne Cooper, Fulvio D'Acquisto
Summary: Social isolation has a significant impact on the immune regulation of mice, enhancing their resistance to bacterial infection. Social housing and huddling behavior may be important factors in regulating the host immune response.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Wenny Santaniemi, Pirjo Astrom, Virpi Glumoff, Nora Pernaa, Ella-Noora Tallgren, Sanna Palosaari, Antti Nissinen, Meri Kaustio, Outi Kuismin, Janna Saarela, Katariina Nurmi, Kari K. Eklund, Mikko R. J. Seppanen, Timo Hautala
Summary: In this study, the impact of a heterozygous NFKB1 c.C936T/p.R157X LOF variant on immunity in sterile fasciitis patients and their family members was explored. The variant resulted in reduced p50 or p105 protein levels and elevated IL-1 beta and IL-8 levels, potentially contributing to the high neutrophil counts observed during fasciitis episodes. The variant also led to reduced phosphorylation of p65/RelA in neutrophils, suggesting defective activation of canonical NF-kappa B, and compromised oxidative burst following activation of NF-kappa B-dependent mechanisms.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Oncology
Holden T. Maecker
Summary: Understanding the interaction of SARS-CoV-2 infection with the host immune system, induction of antibody and T cell responses, importance of innate immune responses, and impact of baseline immune profiles and changes on predicting disease progression are crucial for the development of immune monitoring tools for COVID-19.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Carmen Picon, Amalia Tejeda-Velarde, Jose Ignacio Fernandez-Velasco, Manuel Comabella, Roberto Alvarez-Lafuente, Ester Quintana, Susana Sainz de la Maza, Enric Monreal, Noelia Villarrubia, Jose Carlos Alvarez-Cermeno, Maria Inmaculada Dominguez-Mozo, Lluis Ramio-Torrenta, Eulalia Rodriguez-Martin, Ernesto Roldan, Yolanda Aladro, Silvia Medina, Mercedes Espino, Jaime Masjuan, Clara Matute-Blanch, Marta Munoz-San Martin, Carmen Espejo, Carmen Guaza, Alfonso Muriel, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: Patients with multiple sclerosis (MS) undergo an early immunosenescence process with age, impacting treatment response and infection risks. Lipid-specific oligoclonal IgM bands (LS-OCMB) in MS patients may modify the immunological profile influenced by age. Additionally, age leads to changes in CSF levels of various molecules and cellular subsets, affecting disability in MS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
James S. Griffiths, P. Lewis White, Magdalena A. Czubala, Elena Simonazzi, Mariolina Bruno, Aiysha Thompson, Pierre J. Rizkallah, Mark Gurney, Diogo M. da Fonseca, Julian R. Naglik, Wendy Ingram, Keith Wilson, Frank L. van de Veerdonk, Rosemary Barnes, Philip R. Taylor, Selinda J. Orr
Summary: An immunocompromised patient was found to have a homozygous deletion mutation in the Dectin-2 receptor, resulting in a dysfunctional form of the receptor and an inability to mount a cytokine response to Aspergillus fumigatus. This first identified Dectin-2-deficient patient died of complications of invasive aspergillosis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Alex Kayongo, Nicole M. Robertson, Trishul Siddharthan, Moses Levi Ntayi, Josephine Caren Ndawula, Obondo J. Sande, Bernard S. Bagaya, Bruce Kirenga, Harriet Mayanja-Kizza, Moses L. Joloba, Sofia K. Forslund
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a major contributor to global mortality, with three million deaths reported annually. The impact is expected to increase, with approximately five million people predicted to die from COPD-related causes each year in the next 40 years. The immune mechanisms driving disease progression, as well as the relationship between airway microbiome changes and immune activation, remain unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Antony Hoarau, Myriam Polette, Christelle Coraux
Summary: Hyaluronic acid (HA) is a major component of the extracellular matrix with anti-inflammatory and immunomodulatory functions in the lungs. The size of HA determines its pro-inflammatory or anti-inflammatory effects. The interactions between HA and hyaladherins play a role in HA activities. LMW-HA is involved in pulmonary innate immunity by activating various cells, making it a potential therapeutic target for inflammatory respiratory diseases.
Article
Oncology
Melissa Prat, Kimberley Coulson, Clement Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Helene Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Melissa Parny, Jean-Pierre Delord, Gwenael Ferron, Lise Lefevre, Bettina Couderc, Agnes Coste
Summary: In this study, it was found that activation of PPARγ in treated small peritoneal macrophages can inhibit ovarian adenocarcinoma growth, regulate the proportion of immune cells, and attenuate the immunosuppressive properties of tumor-associated macrophages.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joanne Bowen, Courtney Cross
Summary: This review highlights the potential focus on innate immune response as a research area for understanding the pathogenesis of OM and developing interventions for patients undergoing radiotherapy and chemotherapy. Further investigation is needed into the contribution of barriers, pattern recognition systems, and microbial composition in early damage signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Claudia Molinaro, Mariangela Scalise, Isabella Leo, Luca Salerno, Jolanda Sabatino, Nadia Salerno, Salvatore De Rosa, Daniele Torella, Eleonora Cianflone, Fabiola Marino
Summary: There is growing interest in understanding the role of the immune system, particularly macrophages, in the response to cardiac injury and regeneration. Deciphering these mechanisms could lead to novel therapeutic strategies for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Elsa Anes, David Pires, Manoj Mandal, Jose Miguel Azevedo-Pereira
Summary: This review highlights the spatial localization of cathepsins and their implications in immune activation and resolution pathways during infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sander A. J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
Summary: An increasing number of patients develop non-traditional risk factor-induced myocardial infarction, and this study investigated the role of trained immunity in these patients. It was found that monocytes from patients with myocardial infarction had increased cytokine production capacity, particularly interleukin-10, which was associated with specific histone marks. Considering the lack of intervenable risk factors, trained immunity could be a promising target for future therapy.
