期刊
HPB
卷 20, 期 10, 页码 896-904出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.hpb.2018.05.001
关键词
-
资金
- National Natural Science Foundation of China [81660401]
- Natural Science Foundation of Jiangxi Province [20161BAB205242]
- Scientific Research Foundation of the Health and Family Planning Commission of Jiangxi Province [20155171]
Background: The aim of this systematic review and meta-analysis was to compare the clinical outcomes of central pancreatectomy (CP) with distal pancreatectomy (DP) and pancreaticoduodenectomy (PD). Methods: A systematic literature research in PubMed/Medline, Embase and Cochrane Library was performed to identify articles reporting CP from January 1983 to November 2017. Results: Fifty studies with 1305 patients undergoing CP were identified. The overall morbidity, mortality, pancreatic fistula (PF) rate and reoperation rate was 51%, 0.5%, 35% and 4% respectively. Endocrine and exocrine insufficiency were occurred in 4% and 5% of patients after CP. Meta-analysis of CP versus DP favored CP with regard to less blood loss (WMD = -143.4, P = 0.001), lower rates of endocrine (OR = 0.13, P < 0.001) and exocrine insufficiency (OR = 0.38, P < 0.001). CP was associated with higher morbidity and PF rate. In comparison with PD, CP had a lower risk of endocrine (OR = 0.14, P < 0.001) and exocrine insufficiency (OR = 0.14, P < 0.001), but a higher PF rate (OR = 1.6, P = 0.015). Conclusions: CP maintains pancreatic endocrine and exocrine function better than DP and PD, but is associated with a higher PF rate.
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