Article
Gastroenterology & Hepatology
Akane Hara, Tomohiro Watanabe, Kosuke Minaga, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo
Summary: Research has found that interferon-alpha (IFN-alpha) and interleukin-33 (IL-33) serve as potential biomarkers for the diagnosis and monitoring of autoimmune pancreatitis (AIP) and immunoglobulin G4-related disease (IgG4-RD) activity after successful induction of remission. These biomarkers play a crucial role in identifying and treating these autoimmune disorders.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Medicine, General & Internal
Beuy Joob, Viroj Wiwanitkit
Summary: This letter to the editor discusses the publication on immunoglobulin G4 associated autoimmune cholangitis and pancreatitis following the administration of nivolumab, and raises and discusses concerns on confounding factors.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Gastroenterology & Hepatology
Guan-Zhou Zhou, Jia-Qi Zeng, Lei Wang, Miao Liu, Ke Meng, Zi-Kai Wang, Xiu-Li Zhang, Li-Hua Peng, Bin Yan, Fei Pan
Summary: This study compared the clinical features, treatment efficacy, and outcome of autoimmune pancreatitis (AIP) based on serum IgG4 levels and analyzed predictors of relapse. The study found that AIP patients with high IgG4 levels have a more active immune system and a higher relapse rate.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Xufeng Tao, Hong Xiang, Yue Pan, Dong Shang, Junchao Guo, Ge Gao, Gary Guishan Xiao
Summary: PDAC is a highly malignant lethal disease that is caused by pancreatitis and involves various pancreatic cells interacting in an inflammation-mediated microenvironment. Understanding the players and their interactions is crucial for the development of effective therapies.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ana Dugic, Cristina Verdejo Gil, Claudia Mellenthin, Miroslav Vujasinovic, J-Matthias Lohr, Steffen Muehldorfer
Summary: This systematic review examines the clinical utility of various serum biomarkers in diagnosing AIP, distinguishing it from pancreatic cancer, and predicting disease course, steroid therapy response, and relapse. Several autoantibodies and biomarkers, in addition to IgG4, show potential for AIP diagnosis and differentiation from pancreatic cancer.
Article
Medicine, Research & Experimental
Wenli Zhou, De Zhang, Zhengpeng Li, Huiqing Jiang, Jingnan Li, Rongrong Ren, Xuefeng Gao, Jianfeng Li, Xin Wang, Weifeng Wang, Yunsheng Yang
Summary: The study revealed significant alterations in fecal microbiota and butyrate in patients with PDAC, indicating a potential role of gut microbiota in the pathogenesis of PDAC. Fecal microbial and butyrate as potential biomarkers may facilitate the distinction of patients with PDAC from patients with AIP and healthy controls.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyeon Ha, Sang Hyun Choi, Jae Ho Byun, Kyung Won Kim, So Yeon Kim, Jin Hee Kim, Hyoung Jung Kim
Summary: This study systematically evaluated the diagnostic performance of CT and MRI in differentiating AIP from PDAC. The results showed that MRI had a higher sensitivity than CT, particularly in distinguishing focal AIP from PDAC.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Seung Bae Yoon, Tae Yeon Jeon, Sung-Hoon Moon, Sang Min Lee, Myung-Hwan Kim
Summary: This study aimed to identify reliable MRI features for differentiating autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC) and to summarize their diagnostic accuracy. The results showed that 16 informative MRI features were identified, with diffuse enlargement, capsule-like rim, multiple MPD strictures, and homogeneous delayed enhancement favoring AIP with the highest diagnostic odds ratios (DORs), while discrete mass and target type enhancement favored PDAC.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Bae Yoon, Tae Yeon Jeon, Sung-Hoon Moon, Dong Woo Shin, Sang Min Lee, Moon Hyung Choi, Ji Hye Min, Min-Jeong Kim
Summary: This study identified 11 CT characteristics that can help distinguish autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC). Enlarged pancreas, delayed homogeneous enhancement, and capsule-like rim were indicative of AIP, while discrete pancreatic mass suggested PDAC.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Jia Lu, Nannan Jiang, Yuqing Zhang, Daowei Li
Summary: The study aimed to develop and validate a CT-based radiomics nomogram for distinguishing between focal-type autoimmune pancreatitis and pancreatic ductal adenocarcinoma. The results showed that the model could accurately differentiate between the two diseases and had good sensitivity and specificity.
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Peter Macinga, Lukas Bajer, Marco Del Chiaro, Suresh T. Chari, Petr Dite, Luca Frulloni, Tsukasa Ikeura, Terumi Kamisawa, Kensuke Kubota, Itaru Naitoh, Kazuichi Okazaki, Raffaele Pezzilli, Miroslav Vujasinovic, Julius Spicak, Tomas Hucl, Matthias Lohr
Summary: Numerous cases of PDAC in AIP patients have been reported in the literature. PDAC is more frequent in AIP type 1 patients, typically metachronous in character, and generally found in the part of the pancreas affected by AIP.
Article
Medicine, General & Internal
Li Fen Tan, Rajalingham Sakthiswary, Uma Rajeswaran Veshaaliini, Syahrul Sazliyana Shaharir, Asrul Abdul Wahab, Suraya Aziz, Rosnah Sutan
Summary: This study suggests that elevated serum IgG4 may serve as a potential biomarker for disease activity and functional disability in rheumatoid arthritis (RA). The level of IgG4 is significantly correlated with disease activity, joint damage, and functional disability in RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Dimitri Poddighe
Summary: Despite the debate on the association between autoimmune pancreatitis (AIP) and pancreatic cancer, certain immunopathological aspects and immunosuppressive therapies may create a favorable environment for pancreatic carcinogenesis and progression.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jing Li, Fang Liu, Xu Fang, Kai Cao, Yinghao Meng, Hao Zhang, Jieyu Yu, Xiaochen Feng, Qi Li, Yanfang Liu, Li Wang, Hui Jiang, Chengwei Shao, Jianping Lu, Yun Bian
Summary: The study aimed to evaluate the diagnostic performance of the rad-score in differentiating fAIP from PDAC. A rad-score model was developed based on the analysis of MDCT images, which demonstrated high sensitivity and specificity in distinguishing fAIP from PDAC.
ACADEMIC RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Shih-Ching Lee, Chung-Han Yang, Che-Tzu Chang, Kuang-Hui Yu
Summary: This study examined the utility of serum immunoglobulin G4 (sIgG4) in differentiating between autoimmune pancreatitis (AIP) and pancreatic cancer (PC). Using pooled data from multiple studies, it was found that sIgG4 has moderate sensitivity and high specificity in distinguishing between AIP and PC. The analysis also suggests that the optimal cut-off value for sIgG4 is 140 mg/dL, rather than 280 mg/dL.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)