Letter
Microbiology
Elena Gabrielli, Elena Roselletti, Eva Pericolini, Samuele Sabbatini, Anna Vecchiarelli, Antonio Cassone
Article
Multidisciplinary Sciences
Elena Roselletti, Stefano Perito, Elena Gabrielli, Antonella Mencacci, Eva Pericolini, Samuele Sabbatini, Antonio Cassone, Anna Vecchiarelli
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Elena Roselletti, Claudia Monari, Samuele Sabbatini, Stefano Perito, Anna Vecchiarelli, Jack D. Sobel, Antonio Cassone
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Infectious Diseases
Domenico Benvenuto, Silvia Angeletti, Marta Giovanetti, Martina Bianchi, Stefano Pascarella, Roberto Cauda, Massimo Ciccozzi, Antonio Cassone
JOURNAL OF INFECTION
(2020)
Editorial Material
Public, Environmental & Occupational Health
Antonio Cassone, Donatella Gucciardo, Roberto Cauda
PATHOGENS AND GLOBAL HEALTH
(2020)
Article
Virology
Domenico Benvenuto, Ayse Banu Demir, Marta Giovanetti, Martina Bianchi, Silvia Angeletti, Stefano Pascarella, Roberto Cauda, Massimo Ciccozzi, Antonio Cassone
JOURNAL OF MEDICAL VIROLOGY
(2020)
Article
Public, Environmental & Occupational Health
Antonio Cassone, Andrea Crisanti
Summary: After the outbreak of the epidemic, the two adjacent regions of Lombardy and Veneto in Italy adopted different control strategies, and Veneto's strategy of actively searching for asymptomatic infections resulted in better epidemic outcomes.
PATHOGENS AND GLOBAL HEALTH
(2021)
Article
Virology
Stefano Pascarella, Massimo Ciccozzi, Davide Zella, Martina Bianchi, Francesca Benetti, Domenico Benvenuto, Francesco Broccolo, Roberto Cauda, Arnaldo Caruso, Silvia Angeletti, Marta Giovanetti, Antonio Cassone
Summary: Lineage B.1.617+, also known as G/452R.V3 and denoted by WHO as delta and kappa, is a newly described SARS-CoV-2 variant first identified in India in October 2020. Three sublineages, B.1.617.1 (kappa), B.1.617.2 (delta), and B.1.617.3, have been identified, with their potential impact on the current pandemic under investigation. This variant with 13 amino acid changes, including E484Q, L452R, and P681R, is characterized by a significant alteration in the surface electrostatic potential of the spike protein receptor-binding domain, particularly noticeable in the delta sublineage. The enhanced electrostatic potential change may facilitate the interaction between the B.1.617+ RBD and the ACE2 receptor, potentially increasing virus transmission.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Public, Environmental & Occupational Health
Augusto Di Castelnuovo, Simona Costanzo, Antonio Cassone, Roberto Cauda, Giovanni De Gaetano, Licia Iacoviello
Summary: The study found that HCQ can reduce mortality in COVID-19 patients when used in lower doses, but the association is not significant in most cases. The use of HCQ+AZM may also reduce mortality risk, but more research is needed to confirm this.
PATHOGENS AND GLOBAL HEALTH
(2021)
Letter
Infectious Diseases
Stefano Pascarella, Massimo Ciccozzi, Martina Bianchi, Domenico Benvenuto, Roberto Cauda, Antonio Cassone
JOURNAL OF INFECTION
(2022)
Letter
Virology
Stefano Pascarella, Massimo Ciccozzi, Martina Bianchi, Domenico Benvenuto, Roberto Cauda, Antonio Cassone
JOURNAL OF MEDICAL VIROLOGY
(2022)
Editorial Material
Immunology
Antonio Cassone, Roberto Cauda
Article
Biochemistry & Molecular Biology
Stefano Pascarella, Massimo Ciccozzi, Martina Bianchi, Domenico Benvenuto, Marta Giovanetti, Roberto Cauda, Antonio Cassone
Summary: The Lambda variant of SARS-CoV-2, originating in Peru, has rapidly spread to South American regions and the US. Research suggests that mutations in the Spike protein of this variant may impact its ability to evade host immunity.
Article
Immunology
Antonio Cassone
PERTUSSIS INFECTION AND VACCINES: ADVANCES IN MICROBIOLOGY, INFECTIOUS DISEASES AND PUBLIC HEALTH, VOL 12
(2019)